Broad Protection against Avian Influenza Virus by Using a Modified Vaccinia Ankara Virus Expressing a Mosaic Hemagglutinin Gene
Identifieur interne : 001923 ( Ncbi/Curation ); précédent : 001922; suivant : 001924Broad Protection against Avian Influenza Virus by Using a Modified Vaccinia Ankara Virus Expressing a Mosaic Hemagglutinin Gene
Auteurs : Attapon Kamlangdee [États-Unis] ; Brock Kingstad-Bakke [États-Unis] ; Tavis K. Anderson [États-Unis] ; Tony L. Goldberg [États-Unis] ; Jorge E. Osorio [États-Unis]Source :
- Journal of Virology [ 0022-538X ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse de survie, Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (immunologie), Humains, Infections à Orthomyxoviridae (), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (immunologie), Modèles animaux de maladie humaine, Protection croisée, Protéines de fusion recombinantes (génétique), Protéines de fusion recombinantes (immunologie), Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (immunologie), Vaccination (), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Vecteurs de médicaments (administration et posologie), Vecteurs génétiques, Virus de la vaccine (génétique).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins synthétiques, Vecteurs de médicaments.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Protéines de fusion recombinantes, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins synthétiques, Virus de la vaccine.
- immunologie : Glycoprotéine hémagglutinine du virus influenza, Lymphocytes T CD4+, Lymphocytes T CD8+, Protéines de fusion recombinantes, Sous-type H1N1 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins synthétiques.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Analyse de survie, Animaux, Humains, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Protection croisée, Souris de lignée BALB C, Vaccination, Vecteurs génétiques.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), Cross Protection, Disease Models, Animal, Drug Carriers (administration & dosage), Genetic Vectors, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Mice, Inbred BALB C, Orthomyxoviridae Infections (prevention & control), Recombinant Fusion Proteins (genetics), Recombinant Fusion Proteins (immunology), Survival Analysis, Vaccination (methods), Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Vaccinia virus (genetics).
- MESH :
- chemical , administration & dosage : Drug Carriers, Influenza Vaccines, Vaccines, Synthetic.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Recombinant Fusion Proteins, Vaccines, Synthetic.
- genetics : Influenza A Virus, H5N1 Subtype, Vaccinia virus.
- immunology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype, Influenza Vaccines, Recombinant Fusion Proteins, Vaccines, Synthetic.
- methods : Vaccination.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Cross Protection, Disease Models, Animal, Genetic Vectors, Humans, Mice, Inbred BALB C, Survival Analysis.
Abstract
A critical failure in our preparedness for an influenza pandemic is the lack of a universal vaccine. Influenza virus strains diverge by 1 to 2% per year, and commercially available vaccines often do not elicit protection from one year to the next, necessitating frequent formulation changes. This represents a major challenge to the development of a cross-protective vaccine that can protect against circulating viral antigenic diversity. We have constructed a recombinant modified vaccinia virus Ankara (MVA) that expresses an H5N1 mosaic hemagglutinin (H5M) (MVA-H5M). This mosaic was generated
Url:
DOI: 10.1128/JVI.01532-14
PubMed: 25210173
PubMed Central: 4249068
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PMC:4249068Le document en format XML
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<term>Antibodies, Neutralizing (blood)</term>
<term>Antibodies, Viral (blood)</term>
<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Cross Protection</term>
<term>Disease Models, Animal</term>
<term>Drug Carriers (administration & dosage)</term>
<term>Genetic Vectors</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H5N1 Subtype (genetics)</term>
<term>Influenza A Virus, H5N1 Subtype (immunology)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (genetics)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Mice, Inbred BALB C</term>
<term>Orthomyxoviridae Infections (prevention & control)</term>
<term>Recombinant Fusion Proteins (genetics)</term>
<term>Recombinant Fusion Proteins (immunology)</term>
<term>Survival Analysis</term>
<term>Vaccination (methods)</term>
<term>Vaccines, Synthetic (administration & dosage)</term>
<term>Vaccines, Synthetic (genetics)</term>
<term>Vaccines, Synthetic (immunology)</term>
<term>Vaccinia virus (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de survie</term>
<term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Lymphocytes T CD4+ (immunologie)</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Protection croisée</term>
<term>Protéines de fusion recombinantes (génétique)</term>
<term>Protéines de fusion recombinantes (immunologie)</term>
<term>Souris de lignée BALB C</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H5N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H5N1 du virus de la grippe A (immunologie)</term>
<term>Vaccination ()</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (génétique)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins synthétiques (administration et posologie)</term>
<term>Vaccins synthétiques (génétique)</term>
<term>Vaccins synthétiques (immunologie)</term>
<term>Vecteurs de médicaments (administration et posologie)</term>
<term>Vecteurs génétiques</term>
<term>Virus de la vaccine (génétique)</term>
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<term>Influenza Vaccines</term>
<term>Vaccines, Synthetic</term>
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<term>Antibodies, Viral</term>
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<term>Influenza Vaccines</term>
<term>Recombinant Fusion Proteins</term>
<term>Vaccines, Synthetic</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
<term>Vaccins synthétiques</term>
<term>Vecteurs de médicaments</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
<term>Vaccinia virus</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Protéines de fusion recombinantes</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins synthétiques</term>
<term>Virus de la vaccine</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
<term>Protéines de fusion recombinantes</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins synthétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza Vaccines</term>
<term>Recombinant Fusion Proteins</term>
<term>Vaccines, Synthetic</term>
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</keywords>
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<term>Anticorps neutralisants</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cross Protection</term>
<term>Disease Models, Animal</term>
<term>Genetic Vectors</term>
<term>Humans</term>
<term>Mice, Inbred BALB C</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de survie</term>
<term>Animaux</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae</term>
<term>Modèles animaux de maladie humaine</term>
<term>Protection croisée</term>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>A critical failure in our preparedness for an influenza pandemic is the lack of a universal vaccine. Influenza virus strains diverge by 1 to 2% per year, and commercially available vaccines often do not elicit protection from one year to the next, necessitating frequent formulation changes. This represents a major challenge to the development of a cross-protective vaccine that can protect against circulating viral antigenic diversity. We have constructed a recombinant modified vaccinia virus Ankara (MVA) that expresses an H5N1 mosaic hemagglutinin (H5M) (MVA-H5M). This mosaic was generated <italic>in silico</italic>
using 2,145 field-sourced H5N1 isolates. A single dose of MVA-H5M provided 100% protection in mice against clade 0, 1, and 2 avian influenza viruses and also protected against seasonal H1N1 virus (A/Puerto Rico/8/34). It also provided short-term (10 days) and long-term (6 months) protection postvaccination. Both neutralizing antibodies and antigen-specific CD4<sup>+</sup>
and CD8<sup>+</sup>
T cells were still detected at 5 months postvaccination, suggesting that MVA-H5M provides long-lasting immunity.</p>
<p><bold>IMPORTANCE</bold>
Influenza viruses infect a billion people and cause up to 500,000 deaths every year. A major problem in combating influenza is the lack of broadly effective vaccines. One solution from the field of human immunodeficiency virus vaccinology involves a novel <italic>in silico</italic>
mosaic approach that has been shown to provide broad and robust protection against highly variable viruses. Unlike a consensus algorithm which picks the most frequent residue at each position, the mosaic method chooses the most frequent T-cell epitopes and combines them to form a synthetic antigen. These studies demonstrated that a mosaic influenza virus H5 hemagglutinin expressed by a viral vector can elicit full protection against diverse H5N1 challenges as well as induce broader immunity than a wild-type hemagglutinin.</p>
</div>
</front>
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