Drug susceptibility of influenza A/H3N2 strains co-circulating during 2009 influenza pandemic: first report from Mumbai.
Identifieur interne : 001958 ( Ncbi/Curation ); précédent : 001957; suivant : 001959Drug susceptibility of influenza A/H3N2 strains co-circulating during 2009 influenza pandemic: first report from Mumbai.
Auteurs : Devanshi J. Gohil [Inde] ; Sweta T. Kothari [Inde] ; Pramod S. Shinde [Inde] ; Anand S. Chintakrindi [Inde] ; Rhuta Meharunkar [Inde] ; Rajas V. Warke [Inde] ; Meena A. Kanyalkar [Inde] ; Abhay S. Chowdhary [Inde] ; Ranjana A. Deshmukh [Inde]Source :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [ 1567-7257 ] ; 2015.
Descripteurs français
- KwdFr :
- Amantadine (pharmacologie), Animaux, Antiviraux (pharmacologie), Cellules rénales canines Madin-Darby, Chiens, Grippe humaine (virologie), Humains, Inde, Mutation, Oséltamivir (analogues et dérivés), Oséltamivir (pharmacologie), Pandémies, Partie nasale du pharynx (virologie), Phylogénie, Protéines de la matrice virale (génétique), Résistance virale aux médicaments (), Sialidase (métabolisme), Sous-type H3N2 du virus de la grippe A (), Sous-type H3N2 du virus de la grippe A (génétique).
- MESH :
- analogues et dérivés : Oséltamivir.
- génétique : Protéines de la matrice virale, Sous-type H3N2 du virus de la grippe A.
- métabolisme : Sialidase.
- pharmacologie : Amantadine, Antiviraux, Oséltamivir.
- virologie : Grippe humaine, Partie nasale du pharynx.
- Animaux, Cellules rénales canines Madin-Darby, Chiens, Humains, Inde, Mutation, Pandémies, Phylogénie, Résistance virale aux médicaments, Sous-type H3N2 du virus de la grippe A.
English descriptors
- KwdEn :
- Amantadine (pharmacology), Animals, Antiviral Agents (pharmacology), Dogs, Drug Resistance, Viral (drug effects), Humans, India, Influenza A Virus, H3N2 Subtype (drug effects), Influenza A Virus, H3N2 Subtype (genetics), Influenza, Human (virology), Madin Darby Canine Kidney Cells, Mutation, Nasopharynx (virology), Neuraminidase (metabolism), Oseltamivir (analogs & derivatives), Oseltamivir (pharmacology), Pandemics, Phylogeny, Viral Matrix Proteins (genetics).
- MESH :
- chemical , analogs & derivatives : Oseltamivir.
- chemical , genetics : Viral Matrix Proteins.
- chemical , metabolism : Neuraminidase.
- chemical , pharmacology : Amantadine, Antiviral Agents, Oseltamivir.
- drug effects : Drug Resistance, Viral, Influenza A Virus, H3N2 Subtype.
- genetics : Influenza A Virus, H3N2 Subtype.
- virology : Influenza, Human, Nasopharynx.
- Animals, Dogs, Humans, India, Madin Darby Canine Kidney Cells, Mutation, Pandemics, Phylogeny.
Abstract
From its first instance in 1977, resistance to amantadine, a matrix (M2) inhibitor has been increasing among influenza A/H3N2, thus propelling the use of oseltamivir, a neuraminidase (NA) inhibitor as a next line drug. Information on drug susceptibility to amantadine and neuraminidase inhibitors for influenza A/H3N2 viruses in India is limited with no published data from Mumbai. This study aimed at examining the sensitivity to M2 and NA inhibitors of influenza A/H3N2 strains isolated from 2009 to 2011 in Mumbai.
DOI: 10.1016/j.meegid.2014.11.005
PubMed: 25461259
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Gohil</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra, India. Electronic address: devanshi.gohil@gmail.com.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Kothari, Sweta T" sort="Kothari, Sweta T" uniqKey="Kothari S" first="Sweta T" last="Kothari">Sweta T. Kothari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Shinde, Pramod S" sort="Shinde, Pramod S" uniqKey="Shinde P" first="Pramod S" last="Shinde">Pramod S. 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Warke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra, India; Molecular Biology and Virology, HiMedia Laboratories, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra, India; Molecular Biology and Virology, HiMedia Laboratories, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Kanyalkar, Meena A" sort="Kanyalkar, Meena A" uniqKey="Kanyalkar M" first="Meena A" last="Kanyalkar">Meena A. Kanyalkar</name><affiliation wicri:level="1"><nlm:affiliation>Principal K.M. Kundnani College of Pharmacy, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Principal K.M. Kundnani College of Pharmacy, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Chowdhary, Abhay S" sort="Chowdhary, Abhay S" uniqKey="Chowdhary A" first="Abhay S" last="Chowdhary">Abhay S. Chowdhary</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Deshmukh, Ranjana A" sort="Deshmukh, Ranjana A" uniqKey="Deshmukh R" first="Ranjana A" last="Deshmukh">Ranjana A. Deshmukh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author></analytic><series><title level="j">Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases</title><idno type="eISSN">1567-7257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amantadine (pharmacology)</term><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Dogs</term><term>Drug Resistance, Viral (drug effects)</term><term>Humans</term><term>India</term><term>Influenza A Virus, H3N2 Subtype (drug effects)</term><term>Influenza A Virus, H3N2 Subtype (genetics)</term><term>Influenza, Human (virology)</term><term>Madin Darby Canine Kidney Cells</term><term>Mutation</term><term>Nasopharynx (virology)</term><term>Neuraminidase (metabolism)</term><term>Oseltamivir (analogs & derivatives)</term><term>Oseltamivir (pharmacology)</term><term>Pandemics</term><term>Phylogeny</term><term>Viral Matrix Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amantadine (pharmacologie)</term><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Inde</term><term>Mutation</term><term>Oséltamivir (analogues et dérivés)</term><term>Oséltamivir (pharmacologie)</term><term>Pandémies</term><term>Partie nasale du pharynx (virologie)</term><term>Phylogénie</term><term>Protéines de la matrice virale (génétique)</term><term>Résistance virale aux médicaments ()</term><term>Sialidase (métabolisme)</term><term>Sous-type H3N2 du virus de la grippe A ()</term><term>Sous-type H3N2 du virus de la grippe A (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Oseltamivir</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Amantadine</term><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drug Resistance, Viral</term><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de la matrice virale</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Sialidase</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Amantadine</term><term>Antiviraux</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Partie nasale du pharynx</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Nasopharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Humans</term><term>India</term><term>Madin Darby Canine Kidney Cells</term><term>Mutation</term><term>Pandemics</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Humains</term><term>Inde</term><term>Mutation</term><term>Pandémies</term><term>Phylogénie</term><term>Résistance virale aux médicaments</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">From its first instance in 1977, resistance to amantadine, a matrix (M2) inhibitor has been increasing among influenza A/H3N2, thus propelling the use of oseltamivir, a neuraminidase (NA) inhibitor as a next line drug. Information on drug susceptibility to amantadine and neuraminidase inhibitors for influenza A/H3N2 viruses in India is limited with no published data from Mumbai. This study aimed at examining the sensitivity to M2 and NA inhibitors of influenza A/H3N2 strains isolated from 2009 to 2011 in Mumbai.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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