Potential recombinant vaccine against influenza A virus based on M2e displayed on nodaviral capsid nanoparticles
Identifieur interne : 001A21 ( Ncbi/Curation ); précédent : 001A20; suivant : 001A22Potential recombinant vaccine against influenza A virus based on M2e displayed on nodaviral capsid nanoparticles
Auteurs : Chean Yeah Yong [Malaisie] ; Swee Keong Yeap [Malaisie] ; Kok Lian Ho [Malaisie] ; Abdul Rahman Omar [Malaisie] ; Wen Siang Tan [Malaisie]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Données de séquences moléculaires, Femelle, Immunophénotypage, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Microscopie électronique à transmission, Nanoparticules (), Nanoparticules (métabolisme), Protéines de capside (), Protéines de capside (métabolisme), Protéines de fusion recombinantes (génétique), Protéines de fusion recombinantes (immunologie), Protéines de la matrice virale (), Protéines de la matrice virale (métabolisme), Souris, Souris de lignée BALB C, Séquence d'acides aminés, Séquence nucléotidique, Technique de Western, Test ELISA, Vaccination, Vaccins antigrippaux (immunologie), Vaccins antigrippaux (usage thérapeutique), Vaccins synthétiques (immunologie), Vaccins synthétiques (usage thérapeutique), Virus de la grippe A (), Virus de la grippe A (métabolisme).
- MESH :
- génétique : Protéines de fusion recombinantes.
- immunologie : Infections à Orthomyxoviridae, Protéines de fusion recombinantes, Vaccins antigrippaux, Vaccins synthétiques.
- métabolisme : Nanoparticules, Protéines de capside, Protéines de la matrice virale, Virus de la grippe A.
- usage thérapeutique : Vaccins antigrippaux, Vaccins synthétiques.
- virologie : Infections à Orthomyxoviridae.
- Animaux, Données de séquences moléculaires, Femelle, Immunophénotypage, Infections à Orthomyxoviridae, Microscopie électronique à transmission, Nanoparticules, Protéines de capside, Protéines de la matrice virale, Souris, Souris de lignée BALB C, Séquence d'acides aminés, Séquence nucléotidique, Technique de Western, Test ELISA, Vaccination, Virus de la grippe A.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Base Sequence, Blotting, Western, Capsid Proteins (chemistry), Capsid Proteins (metabolism), Enzyme-Linked Immunosorbent Assay, Female, Immunophenotyping, Influenza A virus (chemistry), Influenza A virus (metabolism), Influenza Vaccines (immunology), Influenza Vaccines (therapeutic use), Mice, Mice, Inbred BALB C, Microscopy, Electron, Transmission, Molecular Sequence Data, Nanoparticles (chemistry), Nanoparticles (metabolism), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (virology), Recombinant Fusion Proteins (genetics), Recombinant Fusion Proteins (immunology), Vaccination, Vaccines, Synthetic (immunology), Vaccines, Synthetic (therapeutic use), Viral Matrix Proteins (chemistry), Viral Matrix Proteins (metabolism).
- MESH :
- chemical , chemistry : Capsid Proteins, Viral Matrix Proteins.
- chemical , genetics : Recombinant Fusion Proteins.
- chemical , immunology : Influenza Vaccines, Recombinant Fusion Proteins, Vaccines, Synthetic.
- chemical , metabolism : Capsid Proteins, Viral Matrix Proteins.
- chemistry : Influenza A virus, Nanoparticles.
- immunology : Orthomyxoviridae Infections.
- metabolism : Influenza A virus, Nanoparticles.
- prevention & control : Orthomyxoviridae Infections.
- chemical , therapeutic use : Influenza Vaccines, Vaccines, Synthetic.
- virology : Orthomyxoviridae Infections.
- Amino Acid Sequence, Animals, Base Sequence, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Female, Immunophenotyping, Mice, Mice, Inbred BALB C, Microscopy, Electron, Transmission, Molecular Sequence Data, Vaccination.
Abstract
Influenza A virus poses a major threat to human health, causing outbreaks from time to time. Currently available vaccines employ inactivated viruses of different strains to provide protection against influenza virus infection. However, high mutation rates of influenza virus hemagglutinin (H) and neuraminidase (N) glycoproteins give rise to vaccine escape mutants. Thus, an effective vaccine providing protection against all strains of influenza virus would be a valuable asset. The ectodomain of matrix 2 protein (M2e) was found to be highly conserved despite mutations of the H and N glycoproteins. Hence, one to five copies of M2e were fused to the carboxyl-terminal end of the recombinant nodavirus capsid protein derived from
Url:
DOI: 10.2147/IJN.S77405
PubMed: 25897220
PubMed Central: 4396508
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000B07
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000B07
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000348
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000665
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000665
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000589
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001A21
Links to Exploration step
PMC:4396508Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potential recombinant vaccine against influenza A virus based on M2e displayed on nodaviral capsid nanoparticles</title><author><name sortKey="Yong, Chean Yeah" sort="Yong, Chean Yeah" uniqKey="Yong C" first="Chean Yeah" last="Yong">Chean Yeah Yong</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-10-2751">Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Yeap, Swee Keong" sort="Yeap, Swee Keong" uniqKey="Yeap S" first="Swee Keong" last="Yeap">Swee Keong Yeap</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-10-2751">Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Kok Lian" sort="Ho, Kok Lian" uniqKey="Ho K" first="Kok Lian" last="Ho">Kok Lian Ho</name><affiliation wicri:level="1"><nlm:aff id="af3-ijn-10-2751">Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Omar, Abdul Rahman" sort="Omar, Abdul Rahman" uniqKey="Omar A" first="Abdul Rahman" last="Omar">Abdul Rahman Omar</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-10-2751">Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ijn-10-2751">Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Wen Siang" sort="Tan, Wen Siang" uniqKey="Tan W" first="Wen Siang" last="Tan">Wen Siang Tan</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-10-2751">Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-10-2751">Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25897220</idno><idno type="pmc">4396508</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396508</idno><idno type="RBID">PMC:4396508</idno><idno type="doi">10.2147/IJN.S77405</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000B07</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B07</idno><idno type="wicri:Area/Pmc/Curation">000B07</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B07</idno><idno type="wicri:Area/Pmc/Checkpoint">000348</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000348</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:25897220</idno><idno type="wicri:Area/PubMed/Corpus">000665</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000665</idno><idno type="wicri:Area/PubMed/Curation">000665</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000665</idno><idno type="wicri:Area/PubMed/Checkpoint">000589</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000589</idno><idno type="wicri:Area/Ncbi/Merge">001A21</idno><idno type="wicri:Area/Ncbi/Curation">001A21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Potential recombinant vaccine against influenza A virus based on M2e displayed on nodaviral capsid nanoparticles</title><author><name sortKey="Yong, Chean Yeah" sort="Yong, Chean Yeah" uniqKey="Yong C" first="Chean Yeah" last="Yong">Chean Yeah Yong</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-10-2751">Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Yeap, Swee Keong" sort="Yeap, Swee Keong" uniqKey="Yeap S" first="Swee Keong" last="Yeap">Swee Keong Yeap</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-10-2751">Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Kok Lian" sort="Ho, Kok Lian" uniqKey="Ho K" first="Kok Lian" last="Ho">Kok Lian Ho</name><affiliation wicri:level="1"><nlm:aff id="af3-ijn-10-2751">Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Omar, Abdul Rahman" sort="Omar, Abdul Rahman" uniqKey="Omar A" first="Abdul Rahman" last="Omar">Abdul Rahman Omar</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-10-2751">Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ijn-10-2751">Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Wen Siang" sort="Tan, Wen Siang" uniqKey="Tan W" first="Wen Siang" last="Tan">Wen Siang Tan</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-10-2751">Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-10-2751">Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Bioscience, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Blotting, Western</term><term>Capsid Proteins (chemistry)</term><term>Capsid Proteins (metabolism)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Immunophenotyping</term><term>Influenza A virus (chemistry)</term><term>Influenza A virus (metabolism)</term><term>Influenza Vaccines (immunology)</term><term>Influenza Vaccines (therapeutic use)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Microscopy, Electron, Transmission</term><term>Molecular Sequence Data</term><term>Nanoparticles (chemistry)</term><term>Nanoparticles (metabolism)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Orthomyxoviridae Infections (virology)</term><term>Recombinant Fusion Proteins (genetics)</term><term>Recombinant Fusion Proteins (immunology)</term><term>Vaccination</term><term>Vaccines, Synthetic (immunology)</term><term>Vaccines, Synthetic (therapeutic use)</term><term>Viral Matrix Proteins (chemistry)</term><term>Viral Matrix Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Immunophénotypage</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Microscopie électronique à transmission</term><term>Nanoparticules ()</term><term>Nanoparticules (métabolisme)</term><term>Protéines de capside ()</term><term>Protéines de capside (métabolisme)</term><term>Protéines de fusion recombinantes (génétique)</term><term>Protéines de fusion recombinantes (immunologie)</term><term>Protéines de la matrice virale ()</term><term>Protéines de la matrice virale (métabolisme)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Technique de Western</term><term>Test ELISA</term><term>Vaccination</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins antigrippaux (usage thérapeutique)</term><term>Vaccins synthétiques (immunologie)</term><term>Vaccins synthétiques (usage thérapeutique)</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Capsid Proteins</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Recombinant Fusion Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term><term>Recombinant Fusion Proteins</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Capsid Proteins</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Influenza A virus</term><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de fusion recombinantes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Protéines de fusion recombinantes</term><term>Vaccins antigrippaux</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A virus</term><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Nanoparticules</term><term>Protéines de capside</term><term>Protéines de la matrice virale</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Blotting, Western</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Immunophenotyping</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Microscopy, Electron, Transmission</term><term>Molecular Sequence Data</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Immunophénotypage</term><term>Infections à Orthomyxoviridae</term><term>Microscopie électronique à transmission</term><term>Nanoparticules</term><term>Protéines de capside</term><term>Protéines de la matrice virale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Technique de Western</term><term>Test ELISA</term><term>Vaccination</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza A virus poses a major threat to human health, causing outbreaks from time to time. Currently available vaccines employ inactivated viruses of different strains to provide protection against influenza virus infection. However, high mutation rates of influenza virus hemagglutinin (H) and neuraminidase (N) glycoproteins give rise to vaccine escape mutants. Thus, an effective vaccine providing protection against all strains of influenza virus would be a valuable asset. The ectodomain of matrix 2 protein (M2e) was found to be highly conserved despite mutations of the H and N glycoproteins. Hence, one to five copies of M2e were fused to the carboxyl-terminal end of the recombinant nodavirus capsid protein derived from <italic>Macrobrachium rosenbergii</italic>. The chimeric proteins harboring up to five copies of M2e formed nanosized virus-like particles approximately 30 nm in diameter, which could be purified easily by immobilized metal affinity chromatography. BALB/c mice immunized subcutaneously with these chimeric proteins developed antibodies specifically against M2e, and the titer was proportional to the copy numbers of M2e displayed on the nodavirus capsid nanoparticles. The fusion proteins also induced a type 1 T helper immune response. Collectively, M2e displayed on the nodavirus capsid nanoparticles could provide an alternative solution to a possible influenza pandemic in the future.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name></author><author><name sortKey="Iuliano, Ad" uniqKey="Iuliano A">AD Iuliano</name></author><author><name sortKey="Reed, C" uniqKey="Reed C">C Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Filette, M" uniqKey="De Filette M">M De Filette</name></author><author><name sortKey="Ramne, A" uniqKey="Ramne A">A Ramne</name></author><author><name sortKey="Birkett, A" uniqKey="Birkett A">A Birkett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reed, C" uniqKey="Reed C">C Reed</name></author><author><name sortKey="Meltzer, Mi" uniqKey="Meltzer M">MI Meltzer</name></author><author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name></author><author><name sortKey="Fiore, A" uniqKey="Fiore A">A Fiore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fang, R" uniqKey="Fang R">R Fang</name></author><author><name sortKey="Min Jou, W" uniqKey="Min Jou W">W Min Jou</name></author><author><name sortKey="Huylebroeck, D" uniqKey="Huylebroeck D">D Huylebroeck</name></author><author><name sortKey="Devos, R" uniqKey="Devos R">R Devos</name></author><author><name sortKey="Fiers, W" uniqKey="Fiers W">W Fiers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author><author><name sortKey="Lai, Cj" uniqKey="Lai C">CJ Lai</name></author><author><name sortKey="Choppin, Pw" uniqKey="Choppin P">PW Choppin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossman, Js" uniqKey="Rossman J">JS Rossman</name></author><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schnell, Jr" uniqKey="Schnell J">JR Schnell</name></author><author><name sortKey="Chou, Jj" uniqKey="Chou J">JJ Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stouffer, Al" uniqKey="Stouffer A">AL Stouffer</name></author><author><name sortKey="Acharya, R" uniqKey="Acharya R">R Acharya</name></author><author><name sortKey="Salom, D" uniqKey="Salom D">D Salom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiers, W" uniqKey="Fiers W">W Fiers</name></author><author><name sortKey="De Filette, M" uniqKey="De Filette M">M De Filette</name></author><author><name sortKey="El Bakkouri, K" uniqKey="El Bakkouri K">K El Bakkouri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, J" uniqKey="Feng J">J Feng</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Mozdzanowska, K" uniqKey="Mozdzanowska K">K Mozdzanowska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goh, Zh" uniqKey="Goh Z">ZH Goh</name></author><author><name sortKey="Tan, Sg" uniqKey="Tan S">SG Tan</name></author><author><name sortKey="Bhassu, S" uniqKey="Bhassu S">S Bhassu</name></author><author><name sortKey="Tan, Ws" uniqKey="Tan W">WS Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, Cw" uniqKey="Ho C">CW Ho</name></author><author><name sortKey="Chew, Tk" uniqKey="Chew T">TK Chew</name></author><author><name sortKey="Ling, Tc" uniqKey="Ling T">TC Ling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yap, Wb" uniqKey="Yap W">WB Yap</name></author><author><name sortKey="Tey, Bt" uniqKey="Tey B">BT Tey</name></author><author><name sortKey="Alitheen, Nb" uniqKey="Alitheen N">NB Alitheen</name></author><author><name sortKey="Tan, Ws" uniqKey="Tan W">WS Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradford, Mm" uniqKey="Bradford M">MM Bradford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iba Ez, Li" uniqKey="Iba Ez L">LI Ibañez</name></author><author><name sortKey="Roose, K" uniqKey="Roose K">K Roose</name></author><author><name sortKey="De Filette, M" uniqKey="De Filette M">M De Filette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, Ge" uniqKey="Price G">GE Price</name></author><author><name sortKey="Soboleski, Mr" uniqKey="Soboleski M">MR Soboleski</name></author><author><name sortKey="Lo, Cy" uniqKey="Lo C">CY Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author><author><name sortKey="Zebedee, Sl" uniqKey="Zebedee S">SL Zebedee</name></author><author><name sortKey="Richardson, Cd" uniqKey="Richardson C">CD Richardson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Black, Ra" uniqKey="Black R">RA Black</name></author><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name></author><author><name sortKey="Gorodkova, N" uniqKey="Gorodkova N">N Gorodkova</name></author><author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name></author><author><name sortKey="Kendal, Ap" uniqKey="Kendal A">AP Kendal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Chen, Yh" uniqKey="Chen Y">YH Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Filette, M" uniqKey="De Filette M">M De Filette</name></author><author><name sortKey="Min Jou, W" uniqKey="Min Jou W">W Min Jou</name></author><author><name sortKey="Birkett, A" uniqKey="Birkett A">A Birkett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neirynck, S" uniqKey="Neirynck S">S Neirynck</name></author><author><name sortKey="Deroo, T" uniqKey="Deroo T">T Deroo</name></author><author><name sortKey="Saelens, X" uniqKey="Saelens X">X Saelens</name></author><author><name sortKey="Vanlandschoot, P" uniqKey="Vanlandschoot P">P Vanlandschoot</name></author><author><name sortKey="Jou, Wm" uniqKey="Jou W">WM Jou</name></author><author><name sortKey="Fiers, W" uniqKey="Fiers W">W Fiers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Bakkouri, K" uniqKey="El Bakkouri K">K El Bakkouri</name></author><author><name sortKey="Descamps, F" uniqKey="Descamps F">F Descamps</name></author><author><name sortKey="De Filette, M" uniqKey="De Filette M">M De Filette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, L" uniqKey="Dong L">L Dong</name></author><author><name sortKey="Mori, I" uniqKey="Mori I">I Mori</name></author><author><name sortKey="Hossain, Mj" uniqKey="Hossain M">MJ Hossain</name></author><author><name sortKey="Kimura, Y" uniqKey="Kimura Y">Y Kimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumgarth, N" uniqKey="Baumgarth N">N Baumgarth</name></author><author><name sortKey="Kelso, A" uniqKey="Kelso A">A Kelso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiers, W" uniqKey="Fiers W">W Fiers</name></author><author><name sortKey="De Filette, M" uniqKey="De Filette M">M De Filette</name></author><author><name sortKey="Birkett, A" uniqKey="Birkett A">A Birkett</name></author><author><name sortKey="Neirynck, S" uniqKey="Neirynck S">S Neirynck</name></author><author><name sortKey="Min Jou, W" uniqKey="Min Jou W">W Min Jou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashemi, H" uniqKey="Hashemi H">H Hashemi</name></author><author><name sortKey="Pouyanfard, S" uniqKey="Pouyanfard S">S Pouyanfard</name></author><author><name sortKey="Bandehpour, M" uniqKey="Bandehpour M">M Bandehpour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Xs" uniqKey="He X">XS He</name></author><author><name sortKey="Draghi, M" uniqKey="Draghi M">M Draghi</name></author><author><name sortKey="Mahmood, K" uniqKey="Mahmood K">K Mahmood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author><author><name sortKey="Mori, I" uniqKey="Mori I">I Mori</name></author><author><name sortKey="Hossain, Mj" uniqKey="Hossain M">MJ Hossain</name></author><author><name sortKey="Dong, L" uniqKey="Dong L">L Dong</name></author><author><name sortKey="Takeda, K" uniqKey="Takeda K">K Takeda</name></author><author><name sortKey="Kimura, Y" uniqKey="Kimura Y">Y Kimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, Id" uniqKey="Weiss I">ID Weiss</name></author><author><name sortKey="Wald, O" uniqKey="Wald O">O Wald</name></author><author><name sortKey="Wald, H" uniqKey="Wald H">H Wald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bordignon, V" uniqKey="Bordignon V">V Bordignon</name></author><author><name sortKey="Cordiali Fei, P" uniqKey="Cordiali Fei P">P Cordiali-Fei</name></author><author><name sortKey="Rinaldi, M" uniqKey="Rinaldi M">M Rinaldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karulin, Ay" uniqKey="Karulin A">AY Karulin</name></author><author><name sortKey="Hesse, Md" uniqKey="Hesse M">MD Hesse</name></author><author><name sortKey="Tary Lehmann, M" uniqKey="Tary Lehmann M">M Tary-Lehmann</name></author><author><name sortKey="Lehmann, Pv" uniqKey="Lehmann P">PV Lehmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, Dg" uniqKey="Lim D">DG Lim</name></author><author><name sortKey="Bieganowska Bourcier, K" uniqKey="Bieganowska Bourcier K">K Bieganowska Bourcier</name></author><author><name sortKey="Freeman, Gj" uniqKey="Freeman G">GJ Freeman</name></author><author><name sortKey="Hafler, Da" uniqKey="Hafler D">DA Hafler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slifka, Mk" uniqKey="Slifka M">MK Slifka</name></author><author><name sortKey="Rodriguez, F" uniqKey="Rodriguez F">F Rodriguez</name></author><author><name sortKey="Whitton, Jl" uniqKey="Whitton J">JL Whitton</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A21 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001A21 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= PandemieGrippaleV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:4396508
|texte= Potential recombinant vaccine against influenza A virus based on M2e displayed on nodaviral capsid nanoparticles
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:25897220" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a PandemieGrippaleV1
| This area was generated with Dilib version V0.6.34. |  |