PandemieGrippaleV1, Ncbi, Merge, bibRecord, 001002

T Cell Responses during Influenza Infection: Getting and Keeping Control

Identifieur interne : 001002 ( Ncbi/Merge ); précédent : 001001; suivant : 001003

T Cell Responses during Influenza Infection: Getting and Keeping Control

Auteurs : Taeg S. Kim [États-Unis] ; Jie Sun [États-Unis] ; Thomas J. Braciale [États-Unis]

Source :

Trends in immunology [ 1471-4906 ] ; 2011.

RBID : PMC:3090469

Descripteurs français

KwdFr :
- Activation des lymphocytes (immunologie), Animaux, Cellules dendritiques (immunologie), Cellules présentatrices d'antigène (immunologie), Grippe humaine (immunologie), Grippe humaine (virologie), Humains, Immunité acquise, Inflammation (immunologie), Lymphocytes T (immunologie), Poumon (immunologie), Poumon (virologie), Souris, Virus de la grippe A (immunologie).
MESH :
- immunologie : Activation des lymphocytes, Cellules dendritiques, Cellules présentatrices d'antigène, Grippe humaine, Inflammation, Lymphocytes T, Poumon, Virus de la grippe A.
- virologie : Grippe humaine, Poumon.
- Animaux, Humains, Immunité acquise, Souris.

English descriptors

KwdEn :
- Adaptive Immunity, Animals, Antigen-Presenting Cells (immunology), Dendritic Cells (immunology), Humans, Inflammation (immunology), Influenza A virus (immunology), Influenza, Human (immunology), Influenza, Human (virology), Lung (immunology), Lung (virology), Lymphocyte Activation (immunology), Mice, T-Lymphocytes (immunology).
MESH :
- immunology : Antigen-Presenting Cells, Dendritic Cells, Inflammation, Influenza A virus, Influenza, Human, Lung, Lymphocyte Activation, T-Lymphocytes.
- virology : Influenza, Human, Lung.
- Adaptive Immunity, Animals, Humans, Mice.

Abstract

The 2009 influenza pandemic highlights the threat that type A influenza poses to human health. Thus there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to both virus elimination and the development of lung injury. This review focuses on the T cell arm of the adaptive host immune response to influenza and assesses recent developments in our understanding of the induction of primary influenza virus-specific T cell responses by antigen-presenting cells, the interaction of activated effector T cells with antigen-bearing cells in the infected lungs, and the contribution of influenza-specific effector T cells to the development and control of lung injury and inflammation during infection.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090469

DOI: 10.1016/j.it.2011.02.006
PubMed: 21435950
PubMed Central: 3090469

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Links to Exploration step

PMC:3090469

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">T cell responses during influenza infection: getting and keeping control.</title>
<author><name sortKey="Kim, Taeg S" sort="Kim, Taeg S" uniqKey="Kim T" first="Taeg S" last="Kim">Taeg S. Kim</name>
<affiliation wicri:level="2"><nlm:affiliation>Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, Jie" sort="Sun, Jie" uniqKey="Sun J" first="Jie" last="Sun">Jie Sun</name>
</author>
<author><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J" last="Braciale">Thomas J. Braciale</name>
</author>
</analytic>
<series><title level="j">Trends in immunology</title>
<idno type="eISSN">1471-4981</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptive Immunity</term>
<term>Animals</term>
<term>Antigen-Presenting Cells (immunology)</term>
<term>Dendritic Cells (immunology)</term>
<term>Humans</term>
<term>Inflammation (immunology)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (virology)</term>
<term>Lung (immunology)</term>
<term>Lung (virology)</term>
<term>Lymphocyte Activation (immunology)</term>
<term>Mice</term>
<term>T-Lymphocytes (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term>
<term>Animaux</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules présentatrices d'antigène (immunologie)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Immunité acquise</term>
<term>Inflammation (immunologie)</term>
<term>Lymphocytes T (immunologie)</term>
<term>Poumon (immunologie)</term>
<term>Poumon (virologie)</term>
<term>Souris</term>
<term>Virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Cellules dendritiques</term>
<term>Cellules présentatrices d'antigène</term>
<term>Grippe humaine</term>
<term>Inflammation</term>
<term>Lymphocytes T</term>
<term>Poumon</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antigen-Presenting Cells</term>
<term>Dendritic Cells</term>
<term>Inflammation</term>
<term>Influenza A virus</term>
<term>Influenza, Human</term>
<term>Lung</term>
<term>Lymphocyte Activation</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adaptive Immunity</term>
<term>Animals</term>
<term>Humans</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Immunité acquise</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The 2009 influenza pandemic highlighted the threat that type A influenza poses to human health. Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to virus elimination and the development of lung injury. This review focuses on the T cell arm of the adaptive host immune response to influenza. We assess recent developments in the understanding of how primary influenza virus-specific T cell responses are induced by antigen-presenting cells, the interaction of activated effector T cells with antigen-bearing cells in the infected lungs. Also examined is the contribution of influenza-specific effector T cells to the development and control of lung injury and inflammation during infection.</div>
</front>
</TEI>
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T Cell Responses during Influenza Infection: Getting and Keeping Control

T Cell Responses during Influenza Infection: Getting and Keeping Control

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