Molecular Evolutionary Analysis of pH1N1 2009 Influenza Virus in Reunion Island, South West Indian Ocean Region: A Cohort Study
Identifieur interne : 001B13 ( Main/Merge ); précédent : 001B12; suivant : 001B14Molecular Evolutionary Analysis of pH1N1 2009 Influenza Virus in Reunion Island, South West Indian Ocean Region: A Cohort Study
Auteurs : Hervé Pascalis [France] ; Sarah Temmam [France] ; David A. Wilkinson [France] ; Najla Dsouli [France] ; Magali Turpin [France] ; Xavier De Lamballerie [France] ; Koussay Dellagi [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (virologie), Grippe humaine (épidémiologie), Génome viral (génétique), Humains, Jeune adulte, Mâle, Océan Indien (épidémiologie), Pandémies, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (pathogénicité), Variation génétique, Études de cohortes, Études de suivi, Évolution moléculaire.
- MESH :
- génétique : Génome viral, Sous-type H1N1 du virus de la grippe A.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine, Océan Indien.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Pandémies, Variation génétique, Études de cohortes, Études de suivi, Évolution moléculaire.
- Wicri :
- topic : Adulte, Enfant, Océan Indien.
English descriptors
- KwdEn :
- Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Evolution, Molecular, Female, Follow-Up Studies, Genetic Variation, Genome, Viral (genetics), Humans, Indian Ocean (epidemiology), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza, Human (epidemiology), Influenza, Human (virology), Male, Middle Aged, Pandemics, Young Adult.
- MESH :
- geographic , epidemiology : Indian Ocean.
- epidemiology : Influenza, Human.
- genetics : Genome, Viral, Influenza A Virus, H1N1 Subtype.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Evolution, Molecular, Female, Follow-Up Studies, Genetic Variation, Humans, Male, Middle Aged, Pandemics, Young Adult.
- mix :
Abstract
Molecular epidemiology is a powerful tool to decipher the dynamics of viral transmission, quasispecies temporal evolution and origins. Little is known about the pH1N1 molecular dynamics in general population. A prospective study (CoPanFlu-RUN) was carried out in Reunion Island to characterize pH1N1 genetic variability and molecular evolution occurring in population during the pH1N1
We directly amplified pH1N1 genomes from 28 different nasal swabs (26 individuals from 21 households). Fifteen strains were fully sequenced and 13 partially. This includes pairs of sequences from different members of 5 separate households; and two pairs from individuals, collected at different times. We assessed the molecular evolution of pH1N1 by genetic variability and phylogenetic analyses.
We found that i) Reunion pH1N1 sequences stemmed from global “clade 7” but shaped two phylogenetic sub-clades; ii) D239E mutation was identified in the hemagglutinin protein of all Reunion sequences, a mutation which has been associated elsewhere with mild-, upper-respiratory tract pH1N1 infecting strains; iii) Date estimates from molecular phylogenies predicted clade emergence some time before the first detection of pH1N1 by the epidemiological surveillance system; iv) Phylogenetic relatedness was observed between Reunion pH1N1 viruses and those from other countries in South-western Indian Ocean area; v) Quasispecies populations were observed within households and individuals of the cohort-study.
Surveillance and/or prevention systems presently based on
Url:
DOI: 10.1371/journal.pone.0043742
PubMed: 22952752
PubMed Central: 3428279
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D50
- to stream Pmc, to step Curation: 000D50
- to stream Pmc, to step Checkpoint: 000703
- to stream PubMed, to step Corpus: 000C12
- to stream PubMed, to step Curation: 000C12
- to stream PubMed, to step Checkpoint: 000C09
- to stream Ncbi, to step Merge: 001461
- to stream Ncbi, to step Curation: 001461
- to stream Ncbi, to step Checkpoint: 001461
- to stream Hal, to step Corpus: 000404
- to stream Hal, to step Curation: 000404
- to stream Hal, to step Checkpoint: 000561
Links to Exploration step
PMC:3428279Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Evolutionary Analysis of pH1N1 2009 <italic>Influenza</italic>
Virus in Reunion Island, South West Indian Ocean Region: A Cohort Study</title>
<author><name sortKey="Pascalis, Herve" sort="Pascalis, Herve" uniqKey="Pascalis H" first="Hervé" last="Pascalis">Hervé Pascalis</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temmam, Sarah" sort="Temmam, Sarah" uniqKey="Temmam S" first="Sarah" last="Temmam">Sarah Temmam</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Ecologie microbienne (UMR 5557) CNRS-Université de Lyon, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ecologie microbienne (UMR 5557) CNRS-Université de Lyon, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilkinson, David A" sort="Wilkinson, David A" uniqKey="Wilkinson D" first="David A." last="Wilkinson">David A. Wilkinson</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université de La Réunion, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de La Réunion, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dsouli, Najla" sort="Dsouli, Najla" uniqKey="Dsouli N" first="Najla" last="Dsouli">Najla Dsouli</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Turpin, Magali" sort="Turpin, Magali" uniqKey="Turpin M" first="Magali" last="Turpin">Magali Turpin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
</affiliation>
</author>
<author><name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22952752</idno>
<idno type="pmc">3428279</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428279</idno>
<idno type="RBID">PMC:3428279</idno>
<idno type="doi">10.1371/journal.pone.0043742</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000D50</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D50</idno>
<idno type="wicri:Area/Pmc/Curation">000D50</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D50</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000703</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000703</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:22952752</idno>
<idno type="wicri:Area/PubMed/Corpus">000C12</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C12</idno>
<idno type="wicri:Area/PubMed/Curation">000C12</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C12</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000C09</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C09</idno>
<idno type="wicri:Area/Ncbi/Merge">001461</idno>
<idno type="wicri:Area/Ncbi/Curation">001461</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001461</idno>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01285448</idno>
<idno type="url">https://hal.univ-reunion.fr/hal-01285448</idno>
<idno type="wicri:Area/Hal/Corpus">000404</idno>
<idno type="wicri:Area/Hal/Curation">000404</idno>
<idno type="wicri:Area/Hal/Checkpoint">000561</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000561</idno>
<idno type="wicri:doubleKey">1932-6203:2012:Pascalis H:molecular:evolutionary:analysis</idno>
<idno type="wicri:Area/Main/Merge">001B13</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Evolutionary Analysis of pH1N1 2009 <italic>Influenza</italic>
Virus in Reunion Island, South West Indian Ocean Region: A Cohort Study</title>
<author><name sortKey="Pascalis, Herve" sort="Pascalis, Herve" uniqKey="Pascalis H" first="Hervé" last="Pascalis">Hervé Pascalis</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temmam, Sarah" sort="Temmam, Sarah" uniqKey="Temmam S" first="Sarah" last="Temmam">Sarah Temmam</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Ecologie microbienne (UMR 5557) CNRS-Université de Lyon, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ecologie microbienne (UMR 5557) CNRS-Université de Lyon, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilkinson, David A" sort="Wilkinson, David A" uniqKey="Wilkinson D" first="David A." last="Wilkinson">David A. Wilkinson</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université de La Réunion, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de La Réunion, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dsouli, Najla" sort="Dsouli, Najla" uniqKey="Dsouli N" first="Najla" last="Dsouli">Najla Dsouli</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Turpin, Magali" sort="Turpin, Magali" uniqKey="Turpin M" first="Magali" last="Turpin">Magali Turpin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
</affiliation>
</author>
<author><name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cohort Studies</term>
<term>Evolution, Molecular</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Variation</term>
<term>Genome, Viral (genetics)</term>
<term>Humans</term>
<term>Indian Ocean (epidemiology)</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (virology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Génome viral (génétique)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Océan Indien (épidémiologie)</term>
<term>Pandémies</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
<term>Variation génétique</term>
<term>Études de cohortes</term>
<term>Études de suivi</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Indian Ocean</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genome, Viral</term>
<term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Génome viral</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Océan Indien</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cohort Studies</term>
<term>Evolution, Molecular</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Variation génétique</term>
<term>Études de cohortes</term>
<term>Études de suivi</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
<term>Enfant</term>
<term>Océan Indien</term>
</keywords>
<keywords scheme="mix" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Child</term>
<term>Cohort Studies</term>
<term>Evolution</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Variation</term>
<term>Genome</term>
<term>H1N1 Subtype</term>
<term>Human</term>
<term>Humans</term>
<term>Indian Ocean</term>
<term>Influenza</term>
<term>Influenza A Virus</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular</term>
<term>Pandemics</term>
<term>Preschool</term>
<term>Viral</term>
<term>Young Adult</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background/Objectives</title>
<p>Molecular epidemiology is a powerful tool to decipher the dynamics of viral transmission, quasispecies temporal evolution and origins. Little is known about the pH1N1 molecular dynamics in general population. A prospective study (CoPanFlu-RUN) was carried out in Reunion Island to characterize pH1N1 genetic variability and molecular evolution occurring in population during the pH1N1 <italic>Influenza</italic>
pandemic in 2009.</p>
</sec>
<sec><title>Methodology</title>
<p>We directly amplified pH1N1 genomes from 28 different nasal swabs (26 individuals from 21 households). Fifteen strains were fully sequenced and 13 partially. This includes pairs of sequences from different members of 5 separate households; and two pairs from individuals, collected at different times. We assessed the molecular evolution of pH1N1 by genetic variability and phylogenetic analyses.</p>
</sec>
<sec><title>Principal Findings</title>
<p>We found that i) Reunion pH1N1 sequences stemmed from global “clade 7” but shaped two phylogenetic sub-clades; ii) D239E mutation was identified in the hemagglutinin protein of all Reunion sequences, a mutation which has been associated elsewhere with mild-, upper-respiratory tract pH1N1 infecting strains; iii) Date estimates from molecular phylogenies predicted clade emergence some time before the first detection of pH1N1 by the epidemiological surveillance system; iv) Phylogenetic relatedness was observed between Reunion pH1N1 viruses and those from other countries in South-western Indian Ocean area; v) Quasispecies populations were observed within households and individuals of the cohort-study.</p>
</sec>
<sec><title>Conclusions</title>
<p>Surveillance and/or prevention systems presently based on <italic>Influenza</italic>
virus sequence variation should take into account that the majority of studies of pH1N1 <italic>Influenza</italic>
generate genetic data for the HA/NA viral segments obtained from hospitalized-patients, which is potentially non-representative of the overall viral diversity within whole populations. Our observations highlight the importance of collecting unbiased data at the community level and conducting whole genome analysis to accurately understand viral dynamics.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
<author><name sortKey="Hanage, Wp" uniqKey="Hanage W">WP Hanage</name>
</author>
<author><name sortKey="Van Kerkhove, Md" uniqKey="Van Kerkhove M">MD Van Kerkhove</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name>
</author>
<author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author><name sortKey="Shaw, Mw" uniqKey="Shaw M">MW Shaw</name>
</author>
<author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name>
</author>
<author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name>
</author>
<author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name>
</author>
<author><name sortKey="Shu, B" uniqKey="Shu B">B Shu</name>
</author>
<author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balcan, D" uniqKey="Balcan D">D Balcan</name>
</author>
<author><name sortKey="Hu, H" uniqKey="Hu H">H Hu</name>
</author>
<author><name sortKey="Goncalves, B" uniqKey="Goncalves B">B Goncalves</name>
</author>
<author><name sortKey="Bajardi, P" uniqKey="Bajardi P">P Bajardi</name>
</author>
<author><name sortKey="Poletto, C" uniqKey="Poletto C">C Poletto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, M" uniqKey="Nelson M">M Nelson</name>
</author>
<author><name sortKey="Spiro, D" uniqKey="Spiro D">D Spiro</name>
</author>
<author><name sortKey="Wentworth, D" uniqKey="Wentworth D">D Wentworth</name>
</author>
<author><name sortKey="Beck, E" uniqKey="Beck E">E Beck</name>
</author>
<author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Potdar, Va" uniqKey="Potdar V">VA Potdar</name>
</author>
<author><name sortKey="Chadha, Ms" uniqKey="Chadha M">MS Chadha</name>
</author>
<author><name sortKey="Jadhav, Sm" uniqKey="Jadhav S">SM Jadhav</name>
</author>
<author><name sortKey="Mullick, J" uniqKey="Mullick J">J Mullick</name>
</author>
<author><name sortKey="Cherian, Ss" uniqKey="Cherian S">SS Cherian</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Barrero, Pr" uniqKey="Barrero P">PR Barrero</name>
</author>
<author><name sortKey="Viegas, M" uniqKey="Viegas M">M Viegas</name>
</author>
<author><name sortKey="Valinotto, Le" uniqKey="Valinotto L">LE Valinotto</name>
</author>
<author><name sortKey="Mistchenko, As" uniqKey="Mistchenko A">AS Mistchenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name>
</author>
<author><name sortKey="Zhang, Aj" uniqKey="Zhang A">AJ Zhang</name>
</author>
<author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furuse, Y" uniqKey="Furuse Y">Y Furuse</name>
</author>
<author><name sortKey="Suzuki, A" uniqKey="Suzuki A">A Suzuki</name>
</author>
<author><name sortKey="Oshitani, H" uniqKey="Oshitani H">H Oshitani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shiino, T" uniqKey="Shiino T">T Shiino</name>
</author>
<author><name sortKey="Okabe, N" uniqKey="Okabe N">N Okabe</name>
</author>
<author><name sortKey="Yasui, Y" uniqKey="Yasui Y">Y Yasui</name>
</author>
<author><name sortKey="Sunagawa, T" uniqKey="Sunagawa T">T Sunagawa</name>
</author>
<author><name sortKey="Ujike, M" uniqKey="Ujike M">M Ujike</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parks, D" uniqKey="Parks D">D Parks</name>
</author>
<author><name sortKey="Macdonald, N" uniqKey="Macdonald N">N Macdonald</name>
</author>
<author><name sortKey="Beiko, R" uniqKey="Beiko R">R Beiko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pariani, E" uniqKey="Pariani E">E Pariani</name>
</author>
<author><name sortKey="Piralla, A" uniqKey="Piralla A">A Piralla</name>
</author>
<author><name sortKey="Frati, E" uniqKey="Frati E">E Frati</name>
</author>
<author><name sortKey="Anselmi, G" uniqKey="Anselmi G">G Anselmi</name>
</author>
<author><name sortKey="Campanini, G" uniqKey="Campanini G">G Campanini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Graham, M" uniqKey="Graham M">M Graham</name>
</author>
<author><name sortKey="Liang, B" uniqKey="Liang B">B Liang</name>
</author>
<author><name sortKey="Van Domselaar, G" uniqKey="Van Domselaar G">G Van Domselaar</name>
</author>
<author><name sortKey="Bastien, N" uniqKey="Bastien N">N Bastien</name>
</author>
<author><name sortKey="Beaudoin, C" uniqKey="Beaudoin C">C Beaudoin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balcan, D" uniqKey="Balcan D">D Balcan</name>
</author>
<author><name sortKey="Hu, H" uniqKey="Hu H">H Hu</name>
</author>
<author><name sortKey="Goncalves, B" uniqKey="Goncalves B">B Goncalves</name>
</author>
<author><name sortKey="Bajardi, P" uniqKey="Bajardi P">P Bajardi</name>
</author>
<author><name sortKey="Poletto, C" uniqKey="Poletto C">C Poletto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brownstein, Js" uniqKey="Brownstein J">JS Brownstein</name>
</author>
<author><name sortKey="Wolfe, Cj" uniqKey="Wolfe C">CJ Wolfe</name>
</author>
<author><name sortKey="Mandl, Kd" uniqKey="Mandl K">KD Mandl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Rtenzio, E" uniqKey="D Rtenzio E">E D’Ortenzio</name>
</author>
<author><name sortKey="Renault, P" uniqKey="Renault P">P Renault</name>
</author>
<author><name sortKey="Jaffar Bandjee, Mc" uniqKey="Jaffar Bandjee M">MC Jaffar-Bandjee</name>
</author>
<author><name sortKey="Gauzere, Ba" uniqKey="Gauzere B">BA Gauzere</name>
</author>
<author><name sortKey="Lagrange Xelot, M" uniqKey="Lagrange Xelot M">M Lagrange-Xelot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dellagi, K" uniqKey="Dellagi K">K Dellagi</name>
</author>
<author><name sortKey="Rollot, O" uniqKey="Rollot O">O Rollot</name>
</author>
<author><name sortKey="Temmam, S" uniqKey="Temmam S">S Temmam</name>
</author>
<author><name sortKey="Salez, N" uniqKey="Salez N">N Salez</name>
</author>
<author><name sortKey="Guernier, V" uniqKey="Guernier V">V Guernier</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ninove, L" uniqKey="Ninove L">L Ninove</name>
</author>
<author><name sortKey="Nougairede, A" uniqKey="Nougairede A">A Nougairede</name>
</author>
<author><name sortKey="Gazin, C" uniqKey="Gazin C">C Gazin</name>
</author>
<author><name sortKey="Thirion, L" uniqKey="Thirion L">L Thirion</name>
</author>
<author><name sortKey="Delogu, I" uniqKey="Delogu I">I Delogu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ninove, L" uniqKey="Ninove L">L Ninove</name>
</author>
<author><name sortKey="Gazin, C" uniqKey="Gazin C">C Gazin</name>
</author>
<author><name sortKey="Gould, Ea" uniqKey="Gould E">EA Gould</name>
</author>
<author><name sortKey="Nougairede, A" uniqKey="Nougairede A">A Nougairede</name>
</author>
<author><name sortKey="Flahault, A" uniqKey="Flahault A">A Flahault</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhirnov, Op" uniqKey="Zhirnov O">OP Zhirnov</name>
</author>
<author><name sortKey="Vorobjeva, Iv" uniqKey="Vorobjeva I">IV Vorobjeva</name>
</author>
<author><name sortKey="Saphonova, Oa" uniqKey="Saphonova O">OA Saphonova</name>
</author>
<author><name sortKey="Poyarkov, Sv" uniqKey="Poyarkov S">SV Poyarkov</name>
</author>
<author><name sortKey="Ovcharenko, Av" uniqKey="Ovcharenko A">AV Ovcharenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Edgar, Rc" uniqKey="Edgar R">RC Edgar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Posada, D" uniqKey="Posada D">D Posada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guindon, S" uniqKey="Guindon S">S Guindon</name>
</author>
<author><name sortKey="Gascuel, O" uniqKey="Gascuel O">O Gascuel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ronquist, F" uniqKey="Ronquist F">F Ronquist</name>
</author>
<author><name sortKey="Huelsenbeck, Jp" uniqKey="Huelsenbeck J">JP Huelsenbeck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name>
</author>
<author><name sortKey="Peterson, D" uniqKey="Peterson D">D Peterson</name>
</author>
<author><name sortKey="Peterson, N" uniqKey="Peterson N">N Peterson</name>
</author>
<author><name sortKey="Stecher, G" uniqKey="Stecher G">G Stecher</name>
</author>
<author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tajima, F" uniqKey="Tajima F">F Tajima</name>
</author>
<author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drummond, Aj" uniqKey="Drummond A">AJ Drummond</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goni, N" uniqKey="Goni N">N Goni</name>
</author>
<author><name sortKey="Fajardo, A" uniqKey="Fajardo A">A Fajardo</name>
</author>
<author><name sortKey="Moratorio, G" uniqKey="Moratorio G">G Moratorio</name>
</author>
<author><name sortKey="Colina, R" uniqKey="Colina R">R Colina</name>
</author>
<author><name sortKey="Cristina, J" uniqKey="Cristina J">J Cristina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, Mi" uniqKey="Nelson M">MI Nelson</name>
</author>
<author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, M" uniqKey="Nelson M">M Nelson</name>
</author>
<author><name sortKey="Spiro, D" uniqKey="Spiro D">D Spiro</name>
</author>
<author><name sortKey="Wentworth, D" uniqKey="Wentworth D">D Wentworth</name>
</author>
<author><name sortKey="Beck, E" uniqKey="Beck E">E Beck</name>
</author>
<author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furuse, Y" uniqKey="Furuse Y">Y Furuse</name>
</author>
<author><name sortKey="Suzuki, A" uniqKey="Suzuki A">A Suzuki</name>
</author>
<author><name sortKey="Oshitani, H" uniqKey="Oshitani H">H Oshitani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferraris, O" uniqKey="Ferraris O">O Ferraris</name>
</author>
<author><name sortKey="Lina, B" uniqKey="Lina B">B Lina</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Glinsky, Gv" uniqKey="Glinsky G">GV Glinsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reid, Ah" uniqKey="Reid A">AH Reid</name>
</author>
<author><name sortKey="Fanning, Tg" uniqKey="Fanning T">TG Fanning</name>
</author>
<author><name sortKey="Hultin, Jv" uniqKey="Hultin J">JV Hultin</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
<author><name sortKey="Kao, Ry" uniqKey="Kao R">RY Kao</name>
</author>
<author><name sortKey="Wu, Wl" uniqKey="Wu W">WL Wu</name>
</author>
<author><name sortKey="Lim, Ww" uniqKey="Lim W">WW Lim</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name>
</author>
<author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Aj" uniqKey="Zhang A">AJ Zhang</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Guo, Ky" uniqKey="Guo K">KY Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Filleul, L" uniqKey="Filleul L">L Filleul</name>
</author>
<author><name sortKey="D Rtenzio, E" uniqKey="D Rtenzio E">E D’Ortenzio</name>
</author>
<author><name sortKey="Kermarec, F" uniqKey="Kermarec F">F Kermarec</name>
</author>
<author><name sortKey="Le Bot, F" uniqKey="Le Bot F">F Le Bot</name>
</author>
<author><name sortKey="Renault, P" uniqKey="Renault P">P Renault</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kelly, Ha" uniqKey="Kelly H">HA Kelly</name>
</author>
<author><name sortKey="Mercer, Gn" uniqKey="Mercer G">GN Mercer</name>
</author>
<author><name sortKey="Fielding, Je" uniqKey="Fielding J">JE Fielding</name>
</author>
<author><name sortKey="Dowse, Gk" uniqKey="Dowse G">GK Dowse</name>
</author>
<author><name sortKey="Glass, K" uniqKey="Glass K">K Glass</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chao, Dy" uniqKey="Chao D">DY Chao</name>
</author>
<author><name sortKey="Cheng, Kf" uniqKey="Cheng K">KF Cheng</name>
</author>
<author><name sortKey="Li, Tc" uniqKey="Li T">TC Li</name>
</author>
<author><name sortKey="Wu, Tn" uniqKey="Wu T">TN Wu</name>
</author>
<author><name sortKey="Chen, Cy" uniqKey="Chen C">CY Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name>
</author>
<author><name sortKey="Novikov, Dv" uniqKey="Novikov D">DV Novikov</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Chu, Dk" uniqKey="Chu D">DK Chu</name>
</author>
<author><name sortKey="Fung, Cc" uniqKey="Fung C">CC Fung</name>
</author>
<author><name sortKey="Cheng, Ck" uniqKey="Cheng C">CK Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boelle, Py" uniqKey="Boelle P">PY Boelle</name>
</author>
<author><name sortKey="Ansart, S" uniqKey="Ansart S">S Ansart</name>
</author>
<author><name sortKey="Cori, A" uniqKey="Cori A">A Cori</name>
</author>
<author><name sortKey="Valleron, Aj" uniqKey="Valleron A">AJ Valleron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, Mi" uniqKey="Nelson M">MI Nelson</name>
</author>
<author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ghedin, E" uniqKey="Ghedin E">E Ghedin</name>
</author>
<author><name sortKey="Laplante, J" uniqKey="Laplante J">J Laplante</name>
</author>
<author><name sortKey="Depasse, J" uniqKey="Depasse J">J DePasse</name>
</author>
<author><name sortKey="Wentworth, De" uniqKey="Wentworth D">DE Wentworth</name>
</author>
<author><name sortKey="Santos, Rp" uniqKey="Santos R">RP Santos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greninger, Al" uniqKey="Greninger A">AL Greninger</name>
</author>
<author><name sortKey="Chen, Ec" uniqKey="Chen E">EC Chen</name>
</author>
<author><name sortKey="Sittler, T" uniqKey="Sittler T">T Sittler</name>
</author>
<author><name sortKey="Scheinerman, A" uniqKey="Scheinerman A">A Scheinerman</name>
</author>
<author><name sortKey="Roubinian, N" uniqKey="Roubinian N">N Roubinian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lauring, As" uniqKey="Lauring A">AS Lauring</name>
</author>
<author><name sortKey="Andino, R" uniqKey="Andino R">R Andino</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<double doi="10.1371/journal.pone.0043742"><HAL><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular evolutionary analysis of pH1N1 2009 influenza virus in Reunion Island, South West Indian Ocean region: a cohort study</title>
<author><name sortKey="Pascalis, Herve" sort="Pascalis, Herve" uniqKey="Pascalis H" first="Hervé" last="Pascalis">Hervé Pascalis</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-234808" status="VALID"> <orgName>Cyclotron Réunion Océan Indien</orgName>
<orgName type="acronym">CYROI</orgName>
<desc> <address> <addrLine>GIP-CYROI, 2 rue Maxime Rivière, 97490 Sainte Clotilde</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.cyroi.fr</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
<relation active="#struct-351465" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-351465" type="direct"><org type="institution" xml:id="struct-351465" status="VALID"> <orgName>Centre Hospitalier Universitaire de La Réunion</orgName>
<orgName type="acronym">CHU La Réunion</orgName>
<desc> <address> <country key="RE"></country>
</address>
<ref type="url">http://www.chu-reunion.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Temmam, Sarah" sort="Temmam, Sarah" uniqKey="Temmam S" first="Sarah" last="Temmam">Sarah Temmam</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-234808" status="VALID"> <orgName>Cyclotron Réunion Océan Indien</orgName>
<orgName type="acronym">CYROI</orgName>
<desc> <address> <addrLine>GIP-CYROI, 2 rue Maxime Rivière, 97490 Sainte Clotilde</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.cyroi.fr</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
<relation active="#struct-351465" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-351465" type="direct"><org type="institution" xml:id="struct-351465" status="VALID"> <orgName>Centre Hospitalier Universitaire de La Réunion</orgName>
<orgName type="acronym">CHU La Réunion</orgName>
<desc> <address> <country key="RE"></country>
</address>
<ref type="url">http://www.chu-reunion.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Wilkinson, David A" sort="Wilkinson, David A" uniqKey="Wilkinson D" first="David A" last="Wilkinson">David A. Wilkinson</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-234808" status="VALID"> <orgName>Cyclotron Réunion Océan Indien</orgName>
<orgName type="acronym">CYROI</orgName>
<desc> <address> <addrLine>GIP-CYROI, 2 rue Maxime Rivière, 97490 Sainte Clotilde</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.cyroi.fr</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
<relation active="#struct-351465" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-351465" type="direct"><org type="institution" xml:id="struct-351465" status="VALID"> <orgName>Centre Hospitalier Universitaire de La Réunion</orgName>
<orgName type="acronym">CHU La Réunion</orgName>
<desc> <address> <country key="RE"></country>
</address>
<ref type="url">http://www.chu-reunion.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Dsouli, Najla" sort="Dsouli, Najla" uniqKey="Dsouli N" first="Najla" last="Dsouli">Najla Dsouli</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Turpin, Magali" sort="Turpin, Magali" uniqKey="Turpin M" first="Magali" last="Turpin">Magali Turpin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174264" status="OLD"> <orgName>Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien</orgName>
<orgName type="acronym">CRVOI</orgName>
<desc> <address> <addrLine>GIS-CRVOI2, rue Maxime Rivière 97490 Sainte Clotilde La Réunion</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.crvoi.org</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Lamballerie, Xavier" sort="Lamballerie, Xavier" uniqKey="Lamballerie X" first="Xavier" last="Lamballerie">Xavier Lamballerie</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-86891" status="OLD"> <idno type="IdRef">124942504</idno>
<idno type="RNSR">200817677J</idno>
<orgName>Emergence des Pathologies Virales</orgName>
<orgName type="acronym">EPV</orgName>
<date type="start">2008</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de médecine27 Bd jean Moulin13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.ird.fr/la-recherche/liste-des-unites-de-recherche/190-emergence-des-pathologies-virales</ref>
</desc>
<listRelation> <relation name="UMR_D 190" active="#struct-303623" type="direct"></relation>
<relation name="UMR_D 190" active="#struct-67872" type="direct"></relation>
<relation name="UMR_D 190" active="#struct-198056" type="direct"></relation>
<relation name="UMR_D 190" active="#struct-300073" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR_D 190" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_D 190" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_D 190" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_D 190" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-234808" status="VALID"> <orgName>Cyclotron Réunion Océan Indien</orgName>
<orgName type="acronym">CYROI</orgName>
<desc> <address> <addrLine>GIP-CYROI, 2 rue Maxime Rivière, 97490 Sainte Clotilde</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.cyroi.fr</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
<relation active="#struct-351465" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-351465" type="direct"><org type="institution" xml:id="struct-351465" status="VALID"> <orgName>Centre Hospitalier Universitaire de La Réunion</orgName>
<orgName type="acronym">CHU La Réunion</orgName>
<desc> <address> <country key="RE"></country>
</address>
<ref type="url">http://www.chu-reunion.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01285448</idno>
<idno type="halId">hal-01285448</idno>
<idno type="halUri">https://hal.univ-reunion.fr/hal-01285448</idno>
<idno type="url">https://hal.univ-reunion.fr/hal-01285448</idno>
<idno type="doi">10.1371/journal.pone.0043742</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Hal/Corpus">000404</idno>
<idno type="wicri:Area/Hal/Curation">000404</idno>
<idno type="wicri:Area/Hal/Checkpoint">000561</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000561</idno>
<idno type="wicri:doubleKey">1932-6203:2012:Pascalis H:molecular:evolutionary:analysis</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular evolutionary analysis of pH1N1 2009 influenza virus in Reunion Island, South West Indian Ocean region: a cohort study</title>
<author><name sortKey="Pascalis, Herve" sort="Pascalis, Herve" uniqKey="Pascalis H" first="Hervé" last="Pascalis">Hervé Pascalis</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-234808" status="VALID"> <orgName>Cyclotron Réunion Océan Indien</orgName>
<orgName type="acronym">CYROI</orgName>
<desc> <address> <addrLine>GIP-CYROI, 2 rue Maxime Rivière, 97490 Sainte Clotilde</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.cyroi.fr</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
<relation active="#struct-351465" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-351465" type="direct"><org type="institution" xml:id="struct-351465" status="VALID"> <orgName>Centre Hospitalier Universitaire de La Réunion</orgName>
<orgName type="acronym">CHU La Réunion</orgName>
<desc> <address> <country key="RE"></country>
</address>
<ref type="url">http://www.chu-reunion.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Temmam, Sarah" sort="Temmam, Sarah" uniqKey="Temmam S" first="Sarah" last="Temmam">Sarah Temmam</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-234808" status="VALID"> <orgName>Cyclotron Réunion Océan Indien</orgName>
<orgName type="acronym">CYROI</orgName>
<desc> <address> <addrLine>GIP-CYROI, 2 rue Maxime Rivière, 97490 Sainte Clotilde</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.cyroi.fr</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
<relation active="#struct-351465" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-351465" type="direct"><org type="institution" xml:id="struct-351465" status="VALID"> <orgName>Centre Hospitalier Universitaire de La Réunion</orgName>
<orgName type="acronym">CHU La Réunion</orgName>
<desc> <address> <country key="RE"></country>
</address>
<ref type="url">http://www.chu-reunion.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Wilkinson, David A" sort="Wilkinson, David A" uniqKey="Wilkinson D" first="David A" last="Wilkinson">David A. Wilkinson</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-234808" status="VALID"> <orgName>Cyclotron Réunion Océan Indien</orgName>
<orgName type="acronym">CYROI</orgName>
<desc> <address> <addrLine>GIP-CYROI, 2 rue Maxime Rivière, 97490 Sainte Clotilde</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.cyroi.fr</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
<relation active="#struct-351465" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-351465" type="direct"><org type="institution" xml:id="struct-351465" status="VALID"> <orgName>Centre Hospitalier Universitaire de La Réunion</orgName>
<orgName type="acronym">CHU La Réunion</orgName>
<desc> <address> <country key="RE"></country>
</address>
<ref type="url">http://www.chu-reunion.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Dsouli, Najla" sort="Dsouli, Najla" uniqKey="Dsouli N" first="Najla" last="Dsouli">Najla Dsouli</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Turpin, Magali" sort="Turpin, Magali" uniqKey="Turpin M" first="Magali" last="Turpin">Magali Turpin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174264" status="OLD"> <orgName>Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien</orgName>
<orgName type="acronym">CRVOI</orgName>
<desc> <address> <addrLine>GIS-CRVOI2, rue Maxime Rivière 97490 Sainte Clotilde La Réunion</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.crvoi.org</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
<author><name sortKey="Lamballerie, Xavier" sort="Lamballerie, Xavier" uniqKey="Lamballerie X" first="Xavier" last="Lamballerie">Xavier Lamballerie</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-86891" status="OLD"> <idno type="IdRef">124942504</idno>
<idno type="RNSR">200817677J</idno>
<orgName>Emergence des Pathologies Virales</orgName>
<orgName type="acronym">EPV</orgName>
<date type="start">2008</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de médecine27 Bd jean Moulin13385 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.ird.fr/la-recherche/liste-des-unites-de-recherche/190-emergence-des-pathologies-virales</ref>
</desc>
<listRelation> <relation name="UMR_D 190" active="#struct-303623" type="direct"></relation>
<relation name="UMR_D 190" active="#struct-67872" type="direct"></relation>
<relation name="UMR_D 190" active="#struct-198056" type="direct"></relation>
<relation name="UMR_D 190" active="#struct-300073" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR_D 190" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_D 190" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_D 190" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR_D 190" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-234808" status="VALID"> <orgName>Cyclotron Réunion Océan Indien</orgName>
<orgName type="acronym">CYROI</orgName>
<desc> <address> <addrLine>GIP-CYROI, 2 rue Maxime Rivière, 97490 Sainte Clotilde</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.cyroi.fr</ref>
</desc>
<listRelation> <relation active="#struct-300316" type="direct"></relation>
<relation active="#struct-351465" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName>
<orgName type="acronym">UR</orgName>
<desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine>
<country key="RE"></country>
</address>
<ref type="url">http://www.univ-reunion.fr</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-351465" type="direct"><org type="institution" xml:id="struct-351465" status="VALID"> <orgName>Centre Hospitalier Universitaire de La Réunion</orgName>
<orgName type="acronym">CHU La Réunion</orgName>
<desc> <address> <country key="RE"></country>
</address>
<ref type="url">http://www.chu-reunion.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Réunion</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1371/journal.pone.0043742</idno>
<series><title level="j">PLoS ONE</title>
<idno type="ISSN">1932-6203</idno>
<imprint><date type="datePub">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Child</term>
<term>Cohort Studies</term>
<term>Evolution</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Variation</term>
<term>Genome</term>
<term>H1N1 Subtype</term>
<term>Human</term>
<term>Humans</term>
<term>Indian Ocean</term>
<term>Influenza</term>
<term>Influenza A Virus</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular</term>
<term>Pandemics</term>
<term>Preschool</term>
<term>Viral</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
<term>Enfant</term>
<term>Océan Indien</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>BACKGROUND/OBJECTIVES: Molecular epidemiology is a powerful tool to decipher the dynamics of viral transmission, quasispecies temporal evolution and origins. Little is known about the pH1N1 molecular dynamics in general population. A prospective study (CoPanFlu-RUN) was carried out in Reunion Island to characterize pH1N1 genetic variability and molecular evolution occurring in population during the pH1N1 Influenza pandemic in 2009. METHODOLOGY: We directly amplified pH1N1 genomes from 28 different nasal swabs (26 individuals from 21 households). Fifteen strains were fully sequenced and 13 partially. This includes pairs of sequences from different members of 5 separate households; and two pairs from individuals, collected at different times. We assessed the molecular evolution of pH1N1 by genetic variability and phylogenetic analyses. PRINCIPAL FINDINGS: We found that i) Reunion pH1N1 sequences stemmed from global "clade 7" but shaped two phylogenetic sub-clades; ii) D239E mutation was identified in the hemagglutinin protein of all Reunion sequences, a mutation which has been associated elsewhere with mild-, upper-respiratory tract pH1N1 infecting strains; iii) Date estimates from molecular phylogenies predicted clade emergence some time before the first detection of pH1N1 by the epidemiological surveillance system; iv) Phylogenetic relatedness was observed between Reunion pH1N1 viruses and those from other countries in South-western Indian Ocean area; v) Quasispecies populations were observed within households and individuals of the cohort-study. CONCLUSIONS: Surveillance and/or prevention systems presently based on Influenza virus sequence variation should take into account that the majority of studies of pH1N1 Influenza generate genetic data for the HA/NA viral segments obtained from hospitalized-patients, which is potentially non-representative of the overall viral diversity within whole populations. Our observations highlight the importance of collecting unbiased data at the community level and conducting whole genome analysis to accurately understand viral dynamics.</p>
</div>
</front>
</TEI>
</HAL>
<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Evolutionary Analysis of pH1N1 2009 <italic>Influenza</italic>
Virus in Reunion Island, South West Indian Ocean Region: A Cohort Study</title>
<author><name sortKey="Pascalis, Herve" sort="Pascalis, Herve" uniqKey="Pascalis H" first="Hervé" last="Pascalis">Hervé Pascalis</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temmam, Sarah" sort="Temmam, Sarah" uniqKey="Temmam S" first="Sarah" last="Temmam">Sarah Temmam</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Ecologie microbienne (UMR 5557) CNRS-Université de Lyon, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ecologie microbienne (UMR 5557) CNRS-Université de Lyon, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilkinson, David A" sort="Wilkinson, David A" uniqKey="Wilkinson D" first="David A." last="Wilkinson">David A. Wilkinson</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université de La Réunion, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de La Réunion, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dsouli, Najla" sort="Dsouli, Najla" uniqKey="Dsouli N" first="Najla" last="Dsouli">Najla Dsouli</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Turpin, Magali" sort="Turpin, Magali" uniqKey="Turpin M" first="Magali" last="Turpin">Magali Turpin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
</affiliation>
</author>
<author><name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22952752</idno>
<idno type="pmc">3428279</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428279</idno>
<idno type="RBID">PMC:3428279</idno>
<idno type="doi">10.1371/journal.pone.0043742</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000D50</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D50</idno>
<idno type="wicri:Area/Pmc/Curation">000D50</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D50</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000703</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000703</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:22952752</idno>
<idno type="wicri:Area/PubMed/Corpus">000C12</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C12</idno>
<idno type="wicri:Area/PubMed/Curation">000C12</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C12</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000C09</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C09</idno>
<idno type="wicri:Area/Ncbi/Merge">001461</idno>
<idno type="wicri:Area/Ncbi/Curation">001461</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001461</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Evolutionary Analysis of pH1N1 2009 <italic>Influenza</italic>
Virus in Reunion Island, South West Indian Ocean Region: A Cohort Study</title>
<author><name sortKey="Pascalis, Herve" sort="Pascalis, Herve" uniqKey="Pascalis H" first="Hervé" last="Pascalis">Hervé Pascalis</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temmam, Sarah" sort="Temmam, Sarah" uniqKey="Temmam S" first="Sarah" last="Temmam">Sarah Temmam</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Ecologie microbienne (UMR 5557) CNRS-Université de Lyon, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ecologie microbienne (UMR 5557) CNRS-Université de Lyon, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilkinson, David A" sort="Wilkinson, David A" uniqKey="Wilkinson D" first="David A." last="Wilkinson">David A. Wilkinson</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université de La Réunion, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de La Réunion, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dsouli, Najla" sort="Dsouli, Najla" uniqKey="Dsouli N" first="Najla" last="Dsouli">Najla Dsouli</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Turpin, Magali" sort="Turpin, Magali" uniqKey="Turpin M" first="Magali" last="Turpin">Magali Turpin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
</affiliation>
</author>
<author><name sortKey="Dellagi, Koussay" sort="Dellagi, Koussay" uniqKey="Dellagi K" first="Koussay" last="Dellagi">Koussay Dellagi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GIS CRVOI, Centre de Recherche et de Veille sur les maladies émergentes dans l’Océan Indien, Plateforme technologique CYROI, Saint-Denis, La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), La Réunion, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Recherche pour le Développement (IRD), La Réunion</wicri:regionArea>
<wicri:noRegion>La Réunion</wicri:noRegion>
<wicri:noRegion>La Réunion</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cohort Studies</term>
<term>Evolution, Molecular</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Variation</term>
<term>Genome, Viral (genetics)</term>
<term>Humans</term>
<term>Indian Ocean (epidemiology)</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (virology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Génome viral (génétique)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Océan Indien (épidémiologie)</term>
<term>Pandémies</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
<term>Variation génétique</term>
<term>Études de cohortes</term>
<term>Études de suivi</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Indian Ocean</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genome, Viral</term>
<term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Génome viral</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Océan Indien</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cohort Studies</term>
<term>Evolution, Molecular</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Variation génétique</term>
<term>Études de cohortes</term>
<term>Études de suivi</term>
<term>Évolution moléculaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background/Objectives</title>
<p>Molecular epidemiology is a powerful tool to decipher the dynamics of viral transmission, quasispecies temporal evolution and origins. Little is known about the pH1N1 molecular dynamics in general population. A prospective study (CoPanFlu-RUN) was carried out in Reunion Island to characterize pH1N1 genetic variability and molecular evolution occurring in population during the pH1N1 <italic>Influenza</italic>
pandemic in 2009.</p>
</sec>
<sec><title>Methodology</title>
<p>We directly amplified pH1N1 genomes from 28 different nasal swabs (26 individuals from 21 households). Fifteen strains were fully sequenced and 13 partially. This includes pairs of sequences from different members of 5 separate households; and two pairs from individuals, collected at different times. We assessed the molecular evolution of pH1N1 by genetic variability and phylogenetic analyses.</p>
</sec>
<sec><title>Principal Findings</title>
<p>We found that i) Reunion pH1N1 sequences stemmed from global “clade 7” but shaped two phylogenetic sub-clades; ii) D239E mutation was identified in the hemagglutinin protein of all Reunion sequences, a mutation which has been associated elsewhere with mild-, upper-respiratory tract pH1N1 infecting strains; iii) Date estimates from molecular phylogenies predicted clade emergence some time before the first detection of pH1N1 by the epidemiological surveillance system; iv) Phylogenetic relatedness was observed between Reunion pH1N1 viruses and those from other countries in South-western Indian Ocean area; v) Quasispecies populations were observed within households and individuals of the cohort-study.</p>
</sec>
<sec><title>Conclusions</title>
<p>Surveillance and/or prevention systems presently based on <italic>Influenza</italic>
virus sequence variation should take into account that the majority of studies of pH1N1 <italic>Influenza</italic>
generate genetic data for the HA/NA viral segments obtained from hospitalized-patients, which is potentially non-representative of the overall viral diversity within whole populations. Our observations highlight the importance of collecting unbiased data at the community level and conducting whole genome analysis to accurately understand viral dynamics.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
<author><name sortKey="Hanage, Wp" uniqKey="Hanage W">WP Hanage</name>
</author>
<author><name sortKey="Van Kerkhove, Md" uniqKey="Van Kerkhove M">MD Van Kerkhove</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name>
</author>
<author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author><name sortKey="Shaw, Mw" uniqKey="Shaw M">MW Shaw</name>
</author>
<author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name>
</author>
<author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name>
</author>
<author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name>
</author>
<author><name sortKey="Shu, B" uniqKey="Shu B">B Shu</name>
</author>
<author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balcan, D" uniqKey="Balcan D">D Balcan</name>
</author>
<author><name sortKey="Hu, H" uniqKey="Hu H">H Hu</name>
</author>
<author><name sortKey="Goncalves, B" uniqKey="Goncalves B">B Goncalves</name>
</author>
<author><name sortKey="Bajardi, P" uniqKey="Bajardi P">P Bajardi</name>
</author>
<author><name sortKey="Poletto, C" uniqKey="Poletto C">C Poletto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, M" uniqKey="Nelson M">M Nelson</name>
</author>
<author><name sortKey="Spiro, D" uniqKey="Spiro D">D Spiro</name>
</author>
<author><name sortKey="Wentworth, D" uniqKey="Wentworth D">D Wentworth</name>
</author>
<author><name sortKey="Beck, E" uniqKey="Beck E">E Beck</name>
</author>
<author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Potdar, Va" uniqKey="Potdar V">VA Potdar</name>
</author>
<author><name sortKey="Chadha, Ms" uniqKey="Chadha M">MS Chadha</name>
</author>
<author><name sortKey="Jadhav, Sm" uniqKey="Jadhav S">SM Jadhav</name>
</author>
<author><name sortKey="Mullick, J" uniqKey="Mullick J">J Mullick</name>
</author>
<author><name sortKey="Cherian, Ss" uniqKey="Cherian S">SS Cherian</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Barrero, Pr" uniqKey="Barrero P">PR Barrero</name>
</author>
<author><name sortKey="Viegas, M" uniqKey="Viegas M">M Viegas</name>
</author>
<author><name sortKey="Valinotto, Le" uniqKey="Valinotto L">LE Valinotto</name>
</author>
<author><name sortKey="Mistchenko, As" uniqKey="Mistchenko A">AS Mistchenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name>
</author>
<author><name sortKey="Zhang, Aj" uniqKey="Zhang A">AJ Zhang</name>
</author>
<author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furuse, Y" uniqKey="Furuse Y">Y Furuse</name>
</author>
<author><name sortKey="Suzuki, A" uniqKey="Suzuki A">A Suzuki</name>
</author>
<author><name sortKey="Oshitani, H" uniqKey="Oshitani H">H Oshitani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shiino, T" uniqKey="Shiino T">T Shiino</name>
</author>
<author><name sortKey="Okabe, N" uniqKey="Okabe N">N Okabe</name>
</author>
<author><name sortKey="Yasui, Y" uniqKey="Yasui Y">Y Yasui</name>
</author>
<author><name sortKey="Sunagawa, T" uniqKey="Sunagawa T">T Sunagawa</name>
</author>
<author><name sortKey="Ujike, M" uniqKey="Ujike M">M Ujike</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parks, D" uniqKey="Parks D">D Parks</name>
</author>
<author><name sortKey="Macdonald, N" uniqKey="Macdonald N">N Macdonald</name>
</author>
<author><name sortKey="Beiko, R" uniqKey="Beiko R">R Beiko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pariani, E" uniqKey="Pariani E">E Pariani</name>
</author>
<author><name sortKey="Piralla, A" uniqKey="Piralla A">A Piralla</name>
</author>
<author><name sortKey="Frati, E" uniqKey="Frati E">E Frati</name>
</author>
<author><name sortKey="Anselmi, G" uniqKey="Anselmi G">G Anselmi</name>
</author>
<author><name sortKey="Campanini, G" uniqKey="Campanini G">G Campanini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Graham, M" uniqKey="Graham M">M Graham</name>
</author>
<author><name sortKey="Liang, B" uniqKey="Liang B">B Liang</name>
</author>
<author><name sortKey="Van Domselaar, G" uniqKey="Van Domselaar G">G Van Domselaar</name>
</author>
<author><name sortKey="Bastien, N" uniqKey="Bastien N">N Bastien</name>
</author>
<author><name sortKey="Beaudoin, C" uniqKey="Beaudoin C">C Beaudoin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balcan, D" uniqKey="Balcan D">D Balcan</name>
</author>
<author><name sortKey="Hu, H" uniqKey="Hu H">H Hu</name>
</author>
<author><name sortKey="Goncalves, B" uniqKey="Goncalves B">B Goncalves</name>
</author>
<author><name sortKey="Bajardi, P" uniqKey="Bajardi P">P Bajardi</name>
</author>
<author><name sortKey="Poletto, C" uniqKey="Poletto C">C Poletto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brownstein, Js" uniqKey="Brownstein J">JS Brownstein</name>
</author>
<author><name sortKey="Wolfe, Cj" uniqKey="Wolfe C">CJ Wolfe</name>
</author>
<author><name sortKey="Mandl, Kd" uniqKey="Mandl K">KD Mandl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Rtenzio, E" uniqKey="D Rtenzio E">E D’Ortenzio</name>
</author>
<author><name sortKey="Renault, P" uniqKey="Renault P">P Renault</name>
</author>
<author><name sortKey="Jaffar Bandjee, Mc" uniqKey="Jaffar Bandjee M">MC Jaffar-Bandjee</name>
</author>
<author><name sortKey="Gauzere, Ba" uniqKey="Gauzere B">BA Gauzere</name>
</author>
<author><name sortKey="Lagrange Xelot, M" uniqKey="Lagrange Xelot M">M Lagrange-Xelot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dellagi, K" uniqKey="Dellagi K">K Dellagi</name>
</author>
<author><name sortKey="Rollot, O" uniqKey="Rollot O">O Rollot</name>
</author>
<author><name sortKey="Temmam, S" uniqKey="Temmam S">S Temmam</name>
</author>
<author><name sortKey="Salez, N" uniqKey="Salez N">N Salez</name>
</author>
<author><name sortKey="Guernier, V" uniqKey="Guernier V">V Guernier</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ninove, L" uniqKey="Ninove L">L Ninove</name>
</author>
<author><name sortKey="Nougairede, A" uniqKey="Nougairede A">A Nougairede</name>
</author>
<author><name sortKey="Gazin, C" uniqKey="Gazin C">C Gazin</name>
</author>
<author><name sortKey="Thirion, L" uniqKey="Thirion L">L Thirion</name>
</author>
<author><name sortKey="Delogu, I" uniqKey="Delogu I">I Delogu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ninove, L" uniqKey="Ninove L">L Ninove</name>
</author>
<author><name sortKey="Gazin, C" uniqKey="Gazin C">C Gazin</name>
</author>
<author><name sortKey="Gould, Ea" uniqKey="Gould E">EA Gould</name>
</author>
<author><name sortKey="Nougairede, A" uniqKey="Nougairede A">A Nougairede</name>
</author>
<author><name sortKey="Flahault, A" uniqKey="Flahault A">A Flahault</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhirnov, Op" uniqKey="Zhirnov O">OP Zhirnov</name>
</author>
<author><name sortKey="Vorobjeva, Iv" uniqKey="Vorobjeva I">IV Vorobjeva</name>
</author>
<author><name sortKey="Saphonova, Oa" uniqKey="Saphonova O">OA Saphonova</name>
</author>
<author><name sortKey="Poyarkov, Sv" uniqKey="Poyarkov S">SV Poyarkov</name>
</author>
<author><name sortKey="Ovcharenko, Av" uniqKey="Ovcharenko A">AV Ovcharenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Edgar, Rc" uniqKey="Edgar R">RC Edgar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Posada, D" uniqKey="Posada D">D Posada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guindon, S" uniqKey="Guindon S">S Guindon</name>
</author>
<author><name sortKey="Gascuel, O" uniqKey="Gascuel O">O Gascuel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ronquist, F" uniqKey="Ronquist F">F Ronquist</name>
</author>
<author><name sortKey="Huelsenbeck, Jp" uniqKey="Huelsenbeck J">JP Huelsenbeck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name>
</author>
<author><name sortKey="Peterson, D" uniqKey="Peterson D">D Peterson</name>
</author>
<author><name sortKey="Peterson, N" uniqKey="Peterson N">N Peterson</name>
</author>
<author><name sortKey="Stecher, G" uniqKey="Stecher G">G Stecher</name>
</author>
<author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tajima, F" uniqKey="Tajima F">F Tajima</name>
</author>
<author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drummond, Aj" uniqKey="Drummond A">AJ Drummond</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goni, N" uniqKey="Goni N">N Goni</name>
</author>
<author><name sortKey="Fajardo, A" uniqKey="Fajardo A">A Fajardo</name>
</author>
<author><name sortKey="Moratorio, G" uniqKey="Moratorio G">G Moratorio</name>
</author>
<author><name sortKey="Colina, R" uniqKey="Colina R">R Colina</name>
</author>
<author><name sortKey="Cristina, J" uniqKey="Cristina J">J Cristina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, Mi" uniqKey="Nelson M">MI Nelson</name>
</author>
<author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, M" uniqKey="Nelson M">M Nelson</name>
</author>
<author><name sortKey="Spiro, D" uniqKey="Spiro D">D Spiro</name>
</author>
<author><name sortKey="Wentworth, D" uniqKey="Wentworth D">D Wentworth</name>
</author>
<author><name sortKey="Beck, E" uniqKey="Beck E">E Beck</name>
</author>
<author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furuse, Y" uniqKey="Furuse Y">Y Furuse</name>
</author>
<author><name sortKey="Suzuki, A" uniqKey="Suzuki A">A Suzuki</name>
</author>
<author><name sortKey="Oshitani, H" uniqKey="Oshitani H">H Oshitani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferraris, O" uniqKey="Ferraris O">O Ferraris</name>
</author>
<author><name sortKey="Lina, B" uniqKey="Lina B">B Lina</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Glinsky, Gv" uniqKey="Glinsky G">GV Glinsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reid, Ah" uniqKey="Reid A">AH Reid</name>
</author>
<author><name sortKey="Fanning, Tg" uniqKey="Fanning T">TG Fanning</name>
</author>
<author><name sortKey="Hultin, Jv" uniqKey="Hultin J">JV Hultin</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
<author><name sortKey="Kao, Ry" uniqKey="Kao R">RY Kao</name>
</author>
<author><name sortKey="Wu, Wl" uniqKey="Wu W">WL Wu</name>
</author>
<author><name sortKey="Lim, Ww" uniqKey="Lim W">WW Lim</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name>
</author>
<author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Aj" uniqKey="Zhang A">AJ Zhang</name>
</author>
<author><name sortKey="To, Kk" uniqKey="To K">KK To</name>
</author>
<author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Guo, Ky" uniqKey="Guo K">KY Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Filleul, L" uniqKey="Filleul L">L Filleul</name>
</author>
<author><name sortKey="D Rtenzio, E" uniqKey="D Rtenzio E">E D’Ortenzio</name>
</author>
<author><name sortKey="Kermarec, F" uniqKey="Kermarec F">F Kermarec</name>
</author>
<author><name sortKey="Le Bot, F" uniqKey="Le Bot F">F Le Bot</name>
</author>
<author><name sortKey="Renault, P" uniqKey="Renault P">P Renault</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kelly, Ha" uniqKey="Kelly H">HA Kelly</name>
</author>
<author><name sortKey="Mercer, Gn" uniqKey="Mercer G">GN Mercer</name>
</author>
<author><name sortKey="Fielding, Je" uniqKey="Fielding J">JE Fielding</name>
</author>
<author><name sortKey="Dowse, Gk" uniqKey="Dowse G">GK Dowse</name>
</author>
<author><name sortKey="Glass, K" uniqKey="Glass K">K Glass</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chao, Dy" uniqKey="Chao D">DY Chao</name>
</author>
<author><name sortKey="Cheng, Kf" uniqKey="Cheng K">KF Cheng</name>
</author>
<author><name sortKey="Li, Tc" uniqKey="Li T">TC Li</name>
</author>
<author><name sortKey="Wu, Tn" uniqKey="Wu T">TN Wu</name>
</author>
<author><name sortKey="Chen, Cy" uniqKey="Chen C">CY Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name>
</author>
<author><name sortKey="Novikov, Dv" uniqKey="Novikov D">DV Novikov</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Chu, Dk" uniqKey="Chu D">DK Chu</name>
</author>
<author><name sortKey="Fung, Cc" uniqKey="Fung C">CC Fung</name>
</author>
<author><name sortKey="Cheng, Ck" uniqKey="Cheng C">CK Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boelle, Py" uniqKey="Boelle P">PY Boelle</name>
</author>
<author><name sortKey="Ansart, S" uniqKey="Ansart S">S Ansart</name>
</author>
<author><name sortKey="Cori, A" uniqKey="Cori A">A Cori</name>
</author>
<author><name sortKey="Valleron, Aj" uniqKey="Valleron A">AJ Valleron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, Mi" uniqKey="Nelson M">MI Nelson</name>
</author>
<author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ghedin, E" uniqKey="Ghedin E">E Ghedin</name>
</author>
<author><name sortKey="Laplante, J" uniqKey="Laplante J">J Laplante</name>
</author>
<author><name sortKey="Depasse, J" uniqKey="Depasse J">J DePasse</name>
</author>
<author><name sortKey="Wentworth, De" uniqKey="Wentworth D">DE Wentworth</name>
</author>
<author><name sortKey="Santos, Rp" uniqKey="Santos R">RP Santos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greninger, Al" uniqKey="Greninger A">AL Greninger</name>
</author>
<author><name sortKey="Chen, Ec" uniqKey="Chen E">EC Chen</name>
</author>
<author><name sortKey="Sittler, T" uniqKey="Sittler T">T Sittler</name>
</author>
<author><name sortKey="Scheinerman, A" uniqKey="Scheinerman A">A Scheinerman</name>
</author>
<author><name sortKey="Roubinian, N" uniqKey="Roubinian N">N Roubinian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lauring, As" uniqKey="Lauring A">AS Lauring</name>
</author>
<author><name sortKey="Andino, R" uniqKey="Andino R">R Andino</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</PMC>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B13 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001B13 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:3428279 |texte= Molecular Evolutionary Analysis of pH1N1 2009 Influenza Virus in Reunion Island, South West Indian Ocean Region: A Cohort Study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:22952752" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a PandemieGrippaleV1
![]() | This area was generated with Dilib version V0.6.34. | ![]() |