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1918 Influenza Pandemic: In Utero Exposure in the United States and Long-Term Impact on Hospitalizations

Identifieur interne : 001C96 ( Ncbi/Curation ); précédent : 001C95; suivant : 001C97

1918 Influenza Pandemic: In Utero Exposure in the United States and Long-Term Impact on Hospitalizations

Auteurs : Joseph Kofi Acquah ; Roshani Dahal ; Frank A. Sloan

Source :

RBID : PMC:5551642

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English descriptors

Abstract

Objectives. To explore associations between in utero exposure to the 1918 influenza pandemic and hospitalization rates in old age (≥ 70 years) in the United States.

Methods. We identified individuals exposed (mild and deadly waves) and unexposed in utero to the 1918 influenza pandemic (a natural experiment) by using birth dates from the Asset and Health Dynamics Among the Oldest Old survey. We analyzed differences in hospitalization rates by exposure status with multivariate linear regression.

Results. In utero exposure to the deadly wave of the 1918 influenza pandemic increased the number of hospital visits by 10.0 per 100 persons. For those exposed in utero to the deadliest wave of the influenza pandemic, high rates of functional limitations are shown to drive the higher rates of hospitalizations in old age.

Conclusions. In utero exposure to the influenza pandemic increased functional limitations and hospitalization rates in old age.

Public Health Implications. To determine investments in influenza pandemic prevention programs that protect fetal health, policymakers should include long-term reductions in hospitalizations in their cost–benefit evaluations.


Url:
DOI: 10.2105/AJPH.2017.303887
PubMed: 28727536
PubMed Central: 5551642

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PMC:5551642

Le document en format XML

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<term>Fetus (physiology)</term>
<term>Hospitalization (statistics & numerical data)</term>
<term>Humans</term>
<term>Influenza, Human (epidemiology)</term>
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<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Hospitalisation ()</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pandémies</term>
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<term>Sujet âgé de 80 ans ou plus</term>
<term>États-Unis d'Amérique</term>
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<term>Influenza, Human</term>
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<term>Grippe humaine</term>
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<term>Mâle</term>
<term>Pandémies</term>
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<p>
<italic>Objectives.</italic>
To explore associations between in utero exposure to the 1918 influenza pandemic and hospitalization rates in old age (≥ 70 years) in the United States.</p>
<p>
<italic>Methods.</italic>
We identified individuals exposed (mild and deadly waves) and unexposed in utero to the 1918 influenza pandemic (a natural experiment) by using birth dates from the Asset and Health Dynamics Among the Oldest Old survey. We analyzed differences in hospitalization rates by exposure status with multivariate linear regression.</p>
<p>
<italic>Results.</italic>
In utero exposure to the deadly wave of the 1918 influenza pandemic increased the number of hospital visits by 10.0 per 100 persons. For those exposed in utero to the deadliest wave of the influenza pandemic, high rates of functional limitations are shown to drive the higher rates of hospitalizations in old age.</p>
<p>
<italic>Conclusions.</italic>
In utero exposure to the influenza pandemic increased functional limitations and hospitalization rates in old age.</p>
<p>
<italic>Public Health Implications.</italic>
To determine investments in influenza pandemic prevention programs that protect fetal health, policymakers should include long-term reductions in hospitalizations in their cost–benefit evaluations.</p>
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