Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants.
Identifieur interne : 000D85 ( Ncbi/Curation ); précédent : 000D84; suivant : 000D86Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants.
Auteurs : Gopal Chandra Ghosh [Japon] ; Norihide Nakada ; Naoyuki Yamashita ; Hiroaki TanakaSource :
- Chemosphere [ 1879-1298 ] ; 2010.
Descripteurs français
- KwdFr :
- Amantadine (), Amantadine (analyse), Amantadine (métabolisme), Antiviraux (analyse), Antiviraux (métabolisme), Chromatographie en phase liquide, Eaux d'égout (), Oséltamivir (), Oséltamivir (analogues et dérivés), Oséltamivir (analyse), Oséltamivir (métabolisme), Ozone (), Polluants chimiques de l'eau (), Polluants chimiques de l'eau (analyse), Polluants chimiques de l'eau (métabolisme), Pollution chimique de l'eau (), Spectrométrie de masse en tandem, Surveillance de l'environnement, Élimination des déchets liquides ().
- MESH :
- analogues et dérivés : Oséltamivir.
- analyse : Amantadine, Antiviraux, Oséltamivir, Polluants chimiques de l'eau.
- métabolisme : Amantadine, Antiviraux, Oséltamivir, Polluants chimiques de l'eau.
- Amantadine, Chromatographie en phase liquide, Eaux d'égout, Oséltamivir, Ozone, Polluants chimiques de l'eau, Pollution chimique de l'eau, Spectrométrie de masse en tandem, Surveillance de l'environnement, Élimination des déchets liquides.
English descriptors
- KwdEn :
- Amantadine (analysis), Amantadine (chemistry), Amantadine (metabolism), Antiviral Agents (analysis), Antiviral Agents (metabolism), Chromatography, Liquid, Environmental Monitoring, Oseltamivir (analogs & derivatives), Oseltamivir (analysis), Oseltamivir (chemistry), Oseltamivir (metabolism), Ozone (chemistry), Sewage (chemistry), Tandem Mass Spectrometry, Waste Disposal, Fluid (methods), Water Pollutants, Chemical (analysis), Water Pollutants, Chemical (chemistry), Water Pollutants, Chemical (metabolism), Water Pollution, Chemical (statistics & numerical data).
- MESH :
- chemical , analogs & derivatives : Oseltamivir.
- chemical , analysis : Amantadine, Antiviral Agents, Oseltamivir, Water Pollutants, Chemical.
- chemical , chemistry : Amantadine, Oseltamivir, Ozone, Sewage, Water Pollutants, Chemical.
- chemical , metabolism : Amantadine, Antiviral Agents, Oseltamivir, Water Pollutants, Chemical.
- methods : Waste Disposal, Fluid.
- statistics & numerical data : Water Pollution, Chemical.
- Chromatography, Liquid, Environmental Monitoring, Tandem Mass Spectrometry.
Abstract
We investigated the occurrence and fate of the two antiviral drugs oseltamivir carboxylate (OC)-the active metabolite of Tamiflu-and amantadine (AMT) at three sewage treatment plants (STPs) during the 2008-2009 and 2009-2010 influenza seasons in Japan. Both compounds were detected in all samples analyzed. The concentrations in raw influents at the STPs ranged from 140 to 460 ng L(-1) OC and from 184 to 538 ng L(-1) AMT. Primary treatment gave no substantial removal of the drugs (OC, 2-9%; AMT, 7-17%). Biological nutrient-removal-based secondary treatment (anoxic-oxic-anoxic-oxic and anaerobic-anoxic-oxic) removed 20-37% of OC, whereas extended-aeration-based conventional activated sludge treatment removed <20%. STPs using primary plus biological secondary treatment removed <50% of the drugs. The incorporation of tertiary treatment by ozonation removed >90%. Ozonation after secondary treatment in STPs will be necessary during an influenza pandemic to reduce the risks associated with the widespread use of antiviral drugs.
DOI: 10.1016/j.chemosphere.2010.07.023
PubMed: 20692015
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xml:lang="fr"><term>Amantadine</term><term>Chromatographie en phase liquide</term><term>Eaux d'égout</term><term>Oséltamivir</term><term>Ozone</term><term>Polluants chimiques de l'eau</term><term>Pollution chimique de l'eau</term><term>Spectrométrie de masse en tandem</term><term>Surveillance de l'environnement</term><term>Élimination des déchets liquides</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the occurrence and fate of the two antiviral drugs oseltamivir carboxylate (OC)-the active metabolite of Tamiflu-and amantadine (AMT) at three sewage treatment plants (STPs) during the 2008-2009 and 2009-2010 influenza seasons in Japan. Both compounds were detected in all samples analyzed. The concentrations in raw influents at the STPs ranged from 140 to 460 ng L(-1) OC and from 184 to 538 ng L(-1) AMT. Primary treatment gave no substantial removal of the drugs (OC, 2-9%; AMT, 7-17%). Biological nutrient-removal-based secondary treatment (anoxic-oxic-anoxic-oxic and anaerobic-anoxic-oxic) removed 20-37% of OC, whereas extended-aeration-based conventional activated sludge treatment removed <20%. STPs using primary plus biological secondary treatment removed <50% of the drugs. The incorporation of tertiary treatment by ozonation removed >90%. Ozonation after secondary treatment in STPs will be necessary during an influenza pandemic to reduce the risks associated with the widespread use of antiviral drugs.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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