Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self‐reported severity and duration of illness
Identifieur interne : 001F06 ( Ncbi/Checkpoint ); précédent : 001F05; suivant : 001F07Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self‐reported severity and duration of illness
Auteurs : Gro Tunheim ; Ida Laake ; Anna Hayman Robertson ; Kristian Waalen ; Olav Hungnes ; Lisbeth M. N Ss ; Rebecca J. Cox ; Siri Mjaaland ; Lill TrogstadSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2019.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Autorapport, Enquêtes et questionnaires, Enregistrements, Femelle, Grippe humaine (immunologie), Grossesse, Humains, Indice de gravité médicale, Jeune adulte, Sous-type H1N1 du virus de la grippe A, Tests d'inhibition de l'hémagglutination, Vaccination (), Vaccins antigrippaux (usage thérapeutique), Études de cohortes.
- MESH :
- immunologie : Grippe humaine.
- sang : Anticorps antiviraux.
- usage thérapeutique : Vaccins antigrippaux.
- Adolescent, Adulte, Adulte d'âge moyen, Autorapport, Enquêtes et questionnaires, Enregistrements, Femelle, Grossesse, Humains, Indice de gravité médicale, Jeune adulte, Sous-type H1N1 du virus de la grippe A, Tests d'inhibition de l'hémagglutination, Vaccination, Études de cohortes.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibodies, Viral (blood), Cohort Studies, Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype, Influenza Vaccines (therapeutic use), Influenza, Human (immunology), Middle Aged, Pregnancy, Registries, Self Report, Severity of Illness Index, Surveys and Questionnaires, Vaccination (statistics & numerical data), Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , therapeutic use : Influenza Vaccines.
- immunology : Influenza, Human.
- statistics & numerical data : Vaccination.
- Adolescent, Adult, Cohort Studies, Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype, Middle Aged, Pregnancy, Registries, Self Report, Severity of Illness Index, Surveys and Questionnaires, Young Adult.
Abstract
A population‐based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy.
We studied maternal A(H1N1)pdm09‐specific hemagglutination inhibition (
Among 1821 pregnant women included, 43.7% were unvaccinated and 19.3% of these had
Antibody waning was similar in vaccinated women and women with
Url:
DOI: 10.1111/irv.12623
PubMed: 30536590
PubMed Central: 6379636
Affiliations:
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PMC:6379636Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self‐reported severity and duration of illness</title>
<author><name sortKey="Tunheim, Gro" sort="Tunheim, Gro" uniqKey="Tunheim G" first="Gro" last="Tunheim">Gro Tunheim</name>
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<series><title level="j">Influenza and Other Respiratory Viruses</title>
<idno type="ISSN">1750-2640</idno>
<idno type="eISSN">1750-2659</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Antibodies, Viral (blood)</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza Vaccines (therapeutic use)</term>
<term>Influenza, Human (immunology)</term>
<term>Middle Aged</term>
<term>Pregnancy</term>
<term>Registries</term>
<term>Self Report</term>
<term>Severity of Illness Index</term>
<term>Surveys and Questionnaires</term>
<term>Vaccination (statistics & numerical data)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps antiviraux (sang)</term>
<term>Autorapport</term>
<term>Enquêtes et questionnaires</term>
<term>Enregistrements</term>
<term>Femelle</term>
<term>Grippe humaine (immunologie)</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Jeune adulte</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Vaccination ()</term>
<term>Vaccins antigrippaux (usage thérapeutique)</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Middle Aged</term>
<term>Pregnancy</term>
<term>Registries</term>
<term>Self Report</term>
<term>Severity of Illness Index</term>
<term>Surveys and Questionnaires</term>
<term>Young Adult</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Autorapport</term>
<term>Enquêtes et questionnaires</term>
<term>Enregistrements</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Jeune adulte</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Tests d'inhibition de l'hémagglutination</term>
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<front><div type="abstract" xml:lang="en"><sec id="irv12623-sec-0001"><title>Background</title>
<p>A population‐based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy.</p>
</sec>
<sec id="irv12623-sec-0002"><title>Objectives</title>
<p>We studied maternal A(H1N1)pdm09‐specific hemagglutination inhibition (<styled-content style="fixed-case">HI</styled-content>
)‐titer levels and waning in women with influenza‐like illness (<styled-content style="fixed-case">ILI</styled-content>
) in pregnancy compared to vaccinated women. Moreover, we studied the association between <styled-content style="fixed-case">HI</styled-content>
‐titers and self‐reported severity and duration of <styled-content style="fixed-case">ILI</styled-content>
.</p>
</sec>
<sec id="irv12623-sec-0003"><title>Methods</title>
<p><styled-content style="fixed-case">HI</styled-content>
‐titers against the pandemic virus were measured in maternal blood samples obtained at birth, 3‐9 months after exposure, and linked with information about pregnancy, influenza and vaccination from national registries and a cohort questionnaire.</p>
</sec>
<sec id="irv12623-sec-0004"><title>Results</title>
<p>Among 1821 pregnant women included, 43.7% were unvaccinated and 19.3% of these had <styled-content style="fixed-case">ILI</styled-content>
. <styled-content style="fixed-case">HI</styled-content>
‐titers were low (geometric mean titer (<styled-content style="fixed-case">GMT</styled-content>
) 11.3) in the unvaccinated women with <styled-content style="fixed-case">ILI</styled-content>
. Higher <styled-content style="fixed-case">HI</styled-content>
‐titers (<styled-content style="fixed-case">GMT</styled-content>
37.8) were measured in the vaccinated women. Estimated <styled-content style="fixed-case">HI</styled-content>
‐titer waning was similar for vaccinated women and women with <styled-content style="fixed-case">ILI</styled-content>
. Most <styled-content style="fixed-case">ILI</styled-content>
episodes were moderate and lasted 3‐5 days. Women with <styled-content style="fixed-case">ILI</styled-content>
reporting specific influenza symptoms such as fever or cough had higher <styled-content style="fixed-case">HI</styled-content>
‐titers than women without these symptoms. Women who reported being “very ill” or illness duration of >5 days had higher <styled-content style="fixed-case">HI</styled-content>
‐titers than women reporting less severe illness or illness of shorter duration, respectively.</p>
</sec>
<sec id="irv12623-sec-0005"><title>Conclusions</title>
<p>Antibody waning was similar in vaccinated women and women with <styled-content style="fixed-case">ILI</styled-content>
. More severe <styled-content style="fixed-case">ILI</styled-content>
or longer duration of illness was associated with higher <styled-content style="fixed-case">HI</styled-content>
‐titers. Most unvaccinated pregnant women with <styled-content style="fixed-case">ILI</styled-content>
had low <styled-content style="fixed-case">HI</styled-content>
‐titers, probably due to moderate illness and <styled-content style="fixed-case">HI</styled-content>
‐titer waning between exposure and sampling.</p>
</sec>
</div>
</front>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Cox, Rebecca J" sort="Cox, Rebecca J" uniqKey="Cox R" first="Rebecca J." last="Cox">Rebecca J. Cox</name>
<name sortKey="Hungnes, Olav" sort="Hungnes, Olav" uniqKey="Hungnes O" first="Olav" last="Hungnes">Olav Hungnes</name>
<name sortKey="Laake, Ida" sort="Laake, Ida" uniqKey="Laake I" first="Ida" last="Laake">Ida Laake</name>
<name sortKey="Mjaaland, Siri" sort="Mjaaland, Siri" uniqKey="Mjaaland S" first="Siri" last="Mjaaland">Siri Mjaaland</name>
<name sortKey="N Ss, Lisbeth M" sort="N Ss, Lisbeth M" uniqKey="N Ss L" first="Lisbeth M." last="N Ss">Lisbeth M. N Ss</name>
<name sortKey="Robertson, Anna Hayman" sort="Robertson, Anna Hayman" uniqKey="Robertson A" first="Anna Hayman" last="Robertson">Anna Hayman Robertson</name>
<name sortKey="Trogstad, Lill" sort="Trogstad, Lill" uniqKey="Trogstad L" first="Lill" last="Trogstad">Lill Trogstad</name>
<name sortKey="Tunheim, Gro" sort="Tunheim, Gro" uniqKey="Tunheim G" first="Gro" last="Tunheim">Gro Tunheim</name>
<name sortKey="Waalen, Kristian" sort="Waalen, Kristian" uniqKey="Waalen K" first="Kristian" last="Waalen">Kristian Waalen</name>
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