National Surveillance of Influenza-Associated Encephalopathy in Japan over Six Years, before and during the 2009–2010 Influenza Pandemic
Identifieur interne : 001571 ( Ncbi/Checkpoint ); précédent : 001570; suivant : 001572National Surveillance of Influenza-Associated Encephalopathy in Japan over Six Years, before and during the 2009–2010 Influenza Pandemic
Auteurs : Yoshiaki Gu [Japon] ; Tomoe Shimada [Japon] ; Yoshinori Yasui [Japon] ; Yuki Tada [Japon] ; Mitsuo Kaku [Japon] ; Nobuhiko Okabe [Japon]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Encéphalopathies (mortalité), Encéphalopathies (étiologie), Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Grippe humaine (), Grippe humaine (mortalité), Humains, Incidence, Japon (épidémiologie), Mâle, Nourrisson, Sous-type H1N1 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Taux de survie, Épidémiosurveillance, Études rétrospectives.
- MESH :
- mortalité : Encéphalopathies, Grippe humaine.
- épidémiologie : Japon.
- étiologie : Encéphalopathies.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Grippe humaine, Humains, Incidence, Mâle, Nourrisson, Sous-type H1N1 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Taux de survie, Épidémiosurveillance, Études rétrospectives.
- Wicri :
- geographic : Japon.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Brain Diseases (etiology), Brain Diseases (mortality), Child, Child, Preschool, Disease-Free Survival, Epidemiological Monitoring, Female, Humans, Incidence, Infant, Influenza A Virus, H1N1 Subtype, Influenza, Human (complications), Influenza, Human (mortality), Japan (epidemiology), Male, Middle Aged, Retrospective Studies, Survival Rate.
- MESH :
- geographic , epidemiology : Japan.
- complications : Influenza, Human.
- etiology : Brain Diseases.
- mortality : Brain Diseases, Influenza, Human.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Disease-Free Survival, Epidemiological Monitoring, Female, Humans, Incidence, Infant, Influenza A Virus, H1N1 Subtype, Male, Middle Aged, Retrospective Studies, Survival Rate.
Abstract
Influenza-associated encephalopathy (IAE) is a serious complication of influenza and is reported most frequently in Japan. This paper presents an assessment of the epidemiological characteristics of influenza A (H1N1) 2009-associated encephalopathy in comparison to seasonal IAE, based on Japanese national surveillance data of influenza-like illness (ILI) and IAE during flu seasons from 2004–2005 through 2009–2010. In each season before the pandemic, 34–55 IAE cases (mean 47.8; 95% confidence interval: 36.1–59.4) were reported, and these cases increased drastically to 331 during the 2009 pandemic (6.9-fold the previous seasons). Of the 331 IAE cases, 322 cases were reported as influenza A (H1N1) 2009-associated encephalopathy. The peaks of IAE were consistent with the peaks of the influenza epidemics and pandemics. A total of 570 cases of IAE (seasonal A, 170; seasonal B, 50; influenza A (H1N1) 2009, 322; unknown, 28) were reported over six seasons. The case fatality rate (CFR) ranged from 4.8 to 18.2% before the pandemic seasons and 3.6% in the 2009 pandemic season. The CFR of pandemic-IAE was 3.7%, which is lower than that of influenza A−/B-associated encephalopathy (12.9%, p<0.001; 14.0%, p = 0.002; respectively). The median age of IAE was 7 years during the pandemic, which is higher than that of influenza A−/B-associated encephalopathy (4, p<0.001; 4.5, p = 0.006; respectively). However, the number of pandemic-IAE cases per estimated ILI outpatients peaked in the 0–4-year age group and data both before and during the pandemic season showed a U-shape pattern. This suggests that the high incidence of influenza infection in the 0–4 year age group may lead to a high incidence of IAE in the same age group in a future influenza season. Further studies should include epidemiologic case definitions and clinical details of IAE to gain a more accurate understanding of the epidemiologic status of IAE.
Url:
DOI: 10.1371/journal.pone.0054786
PubMed: 23355899
PubMed Central: 3552950
Affiliations:
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PMC:3552950Le document en format XML
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<term>Aged, 80 and over</term>
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<term>Brain Diseases (mortality)</term>
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<term>Child, Preschool</term>
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<term>Encéphalopathies (étiologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
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<term>Incidence</term>
<term>Japon (épidémiologie)</term>
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<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Survie sans rechute</term>
<term>Taux de survie</term>
<term>Épidémiosurveillance</term>
<term>Études rétrospectives</term>
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<term>Grippe humaine</term>
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<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
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<term>Enfant d'âge préscolaire</term>
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<front><div type="abstract" xml:lang="en"><p>Influenza-associated encephalopathy (IAE) is a serious complication of influenza and is reported most frequently in Japan. This paper presents an assessment of the epidemiological characteristics of influenza A (H1N1) 2009-associated encephalopathy in comparison to seasonal IAE, based on Japanese national surveillance data of influenza-like illness (ILI) and IAE during flu seasons from 2004–2005 through 2009–2010. In each season before the pandemic, 34–55 IAE cases (mean 47.8; 95% confidence interval: 36.1–59.4) were reported, and these cases increased drastically to 331 during the 2009 pandemic (6.9-fold the previous seasons). Of the 331 IAE cases, 322 cases were reported as influenza A (H1N1) 2009-associated encephalopathy. The peaks of IAE were consistent with the peaks of the influenza epidemics and pandemics. A total of 570 cases of IAE (seasonal A, 170; seasonal B, 50; influenza A (H1N1) 2009, 322; unknown, 28) were reported over six seasons. The case fatality rate (CFR) ranged from 4.8 to 18.2% before the pandemic seasons and 3.6% in the 2009 pandemic season. The CFR of pandemic-IAE was 3.7%, which is lower than that of influenza A−/B-associated encephalopathy (12.9%, p<0.001; 14.0%, p = 0.002; respectively). The median age of IAE was 7 years during the pandemic, which is higher than that of influenza A−/B-associated encephalopathy (4, p<0.001; 4.5, p = 0.006; respectively). However, the number of pandemic-IAE cases per estimated ILI outpatients peaked in the 0–4-year age group and data both before and during the pandemic season showed a U-shape pattern. This suggests that the high incidence of influenza infection in the 0–4 year age group may lead to a high incidence of IAE in the same age group in a future influenza season. Further studies should include epidemiologic case definitions and clinical details of IAE to gain a more accurate understanding of the epidemiologic status of IAE.</p>
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<author><name sortKey="Yokota, S" uniqKey="Yokota S">S Yokota</name>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>Japon</li>
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<region><li>Région de Kantō</li>
</region>
<settlement><li>Tokyo</li>
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<tree><country name="Japon"><noRegion><name sortKey="Gu, Yoshiaki" sort="Gu, Yoshiaki" uniqKey="Gu Y" first="Yoshiaki" last="Gu">Yoshiaki Gu</name>
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<name sortKey="Gu, Yoshiaki" sort="Gu, Yoshiaki" uniqKey="Gu Y" first="Yoshiaki" last="Gu">Yoshiaki Gu</name>
<name sortKey="Kaku, Mitsuo" sort="Kaku, Mitsuo" uniqKey="Kaku M" first="Mitsuo" last="Kaku">Mitsuo Kaku</name>
<name sortKey="Okabe, Nobuhiko" sort="Okabe, Nobuhiko" uniqKey="Okabe N" first="Nobuhiko" last="Okabe">Nobuhiko Okabe</name>
<name sortKey="Okabe, Nobuhiko" sort="Okabe, Nobuhiko" uniqKey="Okabe N" first="Nobuhiko" last="Okabe">Nobuhiko Okabe</name>
<name sortKey="Shimada, Tomoe" sort="Shimada, Tomoe" uniqKey="Shimada T" first="Tomoe" last="Shimada">Tomoe Shimada</name>
<name sortKey="Tada, Yuki" sort="Tada, Yuki" uniqKey="Tada Y" first="Yuki" last="Tada">Yuki Tada</name>
<name sortKey="Yasui, Yoshinori" sort="Yasui, Yoshinori" uniqKey="Yasui Y" first="Yoshinori" last="Yasui">Yoshinori Yasui</name>
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</tree>
</affiliations>
</record>
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