Closely Related Influenza Viruses Induce Contrasting Respiratory Tract Immunopathology
Identifieur interne : 001742 ( Ncbi/Merge ); précédent : 001741; suivant : 001743Closely Related Influenza Viruses Induce Contrasting Respiratory Tract Immunopathology
Auteurs : Vy L. Le [États-Unis] ; Cynthia L. Courtney [États-Unis] ; John Steel [États-Unis] ; Richard W. Compans [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (métabolisme), Cellules myéloïdes (virologie), Cellules rénales canines Madin-Darby, Charge virale, Chiens, Chimiokines (métabolisme), Données de séquences moléculaires, Femelle, Maladies de l'appareil respiratoire (immunologie), Maladies de l'appareil respiratoire (métabolisme), Maladies de l'appareil respiratoire (virologie), Muqueuse respiratoire (immunologie), Muqueuse respiratoire (métabolisme), Muqueuse respiratoire (virologie), Réplication virale, Souris, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H1N1 du virus de la grippe A (pathogénicité), Sous-type H1N1 du virus de la grippe A (physiologie), Spécificité d'espèce, Séquence d'acides aminés.
- MESH :
- immunologie : Maladies de l'appareil respiratoire, Muqueuse respiratoire, Sous-type H1N1 du virus de la grippe A.
- métabolisme : Antigènes viraux, Chimiokines, Maladies de l'appareil respiratoire, Muqueuse respiratoire.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- physiologie : Sous-type H1N1 du virus de la grippe A.
- virologie : Cellules myéloïdes, Maladies de l'appareil respiratoire, Muqueuse respiratoire.
- Animaux, Cellules rénales canines Madin-Darby, Charge virale, Chiens, Données de séquences moléculaires, Femelle, Réplication virale, Souris, Sous-type H1N1 du virus de la grippe A, Spécificité d'espèce, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antigens, Viral (metabolism), Chemokines (metabolism), Dogs, Female, Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza A Virus, H1N1 Subtype (physiology), Madin Darby Canine Kidney Cells, Mice, Molecular Sequence Data, Myeloid Cells (virology), Respiratory Mucosa (immunology), Respiratory Mucosa (metabolism), Respiratory Mucosa (virology), Respiratory Tract Diseases (immunology), Respiratory Tract Diseases (metabolism), Respiratory Tract Diseases (virology), Species Specificity, Viral Load, Virus Replication.
- MESH :
- chemical , metabolism : Antigens, Viral, Chemokines.
- classification : Influenza A Virus, H1N1 Subtype.
- immunology : Influenza A Virus, H1N1 Subtype, Respiratory Mucosa, Respiratory Tract Diseases.
- metabolism : Respiratory Mucosa, Respiratory Tract Diseases.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- physiology : Influenza A Virus, H1N1 Subtype.
- virology : Myeloid Cells, Respiratory Mucosa, Respiratory Tract Diseases.
- Amino Acid Sequence, Animals, Dogs, Female, Madin Darby Canine Kidney Cells, Mice, Molecular Sequence Data, Species Specificity, Viral Load, Virus Replication.
Abstract
The swine-origin H1N1 virus which emerged in 2009 resulted in the first influenza pandemic of the 21st century. Although the majority of infections were moderate, a significant proportion of infections were severe and characterized by acute respiratory distress syndrome and pulmonary edema. We compared two isolates from the 2009 H1N1 pandemic; A/California/07/09 (CA/07) and A/Netherlands/602/09 (NL/602) viruses that share greater than 99% sequence identity. Though genetically similar, these viruses exhibit contrasting pathological effects. Mice that were infected with 800 plaque forming unit (PFU) of CA/07 virus rapidly lost weight, which was concurrent with detection of high pulmonary concentrations of MCP-1, MIG, IP-10 and TIMP-1. Initially, severe bronchiolar epithelial necrosis and acute respiratory distress was observed, followed by marked bronchiolar epithelial hyperplasia. Mononuclear cell infiltration was initially localized to perivascular and peribronchiolar interstitium and then spread to adjacent alveoli. Infiltrating cells were phenotypically CD11bhi, F4/80lo. In contrast, when mice were infected with 800 PFU of NL/602 virus, minimal weight loss was observed, and concentrations of cytokines in the lung were significantly lower. Inflammation was primarily restricted to the bronchioles and perivascular interstitium with minimal spread to alveoli. Infiltrating cells include foamy macrophages and surface markers were characterized as CD11blo/-, F4/80hi. These two genetically similar viruses can be useful strains with which to investigate immune-regulatory determinants of pathogenesis of influenza virus.
Url:
DOI: 10.1371/journal.pone.0076708
PubMed: 24086762
PubMed Central: 3784437
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D73
- to stream Pmc, to step Curation: 000D73
- to stream Pmc, to step Checkpoint: 000624
- to stream PubMed, to step Corpus: 000937
- to stream PubMed, to step Curation: 000937
- to stream PubMed, to step Checkpoint: 000A55
Links to Exploration step
PMC:3784437Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Closely Related Influenza Viruses Induce Contrasting Respiratory Tract Immunopathology</title>
<author><name sortKey="Le, Vy L" sort="Le, Vy L" uniqKey="Le V" first="Vy L." last="Le">Vy L. Le</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Courtney, Cynthia L" sort="Courtney, Cynthia L" uniqKey="Courtney C" first="Cynthia L." last="Courtney">Cynthia L. Courtney</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steel, John" sort="Steel, John" uniqKey="Steel J" first="John" last="Steel">John Steel</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24086762</idno>
<idno type="pmc">3784437</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784437</idno>
<idno type="RBID">PMC:3784437</idno>
<idno type="doi">10.1371/journal.pone.0076708</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000D73</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D73</idno>
<idno type="wicri:Area/Pmc/Curation">000D73</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D73</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000624</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000624</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:24086762</idno>
<idno type="wicri:Area/PubMed/Corpus">000937</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000937</idno>
<idno type="wicri:Area/PubMed/Curation">000937</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000937</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000A55</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A55</idno>
<idno type="wicri:Area/Ncbi/Merge">001742</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Closely Related Influenza Viruses Induce Contrasting Respiratory Tract Immunopathology</title>
<author><name sortKey="Le, Vy L" sort="Le, Vy L" uniqKey="Le V" first="Vy L." last="Le">Vy L. Le</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Courtney, Cynthia L" sort="Courtney, Cynthia L" uniqKey="Courtney C" first="Cynthia L." last="Courtney">Cynthia L. Courtney</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steel, John" sort="Steel, John" uniqKey="Steel J" first="John" last="Steel">John Steel</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antigens, Viral (metabolism)</term>
<term>Chemokines (metabolism)</term>
<term>Dogs</term>
<term>Female</term>
<term>Influenza A Virus, H1N1 Subtype (classification)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H1N1 Subtype (physiology)</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Myeloid Cells (virology)</term>
<term>Respiratory Mucosa (immunology)</term>
<term>Respiratory Mucosa (metabolism)</term>
<term>Respiratory Mucosa (virology)</term>
<term>Respiratory Tract Diseases (immunology)</term>
<term>Respiratory Tract Diseases (metabolism)</term>
<term>Respiratory Tract Diseases (virology)</term>
<term>Species Specificity</term>
<term>Viral Load</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antigènes viraux (métabolisme)</term>
<term>Cellules myéloïdes (virologie)</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Charge virale</term>
<term>Chiens</term>
<term>Chimiokines (métabolisme)</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Maladies de l'appareil respiratoire (immunologie)</term>
<term>Maladies de l'appareil respiratoire (métabolisme)</term>
<term>Maladies de l'appareil respiratoire (virologie)</term>
<term>Muqueuse respiratoire (immunologie)</term>
<term>Muqueuse respiratoire (métabolisme)</term>
<term>Muqueuse respiratoire (virologie)</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Sous-type H1N1 du virus de la grippe A ()</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
<term>Spécificité d'espèce</term>
<term>Séquence d'acides aminés</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Viral</term>
<term>Chemokines</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladies de l'appareil respiratoire</term>
<term>Muqueuse respiratoire</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Respiratory Mucosa</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Respiratory Mucosa</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes viraux</term>
<term>Chimiokines</term>
<term>Maladies de l'appareil respiratoire</term>
<term>Muqueuse respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules myéloïdes</term>
<term>Maladies de l'appareil respiratoire</term>
<term>Muqueuse respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Myeloid Cells</term>
<term>Respiratory Mucosa</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Dogs</term>
<term>Female</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Species Specificity</term>
<term>Viral Load</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Charge virale</term>
<term>Chiens</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Spécificité d'espèce</term>
<term>Séquence d'acides aminés</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The swine-origin H1N1 virus which emerged in 2009 resulted in the first influenza pandemic of the 21<sup>st</sup>
century. Although the majority of infections were moderate, a significant proportion of infections were severe and characterized by acute respiratory distress syndrome and pulmonary edema. We compared two isolates from the 2009 H1N1 pandemic; A/California/07/09 (CA/07) and A/Netherlands/602/09 (NL/602) viruses that share greater than 99% sequence identity. Though genetically similar, these viruses exhibit contrasting pathological effects. Mice that were infected with 800 plaque forming unit (PFU) of CA/07 virus rapidly lost weight, which was concurrent with detection of high pulmonary concentrations of MCP-1, MIG, IP-10 and TIMP-1. Initially, severe bronchiolar epithelial necrosis and acute respiratory distress was observed, followed by marked bronchiolar epithelial hyperplasia. Mononuclear cell infiltration was initially localized to perivascular and peribronchiolar interstitium and then spread to adjacent alveoli. Infiltrating cells were phenotypically CD11b<sup>hi</sup>
, F4/80<sup>lo</sup>
. In contrast, when mice were infected with 800 PFU of NL/602 virus, minimal weight loss was observed, and concentrations of cytokines in the lung were significantly lower. Inflammation was primarily restricted to the bronchioles and perivascular interstitium with minimal spread to alveoli. Infiltrating cells include foamy macrophages and surface markers were characterized as CD11b<sup>lo/-</sup>
, F4/80<sup>hi</sup>
. These two genetically similar viruses can be useful strains with which to investigate immune-regulatory determinants of pathogenesis of influenza virus.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Harvey, Ha" uniqKey="Harvey H">HA Harvey</name>
</author>
<author><name sortKey="Memoli, Mj" uniqKey="Memoli M">MJ Memoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baskin, Cr" uniqKey="Baskin C">CR Baskin</name>
</author>
<author><name sortKey="Bielefeldt Ohmann, H" uniqKey="Bielefeldt Ohmann H">H Bielefeldt-Ohmann</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Sabourin, Pj" uniqKey="Sabourin P">PJ Sabourin</name>
</author>
<author><name sortKey="Long, Jp" uniqKey="Long J">JP Long</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name>
</author>
<author><name sortKey="Simmons, Cp" uniqKey="Simmons C">CP Simmons</name>
</author>
<author><name sortKey="Thanh, Tt" uniqKey="Thanh T">TT Thanh</name>
</author>
<author><name sortKey="Hien, Vm" uniqKey="Hien V">VM Hien</name>
</author>
<author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Korteweg, C" uniqKey="Korteweg C">C Korteweg</name>
</author>
<author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name>
</author>
<author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name>
</author>
<author><name sortKey="Xiang, N" uniqKey="Xiang N">N Xiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perez Padilla, R" uniqKey="Perez Padilla R">R Perez-Padilla</name>
</author>
<author><name sortKey="De La Rosa Zamboni, D" uniqKey="De La Rosa Zamboni D">D de la Rosa-Zamboni</name>
</author>
<author><name sortKey="Ponce De Leon, S" uniqKey="Ponce De Leon S">S Ponce de Leon</name>
</author>
<author><name sortKey="Hernandez, M" uniqKey="Hernandez M">M Hernandez</name>
</author>
<author><name sortKey="Qui Ones Falconi, F" uniqKey="Qui Ones Falconi F">F Quiñones-Falconi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takiyama, A" uniqKey="Takiyama A">A Takiyama</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Tanino, M" uniqKey="Tanino M">M Tanino</name>
</author>
<author><name sortKey="Kimura, T" uniqKey="Kimura T">T Kimura</name>
</author>
<author><name sortKey="Kawagishi, N" uniqKey="Kawagishi N">N Kawagishi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
<author><name sortKey="Bertozzi, Sm" uniqKey="Bertozzi S">SM Bertozzi</name>
</author>
<author><name sortKey="Colchero, Ma" uniqKey="Colchero M">MA Colchero</name>
</author>
<author><name sortKey="Lopez Gatell, H" uniqKey="Lopez Gatell H">H Lopez-Gatell</name>
</author>
<author><name sortKey="Alpuche Aranda, C" uniqKey="Alpuche Aranda C">C Alpuche-Aranda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name>
</author>
<author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author><name sortKey="Shaw, Mw" uniqKey="Shaw M">MW Shaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Basler, Cf" uniqKey="Basler C">CF Basler</name>
</author>
<author><name sortKey="Aguilar, Pv" uniqKey="Aguilar P">PV Aguilar</name>
</author>
<author><name sortKey="Zeng, H" uniqKey="Zeng H">H Zeng</name>
</author>
<author><name sortKey="Sol Rzano, A" uniqKey="Sol Rzano A">A Solórzano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name>
</author>
<author><name sortKey="Swayne, De" uniqKey="Swayne D">DE Swayne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernandez Sesma, A" uniqKey="Fernandez Sesma A">A Fernandez-Sesma</name>
</author>
<author><name sortKey="Marukian, S" uniqKey="Marukian S">S Marukian</name>
</author>
<author><name sortKey="Ebersole, Bj" uniqKey="Ebersole B">BJ Ebersole</name>
</author>
<author><name sortKey="Kaminski, D" uniqKey="Kaminski D">D Kaminski</name>
</author>
<author><name sortKey="Park, Ms" uniqKey="Park M">MS Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name>
</author>
<author><name sortKey="Calvo, Pa" uniqKey="Calvo P">PA Calvo</name>
</author>
<author><name sortKey="Malide, D" uniqKey="Malide D">D Malide</name>
</author>
<author><name sortKey="Gibbs, J" uniqKey="Gibbs J">J Gibbs</name>
</author>
<author><name sortKey="Schubert, U" uniqKey="Schubert U">U Schubert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
<author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Chan, Wy" uniqKey="Chan W">WY Chan</name>
</author>
<author><name sortKey="Wong, Hk" uniqKey="Wong H">HK Wong</name>
</author>
<author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lycett, Sj" uniqKey="Lycett S">SJ Lycett</name>
</author>
<author><name sortKey="Ward, Mj" uniqKey="Ward M">MJ Ward</name>
</author>
<author><name sortKey="Lewis, Fi" uniqKey="Lewis F">FI Lewis</name>
</author>
<author><name sortKey="Poon, Af" uniqKey="Poon A">AF Poon</name>
</author>
<author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luk, J" uniqKey="Luk J">J Luk</name>
</author>
<author><name sortKey="Gross, P" uniqKey="Gross P">P Gross</name>
</author>
<author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, Wc" uniqKey="Yu W">WC Yu</name>
</author>
<author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Travanty, Ea" uniqKey="Travanty E">EA Travanty</name>
</author>
<author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name>
</author>
<author><name sortKey="Leijten, Lm" uniqKey="Leijten L">LM Leijten</name>
</author>
<author><name sortKey="Van Der Eerden, M" uniqKey="Van Der Eerden M">M van der Eerden</name>
</author>
<author><name sortKey="Hoogsteden, Hc" uniqKey="Hoogsteden H">HC Hoogsteden</name>
</author>
<author><name sortKey="Boven, La" uniqKey="Boven L">LA Boven</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="La Gruta, Nl" uniqKey="La Gruta N">NL La Gruta</name>
</author>
<author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name>
</author>
<author><name sortKey="Stambas, J" uniqKey="Stambas J">J Stambas</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name>
</author>
<author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name>
</author>
<author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name>
</author>
<author><name sortKey="Shu, B" uniqKey="Shu B">B Shu</name>
</author>
<author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Ebina, M" uniqKey="Ebina M">M Ebina</name>
</author>
<author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name>
</author>
<author><name sortKey="Ono, M" uniqKey="Ono M">M Ono</name>
</author>
<author><name sortKey="Kasai, N" uniqKey="Kasai N">N Kasai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name>
</author>
<author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name>
</author>
<author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name>
</author>
<author><name sortKey="Schrauwen, Ej" uniqKey="Schrauwen E">EJ Schrauwen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le, Tv" uniqKey="Le T">TV Le</name>
</author>
<author><name sortKey="Mironova, E" uniqKey="Mironova E">E Mironova</name>
</author>
<author><name sortKey="Garcin, D" uniqKey="Garcin D">D Garcin</name>
</author>
<author><name sortKey="Compans, Rw" uniqKey="Compans R">RW Compans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reed, Lj" uniqKey="Reed L">LJ Reed</name>
</author>
<author><name sortKey="Muench, H" uniqKey="Muench H">H Muench</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le, Tv" uniqKey="Le T">TV Le</name>
</author>
<author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name>
</author>
<author><name sortKey="Chaplin, Dd" uniqKey="Chaplin D">DD Chaplin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pica, N" uniqKey="Pica N">N Pica</name>
</author>
<author><name sortKey="Iyer, A" uniqKey="Iyer A">A Iyer</name>
</author>
<author><name sortKey="Ramos, I" uniqKey="Ramos I">I Ramos</name>
</author>
<author><name sortKey="Bouvier, Nm" uniqKey="Bouvier N">NM Bouvier</name>
</author>
<author><name sortKey="Fernandez Sesma, A" uniqKey="Fernandez Sesma A">A Fernandez-Sesma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, R" uniqKey="Xu R">R Xu</name>
</author>
<author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name>
</author>
<author><name sortKey="Mcbride, R" uniqKey="Mcbride R">R McBride</name>
</author>
<author><name sortKey="Nycholat, Cm" uniqKey="Nycholat C">CM Nycholat</name>
</author>
<author><name sortKey="Yu, W" uniqKey="Yu W">W Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Proll, Sc" uniqKey="Proll S">SC Proll</name>
</author>
<author><name sortKey="Carter, V" uniqKey="Carter V">V Carter</name>
</author>
<author><name sortKey="Perwitasari, O" uniqKey="Perwitasari O">O Perwitasari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arai, K" uniqKey="Arai K">K Arai</name>
</author>
<author><name sortKey="Liu, Zx" uniqKey="Liu Z">ZX Liu</name>
</author>
<author><name sortKey="Lane, T" uniqKey="Lane T">T Lane</name>
</author>
<author><name sortKey="Dennert, G" uniqKey="Dennert G">G Dennert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, W" uniqKey="Cao W">W Cao</name>
</author>
<author><name sortKey="Taylor, Ak" uniqKey="Taylor A">AK Taylor</name>
</author>
<author><name sortKey="Biber, Re" uniqKey="Biber R">RE Biber</name>
</author>
<author><name sortKey="Davis, Wg" uniqKey="Davis W">WG Davis</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hui, Kp" uniqKey="Hui K">KP Hui</name>
</author>
<author><name sortKey="Lee, Sm" uniqKey="Lee S">SM Lee</name>
</author>
<author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name>
</author>
<author><name sortKey="Ng, Ih" uniqKey="Ng I">IH Ng</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moore, Cs" uniqKey="Moore C">CS Moore</name>
</author>
<author><name sortKey="Crocker, Sj" uniqKey="Crocker S">SJ Crocker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neville, Lf" uniqKey="Neville L">LF Neville</name>
</author>
<author><name sortKey="Mathiak, G" uniqKey="Mathiak G">G Mathiak</name>
</author>
<author><name sortKey="Bagasra, O" uniqKey="Bagasra O">O Bagasra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Molinari, Na" uniqKey="Molinari N">NA Molinari</name>
</author>
<author><name sortKey="Ortega Sanchez, Ir" uniqKey="Ortega Sanchez I">IR Ortega-Sanchez</name>
</author>
<author><name sortKey="Messonnier, Ml" uniqKey="Messonnier M">ML Messonnier</name>
</author>
<author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name>
</author>
<author><name sortKey="Wortley, Pm" uniqKey="Wortley P">PM Wortley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanders, Cj" uniqKey="Sanders C">CJ Sanders</name>
</author>
<author><name sortKey="Vogel, P" uniqKey="Vogel P">P Vogel</name>
</author>
<author><name sortKey="Mcclaren, Jl" uniqKey="Mcclaren J">JL McClaren</name>
</author>
<author><name sortKey="Bajracharya, R" uniqKey="Bajracharya R">R Bajracharya</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herold, S" uniqKey="Herold S">S Herold</name>
</author>
<author><name sortKey="Steinmueller, M" uniqKey="Steinmueller M">M Steinmueller</name>
</author>
<author><name sortKey="Von Wulffen, W" uniqKey="Von Wulffen W">W von Wulffen</name>
</author>
<author><name sortKey="Cakarova, L" uniqKey="Cakarova L">L Cakarova</name>
</author>
<author><name sortKey="Pinto, R" uniqKey="Pinto R">R Pinto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanders, Cj" uniqKey="Sanders C">CJ Sanders</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
<author><name sortKey="Thomas, Pg" uniqKey="Thomas P">PG Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peranzoni, E" uniqKey="Peranzoni E">E Peranzoni</name>
</author>
<author><name sortKey="Zilio, S" uniqKey="Zilio S">S Zilio</name>
</author>
<author><name sortKey="Marigo, I" uniqKey="Marigo I">I Marigo</name>
</author>
<author><name sortKey="Dolcetti, L" uniqKey="Dolcetti L">L Dolcetti</name>
</author>
<author><name sortKey="Zanovello, P" uniqKey="Zanovello P">P Zanovello</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tate, Md" uniqKey="Tate M">MD Tate</name>
</author>
<author><name sortKey="Pickett, Dl" uniqKey="Pickett D">DL Pickett</name>
</author>
<author><name sortKey="Van Rooijen, N" uniqKey="Van Rooijen N">N van Rooijen</name>
</author>
<author><name sortKey="Brooks, Ag" uniqKey="Brooks A">AG Brooks</name>
</author>
<author><name sortKey="Reading, Pc" uniqKey="Reading P">PC Reading</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teijaro, Jr" uniqKey="Teijaro J">JR Teijaro</name>
</author>
<author><name sortKey="Walsh, Kb" uniqKey="Walsh K">KB Walsh</name>
</author>
<author><name sortKey="Cahalan, S" uniqKey="Cahalan S">S Cahalan</name>
</author>
<author><name sortKey="Fremgen, Dm" uniqKey="Fremgen D">DM Fremgen</name>
</author>
<author><name sortKey="Roberts, E" uniqKey="Roberts E">E Roberts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reading, Pc" uniqKey="Reading P">PC Reading</name>
</author>
<author><name sortKey="Whitney, Pg" uniqKey="Whitney P">PG Whitney</name>
</author>
<author><name sortKey="Pickett, Dl" uniqKey="Pickett D">DL Pickett</name>
</author>
<author><name sortKey="Tate, Md" uniqKey="Tate M">MD Tate</name>
</author>
<author><name sortKey="Brooks, Ag" uniqKey="Brooks A">AG Brooks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Basler, Cf" uniqKey="Basler C">CF Basler</name>
</author>
<author><name sortKey="Reid, Ah" uniqKey="Reid A">AH Reid</name>
</author>
<author><name sortKey="Dybing, Jk" uniqKey="Dybing J">JK Dybing</name>
</author>
<author><name sortKey="Janczewski, Ta" uniqKey="Janczewski T">TA Janczewski</name>
</author>
<author><name sortKey="Fanning, Tg" uniqKey="Fanning T">TG Fanning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Yu, Wc" uniqKey="Yu W">WC Yu</name>
</author>
<author><name sortKey="Ho, Cc" uniqKey="Ho C">CC Ho</name>
</author>
<author><name sortKey="Yuen, Km" uniqKey="Yuen K">KM Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peper, Rl" uniqKey="Peper R">RL Peper</name>
</author>
<author><name sortKey="Van Campen, H" uniqKey="Van Campen H">H Van Campen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marsolais, D" uniqKey="Marsolais D">D Marsolais</name>
</author>
<author><name sortKey="Hahm, B" uniqKey="Hahm B">B Hahm</name>
</author>
<author><name sortKey="Walsh, Kb" uniqKey="Walsh K">KB Walsh</name>
</author>
<author><name sortKey="Edelmann, Kh" uniqKey="Edelmann K">KH Edelmann</name>
</author>
<author><name sortKey="Mcgavern, D" uniqKey="Mcgavern D">D McGavern</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<double pmid="24086762"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Closely Related Influenza Viruses Induce Contrasting Respiratory Tract Immunopathology</title>
<author><name sortKey="Le, Vy L" sort="Le, Vy L" uniqKey="Le V" first="Vy L." last="Le">Vy L. Le</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Courtney, Cynthia L" sort="Courtney, Cynthia L" uniqKey="Courtney C" first="Cynthia L." last="Courtney">Cynthia L. Courtney</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steel, John" sort="Steel, John" uniqKey="Steel J" first="John" last="Steel">John Steel</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24086762</idno>
<idno type="pmc">3784437</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784437</idno>
<idno type="RBID">PMC:3784437</idno>
<idno type="doi">10.1371/journal.pone.0076708</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000D73</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D73</idno>
<idno type="wicri:Area/Pmc/Curation">000D73</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D73</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000624</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000624</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Closely Related Influenza Viruses Induce Contrasting Respiratory Tract Immunopathology</title>
<author><name sortKey="Le, Vy L" sort="Le, Vy L" uniqKey="Le V" first="Vy L." last="Le">Vy L. Le</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Courtney, Cynthia L" sort="Courtney, Cynthia L" uniqKey="Courtney C" first="Cynthia L." last="Courtney">Cynthia L. Courtney</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steel, John" sort="Steel, John" uniqKey="Steel J" first="John" last="Steel">John Steel</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The swine-origin H1N1 virus which emerged in 2009 resulted in the first influenza pandemic of the 21<sup>st</sup>
century. Although the majority of infections were moderate, a significant proportion of infections were severe and characterized by acute respiratory distress syndrome and pulmonary edema. We compared two isolates from the 2009 H1N1 pandemic; A/California/07/09 (CA/07) and A/Netherlands/602/09 (NL/602) viruses that share greater than 99% sequence identity. Though genetically similar, these viruses exhibit contrasting pathological effects. Mice that were infected with 800 plaque forming unit (PFU) of CA/07 virus rapidly lost weight, which was concurrent with detection of high pulmonary concentrations of MCP-1, MIG, IP-10 and TIMP-1. Initially, severe bronchiolar epithelial necrosis and acute respiratory distress was observed, followed by marked bronchiolar epithelial hyperplasia. Mononuclear cell infiltration was initially localized to perivascular and peribronchiolar interstitium and then spread to adjacent alveoli. Infiltrating cells were phenotypically CD11b<sup>hi</sup>
, F4/80<sup>lo</sup>
. In contrast, when mice were infected with 800 PFU of NL/602 virus, minimal weight loss was observed, and concentrations of cytokines in the lung were significantly lower. Inflammation was primarily restricted to the bronchioles and perivascular interstitium with minimal spread to alveoli. Infiltrating cells include foamy macrophages and surface markers were characterized as CD11b<sup>lo/-</sup>
, F4/80<sup>hi</sup>
. These two genetically similar viruses can be useful strains with which to investigate immune-regulatory determinants of pathogenesis of influenza virus.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Harvey, Ha" uniqKey="Harvey H">HA Harvey</name>
</author>
<author><name sortKey="Memoli, Mj" uniqKey="Memoli M">MJ Memoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baskin, Cr" uniqKey="Baskin C">CR Baskin</name>
</author>
<author><name sortKey="Bielefeldt Ohmann, H" uniqKey="Bielefeldt Ohmann H">H Bielefeldt-Ohmann</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Sabourin, Pj" uniqKey="Sabourin P">PJ Sabourin</name>
</author>
<author><name sortKey="Long, Jp" uniqKey="Long J">JP Long</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name>
</author>
<author><name sortKey="Simmons, Cp" uniqKey="Simmons C">CP Simmons</name>
</author>
<author><name sortKey="Thanh, Tt" uniqKey="Thanh T">TT Thanh</name>
</author>
<author><name sortKey="Hien, Vm" uniqKey="Hien V">VM Hien</name>
</author>
<author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Korteweg, C" uniqKey="Korteweg C">C Korteweg</name>
</author>
<author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name>
</author>
<author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name>
</author>
<author><name sortKey="Xiang, N" uniqKey="Xiang N">N Xiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perez Padilla, R" uniqKey="Perez Padilla R">R Perez-Padilla</name>
</author>
<author><name sortKey="De La Rosa Zamboni, D" uniqKey="De La Rosa Zamboni D">D de la Rosa-Zamboni</name>
</author>
<author><name sortKey="Ponce De Leon, S" uniqKey="Ponce De Leon S">S Ponce de Leon</name>
</author>
<author><name sortKey="Hernandez, M" uniqKey="Hernandez M">M Hernandez</name>
</author>
<author><name sortKey="Qui Ones Falconi, F" uniqKey="Qui Ones Falconi F">F Quiñones-Falconi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takiyama, A" uniqKey="Takiyama A">A Takiyama</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Tanino, M" uniqKey="Tanino M">M Tanino</name>
</author>
<author><name sortKey="Kimura, T" uniqKey="Kimura T">T Kimura</name>
</author>
<author><name sortKey="Kawagishi, N" uniqKey="Kawagishi N">N Kawagishi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
<author><name sortKey="Bertozzi, Sm" uniqKey="Bertozzi S">SM Bertozzi</name>
</author>
<author><name sortKey="Colchero, Ma" uniqKey="Colchero M">MA Colchero</name>
</author>
<author><name sortKey="Lopez Gatell, H" uniqKey="Lopez Gatell H">H Lopez-Gatell</name>
</author>
<author><name sortKey="Alpuche Aranda, C" uniqKey="Alpuche Aranda C">C Alpuche-Aranda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name>
</author>
<author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author><name sortKey="Shaw, Mw" uniqKey="Shaw M">MW Shaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Basler, Cf" uniqKey="Basler C">CF Basler</name>
</author>
<author><name sortKey="Aguilar, Pv" uniqKey="Aguilar P">PV Aguilar</name>
</author>
<author><name sortKey="Zeng, H" uniqKey="Zeng H">H Zeng</name>
</author>
<author><name sortKey="Sol Rzano, A" uniqKey="Sol Rzano A">A Solórzano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name>
</author>
<author><name sortKey="Swayne, De" uniqKey="Swayne D">DE Swayne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernandez Sesma, A" uniqKey="Fernandez Sesma A">A Fernandez-Sesma</name>
</author>
<author><name sortKey="Marukian, S" uniqKey="Marukian S">S Marukian</name>
</author>
<author><name sortKey="Ebersole, Bj" uniqKey="Ebersole B">BJ Ebersole</name>
</author>
<author><name sortKey="Kaminski, D" uniqKey="Kaminski D">D Kaminski</name>
</author>
<author><name sortKey="Park, Ms" uniqKey="Park M">MS Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name>
</author>
<author><name sortKey="Calvo, Pa" uniqKey="Calvo P">PA Calvo</name>
</author>
<author><name sortKey="Malide, D" uniqKey="Malide D">D Malide</name>
</author>
<author><name sortKey="Gibbs, J" uniqKey="Gibbs J">J Gibbs</name>
</author>
<author><name sortKey="Schubert, U" uniqKey="Schubert U">U Schubert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
<author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Chan, Wy" uniqKey="Chan W">WY Chan</name>
</author>
<author><name sortKey="Wong, Hk" uniqKey="Wong H">HK Wong</name>
</author>
<author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lycett, Sj" uniqKey="Lycett S">SJ Lycett</name>
</author>
<author><name sortKey="Ward, Mj" uniqKey="Ward M">MJ Ward</name>
</author>
<author><name sortKey="Lewis, Fi" uniqKey="Lewis F">FI Lewis</name>
</author>
<author><name sortKey="Poon, Af" uniqKey="Poon A">AF Poon</name>
</author>
<author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luk, J" uniqKey="Luk J">J Luk</name>
</author>
<author><name sortKey="Gross, P" uniqKey="Gross P">P Gross</name>
</author>
<author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, Wc" uniqKey="Yu W">WC Yu</name>
</author>
<author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Travanty, Ea" uniqKey="Travanty E">EA Travanty</name>
</author>
<author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name>
</author>
<author><name sortKey="Leijten, Lm" uniqKey="Leijten L">LM Leijten</name>
</author>
<author><name sortKey="Van Der Eerden, M" uniqKey="Van Der Eerden M">M van der Eerden</name>
</author>
<author><name sortKey="Hoogsteden, Hc" uniqKey="Hoogsteden H">HC Hoogsteden</name>
</author>
<author><name sortKey="Boven, La" uniqKey="Boven L">LA Boven</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="La Gruta, Nl" uniqKey="La Gruta N">NL La Gruta</name>
</author>
<author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name>
</author>
<author><name sortKey="Stambas, J" uniqKey="Stambas J">J Stambas</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name>
</author>
<author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name>
</author>
<author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name>
</author>
<author><name sortKey="Shu, B" uniqKey="Shu B">B Shu</name>
</author>
<author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Ebina, M" uniqKey="Ebina M">M Ebina</name>
</author>
<author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name>
</author>
<author><name sortKey="Ono, M" uniqKey="Ono M">M Ono</name>
</author>
<author><name sortKey="Kasai, N" uniqKey="Kasai N">N Kasai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name>
</author>
<author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name>
</author>
<author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name>
</author>
<author><name sortKey="Schrauwen, Ej" uniqKey="Schrauwen E">EJ Schrauwen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le, Tv" uniqKey="Le T">TV Le</name>
</author>
<author><name sortKey="Mironova, E" uniqKey="Mironova E">E Mironova</name>
</author>
<author><name sortKey="Garcin, D" uniqKey="Garcin D">D Garcin</name>
</author>
<author><name sortKey="Compans, Rw" uniqKey="Compans R">RW Compans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reed, Lj" uniqKey="Reed L">LJ Reed</name>
</author>
<author><name sortKey="Muench, H" uniqKey="Muench H">H Muench</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le, Tv" uniqKey="Le T">TV Le</name>
</author>
<author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name>
</author>
<author><name sortKey="Chaplin, Dd" uniqKey="Chaplin D">DD Chaplin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pica, N" uniqKey="Pica N">N Pica</name>
</author>
<author><name sortKey="Iyer, A" uniqKey="Iyer A">A Iyer</name>
</author>
<author><name sortKey="Ramos, I" uniqKey="Ramos I">I Ramos</name>
</author>
<author><name sortKey="Bouvier, Nm" uniqKey="Bouvier N">NM Bouvier</name>
</author>
<author><name sortKey="Fernandez Sesma, A" uniqKey="Fernandez Sesma A">A Fernandez-Sesma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, R" uniqKey="Xu R">R Xu</name>
</author>
<author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name>
</author>
<author><name sortKey="Mcbride, R" uniqKey="Mcbride R">R McBride</name>
</author>
<author><name sortKey="Nycholat, Cm" uniqKey="Nycholat C">CM Nycholat</name>
</author>
<author><name sortKey="Yu, W" uniqKey="Yu W">W Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Proll, Sc" uniqKey="Proll S">SC Proll</name>
</author>
<author><name sortKey="Carter, V" uniqKey="Carter V">V Carter</name>
</author>
<author><name sortKey="Perwitasari, O" uniqKey="Perwitasari O">O Perwitasari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arai, K" uniqKey="Arai K">K Arai</name>
</author>
<author><name sortKey="Liu, Zx" uniqKey="Liu Z">ZX Liu</name>
</author>
<author><name sortKey="Lane, T" uniqKey="Lane T">T Lane</name>
</author>
<author><name sortKey="Dennert, G" uniqKey="Dennert G">G Dennert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, W" uniqKey="Cao W">W Cao</name>
</author>
<author><name sortKey="Taylor, Ak" uniqKey="Taylor A">AK Taylor</name>
</author>
<author><name sortKey="Biber, Re" uniqKey="Biber R">RE Biber</name>
</author>
<author><name sortKey="Davis, Wg" uniqKey="Davis W">WG Davis</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hui, Kp" uniqKey="Hui K">KP Hui</name>
</author>
<author><name sortKey="Lee, Sm" uniqKey="Lee S">SM Lee</name>
</author>
<author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name>
</author>
<author><name sortKey="Ng, Ih" uniqKey="Ng I">IH Ng</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moore, Cs" uniqKey="Moore C">CS Moore</name>
</author>
<author><name sortKey="Crocker, Sj" uniqKey="Crocker S">SJ Crocker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neville, Lf" uniqKey="Neville L">LF Neville</name>
</author>
<author><name sortKey="Mathiak, G" uniqKey="Mathiak G">G Mathiak</name>
</author>
<author><name sortKey="Bagasra, O" uniqKey="Bagasra O">O Bagasra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Molinari, Na" uniqKey="Molinari N">NA Molinari</name>
</author>
<author><name sortKey="Ortega Sanchez, Ir" uniqKey="Ortega Sanchez I">IR Ortega-Sanchez</name>
</author>
<author><name sortKey="Messonnier, Ml" uniqKey="Messonnier M">ML Messonnier</name>
</author>
<author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name>
</author>
<author><name sortKey="Wortley, Pm" uniqKey="Wortley P">PM Wortley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanders, Cj" uniqKey="Sanders C">CJ Sanders</name>
</author>
<author><name sortKey="Vogel, P" uniqKey="Vogel P">P Vogel</name>
</author>
<author><name sortKey="Mcclaren, Jl" uniqKey="Mcclaren J">JL McClaren</name>
</author>
<author><name sortKey="Bajracharya, R" uniqKey="Bajracharya R">R Bajracharya</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herold, S" uniqKey="Herold S">S Herold</name>
</author>
<author><name sortKey="Steinmueller, M" uniqKey="Steinmueller M">M Steinmueller</name>
</author>
<author><name sortKey="Von Wulffen, W" uniqKey="Von Wulffen W">W von Wulffen</name>
</author>
<author><name sortKey="Cakarova, L" uniqKey="Cakarova L">L Cakarova</name>
</author>
<author><name sortKey="Pinto, R" uniqKey="Pinto R">R Pinto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanders, Cj" uniqKey="Sanders C">CJ Sanders</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
<author><name sortKey="Thomas, Pg" uniqKey="Thomas P">PG Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peranzoni, E" uniqKey="Peranzoni E">E Peranzoni</name>
</author>
<author><name sortKey="Zilio, S" uniqKey="Zilio S">S Zilio</name>
</author>
<author><name sortKey="Marigo, I" uniqKey="Marigo I">I Marigo</name>
</author>
<author><name sortKey="Dolcetti, L" uniqKey="Dolcetti L">L Dolcetti</name>
</author>
<author><name sortKey="Zanovello, P" uniqKey="Zanovello P">P Zanovello</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tate, Md" uniqKey="Tate M">MD Tate</name>
</author>
<author><name sortKey="Pickett, Dl" uniqKey="Pickett D">DL Pickett</name>
</author>
<author><name sortKey="Van Rooijen, N" uniqKey="Van Rooijen N">N van Rooijen</name>
</author>
<author><name sortKey="Brooks, Ag" uniqKey="Brooks A">AG Brooks</name>
</author>
<author><name sortKey="Reading, Pc" uniqKey="Reading P">PC Reading</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teijaro, Jr" uniqKey="Teijaro J">JR Teijaro</name>
</author>
<author><name sortKey="Walsh, Kb" uniqKey="Walsh K">KB Walsh</name>
</author>
<author><name sortKey="Cahalan, S" uniqKey="Cahalan S">S Cahalan</name>
</author>
<author><name sortKey="Fremgen, Dm" uniqKey="Fremgen D">DM Fremgen</name>
</author>
<author><name sortKey="Roberts, E" uniqKey="Roberts E">E Roberts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reading, Pc" uniqKey="Reading P">PC Reading</name>
</author>
<author><name sortKey="Whitney, Pg" uniqKey="Whitney P">PG Whitney</name>
</author>
<author><name sortKey="Pickett, Dl" uniqKey="Pickett D">DL Pickett</name>
</author>
<author><name sortKey="Tate, Md" uniqKey="Tate M">MD Tate</name>
</author>
<author><name sortKey="Brooks, Ag" uniqKey="Brooks A">AG Brooks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Basler, Cf" uniqKey="Basler C">CF Basler</name>
</author>
<author><name sortKey="Reid, Ah" uniqKey="Reid A">AH Reid</name>
</author>
<author><name sortKey="Dybing, Jk" uniqKey="Dybing J">JK Dybing</name>
</author>
<author><name sortKey="Janczewski, Ta" uniqKey="Janczewski T">TA Janczewski</name>
</author>
<author><name sortKey="Fanning, Tg" uniqKey="Fanning T">TG Fanning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Yu, Wc" uniqKey="Yu W">WC Yu</name>
</author>
<author><name sortKey="Ho, Cc" uniqKey="Ho C">CC Ho</name>
</author>
<author><name sortKey="Yuen, Km" uniqKey="Yuen K">KM Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peper, Rl" uniqKey="Peper R">RL Peper</name>
</author>
<author><name sortKey="Van Campen, H" uniqKey="Van Campen H">H Van Campen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marsolais, D" uniqKey="Marsolais D">D Marsolais</name>
</author>
<author><name sortKey="Hahm, B" uniqKey="Hahm B">B Hahm</name>
</author>
<author><name sortKey="Walsh, Kb" uniqKey="Walsh K">KB Walsh</name>
</author>
<author><name sortKey="Edelmann, Kh" uniqKey="Edelmann K">KH Edelmann</name>
</author>
<author><name sortKey="Mcgavern, D" uniqKey="Mcgavern D">D McGavern</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Closely related influenza viruses induce contrasting respiratory tract immunopathology.</title>
<author><name sortKey="Le, Vy L" sort="Le, Vy L" uniqKey="Le V" first="Vy L" last="Le">Vy L. Le</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Courtney, Cynthia L" sort="Courtney, Cynthia L" uniqKey="Courtney C" first="Cynthia L" last="Courtney">Cynthia L. Courtney</name>
</author>
<author><name sortKey="Steel, John" sort="Steel, John" uniqKey="Steel J" first="John" last="Steel">John Steel</name>
</author>
<author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W" last="Compans">Richard W. Compans</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:24086762</idno>
<idno type="pmid">24086762</idno>
<idno type="doi">10.1371/journal.pone.0076708</idno>
<idno type="wicri:Area/PubMed/Corpus">000937</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000937</idno>
<idno type="wicri:Area/PubMed/Curation">000937</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000937</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000A55</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A55</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Closely related influenza viruses induce contrasting respiratory tract immunopathology.</title>
<author><name sortKey="Le, Vy L" sort="Le, Vy L" uniqKey="Le V" first="Vy L" last="Le">Vy L. Le</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Courtney, Cynthia L" sort="Courtney, Cynthia L" uniqKey="Courtney C" first="Cynthia L" last="Courtney">Cynthia L. Courtney</name>
</author>
<author><name sortKey="Steel, John" sort="Steel, John" uniqKey="Steel J" first="John" last="Steel">John Steel</name>
</author>
<author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W" last="Compans">Richard W. Compans</name>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antigens, Viral (metabolism)</term>
<term>Chemokines (metabolism)</term>
<term>Dogs</term>
<term>Female</term>
<term>Influenza A Virus, H1N1 Subtype (classification)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H1N1 Subtype (physiology)</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Myeloid Cells (virology)</term>
<term>Respiratory Mucosa (immunology)</term>
<term>Respiratory Mucosa (metabolism)</term>
<term>Respiratory Mucosa (virology)</term>
<term>Respiratory Tract Diseases (immunology)</term>
<term>Respiratory Tract Diseases (metabolism)</term>
<term>Respiratory Tract Diseases (virology)</term>
<term>Species Specificity</term>
<term>Viral Load</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antigènes viraux (métabolisme)</term>
<term>Cellules myéloïdes (virologie)</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Charge virale</term>
<term>Chiens</term>
<term>Chimiokines (métabolisme)</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Maladies de l'appareil respiratoire (immunologie)</term>
<term>Maladies de l'appareil respiratoire (métabolisme)</term>
<term>Maladies de l'appareil respiratoire (virologie)</term>
<term>Muqueuse respiratoire (immunologie)</term>
<term>Muqueuse respiratoire (métabolisme)</term>
<term>Muqueuse respiratoire (virologie)</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Sous-type H1N1 du virus de la grippe A ()</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
<term>Spécificité d'espèce</term>
<term>Séquence d'acides aminés</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Viral</term>
<term>Chemokines</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladies de l'appareil respiratoire</term>
<term>Muqueuse respiratoire</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Respiratory Mucosa</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Respiratory Mucosa</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes viraux</term>
<term>Chimiokines</term>
<term>Maladies de l'appareil respiratoire</term>
<term>Muqueuse respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules myéloïdes</term>
<term>Maladies de l'appareil respiratoire</term>
<term>Muqueuse respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Myeloid Cells</term>
<term>Respiratory Mucosa</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Dogs</term>
<term>Female</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Species Specificity</term>
<term>Viral Load</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Charge virale</term>
<term>Chiens</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Spécificité d'espèce</term>
<term>Séquence d'acides aminés</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The swine-origin H1N1 virus which emerged in 2009 resulted in the first influenza pandemic of the 21(st) century. Although the majority of infections were moderate, a significant proportion of infections were severe and characterized by acute respiratory distress syndrome and pulmonary edema. We compared two isolates from the 2009 H1N1 pandemic; A/California/07/09 (CA/07) and A/Netherlands/602/09 (NL/602) viruses that share greater than 99% sequence identity. Though genetically similar, these viruses exhibit contrasting pathological effects. Mice that were infected with 800 plaque forming unit (PFU) of CA/07 virus rapidly lost weight, which was concurrent with detection of high pulmonary concentrations of MCP-1, MIG, IP-10 and TIMP-1. Initially, severe bronchiolar epithelial necrosis and acute respiratory distress was observed, followed by marked bronchiolar epithelial hyperplasia. Mononuclear cell infiltration was initially localized to perivascular and peribronchiolar interstitium and then spread to adjacent alveoli. Infiltrating cells were phenotypically CD11b(hi), F4/80(lo). In contrast, when mice were infected with 800 PFU of NL/602 virus, minimal weight loss was observed, and concentrations of cytokines in the lung were significantly lower. Inflammation was primarily restricted to the bronchioles and perivascular interstitium with minimal spread to alveoli. Infiltrating cells include foamy macrophages and surface markers were characterized as CD11b(lo/-), F4/80(hi). These two genetically similar viruses can be useful strains with which to investigate immune-regulatory determinants of pathogenesis of influenza virus.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001742 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001742 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:3784437 |texte= Closely Related Influenza Viruses Induce Contrasting Respiratory Tract Immunopathology }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:24086762" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a PandemieGrippaleV1
![]() | This area was generated with Dilib version V0.6.34. | ![]() |