Vaccines against pandemic influenza: what can be done before the next pandemic?
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Auteurs : Victor C. Huber [États-Unis] ; Jonathan A. MccullersSource :
- The Pediatric infectious disease journal [ 0891-3668 ] ; 2008.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques, Alun, Flambées de maladies, Grippe humaine (), Grippe humaine (épidémiologie), Humains, Hémagglutinines virales (immunologie), Polysorbates, Squalène (immunologie), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Vaccins antigrippaux (économie), Vaccins inactivés (effets indésirables), Vaccins inactivés (immunologie), Vaccins inactivés (économie), Virus de la grippe A (immunologie).
- MESH :
- effets indésirables : Vaccins antigrippaux, Vaccins inactivés.
- immunologie : Hémagglutinines virales, Squalène, Vaccins antigrippaux, Vaccins inactivés, Virus de la grippe A.
- économie : Vaccins antigrippaux, Vaccins inactivés.
- épidémiologie : Grippe humaine.
- Adjuvants immunologiques, Alun, Flambées de maladies, Grippe humaine, Humains, Polysorbates.
English descriptors
- KwdEn :
- Adjuvants, Immunologic, Alum Compounds, Disease Outbreaks, Hemagglutinins, Viral (immunology), Humans, Influenza A virus (immunology), Influenza Vaccines (adverse effects), Influenza Vaccines (economics), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Polysorbates, Squalene (immunology), Vaccines, Inactivated (adverse effects), Vaccines, Inactivated (economics), Vaccines, Inactivated (immunology).
- MESH :
- chemical , adverse effects : Influenza Vaccines, Vaccines, Inactivated.
- chemical , economics : Influenza Vaccines, Vaccines, Inactivated.
- chemical , immunology : Hemagglutinins, Viral, Influenza Vaccines, Squalene, Vaccines, Inactivated.
- chemical : Adjuvants, Immunologic, Alum Compounds, Polysorbates.
- epidemiology : Influenza, Human.
- immunology : Influenza A virus.
- prevention & control : Influenza, Human.
- Disease Outbreaks, Humans.
Abstract
We currently do not know which specific influenza subtype or isolate will cause the next influenza pandemic. However, 4 influenza virus hemagglutinin subtypes (H2, H5, H7, and H9) are considered the most likely candidates. Avian influenza viruses of the H5N1 subtype have received the most attention to this point, as their ability to spread within the human population remains the only barrier to emergence of a pandemic strain. Several vaccines have been tested against these potential pandemic viruses using standard methods for developing inactivated vaccines. In general, these vaccines have been poorly immunogenic, requiring high doses and multiple exposures to generate even modest antibody titers. The use of adjuvants to improve presentation of antigen and stimulate the immune system offers promise for enhanced immunity. Currently approved adjuvants, MF59 and Alum, can be readily incorporated into pandemic vaccines, while novel adjuvants are moving toward approval, but may still be years away from routine use. Thus, a prepandemic vaccine strategy that involves the stockpiling of both potential antigens and proven adjuvants may represent the best approach to deal with this looming threat.
DOI: 10.1097/INF.0b013e318168b749
PubMed: 18820570
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pubmed:18820570Le document en format XML
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Huber</name><affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-2794</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A" last="Mccullers">Jonathan A. Mccullers</name></author></analytic><series><title level="j">The Pediatric infectious disease journal</title><idno type="ISSN">0891-3668</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Alum Compounds</term><term>Disease Outbreaks</term><term>Hemagglutinins, Viral (immunology)</term><term>Humans</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza Vaccines (economics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (prevention & control)</term><term>Polysorbates</term><term>Squalene (immunology)</term><term>Vaccines, Inactivated (adverse effects)</term><term>Vaccines, Inactivated (economics)</term><term>Vaccines, Inactivated (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Alun</term><term>Flambées de maladies</term><term>Grippe humaine ()</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Hémagglutinines virales (immunologie)</term><term>Polysorbates</term><term>Squalène (immunologie)</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins antigrippaux (économie)</term><term>Vaccins inactivés (effets indésirables)</term><term>Vaccins inactivés (immunologie)</term><term>Vaccins inactivés (économie)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="economics" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Influenza Vaccines</term><term>Squalene</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Alum Compounds</term><term>Polysorbates</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Hémagglutinines virales</term><term>Squalène</term><term>Vaccins antigrippaux</term><term>Vaccins inactivés</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="économie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Outbreaks</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Alun</term><term>Flambées de maladies</term><term>Grippe humaine</term><term>Humains</term><term>Polysorbates</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We currently do not know which specific influenza subtype or isolate will cause the next influenza pandemic. However, 4 influenza virus hemagglutinin subtypes (H2, H5, H7, and H9) are considered the most likely candidates. Avian influenza viruses of the H5N1 subtype have received the most attention to this point, as their ability to spread within the human population remains the only barrier to emergence of a pandemic strain. Several vaccines have been tested against these potential pandemic viruses using standard methods for developing inactivated vaccines. In general, these vaccines have been poorly immunogenic, requiring high doses and multiple exposures to generate even modest antibody titers. The use of adjuvants to improve presentation of antigen and stimulate the immune system offers promise for enhanced immunity. Currently approved adjuvants, MF59 and Alum, can be readily incorporated into pandemic vaccines, while novel adjuvants are moving toward approval, but may still be years away from routine use. Thus, a prepandemic vaccine strategy that involves the stockpiling of both potential antigens and proven adjuvants may represent the best approach to deal with this looming threat.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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