An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants.
Identifieur interne : 001422 ( Main/Merge ); précédent : 001421; suivant : 001423An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants.
Auteurs : Christopher B. Fox [États-Unis] ; Jean HaenslerSource :
- Expert review of vaccines [ 1744-8395 ] ; 2013.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (), Adjuvants immunologiques (administration et posologie), Adjuvants immunologiques (effets indésirables), Adjuvants immunologiques (histoire), Association médicamenteuse, Essais cliniques comme sujet, Histoire du 20ème siècle, Histoire du 21ème siècle, Humains, Polysorbates (), Polysorbates (administration et posologie), Polysorbates (effets indésirables), Polysorbates (histoire), Squalène (), Squalène (administration et posologie), Squalène (effets indésirables), Squalène (histoire), Surveillance post-commercialisation des produits de santé, Vaccins (administration et posologie), Vaccins (effets indésirables), Vaccins (immunologie), alpha-Tocophérol (), alpha-Tocophérol (administration et posologie), alpha-Tocophérol (effets indésirables), alpha-Tocophérol (histoire), Émulsions (), Émulsions (administration et posologie), Émulsions (effets indésirables), Émulsions (histoire).
- MESH :
- administration et posologie : Adjuvants immunologiques, Polysorbates, Squalène, Vaccins, alpha-Tocophérol, Émulsions.
- effets indésirables : Adjuvants immunologiques, Polysorbates, Squalène, Vaccins, alpha-Tocophérol, Émulsions.
- histoire : Adjuvants immunologiques, Polysorbates, Squalène, alpha-Tocophérol, Émulsions.
- immunologie : Vaccins.
- Adjuvants immunologiques, Association médicamenteuse, Essais cliniques comme sujet, Histoire du 20ème siècle, Histoire du 21ème siècle, Humains, Polysorbates, Squalène, Surveillance post-commercialisation des produits de santé, alpha-Tocophérol, Émulsions.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Adjuvants, Immunologic (adverse effects), Adjuvants, Immunologic (chemistry), Adjuvants, Immunologic (history), Clinical Trials as Topic, Drug Combinations, Emulsions (administration & dosage), Emulsions (adverse effects), Emulsions (chemistry), Emulsions (history), History, 20th Century, History, 21st Century, Humans, Polysorbates (administration & dosage), Polysorbates (adverse effects), Polysorbates (chemistry), Polysorbates (history), Product Surveillance, Postmarketing, Squalene (administration & dosage), Squalene (adverse effects), Squalene (chemistry), Squalene (history), Vaccines (administration & dosage), Vaccines (adverse effects), Vaccines (immunology), alpha-Tocopherol (administration & dosage), alpha-Tocopherol (adverse effects), alpha-Tocopherol (chemistry), alpha-Tocopherol (history).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Emulsions, Polysorbates, Squalene, Vaccines, alpha-Tocopherol.
- chemical , adverse effects : Adjuvants, Immunologic, Emulsions, Polysorbates, Squalene, Vaccines, alpha-Tocopherol.
- chemical , chemistry : Adjuvants, Immunologic, Emulsions, Polysorbates, Squalene, alpha-Tocopherol.
- chemical , history : Adjuvants, Immunologic, Emulsions, Polysorbates, Squalene, alpha-Tocopherol.
- chemical , immunology : Vaccines.
- Clinical Trials as Topic, Drug Combinations, History, 20th Century, History, 21st Century, Humans, Product Surveillance, Postmarketing.
Abstract
With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In this review, the authors introduce emulsion adjuvant composition and history before detailing the most recent findings from clinical and postmarketing data regarding the effects of emulsion adjuvants on vaccine immunogenicity and safety, with emphasis on the most widely distributed emulsion adjuvants, MF59® and AS03. The authors also present a summary of other emulsion adjuvants in clinical development and indicate promising avenues for future emulsion-based adjuvant development. Overall, emulsion adjuvants have demonstrated potent adjuvant activity across a number of disease indications along with acceptable safety profiles.
DOI: 10.1586/14760584.2013.811188
PubMed: 23885820
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pubmed:23885820Le document en format XML
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<term>Histoire du 21ème siècle</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en">With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In this review, the authors introduce emulsion adjuvant composition and history before detailing the most recent findings from clinical and postmarketing data regarding the effects of emulsion adjuvants on vaccine immunogenicity and safety, with emphasis on the most widely distributed emulsion adjuvants, MF59® and AS03. The authors also present a summary of other emulsion adjuvants in clinical development and indicate promising avenues for future emulsion-based adjuvant development. Overall, emulsion adjuvants have demonstrated potent adjuvant activity across a number of disease indications along with acceptable safety profiles. </div>
</front>
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