Immunogenicity of Trivalent Inactivated Influenza Vaccination Received During Pregnancy or Postpartum
Identifieur interne : 002134 ( Main/Merge ); précédent : 002133; suivant : 002135Immunogenicity of Trivalent Inactivated Influenza Vaccination Received During Pregnancy or Postpartum
Auteurs : Rhoda S. Sperling [États-Unis] ; Stephanie M. Engel ; Sylvan Wallenstein ; Thomas A. Kraus ; Jose Garrido ; Tricia Singh ; Lisa Kellerman ; Thomas M. MoranSource :
- Obstetrics and gynecology : (New York. 1953) [ 0029-7844 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccination, Gynécologie.
English descriptors
- KwdEn :
Abstract
OBJECTIVE: To estimate the effects of gestational age and other maternal factors on immunologic responses to influenza vaccination. METHODS: Antepartum and postpartum women receiving influenza vaccination as part of routine clinical care were enrolled through four consecutive vaccination seasons (starting October 2006 through January 2010). Immunologic responses to trivalent inactivated influenza vaccine and monovalent H1 N1 were assessed as well as factors influencing vaccine responsiveness. Serum samples were obtained at baseline and 4-8 weeks postvaccination. RESULTS: Two hundred thirty-nine participants were included in the current analysis. Seroconversion rates to trivalent inactivated influenza vaccine strains were lowest in the first trimester (54.8%) and immediately postpartum (54.8%) and were highest in the late third trimester (69.6%) and late postpartum (69.4%); these differences were not statistically significant (P=.23). In a multivariable model, higher baseline antibody levels (P<.001) and prior year flu vaccination (P=.03) were both significantly associated with reduced odds of seroconversion. Overall, results were consistent when comparing trivalent inactivated influenza vaccine and monovalent pandemic H1 N1 responses. Although there was overall no significant association between gestational age at vaccination (P=.23) or prepregnancy body mass index (P=.16), we observed somewhat lower rates of seroconversion for women vaccinated in the first trimester and for obese women. CONCLUSION: Adequate immunologic responses to inactivated influenza vaccines were demonstrated during pregnancy and the postpartum period. No diminution of immunogenicity was observed in the third trimester, a time of increased clinical vulnerability to influenza.
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Sperling</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Departments of Obstetrics, Gynecology, and Reproductive Science, Preventive Medicine, and Microbiology, Mount Sinai School of Medicine</s1><s2>New York, New York</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Epidemiology, Gillings School of Global Public HealthUS, University of North Carolina at Chapel Hill</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Engel, Stephanie M" sort="Engel, Stephanie M" uniqKey="Engel S" first="Stephanie M." last="Engel">Stephanie M. Engel</name></author><author><name sortKey="Wallenstein, Sylvan" sort="Wallenstein, Sylvan" uniqKey="Wallenstein S" first="Sylvan" last="Wallenstein">Sylvan Wallenstein</name></author><author><name sortKey="Kraus, Thomas A" sort="Kraus, Thomas A" uniqKey="Kraus T" first="Thomas A." last="Kraus">Thomas A. Kraus</name></author><author><name sortKey="Garrido, Jose" sort="Garrido, Jose" uniqKey="Garrido J" first="Jose" last="Garrido">Jose Garrido</name></author><author><name sortKey="Singh, Tricia" sort="Singh, Tricia" uniqKey="Singh T" first="Tricia" last="Singh">Tricia Singh</name></author><author><name sortKey="Kellerman, Lisa" sort="Kellerman, Lisa" uniqKey="Kellerman L" first="Lisa" last="Kellerman">Lisa Kellerman</name></author><author><name sortKey="Moran, Thomas M" sort="Moran, Thomas M" uniqKey="Moran T" first="Thomas M." last="Moran">Thomas M. 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Sperling</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Departments of Obstetrics, Gynecology, and Reproductive Science, Preventive Medicine, and Microbiology, Mount Sinai School of Medicine</s1><s2>New York, New York</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Epidemiology, Gillings School of Global Public HealthUS, University of North Carolina at Chapel Hill</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Engel, Stephanie M" sort="Engel, Stephanie M" uniqKey="Engel S" first="Stephanie M." last="Engel">Stephanie M. Engel</name></author><author><name sortKey="Wallenstein, Sylvan" sort="Wallenstein, Sylvan" uniqKey="Wallenstein S" first="Sylvan" last="Wallenstein">Sylvan Wallenstein</name></author><author><name sortKey="Kraus, Thomas A" sort="Kraus, Thomas A" uniqKey="Kraus T" first="Thomas A." last="Kraus">Thomas A. Kraus</name></author><author><name sortKey="Garrido, Jose" sort="Garrido, Jose" uniqKey="Garrido J" first="Jose" last="Garrido">Jose Garrido</name></author><author><name sortKey="Singh, Tricia" sort="Singh, Tricia" uniqKey="Singh T" first="Tricia" last="Singh">Tricia Singh</name></author><author><name sortKey="Kellerman, Lisa" sort="Kellerman, Lisa" uniqKey="Kellerman L" first="Lisa" last="Kellerman">Lisa Kellerman</name></author><author><name sortKey="Moran, Thomas M" sort="Moran, Thomas M" uniqKey="Moran T" first="Thomas M." last="Moran">Thomas M. Moran</name></author></analytic><series><title level="j" type="main">Obstetrics and gynecology : (New York. 1953)</title><title level="j" type="abbreviated">Obstet. gynecol. : (N. Y., 1953)</title><idno type="ISSN">0029-7844</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Obstetrics and gynecology : (New York. 1953)</title><title level="j" type="abbreviated">Obstet. gynecol. : (N. Y., 1953)</title><idno type="ISSN">0029-7844</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gynecology</term><term>Immunogenicity</term><term>Immunoprophylaxis</term><term>Influenza</term><term>Obstetrics</term><term>Pregnancy</term><term>Puerperium</term><term>Vaccination</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Grippe</term><term>Immunogénicité</term><term>Vaccination</term><term>Immunoprophylaxie</term><term>Gestation</term><term>Postpartum</term><term>Gynécologie</term><term>Obstétrique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccination</term><term>Gynécologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE: To estimate the effects of gestational age and other maternal factors on immunologic responses to influenza vaccination. METHODS: Antepartum and postpartum women receiving influenza vaccination as part of routine clinical care were enrolled through four consecutive vaccination seasons (starting October 2006 through January 2010). Immunologic responses to trivalent inactivated influenza vaccine and monovalent H1 N1 were assessed as well as factors influencing vaccine responsiveness. Serum samples were obtained at baseline and 4-8 weeks postvaccination. RESULTS: Two hundred thirty-nine participants were included in the current analysis. Seroconversion rates to trivalent inactivated influenza vaccine strains were lowest in the first trimester (54.8%) and immediately postpartum (54.8%) and were highest in the late third trimester (69.6%) and late postpartum (69.4%); these differences were not statistically significant (P=.23). In a multivariable model, higher baseline antibody levels (P<.001) and prior year flu vaccination (P=.<sub>03</sub>) were both significantly associated with reduced odds of seroconversion. Overall, results were consistent when comparing trivalent inactivated influenza vaccine and monovalent pandemic H1 N1 responses. Although there was overall no significant association between gestational age at vaccination (P=.23) or prepregnancy body mass index (P=.16), we observed somewhat lower rates of seroconversion for women vaccinated in the first trimester and for obese women. CONCLUSION: Adequate immunologic responses to inactivated influenza vaccines were demonstrated during pregnancy and the postpartum period. No diminution of immunogenicity was observed in the third trimester, a time of increased clinical vulnerability to influenza.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>État de New York</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li></settlement><orgName><li>Université de Caroline du Nord à Chapel Hill</li></orgName></list><tree><noCountry><name sortKey="Engel, Stephanie M" sort="Engel, Stephanie M" uniqKey="Engel S" first="Stephanie M." last="Engel">Stephanie M. Engel</name><name sortKey="Garrido, Jose" sort="Garrido, Jose" uniqKey="Garrido J" first="Jose" last="Garrido">Jose Garrido</name><name sortKey="Kellerman, Lisa" sort="Kellerman, Lisa" uniqKey="Kellerman L" first="Lisa" last="Kellerman">Lisa Kellerman</name><name sortKey="Kraus, Thomas A" sort="Kraus, Thomas A" uniqKey="Kraus T" first="Thomas A." last="Kraus">Thomas A. Kraus</name><name sortKey="Moran, Thomas M" sort="Moran, Thomas M" uniqKey="Moran T" first="Thomas M." last="Moran">Thomas M. Moran</name><name sortKey="Singh, Tricia" sort="Singh, Tricia" uniqKey="Singh T" first="Tricia" last="Singh">Tricia Singh</name><name sortKey="Wallenstein, Sylvan" sort="Wallenstein, Sylvan" uniqKey="Wallenstein S" first="Sylvan" last="Wallenstein">Sylvan Wallenstein</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Sperling, Rhoda S" sort="Sperling, Rhoda S" uniqKey="Sperling R" first="Rhoda S." last="Sperling">Rhoda S. Sperling</name></region><name sortKey="Sperling, Rhoda S" sort="Sperling, Rhoda S" uniqKey="Sperling R" first="Rhoda S." last="Sperling">Rhoda S. Sperling</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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