Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
Identifieur interne : 005634 ( Main/Merge ); précédent : 005633; suivant : 005635Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
Auteurs : Darwyn Kobasa ; Steven M. Jones [Canada] ; Kyoko Shinya [Japon] ; John C. Kash ; John Copps [Canada] ; Hideki Ebihara [Canada, Japon] ; Yasuko Hatta [États-Unis] ; Jin Hyun Kim [États-Unis] ; Peter Halfmann [États-Unis] ; Masato Hatta [États-Unis] ; Friederike Feldmann [Canada] ; Judie B. Alimonti [Canada] ; Lisa Fernando [Canada] ; Yan Li ; Michael G. Katze [États-Unis] ; Heinz Feldmann [Canada] ; Yoshihiro Kawaoka [États-Unis, Japon]Source :
- Nature [ 0028-0836 ] ; 2007-01-18.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Animaux, Chimiokines (sang), Cytokines (sang), Facteurs temps, Femelle, Grippe humaine (immunologie), Grippe humaine (sang), Grippe humaine (virologie), Humains, Immunité innée (immunologie), Macaca fascicularis (immunologie), Macaca fascicularis (virologie), Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (métabolisme), Poumon (virologie), Régulation de l'expression des gènes, Réplication virale, Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H1N1 du virus de la grippe A (pathogénicité), Séquençage par oligonucléotides en batterie, Taux de survie.
- MESH :
- anatomopathologie : Poumon.
- génétique : Sous-type H1N1 du virus de la grippe A.
- immunologie : Grippe humaine, Immunité innée, Macaca fascicularis, Sous-type H1N1 du virus de la grippe A.
- métabolisme : Poumon.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- sang : Chimiokines, Cytokines, Grippe humaine.
- virologie : Grippe humaine, Macaca fascicularis, Poumon.
- Analyse de profil d'expression de gènes, Animaux, Facteurs temps, Femelle, Humains, Modèles animaux de maladie humaine, Régulation de l'expression des gènes, Réplication virale, Souris, Souris de lignée BALB C, Séquençage par oligonucléotides en batterie, Taux de survie.
English descriptors
- KwdEn :
- Animals, Chemokines (blood), Cytokines (blood), Disease Models, Animal, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Immunity, Innate (immunology), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza, Human (blood), Influenza, Human (immunology), Influenza, Human (virology), Lung (metabolism), Lung (pathology), Lung (virology), Macaca fascicularis (immunology), Macaca fascicularis (virology), Mice, Mice, Inbred BALB C, Oligonucleotide Array Sequence Analysis, Survival Rate, Time Factors, Virus Replication.
- MESH :
- chemical , blood : Chemokines, Cytokines.
- blood : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- immunology : Immunity, Innate, Influenza A Virus, H1N1 Subtype, Influenza, Human, Macaca fascicularis.
- metabolism : Lung.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- pathology : Lung.
- virology : Influenza, Human, Lung, Macaca fascicularis.
- Animals, Disease Models, Animal, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Mice, Mice, Inbred BALB C, Oligonucleotide Array Sequence Analysis, Survival Rate, Time Factors, Virus Replication.
Url:
DOI: 10.1038/nature05495
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Manitoba, Winnipeg, Manitoba R3E 3R2</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName 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scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chemokines (blood)</term><term>Cytokines (blood)</term><term>Disease Models, Animal</term><term>Female</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Humans</term><term>Immunity, Innate (immunology)</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza, Human (blood)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (virology)</term><term>Lung (metabolism)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Macaca fascicularis (immunology)</term><term>Macaca fascicularis (virology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Oligonucleotide Array Sequence Analysis</term><term>Survival Rate</term><term>Time Factors</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Chimiokines (sang)</term><term>Cytokines (sang)</term><term>Facteurs temps</term><term>Femelle</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (sang)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Immunité innée (immunologie)</term><term>Macaca fascicularis (immunologie)</term><term>Macaca fascicularis (virologie)</term><term>Modèles animaux de maladie humaine</term><term>Poumon (anatomopathologie)</term><term>Poumon (métabolisme)</term><term>Poumon (virologie)</term><term>Régulation de l'expression des gènes</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term><term>Séquençage par oligonucléotides en batterie</term><term>Taux de survie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Chemokines</term><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Immunité innée</term><term>Macaca fascicularis</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immunity, Innate</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza, Human</term><term>Macaca fascicularis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Chimiokines</term><term>Cytokines</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Macaca fascicularis</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Lung</term><term>Macaca fascicularis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Oligonucleotide Array Sequence Analysis</term><term>Survival Rate</term><term>Time Factors</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Régulation de l'expression des gènes</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Séquençage par oligonucléotides en batterie</term><term>Taux de survie</term></keywords></textClass></profileDesc></teiHeader></TEI><double doi="10.1038/nature05495"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus</title><author><name sortKey="Kobasa, Darwyn" sort="Kobasa, Darwyn" uniqKey="Kobasa D" first="Darwyn" last="Kobasa">Darwyn Kobasa</name></author><author><name sortKey="Jones, Steven M" sort="Jones, Steven M" uniqKey="Jones S" first="Steven M." last="Jones">Steven M. Jones</name></author><author><name sortKey="Shinya, Kyoko" sort="Shinya, Kyoko" uniqKey="Shinya K" first="Kyoko" last="Shinya">Kyoko Shinya</name></author><author><name sortKey="Kash, John C" sort="Kash, John C" uniqKey="Kash J" first="John C." last="Kash">John C. Kash</name></author><author><name sortKey="Copps, John" sort="Copps, John" uniqKey="Copps J" first="John" last="Copps">John Copps</name></author><author><name sortKey="Ebihara, Hideki" sort="Ebihara, Hideki" uniqKey="Ebihara H" first="Hideki" last="Ebihara">Hideki Ebihara</name></author><author><name sortKey="Hatta, Yasuko" sort="Hatta, Yasuko" uniqKey="Hatta Y" first="Yasuko" last="Hatta">Yasuko Hatta</name></author><author><name sortKey="Hyun Kim, Jin" sort="Hyun Kim, Jin" uniqKey="Hyun Kim J" first="Jin" last="Hyun Kim">Jin Hyun Kim</name></author><author><name sortKey="Halfmann, Peter" sort="Halfmann, Peter" uniqKey="Halfmann P" first="Peter" last="Halfmann">Peter Halfmann</name></author><author><name sortKey="Hatta, Masato" sort="Hatta, Masato" uniqKey="Hatta M" first="Masato" last="Hatta">Masato Hatta</name></author><author><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name></author><author><name sortKey="Alimonti, Judie B" sort="Alimonti, Judie B" uniqKey="Alimonti J" first="Judie B." last="Alimonti">Judie B. Alimonti</name></author><author><name sortKey="Fernando, Lisa" sort="Fernando, Lisa" uniqKey="Fernando L" first="Lisa" last="Fernando">Lisa Fernando</name></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name></author><author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G." last="Katze">Michael G. Katze</name></author><author><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AABDE6788235E3A8991E03EA4D45C9A8731E4AD1</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1038/nature05495</idno><idno type="url">https://api.istex.fr/ark:/67375/GT4-0GHJCG7H-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000E52</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E52</idno><idno type="wicri:Area/Istex/Curation">000E52</idno><idno type="wicri:Area/Istex/Checkpoint">001934</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001934</idno><idno type="wicri:doubleKey">0028-0836:2006:Kobasa D:aberrant:innate:immune</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus</title><author><name sortKey="Kobasa, Darwyn" sort="Kobasa, Darwyn" uniqKey="Kobasa D" first="Darwyn" last="Kobasa">Darwyn Kobasa</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Jones, Steven M" sort="Jones, Steven M" uniqKey="Jones S" first="Steven M." last="Jones">Steven M. Jones</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Special Pathogens Program National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2</wicri:regionArea><wicri:noRegion>Manitoba R3E 3R2</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Shinya, Kyoko" sort="Shinya, Kyoko" uniqKey="Shinya K" first="Kyoko" last="Shinya">Kyoko Shinya</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>The Avian Zoonosis Research Centre, Tottori University, Tottori 680-8550</wicri:regionArea><wicri:noRegion>Tottori 680-8550</wicri:noRegion></affiliation></author><author><name sortKey="Kash, John C" sort="Kash, John C" uniqKey="Kash J" first="John C." last="Kash">John C. Kash</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Copps, John" sort="Copps, John" uniqKey="Copps J" first="John" last="Copps">John Copps</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba R3E 3M4</wicri:regionArea><wicri:noRegion>Manitoba R3E 3M4</wicri:noRegion></affiliation></author><author><name sortKey="Ebihara, Hideki" sort="Ebihara, Hideki" uniqKey="Ebihara H" first="Hideki" last="Ebihara">Hideki Ebihara</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Special Pathogens Program National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2</wicri:regionArea><wicri:noRegion>Manitoba R3E 3R2</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>CREST, Japan Science and Technology Agency, Saitama 322-0012</wicri:regionArea><wicri:noRegion>Saitama 322-0012</wicri:noRegion></affiliation></author><author><name sortKey="Hatta, Yasuko" sort="Hatta, Yasuko" uniqKey="Hatta Y" first="Yasuko" last="Hatta">Yasuko Hatta</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706</wicri:regionArea><wicri:noRegion>Wisconsin 53706</wicri:noRegion></affiliation></author><author><name sortKey="Hyun Kim, Jin" sort="Hyun Kim, Jin" uniqKey="Hyun Kim J" first="Jin" last="Hyun Kim">Jin Hyun Kim</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706</wicri:regionArea><wicri:noRegion>Wisconsin 53706</wicri:noRegion></affiliation></author><author><name sortKey="Halfmann, Peter" sort="Halfmann, Peter" uniqKey="Halfmann P" first="Peter" last="Halfmann">Peter Halfmann</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706</wicri:regionArea><wicri:noRegion>Wisconsin 53706</wicri:noRegion></affiliation></author><author><name sortKey="Hatta, Masato" sort="Hatta, Masato" uniqKey="Hatta M" first="Masato" last="Hatta">Masato Hatta</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706</wicri:regionArea><wicri:noRegion>Wisconsin 53706</wicri:noRegion></affiliation></author><author><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Special Pathogens Program National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2</wicri:regionArea><wicri:noRegion>Manitoba R3E 3R2</wicri:noRegion></affiliation></author><author><name sortKey="Alimonti, Judie B" sort="Alimonti, Judie B" uniqKey="Alimonti J" first="Judie B." last="Alimonti">Judie B. Alimonti</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Special Pathogens Program National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2</wicri:regionArea><wicri:noRegion>Manitoba R3E 3R2</wicri:noRegion></affiliation></author><author><name sortKey="Fernando, Lisa" sort="Fernando, Lisa" uniqKey="Fernando L" first="Lisa" last="Fernando">Lisa Fernando</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Special Pathogens Program National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2</wicri:regionArea><wicri:noRegion>Manitoba R3E 3R2</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G." last="Katze">Michael G. Katze</name><affiliation></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington National Primate Research Center, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Special Pathogens Program National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2</wicri:regionArea><wicri:noRegion>Manitoba R3E 3R2</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 3R2</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>CREST, Japan Science and Technology Agency, Saitama 322-0012</wicri:regionArea><wicri:noRegion>Saitama 322-0012</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706</wicri:regionArea><wicri:noRegion>Wisconsin 53706</wicri:noRegion><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><publisher>Nature Publishing Group</publisher><date when="2007-01-18">2007-01-18</date><biblScope unit="vol">445</biblScope><biblScope unit="issue">7125</biblScope><biblScope unit="page" from="319">319</biblScope><biblScope unit="page" to="323">323</biblScope><date type="Copyright" when="2006">2006</date></imprint><idno type="ISSN">0028-0836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.</title><author><name sortKey="Kobasa, Darwyn" sort="Kobasa, Darwyn" uniqKey="Kobasa D" first="Darwyn" last="Kobasa">Darwyn Kobasa</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Viruses, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Respiratory Viruses, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2</wicri:regionArea><wicri:noRegion>Manitoba R3E 3R2</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Steven M" sort="Jones, Steven M" uniqKey="Jones S" first="Steven M" last="Jones">Steven M. Jones</name></author><author><name sortKey="Shinya, Kyoko" sort="Shinya, Kyoko" uniqKey="Shinya K" first="Kyoko" last="Shinya">Kyoko Shinya</name></author><author><name sortKey="Kash, John C" sort="Kash, John C" uniqKey="Kash J" first="John C" last="Kash">John C. Kash</name></author><author><name sortKey="Copps, John" sort="Copps, John" uniqKey="Copps J" first="John" last="Copps">John Copps</name></author><author><name sortKey="Ebihara, Hideki" sort="Ebihara, Hideki" uniqKey="Ebihara H" first="Hideki" last="Ebihara">Hideki Ebihara</name></author><author><name sortKey="Hatta, Yasuko" sort="Hatta, Yasuko" uniqKey="Hatta Y" first="Yasuko" last="Hatta">Yasuko Hatta</name></author><author><name sortKey="Kim, Jin Hyun" sort="Kim, Jin Hyun" uniqKey="Kim J" first="Jin Hyun" last="Kim">Jin Hyun Kim</name></author><author><name sortKey="Halfmann, Peter" sort="Halfmann, Peter" uniqKey="Halfmann P" first="Peter" last="Halfmann">Peter Halfmann</name></author><author><name sortKey="Hatta, Masato" sort="Hatta, Masato" uniqKey="Hatta M" first="Masato" last="Hatta">Masato Hatta</name></author><author><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name></author><author><name sortKey="Alimonti, Judie B" sort="Alimonti, Judie B" uniqKey="Alimonti J" first="Judie B" last="Alimonti">Judie B. 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temps</term><term>Femelle</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (sang)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Immunité innée (immunologie)</term><term>Macaca fascicularis (immunologie)</term><term>Macaca fascicularis (virologie)</term><term>Modèles animaux de maladie humaine</term><term>Poumon (anatomopathologie)</term><term>Poumon (métabolisme)</term><term>Poumon (virologie)</term><term>Régulation de l'expression des gènes</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term><term>Séquençage par oligonucléotides en batterie</term><term>Taux de survie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Chemokines</term><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Immunité innée</term><term>Macaca fascicularis</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immunity, Innate</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza, Human</term><term>Macaca fascicularis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Chimiokines</term><term>Cytokines</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Macaca fascicularis</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Lung</term><term>Macaca fascicularis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Oligonucleotide Array Sequence Analysis</term><term>Survival Rate</term><term>Time Factors</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Régulation de l'expression des gènes</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Séquençage par oligonucléotides en batterie</term><term>Taux de survie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The 1918 influenza pandemic was unusually severe, resulting in about 50 million deaths worldwide. The 1918 virus is also highly pathogenic in mice, and studies have identified a multigenic origin of this virulent phenotype in mice. However, these initial characterizations of the 1918 virus did not address the question of its pathogenic potential in primates. Here we demonstrate that the 1918 virus caused a highly pathogenic respiratory infection in a cynomolgus macaque model that culminated in acute respiratory distress and a fatal outcome. Furthermore, infected animals mounted an immune response, characterized by dysregulation of the antiviral response, that was insufficient for protection, indicating that atypical host innate immune responses may contribute to lethality. The ability of influenza viruses to modulate host immune responses, such as that demonstrated for the avian H5N1 influenza viruses, may be a feature shared by the virulent influenza viruses.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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