Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients
Identifieur interne : 002525 ( Main/Merge ); précédent : 002524; suivant : 002526Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients
Auteurs : Per Ljungman [Suède] ; Rafael De La Camara [Espagne] ; Lena Perez-Bercoff [Suède] ; Manuel Abecasis [Portugal] ; Jose Bartolo Nieto Campuzano [Espagne] ; M. Jimena Cannata-Ortiz [Espagne] ; Catherine Cordonnier [France] ; Hermann Einsele [Allemagne] ; Marta Gonzalez-Vicent [Espagne] ; Ildefonso Espigado [Espagne] ; Jörg Halter [Suisse] ; Rodrigo Martino [Espagne] ; Bilal Mohty [Suisse] ; Gülsan Sucak [Turquie] ; Andrew J. Ullmann [Allemagne] ; Lourdes Vázquez [Espagne] ; Katherine N. Ward [Royaume-Uni] ; Dan Engelhard [Israël]Source :
- Haematologica [ 0390-6078 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antiviraux (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Facteurs de risque, Grippe humaine (), Grippe humaine (mortalité), Grippe humaine (épidémiologie), Humains, Jeune adulte, Lymphopénie (), Oséltamivir (usage thérapeutique), Pandémies, Pneumopathie infectieuse (), Résultat thérapeutique, Sous-type H1N1 du virus de la grippe A, Sujet âgé, Transplantation de cellules souches hématopoïétiques (mortalité), Vaccination.
- MESH :
- mortalité : Grippe humaine, Transplantation de cellules souches hématopoïétiques.
- usage thérapeutique : Antiviraux, Oséltamivir.
- épidémiologie : Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Grippe humaine, Humains, Jeune adulte, Lymphopénie, Pandémies, Pneumopathie infectieuse, Résultat thérapeutique, Sous-type H1N1 du virus de la grippe A, Sujet âgé, Vaccination.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antiviral Agents (therapeutic use), Child, Child, Preschool, Hematopoietic Stem Cell Transplantation (mortality), Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human (complications), Influenza, Human (epidemiology), Influenza, Human (mortality), Lymphopenia (complications), Middle Aged, Oseltamivir (therapeutic use), Pandemics, Pneumonia (complications), Risk Factors, Treatment Outcome, Vaccination, Young Adult.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Oseltamivir.
- complications : Influenza, Human, Lymphopenia, Pneumonia.
- epidemiology : Influenza, Human.
- mortality : Hematopoietic Stem Cell Transplantation, Influenza, Human.
- Adolescent, Adult, Aged, Child, Child, Preschool, Humans, Influenza A Virus, H1N1 Subtype, Middle Aged, Pandemics, Risk Factors, Treatment Outcome, Vaccination, Young Adult.
Abstract
During 2009, a new strain of A/H1N1 influenza appeared and became pandemic. A prospective study was performed to collect data regarding risk factors and outcome of A/H1N1 in hematopoietic stem cell transplant recipients. Only verified pandemic A/H1N1 influenza strains were included: 286 patients were reported, 222 allogeneic and 64 autologous recipients. The median age was 38.3 years and the median time from transplant was 19.4 months. Oseltamivir was administered to 267 patients and 15 patients received zanamivir. One hundred and twenty-five patients (43.7%) were hospitalized. Ninety-three patients (32.5%) developed lower respiratory tract disease. In multivariate analysis, risk factors were age (OR 1.025; 1.01–1.04;
Url:
DOI: 10.3324/haematol.2011.041913
PubMed: 21546495
PubMed Central: 3148919
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Jimena Cannata-Ortiz</name><affiliation wicri:level="3"><nlm:aff id="af2-0961231">Dept. of Hematology, University Hospital “La Princesa”, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Dept. of Hematology, University Hospital “La Princesa”, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Cordonnier, Catherine" sort="Cordonnier, Catherine" uniqKey="Cordonnier C" first="Catherine" last="Cordonnier">Catherine Cordonnier</name><affiliation wicri:level="3"><nlm:aff id="af5-0961231">Dept. of Hematology, Henri Mondor Teaching Hospital, Assistance Publique-Hopitaux de Paris and Paris Est-Créteil University, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Dept. of Hematology, Henri Mondor Teaching Hospital, Assistance Publique-Hopitaux de Paris and Paris Est-Créteil University, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Einsele, Hermann" sort="Einsele, Hermann" uniqKey="Einsele H" first="Hermann" last="Einsele">Hermann Einsele</name><affiliation wicri:level="3"><nlm:aff id="af6-0961231">Allogeneic Stem Cell Transplant Center, Div. of Haematology and Oncology, Dept. Int Med II, Julius Maximilian University, Würzburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Allogeneic Stem Cell Transplant Center, Div. of Haematology and Oncology, Dept. Int Med II, Julius Maximilian University, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Gonzalez Vicent, Marta" sort="Gonzalez Vicent, Marta" uniqKey="Gonzalez Vicent M" first="Marta" last="Gonzalez-Vicent">Marta Gonzalez-Vicent</name><affiliation wicri:level="3"><nlm:aff id="af7-0961231">University Hospital “Niño Jesús”, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital “Niño Jesús”, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Espigado, Ildefonso" sort="Espigado, Ildefonso" uniqKey="Espigado I" first="Ildefonso" last="Espigado">Ildefonso Espigado</name><affiliation wicri:level="1"><nlm:aff id="af8-0961231">Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBiS), Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBiS)</wicri:regionArea><wicri:noRegion>Instituto de Biomedicina de Sevilla (IBiS)</wicri:noRegion></affiliation></author><author><name sortKey="Halter, Jorg" sort="Halter, Jorg" uniqKey="Halter J" first="Jörg" last="Halter">Jörg Halter</name><affiliation wicri:level="1"><nlm:aff id="af9-0961231">Dept. of Hematology, University Hospital, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Dept. of Hematology, University Hospital, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name><affiliation wicri:level="3"><nlm:aff id="af10-0961231">Clinical Hematology Division, Hospital Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Hematology Division, Hospital Santa Creu i Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mohty, Bilal" sort="Mohty, Bilal" uniqKey="Mohty B" first="Bilal" last="Mohty">Bilal Mohty</name><affiliation wicri:level="1"><nlm:aff id="af11-0961231">Dept. of Hematology, University Hospital, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Dept. of Hematology, University Hospital, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Sucak, Gulsan" sort="Sucak, Gulsan" uniqKey="Sucak G" first="Gülsan" last="Sucak">Gülsan Sucak</name><affiliation wicri:level="1"><nlm:aff id="af12-0961231">Dept. of Hematology, Gazi University Hospital, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Dept. of Hematology, Gazi University Hospital, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Ullmann, Andrew J" sort="Ullmann, Andrew J" uniqKey="Ullmann A" first="Andrew J" last="Ullmann">Andrew J. Ullmann</name><affiliation wicri:level="3"><nlm:aff id="af13-0961231">3<sup>rd</sup> Dept. of Medicine, Johannes-Gutenberg-University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. of Medicine, Johannes-Gutenberg-University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Vazquez, Lourdes" sort="Vazquez, Lourdes" uniqKey="Vazquez L" first="Lourdes" last="Vázquez">Lourdes Vázquez</name><affiliation wicri:level="1"><nlm:aff id="af14-0961231">University Hospital “Clínico”, Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital “Clínico”, Salamanca</wicri:regionArea><wicri:noRegion>Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Ward, Katherine N" sort="Ward, Katherine N" uniqKey="Ward K" first="Katherine N." last="Ward">Katherine N. Ward</name><affiliation wicri:level="4"><nlm:aff id="af15-0961231">Dept. of Infection, University College London, Windeyer Institute of Medical Sciences, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dept. of Infection, University College London, Windeyer Institute of Medical Sciences, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Engelhard, Dan" sort="Engelhard, Dan" uniqKey="Engelhard D" first="Dan" last="Engelhard">Dan Engelhard</name><affiliation wicri:level="1"><nlm:aff id="af16-0961231">Dept. of Pediatrics, Hadassah–Hebrew University Medical Center, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Dept. of Pediatrics, Hadassah–Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21546495</idno><idno type="pmc">3148919</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148919</idno><idno type="RBID">PMC:3148919</idno><idno type="doi">10.3324/haematol.2011.041913</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000688</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000688</idno><idno type="wicri:Area/Pmc/Curation">000688</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000688</idno><idno type="wicri:Area/Pmc/Checkpoint">000843</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000843</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:21546495</idno><idno type="wicri:Area/PubMed/Corpus">001025</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001025</idno><idno type="wicri:Area/PubMed/Curation">001025</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001025</idno><idno type="wicri:Area/PubMed/Checkpoint">000F03</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F03</idno><idno type="wicri:Area/Ncbi/Merge">001035</idno><idno type="wicri:Area/Ncbi/Curation">001035</idno><idno type="wicri:Area/Ncbi/Checkpoint">001035</idno><idno type="wicri:doubleKey">0390-6078:2011:Ljungman P:outcome:of:pandemic</idno><idno type="wicri:Area/Main/Merge">002525</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients</title><author><name sortKey="Ljungman, Per" sort="Ljungman, Per" uniqKey="Ljungman P" first="Per" last="Ljungman">Per Ljungman</name><affiliation wicri:level="3"><nlm:aff id="af1-0961231">Dept. of Haematology, Karolinska University Hospital and Div. of Haematology, Dept. of Medicine, Karolinska Institutet/Huddinge, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Dept. of Haematology, Karolinska University Hospital and Div. of Haematology, Dept. of Medicine, Karolinska Institutet/Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="De La Camara, Rafael" sort="De La Camara, Rafael" uniqKey="De La Camara R" first="Rafael" last="De La Camara">Rafael De La Camara</name><affiliation wicri:level="3"><nlm:aff id="af2-0961231">Dept. of Hematology, University Hospital “La Princesa”, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Dept. of Hematology, University Hospital “La Princesa”, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Perez Bercoff, Lena" sort="Perez Bercoff, Lena" uniqKey="Perez Bercoff L" first="Lena" last="Perez-Bercoff">Lena Perez-Bercoff</name><affiliation wicri:level="3"><nlm:aff id="af1-0961231">Dept. of Haematology, Karolinska University Hospital and Div. of Haematology, Dept. of Medicine, Karolinska Institutet/Huddinge, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Dept. of Haematology, Karolinska University Hospital and Div. of Haematology, Dept. of Medicine, Karolinska Institutet/Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Abecasis, Manuel" sort="Abecasis, Manuel" uniqKey="Abecasis M" first="Manuel" last="Abecasis">Manuel Abecasis</name><affiliation wicri:level="1"><nlm:aff id="af3-0961231">BMT Unit, Inst. Portugues Oncologia, Lisbon, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>BMT Unit, Inst. Portugues Oncologia, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Nieto Campuzano, Jose Bartolo" sort="Nieto Campuzano, Jose Bartolo" uniqKey="Nieto Campuzano J" first="Jose Bartolo" last="Nieto Campuzano">Jose Bartolo Nieto Campuzano</name><affiliation wicri:level="1"><nlm:aff id="af4-0961231">University Hospital “Morales Meseguer”, Murcia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital “Morales Meseguer”, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation></author><author><name sortKey="Cannata Ortiz, M Jimena" sort="Cannata Ortiz, M Jimena" uniqKey="Cannata Ortiz M" first="M. Jimena" last="Cannata-Ortiz">M. Jimena Cannata-Ortiz</name><affiliation wicri:level="3"><nlm:aff id="af2-0961231">Dept. of Hematology, University Hospital “La Princesa”, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Dept. of Hematology, University Hospital “La Princesa”, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Cordonnier, Catherine" sort="Cordonnier, Catherine" uniqKey="Cordonnier C" first="Catherine" last="Cordonnier">Catherine Cordonnier</name><affiliation wicri:level="3"><nlm:aff id="af5-0961231">Dept. of Hematology, Henri Mondor Teaching Hospital, Assistance Publique-Hopitaux de Paris and Paris Est-Créteil University, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Dept. of Hematology, Henri Mondor Teaching Hospital, Assistance Publique-Hopitaux de Paris and Paris Est-Créteil University, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Einsele, Hermann" sort="Einsele, Hermann" uniqKey="Einsele H" first="Hermann" last="Einsele">Hermann Einsele</name><affiliation wicri:level="3"><nlm:aff id="af6-0961231">Allogeneic Stem Cell Transplant Center, Div. of Haematology and Oncology, Dept. Int Med II, Julius Maximilian University, Würzburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Allogeneic Stem Cell Transplant Center, Div. of Haematology and Oncology, Dept. Int Med II, Julius Maximilian University, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Gonzalez Vicent, Marta" sort="Gonzalez Vicent, Marta" uniqKey="Gonzalez Vicent M" first="Marta" last="Gonzalez-Vicent">Marta Gonzalez-Vicent</name><affiliation wicri:level="3"><nlm:aff id="af7-0961231">University Hospital “Niño Jesús”, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital “Niño Jesús”, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Espigado, Ildefonso" sort="Espigado, Ildefonso" uniqKey="Espigado I" first="Ildefonso" last="Espigado">Ildefonso Espigado</name><affiliation wicri:level="1"><nlm:aff id="af8-0961231">Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBiS), Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBiS)</wicri:regionArea><wicri:noRegion>Instituto de Biomedicina de Sevilla (IBiS)</wicri:noRegion></affiliation></author><author><name sortKey="Halter, Jorg" sort="Halter, Jorg" uniqKey="Halter J" first="Jörg" last="Halter">Jörg Halter</name><affiliation wicri:level="1"><nlm:aff id="af9-0961231">Dept. of Hematology, University Hospital, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Dept. of Hematology, University Hospital, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name><affiliation wicri:level="3"><nlm:aff id="af10-0961231">Clinical Hematology Division, Hospital Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Hematology Division, Hospital Santa Creu i Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mohty, Bilal" sort="Mohty, Bilal" uniqKey="Mohty B" first="Bilal" last="Mohty">Bilal Mohty</name><affiliation wicri:level="1"><nlm:aff id="af11-0961231">Dept. of Hematology, University Hospital, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Dept. of Hematology, University Hospital, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Sucak, Gulsan" sort="Sucak, Gulsan" uniqKey="Sucak G" first="Gülsan" last="Sucak">Gülsan Sucak</name><affiliation wicri:level="1"><nlm:aff id="af12-0961231">Dept. of Hematology, Gazi University Hospital, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Dept. of Hematology, Gazi University Hospital, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Ullmann, Andrew J" sort="Ullmann, Andrew J" uniqKey="Ullmann A" first="Andrew J" last="Ullmann">Andrew J. Ullmann</name><affiliation wicri:level="3"><nlm:aff id="af13-0961231">3<sup>rd</sup> Dept. of Medicine, Johannes-Gutenberg-University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. of Medicine, Johannes-Gutenberg-University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Vazquez, Lourdes" sort="Vazquez, Lourdes" uniqKey="Vazquez L" first="Lourdes" last="Vázquez">Lourdes Vázquez</name><affiliation wicri:level="1"><nlm:aff id="af14-0961231">University Hospital “Clínico”, Salamanca, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital “Clínico”, Salamanca</wicri:regionArea><wicri:noRegion>Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Ward, Katherine N" sort="Ward, Katherine N" uniqKey="Ward K" first="Katherine N." last="Ward">Katherine N. Ward</name><affiliation wicri:level="4"><nlm:aff id="af15-0961231">Dept. of Infection, University College London, Windeyer Institute of Medical Sciences, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dept. of Infection, University College London, Windeyer Institute of Medical Sciences, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Engelhard, Dan" sort="Engelhard, Dan" uniqKey="Engelhard D" first="Dan" last="Engelhard">Dan Engelhard</name><affiliation wicri:level="1"><nlm:aff id="af16-0961231">Dept. of Pediatrics, Hadassah–Hebrew University Medical Center, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Dept. of Pediatrics, Hadassah–Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author></analytic><series><title level="j">Haematologica</title><idno type="ISSN">0390-6078</idno><idno type="eISSN">1592-8721</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antiviral Agents (therapeutic use)</term><term>Child</term><term>Child, Preschool</term><term>Hematopoietic Stem Cell Transplantation (mortality)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza, Human (complications)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (mortality)</term><term>Lymphopenia (complications)</term><term>Middle Aged</term><term>Oseltamivir (therapeutic use)</term><term>Pandemics</term><term>Pneumonia (complications)</term><term>Risk Factors</term><term>Treatment Outcome</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antiviraux (usage thérapeutique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Grippe humaine ()</term><term>Grippe humaine (mortalité)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Jeune adulte</term><term>Lymphopénie ()</term><term>Oséltamivir (usage thérapeutique)</term><term>Pandémies</term><term>Pneumopathie infectieuse ()</term><term>Résultat thérapeutique</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sujet âgé</term><term>Transplantation de cellules souches hématopoïétiques (mortalité)</term><term>Vaccination</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term><term>Lymphopenia</term><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term><term>Transplantation de cellules souches hématopoïétiques</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Child, Preschool</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Middle Aged</term><term>Pandemics</term><term>Risk Factors</term><term>Treatment Outcome</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Grippe humaine</term><term>Humains</term><term>Jeune adulte</term><term>Lymphopénie</term><term>Pandémies</term><term>Pneumopathie infectieuse</term><term>Résultat thérapeutique</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sujet âgé</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>During 2009, a new strain of A/H1N1 influenza appeared and became pandemic. A prospective study was performed to collect data regarding risk factors and outcome of A/H1N1 in hematopoietic stem cell transplant recipients. Only verified pandemic A/H1N1 influenza strains were included: 286 patients were reported, 222 allogeneic and 64 autologous recipients. The median age was 38.3 years and the median time from transplant was 19.4 months. Oseltamivir was administered to 267 patients and 15 patients received zanamivir. One hundred and twenty-five patients (43.7%) were hospitalized. Ninety-three patients (32.5%) developed lower respiratory tract disease. In multivariate analysis, risk factors were age (OR 1.025; 1.01–1.04; <italic>P</italic>=0.002) and lymphopenia (OR 2.49; 1.33–4.67; <italic>P</italic><0.001). Thirty-three patients (11.5%) required mechanical ventilation. Eighteen patients (6.3%) died from A/H1N1 infection or its complications. Neutropenia (<italic>P</italic>=0.03) and patient age (<italic>P</italic>=0.04) were significant risk factors for death. The 2009 A/H1N1 influenza pandemic caused severe complications in stem cell transplant recipients.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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