Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus.
Identifieur interne : 000511 ( Ncbi/Checkpoint ); précédent : 000510; suivant : 000512Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus.
Auteurs : Takeshi Ichinohe [Japon] ; Noriyo Nagata ; Peter Strong ; Shin-Ichi Tamura ; Hidehiro Takahashi ; Ai Ninomiya ; Masaki Imai ; Takato Odagiri ; Masato Tashiro ; Hirofumi Sawa ; Joe Chiba ; Takeshi Kurata ; Tetsutaro Sata ; Hideki HasegawaSource :
- Journal of medical virology [ 0146-6615 ] ; 2007.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Analyse de survie, Animaux, Antiviraux (), Antiviraux (administration et posologie), Antiviraux (immunologie), Cellules tueuses naturelles (immunologie), Chimiokine CXCL10, Chimiokines CXC (analyse), Chimiokines CXC (immunologie), Chitine (), Chitine (administration et posologie), Chitine (immunologie), Femelle, Immunité innée, Immunité muqueuse, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Interleukine-6 (analyse), Interleukine-6 (immunologie), Ligand TRAIL (biosynthèse), Modèles animaux de maladie humaine, Muqueuse nasale (), Muqueuse nasale (immunologie), Noeuds lymphatiques (immunologie), Organismes exempts d'organismes pathogènes spécifiques, Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (immunologie).
- MESH :
- administration et posologie : Antiviraux, Chitine.
- analyse : Chimiokines CXC, Interleukine-6.
- biosynthèse : Ligand TRAIL.
- immunologie : Antiviraux, Cellules tueuses naturelles, Chimiokines CXC, Chitine, Infections à Orthomyxoviridae, Interleukine-6, Muqueuse nasale, Noeuds lymphatiques, Sous-type H1N1 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A.
- Administration par voie nasale, Analyse de survie, Animaux, Antiviraux, Chimiokine CXCL10, Chitine, Femelle, Immunité innée, Immunité muqueuse, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Muqueuse nasale, Organismes exempts d'organismes pathogènes spécifiques, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Antiviral Agents (administration & dosage), Antiviral Agents (chemistry), Antiviral Agents (immunology), Chemokine CXCL10, Chemokines, CXC (analysis), Chemokines, CXC (immunology), Chitin (administration & dosage), Chitin (chemistry), Chitin (immunology), Disease Models, Animal, Female, Immunity, Innate, Immunity, Mucosal, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (immunology), Interleukin-6 (analysis), Interleukin-6 (immunology), Killer Cells, Natural (immunology), Lymph Nodes (immunology), Mice, Mice, Inbred BALB C, Nasal Mucosa (chemistry), Nasal Mucosa (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Specific Pathogen-Free Organisms, Survival Analysis, TNF-Related Apoptosis-Inducing Ligand (biosynthesis).
- MESH :
- chemical , administration & dosage : Antiviral Agents, Chitin.
- chemical , analysis : Chemokines, CXC, Interleukin-6.
- chemical , biosynthesis : TNF-Related Apoptosis-Inducing Ligand.
- chemical , chemistry : Antiviral Agents, Chitin.
- chemical , immunology : Antiviral Agents, Chemokines, CXC, Chitin, Interleukin-6.
- chemistry : Nasal Mucosa.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype, Killer Cells, Natural, Lymph Nodes, Nasal Mucosa, Orthomyxoviridae Infections.
- prevention & control : Orthomyxoviridae Infections.
- Administration, Intranasal, Animals, Chemokine CXCL10, Disease Models, Animal, Female, Immunity, Innate, Immunity, Mucosal, Mice, Mice, Inbred BALB C, Specific Pathogen-Free Organisms, Survival Analysis.
Abstract
Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor-alpha. However, the mechanism of interferon-independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non-treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26-fold) after intranasal treatment with chitin microparticles. In addition, the level of IL-6 and interferon-gamma-inducible protein-10 (IP-10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper-induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus.
DOI: 10.1002/jmv.20837
PubMed: 17457919
Affiliations:
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uniqKey="Strong P" first="Peter" last="Strong">Peter Strong</name></author><author><name sortKey="Tamura, Shin Ichi" sort="Tamura, Shin Ichi" uniqKey="Tamura S" first="Shin-Ichi" last="Tamura">Shin-Ichi Tamura</name></author><author><name sortKey="Takahashi, Hidehiro" sort="Takahashi, Hidehiro" uniqKey="Takahashi H" first="Hidehiro" last="Takahashi">Hidehiro Takahashi</name></author><author><name sortKey="Ninomiya, Ai" sort="Ninomiya, Ai" uniqKey="Ninomiya A" first="Ai" last="Ninomiya">Ai Ninomiya</name></author><author><name sortKey="Imai, Masaki" sort="Imai, Masaki" uniqKey="Imai M" first="Masaki" last="Imai">Masaki Imai</name></author><author><name sortKey="Odagiri, Takato" sort="Odagiri, Takato" uniqKey="Odagiri T" first="Takato" last="Odagiri">Takato Odagiri</name></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name></author><author><name sortKey="Sawa, Hirofumi" sort="Sawa, Hirofumi" 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National Institute of Infectious Diseases, Gakuen, Musashimurayama-shi, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name></author><author><name sortKey="Strong, Peter" sort="Strong, Peter" uniqKey="Strong P" first="Peter" last="Strong">Peter Strong</name></author><author><name sortKey="Tamura, Shin Ichi" sort="Tamura, Shin Ichi" uniqKey="Tamura S" first="Shin-Ichi" last="Tamura">Shin-Ichi Tamura</name></author><author><name sortKey="Takahashi, Hidehiro" sort="Takahashi, Hidehiro" uniqKey="Takahashi H" first="Hidehiro" last="Takahashi">Hidehiro Takahashi</name></author><author><name sortKey="Ninomiya, Ai" sort="Ninomiya, Ai" uniqKey="Ninomiya A" first="Ai" last="Ninomiya">Ai Ninomiya</name></author><author><name sortKey="Imai, Masaki" sort="Imai, Masaki" uniqKey="Imai M" first="Masaki" last="Imai">Masaki Imai</name></author><author><name sortKey="Odagiri, Takato" sort="Odagiri, Takato" uniqKey="Odagiri T" first="Takato" last="Odagiri">Takato Odagiri</name></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name></author><author><name sortKey="Sawa, Hirofumi" sort="Sawa, Hirofumi" uniqKey="Sawa H" first="Hirofumi" last="Sawa">Hirofumi Sawa</name></author><author><name sortKey="Chiba, Joe" sort="Chiba, Joe" uniqKey="Chiba J" first="Joe" last="Chiba">Joe Chiba</name></author><author><name sortKey="Kurata, Takeshi" sort="Kurata, Takeshi" uniqKey="Kurata T" first="Takeshi" last="Kurata">Takeshi Kurata</name></author><author><name sortKey="Sata, Tetsutaro" sort="Sata, Tetsutaro" uniqKey="Sata T" first="Tetsutaro" last="Sata">Tetsutaro Sata</name></author><author><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name></author></analytic><series><title level="j">Journal of medical virology</title><idno type="ISSN">0146-6615</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Antiviral Agents (administration & dosage)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (immunology)</term><term>Chemokine CXCL10</term><term>Chemokines, CXC (analysis)</term><term>Chemokines, CXC (immunology)</term><term>Chitin (administration & dosage)</term><term>Chitin (chemistry)</term><term>Chitin (immunology)</term><term>Disease Models, Animal</term><term>Female</term><term>Immunity, Innate</term><term>Immunity, Mucosal</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Interleukin-6 (analysis)</term><term>Interleukin-6 (immunology)</term><term>Killer Cells, Natural (immunology)</term><term>Lymph Nodes (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Nasal Mucosa (chemistry)</term><term>Nasal Mucosa (immunology)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Specific Pathogen-Free Organisms</term><term>Survival Analysis</term><term>TNF-Related Apoptosis-Inducing Ligand (biosynthesis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie nasale</term><term>Analyse de survie</term><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (administration et posologie)</term><term>Antiviraux (immunologie)</term><term>Cellules tueuses naturelles (immunologie)</term><term>Chimiokine CXCL10</term><term>Chimiokines CXC (analyse)</term><term>Chimiokines CXC (immunologie)</term><term>Chitine ()</term><term>Chitine (administration et posologie)</term><term>Chitine (immunologie)</term><term>Femelle</term><term>Immunité innée</term><term>Immunité muqueuse</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Interleukine-6 (analyse)</term><term>Interleukine-6 (immunologie)</term><term>Ligand TRAIL (biosynthèse)</term><term>Modèles animaux de maladie humaine</term><term>Muqueuse nasale ()</term><term>Muqueuse nasale (immunologie)</term><term>Noeuds lymphatiques (immunologie)</term><term>Organismes exempts d'organismes pathogènes spécifiques</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Chitin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Chemokines, CXC</term><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>TNF-Related Apoptosis-Inducing Ligand</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Chitin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antiviral Agents</term><term>Chemokines, CXC</term><term>Chitin</term><term>Interleukin-6</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term><term>Chitine</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Chimiokines CXC</term><term>Interleukine-6</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Ligand TRAIL</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nasal Mucosa</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antiviraux</term><term>Cellules tueuses naturelles</term><term>Chimiokines CXC</term><term>Chitine</term><term>Infections à Orthomyxoviridae</term><term>Interleukine-6</term><term>Muqueuse nasale</term><term>Noeuds lymphatiques</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Killer Cells, Natural</term><term>Lymph Nodes</term><term>Nasal Mucosa</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Chemokine CXCL10</term><term>Disease Models, Animal</term><term>Female</term><term>Immunity, Innate</term><term>Immunity, Mucosal</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Specific Pathogen-Free Organisms</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Analyse de survie</term><term>Animaux</term><term>Antiviraux</term><term>Chimiokine CXCL10</term><term>Chitine</term><term>Femelle</term><term>Immunité innée</term><term>Immunité muqueuse</term><term>Infections à Orthomyxoviridae</term><term>Modèles animaux de maladie humaine</term><term>Muqueuse nasale</term><term>Organismes exempts d'organismes pathogènes spécifiques</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor-alpha. However, the mechanism of interferon-independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non-treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26-fold) after intranasal treatment with chitin microparticles. In addition, the level of IL-6 and interferon-gamma-inducible protein-10 (IP-10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactic treatment with chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper-induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Chiba, Joe" sort="Chiba, Joe" uniqKey="Chiba J" first="Joe" last="Chiba">Joe Chiba</name><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name><name sortKey="Imai, Masaki" sort="Imai, Masaki" uniqKey="Imai M" first="Masaki" last="Imai">Masaki Imai</name><name sortKey="Kurata, Takeshi" sort="Kurata, Takeshi" uniqKey="Kurata T" first="Takeshi" last="Kurata">Takeshi Kurata</name><name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name><name sortKey="Ninomiya, Ai" sort="Ninomiya, Ai" uniqKey="Ninomiya A" first="Ai" last="Ninomiya">Ai Ninomiya</name><name sortKey="Odagiri, Takato" sort="Odagiri, Takato" uniqKey="Odagiri T" first="Takato" last="Odagiri">Takato Odagiri</name><name sortKey="Sata, Tetsutaro" sort="Sata, Tetsutaro" uniqKey="Sata T" first="Tetsutaro" last="Sata">Tetsutaro Sata</name><name sortKey="Sawa, Hirofumi" sort="Sawa, Hirofumi" uniqKey="Sawa H" first="Hirofumi" last="Sawa">Hirofumi Sawa</name><name sortKey="Strong, Peter" sort="Strong, Peter" uniqKey="Strong P" first="Peter" last="Strong">Peter Strong</name><name sortKey="Takahashi, Hidehiro" sort="Takahashi, Hidehiro" uniqKey="Takahashi H" first="Hidehiro" last="Takahashi">Hidehiro Takahashi</name><name sortKey="Tamura, Shin Ichi" sort="Tamura, Shin Ichi" uniqKey="Tamura S" first="Shin-Ichi" last="Tamura">Shin-Ichi Tamura</name><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Ichinohe, Takeshi" sort="Ichinohe, Takeshi" uniqKey="Ichinohe T" first="Takeshi" last="Ichinohe">Takeshi Ichinohe</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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