Viral Infections During Pregnancy
Identifieur interne : 000C28 ( Main/Merge ); précédent : 000C27; suivant : 000C29Viral Infections During Pregnancy
Auteurs : Michelle Silasi [États-Unis] ; Ingrid Cardenas [États-Unis] ; Ja-Young Kwon [Corée du Sud] ; Karen Racicot [États-Unis] ; Paula Aldo [États-Unis] ; Gil Mor [États-Unis]Source :
- American Journal of Reproductive Immunology [ 1046-7408 ] ; 2015-03.
Abstract
Viral infections during pregnancy have long been considered benign conditions with a few notable exceptions, such as herpes virus. The recent Ebola outbreak and other viral epidemics and pandemics show how pregnant women suffer worse outcomes (such as preterm labor and adverse fetal outcomes) than the general population and non‐pregnant women. New knowledge about the ways the maternal–fetal interface and placenta interact with the maternal immune system may explain these findings. Once thought to be ‘immunosuppressed’, the pregnant woman actually undergoes an immunological transformation, where the immune system is necessary to promote and support the pregnancy and growing fetus. When this protection is breached, as in a viral infection, this security is weakened and infection with other microorganisms can then propagate and lead to outcomes, such as preterm labor. In this manuscript, we review the major viral infections relevant to pregnancy and offer potential mechanisms for the associated adverse pregnancy outcomes.
Url:
DOI: 10.1111/aji.12355
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The recent Ebola outbreak and other viral epidemics and pandemics show how pregnant women suffer worse outcomes (such as preterm labor and adverse fetal outcomes) than the general population and non‐pregnant women. New knowledge about the ways the maternal–fetal interface and placenta interact with the maternal immune system may explain these findings. Once thought to be ‘immunosuppressed’, the pregnant woman actually undergoes an immunological transformation, where the immune system is necessary to promote and support the pregnancy and growing fetus. When this protection is breached, as in a viral infection, this security is weakened and infection with other microorganisms can then propagate and lead to outcomes, such as preterm labor. In this manuscript, we review the major viral infections relevant to pregnancy and offer potential mechanisms for the associated adverse pregnancy outcomes.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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