A cell culture-derived whole-virus H5N1 vaccine induces long-lasting cross-clade protective immunity in mice which is augmented by a homologous or heterologous booster vaccination.
Identifieur interne : 001407 ( Ncbi/Checkpoint ); précédent : 001406; suivant : 001408A cell culture-derived whole-virus H5N1 vaccine induces long-lasting cross-clade protective immunity in mice which is augmented by a homologous or heterologous booster vaccination.
Auteurs : Nicolas Sabarth [Autriche] ; Helga Savidis-Dacho ; Michael G. Schwendinger ; Peter Brühl ; Daniel Portsmouth ; Brian A. Crowe ; Otfried Kistner ; P Noel Barrett ; Thomas R. Kreil ; M Keith HowardSource :
- Vaccine [ 1873-2518 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Anticorps hétérophiles, Anticorps neutralisants, Calendrier vaccinal, Cellules Vero (virologie), Femelle, Immunité cellulaire (immunologie), Immunité humorale, Rappel de vaccin, Relation dose-réponse (immunologie), Réactions croisées (immunologie), Souris, Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (pathogénicité), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Immunité cellulaire, Réactions croisées, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux.
- pathogénicité : Sous-type H5N1 du virus de la grippe A.
- virologie : Cellules Vero.
- Animaux, Anticorps hétérophiles, Anticorps neutralisants, Calendrier vaccinal, Femelle, Immunité humorale, Rappel de vaccin, Relation dose-réponse (immunologie), Souris.
English descriptors
- KwdEn :
- Animals, Antibodies, Heterophile, Antibodies, Neutralizing, Chlorocebus aethiops, Cross Reactions (immunology), Dose-Response Relationship, Immunologic, Female, Immunity, Cellular (immunology), Immunity, Humoral, Immunization Schedule, Immunization, Secondary, Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Mice, Vero Cells (virology).
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , immunology : Influenza Vaccines.
- chemical : Antibodies, Heterophile, Antibodies, Neutralizing.
- immunology : Cross Reactions, Immunity, Cellular, Influenza A Virus, H5N1 Subtype.
- pathogenicity : Influenza A Virus, H5N1 Subtype.
- virology : Vero Cells.
- Animals, Chlorocebus aethiops, Dose-Response Relationship, Immunologic, Female, Immunity, Humoral, Immunization Schedule, Immunization, Secondary, Mice.
Abstract
Preparation for an H5N1 influenza pandemic in humans could include priming the population in the pre-pandemic period with a vaccine produced from an existing H5N1 vaccine strain, with the possibility of boosting with a pandemic virus vaccine when it becomes available. We investigated the longevity of the immune response after one or two priming immunizations with a whole-virus H5N1 vaccine and the extent to which this can be boosted by later immunization with either a homologous or heterologous vaccine.
DOI: 10.1016/j.vaccine.2012.06.043
PubMed: 22749797
Affiliations:
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pubmed:22749797Le document en format XML
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We investigated the longevity of the immune response after one or two priming immunizations with a whole-virus H5N1 vaccine and the extent to which this can be boosted by later immunization with either a homologous or heterologous vaccine.</div></front></TEI><affiliations><list><country><li>Autriche</li></country></list><tree><noCountry><name sortKey="Barrett, P Noel" sort="Barrett, P Noel" uniqKey="Barrett P" first="P Noel" last="Barrett">P Noel Barrett</name><name sortKey="Bruhl, Peter" sort="Bruhl, Peter" uniqKey="Bruhl P" first="Peter" last="Brühl">Peter Brühl</name><name sortKey="Crowe, Brian A" sort="Crowe, Brian A" uniqKey="Crowe B" first="Brian A" last="Crowe">Brian A. Crowe</name><name sortKey="Howard, M Keith" sort="Howard, M Keith" uniqKey="Howard M" first="M Keith" last="Howard">M Keith Howard</name><name sortKey="Kistner, Otfried" sort="Kistner, Otfried" uniqKey="Kistner O" first="Otfried" last="Kistner">Otfried Kistner</name><name sortKey="Kreil, Thomas R" sort="Kreil, Thomas R" uniqKey="Kreil T" first="Thomas R" last="Kreil">Thomas R. Kreil</name><name sortKey="Portsmouth, Daniel" sort="Portsmouth, Daniel" uniqKey="Portsmouth D" first="Daniel" last="Portsmouth">Daniel Portsmouth</name><name sortKey="Savidis Dacho, Helga" sort="Savidis Dacho, Helga" uniqKey="Savidis Dacho H" first="Helga" last="Savidis-Dacho">Helga Savidis-Dacho</name><name sortKey="Schwendinger, Michael G" sort="Schwendinger, Michael G" uniqKey="Schwendinger M" first="Michael G" last="Schwendinger">Michael G. Schwendinger</name></noCountry><country name="Autriche"><noRegion><name sortKey="Sabarth, Nicolas" sort="Sabarth, Nicolas" uniqKey="Sabarth N" first="Nicolas" last="Sabarth">Nicolas Sabarth</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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