Universal influenza vaccines, science fiction or soon reality?
Identifieur interne : 001A47 ( Ncbi/Merge ); précédent : 001A46; suivant : 001A48Universal influenza vaccines, science fiction or soon reality?
Auteurs : Rory D. De Vries [Pays-Bas] ; Arwen F. Altenburg [Pays-Bas] ; Guus F. Rimmelzwaan [Pays-Bas]Source :
- Expert review of vaccines [ 1744-8395 ] ; 2015.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (immunologie), Antigènes viraux (immunologie), Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (), Grippe humaine (immunologie), Humains, Pandémies (), Protection croisée (immunologie), Protéines de la matrice virale (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Vaccins antigrippaux (immunologie), Variation des antigènes (immunologie).
- MESH :
- immunologie : Anticorps antiviraux, Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Protection croisée, Protéines de la matrice virale, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux, Variation des antigènes.
- Grippe humaine, Humains, Pandémies.
English descriptors
- KwdEn :
- Antibodies, Viral (immunology), Antigenic Variation (immunology), Antigens, Viral (immunology), Cross Protection (immunology), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Pandemics (prevention & control), Viral Matrix Proteins (immunology).
- MESH :
- chemical , immunology : Antibodies, Viral, Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Viral Matrix Proteins.
- immunology : Antigenic Variation, Cross Protection, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human.
- prevention & control : Influenza, Human, Pandemics.
- Humans.
Abstract
Currently used influenza vaccines are only effective when the vaccine strains match the epidemic strains antigenically. To this end, seasonal influenza vaccines must be updated almost annually. Furthermore, seasonal influenza vaccines fail to afford protection against antigenically distinct pandemic influenza viruses. Because of an ever-present threat of the next influenza pandemic and the continuous emergence of drift variants of seasonal influenza A viruses, there is a need for an universal influenza vaccine that induces protective immunity against all influenza A viruses. Here, we summarize some of the efforts that are ongoing to develop universal influenza vaccines.
DOI: 10.1586/14760584.2015.1060860
PubMed: 26104835
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To this end, seasonal influenza vaccines must be updated almost annually. Furthermore, seasonal influenza vaccines fail to afford protection against antigenically distinct pandemic influenza viruses. Because of an ever-present threat of the next influenza pandemic and the continuous emergence of drift variants of seasonal influenza A viruses, there is a need for an universal influenza vaccine that induces protective immunity against all influenza A viruses. Here, we summarize some of the efforts that are ongoing to develop universal influenza vaccines. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Vries</LastName><ForeName>Rory D</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>a Department of Viroscience, Erasmus Medical Center, P.O. 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De Vries</name></noRegion><name sortKey="Altenburg, Arwen F" sort="Altenburg, Arwen F" uniqKey="Altenburg A" first="Arwen F" last="Altenburg">Arwen F. Altenburg</name><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F" last="Rimmelzwaan">Guus F. Rimmelzwaan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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