The immune response and within-host emergence of pandemic influenza virus
Identifieur interne : 001011 ( Main/Merge ); précédent : 001010; suivant : 001012The immune response and within-host emergence of pandemic influenza virus
Auteurs : Leslie A. Reperant [Pays-Bas] ; Thijs Kuiken [Pays-Bas] ; Bryan T. Grenfell [États-Unis] ; Albert D. M. E. Osterhaus [Pays-Bas]Source :
- Lancet : (British edition) [ 0140-6736 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Médecine.
English descriptors
- KwdEn :
Abstract
Zoonotic influenza viruses that are a few mutations away from pandemic viruses circulate in animals, and can evolve into airborne-transmissible viruses in human beings. Paradoxically, such viruses only occasionally emerge in people; the four influenza pandemics that occurred in the past 100 years were caused by zoonotic viruses that acquired efficient transmissibility. Emergence of a pandemic virus in people can happen when transmissible viruses evolve in individuals with zoonotic influenza and replicate to titres allowing transmission. We postulate that this step in the genesis of a pandemic virus only occasionally occurs in human beings, because the immune response triggered by zoonotic influenza virus also controls transmissible mutants that emerge during infection. Therefore, an impaired immune response might be needed for within-host emergence of a pandemic virus and replication to titres allowing transmission. Immunocompromised individuals-eg, those with comorbidities, of advanced age, or receiving immunosuppressive treatment-could be at increased risk of generating transmissible viruses and initiating chains of human-to-human infection.
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Reperant</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Viroscience, Erasmus Medical Centre</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Artemis Research Institute for One Health in Europe</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Viroscience, Erasmus Medical Centre</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Grenfell, Bryan T" sort="Grenfell, Bryan T" uniqKey="Grenfell B" first="Bryan T." last="Grenfell">Bryan T. 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Osterhaus</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Viroscience, Erasmus Medical Centre</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Artemis Research Institute for One Health in Europe</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emergence</term><term>Epidemiology</term><term>Host</term><term>Immune response</term><term>Influenza</term><term>Influenzavirus</term><term>Medicine</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Réponse immune</term><term>Hôte</term><term>Emergence</term><term>Epidémiologie</term><term>Grippe</term><term>Influenzavirus</term><term>Médecine</term><term>Pandémie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Zoonotic influenza viruses that are a few mutations away from pandemic viruses circulate in animals, and can evolve into airborne-transmissible viruses in human beings. Paradoxically, such viruses only occasionally emerge in people; the four influenza pandemics that occurred in the past 100 years were caused by zoonotic viruses that acquired efficient transmissibility. Emergence of a pandemic virus in people can happen when transmissible viruses evolve in individuals with zoonotic influenza and replicate to titres allowing transmission. We postulate that this step in the genesis of a pandemic virus only occasionally occurs in human beings, because the immune response triggered by zoonotic influenza virus also controls transmissible mutants that emerge during infection. Therefore, an impaired immune response might be needed for within-host emergence of a pandemic virus and replication to titres allowing transmission. Immunocompromised individuals-eg, those with comorbidities, of advanced age, or receiving immunosuppressive treatment-could be at increased risk of generating transmissible viruses and initiating chains of human-to-human infection.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Hollande-Méridionale</li><li>Maryland</li><li>New Jersey</li><li>Utrecht (province)</li></region><settlement><li>Princeton (New Jersey)</li><li>Rotterdam</li><li>Utrecht</li></settlement><orgName><li>Université de Princeton</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Reperant, Leslie A" sort="Reperant, Leslie A" uniqKey="Reperant L" first="Leslie A." last="Reperant">Leslie A. Reperant</name></region><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Reperant, Leslie A" sort="Reperant, Leslie A" uniqKey="Reperant L" first="Leslie A." last="Reperant">Leslie A. Reperant</name></country><country name="États-Unis"><region name="New Jersey"><name sortKey="Grenfell, Bryan T" sort="Grenfell, Bryan T" uniqKey="Grenfell B" first="Bryan T." last="Grenfell">Bryan T. Grenfell</name></region><name sortKey="Grenfell, Bryan T" sort="Grenfell, Bryan T" uniqKey="Grenfell B" first="Bryan T." last="Grenfell">Bryan T. Grenfell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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