The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses
Identifieur interne : 001F19 ( Ncbi/Curation ); précédent : 001F18; suivant : 001F20The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses
Auteurs : M. Linster [Pays-Bas, Singapour] ; E. J. A. Schrauwen [Pays-Bas] ; S. Van Der Vliet [Pays-Bas] ; D. F. Burke [Royaume-Uni] ; P. Lexmond [Pays-Bas] ; T. M. Bestebroer [Pays-Bas] ; D. J. Smith [Royaume-Uni] ; S. Herfst [Pays-Bas] ; B. F. Koel [Pays-Bas] ; R. A. M. Fouchier [Pays-Bas]Source :
- Journal of Virology [ 0022-538X ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (génétique), Antigènes viraux (immunologie), Cellules rénales canines Madin-Darby, Chiens, Facteurs temps, Furets, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (génétique), Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Mutation faux-sens, Pandémies, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Substitution d'acide aminé, Évolution moléculaire.
- MESH :
- génétique : Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Sous-type H2N2 du virus de la grippe A.
- immunologie : Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Sous-type H2N2 du virus de la grippe A.
- épidémiologie : Grippe humaine.
- Animaux, Cellules rénales canines Madin-Darby, Chiens, Facteurs temps, Furets, Humains, Mutation faux-sens, Pandémies, Substitution d'acide aminé, Évolution moléculaire.
English descriptors
- KwdEn :
- Amino Acid Substitution, Animals, Antigens, Viral (genetics), Antigens, Viral (immunology), Dogs, Evolution, Molecular, Ferrets, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (genetics), Influenza, Human (immunology), Madin Darby Canine Kidney Cells, Mutation, Missense, Pandemics, Time Factors.
- MESH :
- chemical , genetics : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , immunology : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H2N2 Subtype, Influenza, Human.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza, Human.
- Amino Acid Substitution, Animals, Dogs, Evolution, Molecular, Ferrets, Humans, Madin Darby Canine Kidney Cells, Mutation, Missense, Pandemics, Time Factors.
Abstract
While influenza A viruses of subtype H2N2 were at the origin of the Asian influenza pandemic, little is known about the antigenic changes that occurred during the twelve years of circulation in humans, the role of preexisting immunity, and the evolutionary rates of the virus. In this study, the antigenic map derived from hemagglutination inhibition (HI) titers of cell-cultured virus isolates and ferret postinfection sera displayed a directional evolution of viruses away from earlier isolates. Furthermore, individual mutations in close proximity to the receptor-binding site of the HA molecule determined the antigenic reactivity, confirming that individual amino acid substitutions in A/H2N2 viruses can confer major antigenic changes. This study adds to our understanding of virus evolution with respect to antigenic variability, rates of virus evolution, and potential escape mutants of A/H2N2.
Url:
DOI: 10.1128/JVI.01907-18
PubMed: 30700609
PubMed Central: 6450109
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PMC:6450109Le document en format XML
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<author><name sortKey="Bestebroer, T M" sort="Bestebroer, T M" uniqKey="Bestebroer T" first="T. M." last="Bestebroer">T. M. Bestebroer</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Substitution</term>
<term>Animals</term>
<term>Antigens, Viral (genetics)</term>
<term>Antigens, Viral (immunology)</term>
<term>Dogs</term>
<term>Evolution, Molecular</term>
<term>Ferrets</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (genetics)</term>
<term>Influenza, Human (immunology)</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Mutation, Missense</term>
<term>Pandemics</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antigènes viraux (génétique)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Chiens</term>
<term>Facteurs temps</term>
<term>Furets</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Grippe humaine (génétique)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Mutation faux-sens</term>
<term>Pandémies</term>
<term>Sous-type H2N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Substitution d'acide aminé</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes viraux</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Grippe humaine</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Grippe humaine</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Substitution</term>
<term>Animals</term>
<term>Dogs</term>
<term>Evolution, Molecular</term>
<term>Ferrets</term>
<term>Humans</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Mutation, Missense</term>
<term>Pandemics</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Chiens</term>
<term>Facteurs temps</term>
<term>Furets</term>
<term>Humains</term>
<term>Mutation faux-sens</term>
<term>Pandémies</term>
<term>Substitution d'acide aminé</term>
<term>Évolution moléculaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>While influenza A viruses of subtype H2N2 were at the origin of the Asian influenza pandemic, little is known about the antigenic changes that occurred during the twelve years of circulation in humans, the role of preexisting immunity, and the evolutionary rates of the virus. In this study, the antigenic map derived from hemagglutination inhibition (HI) titers of cell-cultured virus isolates and ferret postinfection sera displayed a directional evolution of viruses away from earlier isolates. Furthermore, individual mutations in close proximity to the receptor-binding site of the HA molecule determined the antigenic reactivity, confirming that individual amino acid substitutions in A/H2N2 viruses can confer major antigenic changes. This study adds to our understanding of virus evolution with respect to antigenic variability, rates of virus evolution, and potential escape mutants of A/H2N2.</p>
</div>
</front>
</TEI>
</record>
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