Molecular Basis of a Pandemic of Avian-Type Influenza Virus
Identifieur interne : 001906 ( Ncbi/Curation ); précédent : 001905; suivant : 001907Molecular Basis of a Pandemic of Avian-Type Influenza Virus
Auteurs :Source :
- Lectins ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : DNA-directed RNA polymerases, Glycoprotéine hémagglutinine du virus influenza, Virus de la grippe A.
- physiologie : Virus de la grippe A.
- virologie : Oiseaux.
- épidémiologie : Grippe chez les oiseaux.
- Animaux, Grippe chez les oiseaux, Humains, Pandémies.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : DNA-Directed RNA Polymerases, Hemagglutinin Glycoproteins, Influenza Virus.
- epidemiology : Influenza in Birds.
- metabolism : Influenza A virus.
- physiology : Influenza A virus.
- prevention & control : Influenza in Birds.
- virology : Birds.
- Animals, Humans, Pandemics.
Abstract
Despite heroic efforts to prevent the emergence of an influenza pandemic, avian influenza A virus has prevailed by crossing the species barriers to infect humans worldwide, occasionally with morbidity and mortality at unprecedented levels, and the virus later usually continues circulation in humans as a seasonal influenza virus, resulting in health-social-economic problems each year. Here, we review current knowledge of influenza viruses, their life cycle, interspecies transmission, and past pandemics and discuss the molecular basis of pandemic acquisition, notably of hemagglutinin (lectin) acting as a key contributor to change in host specificity in viral infection.
Url:
DOI: 10.1007/978-1-4939-1292-6_38
PubMed: 25117257
PubMed Central: 7121456
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PMC:7121456Le document en format XML
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<term>DNA-Directed RNA Polymerases (metabolism)</term>
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<term>Influenza A virus (metabolism)</term>
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<front><div type="abstract" xml:lang="en"><p>Despite heroic efforts to prevent the emergence of an influenza pandemic, avian influenza A virus has prevailed by crossing the species barriers to infect humans worldwide, occasionally with morbidity and mortality at unprecedented levels, and the virus later usually continues circulation in humans as a seasonal influenza virus, resulting in health-social-economic problems each year. Here, we review current knowledge of influenza viruses, their life cycle, interspecies transmission, and past pandemics and discuss the molecular basis of pandemic acquisition, notably of hemagglutinin (lectin) acting as a key contributor to change in host specificity in viral infection.</p>
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