Genetic Recombination between Human and Animal Parasites Creates Novel Strains of Human Pathogen
Identifieur interne : 000B74 ( Main/Merge ); précédent : 000B73; suivant : 000B75Genetic Recombination between Human and Animal Parasites Creates Novel Strains of Human Pathogen
Auteurs : Wendy Gibson [Royaume-Uni] ; Lori Peacock [Royaume-Uni] ; Vanessa Ferris [Royaume-Uni] ; Katrin Fischer [Royaume-Uni] ; Jennifer Livingstone [Royaume-Uni] ; James Thomas [Royaume-Uni] ; Mick Bailey [Royaume-Uni]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2015.
Descripteurs français
- KwdFr :
- Afrique de l'Est (épidémiologie), Animaux, Croisements génétiques, Fluorescence, Glycoprotéines membranaires (génétique), Humains, Maladie du sommeil (parasitologie), Maladie du sommeil (épidémiologie), Protéines de protozoaire (génétique), Recombinaison génétique (génétique), Spécificité d'espèce, Transfert horizontal de gène, Trypanosoma brucei rhodesiense (génétique), Variation génétique.
- MESH :
- génétique : Glycoprotéines membranaires, Protéines de protozoaire, Recombinaison génétique, Trypanosoma brucei rhodesiense.
- parasitologie : Maladie du sommeil.
- épidémiologie : Afrique de l'Est, Maladie du sommeil.
- Animaux, Croisements génétiques, Fluorescence, Humains, Spécificité d'espèce, Transfert horizontal de gène, Variation génétique.
English descriptors
- KwdEn :
- Africa, Eastern (epidemiology), Animals, Crosses, Genetic, Fluorescence, Gene Transfer, Horizontal, Genetic Variation, Humans, Membrane Glycoproteins (genetics), Protozoan Proteins (genetics), Recombination, Genetic (genetics), Species Specificity, Trypanosoma brucei rhodesiense (genetics), Trypanosomiasis, African (epidemiology), Trypanosomiasis, African (parasitology).
- MESH :
- chemical , genetics : Membrane Glycoproteins, Protozoan Proteins.
- epidemiology : Africa, Eastern, Trypanosomiasis, African.
- genetics : Recombination, Genetic, Trypanosoma brucei rhodesiense.
- parasitology : Trypanosomiasis, African.
- Animals, Crosses, Genetic, Fluorescence, Gene Transfer, Horizontal, Genetic Variation, Humans, Species Specificity.
Abstract
Genetic recombination between pathogens derived from humans and livestock has the potential to create novel pathogen strains, highlighted by the influenza pandemic H1N1/09, which was derived from a re-assortment of swine, avian and human influenza A viruses. Here we investigated whether genetic recombination between subspecies of the protozoan parasite,
Url:
DOI: 10.1371/journal.pntd.0003665
PubMed: 25816228
PubMed Central: 4376878
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PMC:4376878Le document en format XML
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first="Lori" last="Peacock">Lori Peacock</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of Biological Sciences University of Bristol, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological Sciences University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Ferris, Vanessa" sort="Ferris, Vanessa" uniqKey="Ferris V" first="Vanessa" last="Ferris">Vanessa Ferris</name><affiliation wicri:level="1"><nlm:aff 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Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological Sciences University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Livingstone, Jennifer" sort="Livingstone, Jennifer" uniqKey="Livingstone J" first="Jennifer" last="Livingstone">Jennifer Livingstone</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of Biological Sciences University of Bristol, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological Sciences University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, James" sort="Thomas, James" uniqKey="Thomas J" first="James" last="Thomas">James Thomas</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>School of Biological Sciences University of Bristol, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological Sciences University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Bailey, Mick" sort="Bailey, Mick" uniqKey="Bailey M" first="Mick" last="Bailey">Mick Bailey</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa, Eastern (epidemiology)</term><term>Animals</term><term>Crosses, Genetic</term><term>Fluorescence</term><term>Gene Transfer, Horizontal</term><term>Genetic Variation</term><term>Humans</term><term>Membrane Glycoproteins (genetics)</term><term>Protozoan Proteins (genetics)</term><term>Recombination, Genetic (genetics)</term><term>Species Specificity</term><term>Trypanosoma brucei rhodesiense (genetics)</term><term>Trypanosomiasis, African (epidemiology)</term><term>Trypanosomiasis, African (parasitology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Afrique de l'Est (épidémiologie)</term><term>Animaux</term><term>Croisements génétiques</term><term>Fluorescence</term><term>Glycoprotéines membranaires (génétique)</term><term>Humains</term><term>Maladie du sommeil (parasitologie)</term><term>Maladie du sommeil (épidémiologie)</term><term>Protéines de protozoaire (génétique)</term><term>Recombinaison génétique (génétique)</term><term>Spécificité d'espèce</term><term>Transfert horizontal de gène</term><term>Trypanosoma brucei rhodesiense (génétique)</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term><term>Protozoan Proteins</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Africa, Eastern</term><term>Trypanosomiasis, African</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Recombination, Genetic</term><term>Trypanosoma brucei rhodesiense</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de protozoaire</term><term>Recombinaison génétique</term><term>Trypanosoma brucei rhodesiense</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Maladie du sommeil</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Trypanosomiasis, African</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Afrique de l'Est</term><term>Maladie du sommeil</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Crosses, Genetic</term><term>Fluorescence</term><term>Gene Transfer, Horizontal</term><term>Genetic Variation</term><term>Humans</term><term>Species Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Croisements génétiques</term><term>Fluorescence</term><term>Humains</term><term>Spécificité d'espèce</term><term>Transfert horizontal de gène</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Genetic recombination between pathogens derived from humans and livestock has the potential to create novel pathogen strains, highlighted by the influenza pandemic H1N1/09, which was derived from a re-assortment of swine, avian and human influenza A viruses. Here we investigated whether genetic recombination between subspecies of the protozoan parasite, <italic>Trypanosoma brucei</italic>, from humans and animals can generate new strains of human pathogen, <italic>T</italic>. <italic>b</italic>. <italic>rhodesiense</italic> (<italic>Tbr</italic>) responsible for sleeping sickness (Human African Trypanosomiasis, HAT) in East Africa. The trait of human infectivity in <italic>Tbr</italic> is conferred by a single gene, <italic>SRA</italic>, which is potentially transferable to the animal pathogen <italic>Tbb</italic> by sexual reproduction. We tracked the inheritance of <italic>SRA</italic> in crosses of <italic>Tbr</italic> and <italic>Tbb</italic> set up by co-transmitting genetically-engineered fluorescent parental trypanosome lines through tsetse flies. <italic>SRA</italic> was readily transferred into new genetic backgrounds by sexual reproduction between <italic>Tbr</italic> and <italic>Tbb</italic>, thus creating new strains of the human pathogen, <italic>Tbr</italic>. There was no evidence of diminished growth or transmissibility of hybrid trypanosomes carrying <italic>SRA</italic>. Although expression of <italic>SRA</italic> is critical to survival of <italic>Tbr</italic> in the human host, we show that the gene exists as a single copy in a representative collection of <italic>Tbr</italic> strains. <italic>SRA</italic> was found on one homologue of chromosome IV in the majority of <italic>Tbr</italic> isolates examined, but some Ugandan <italic>Tbr</italic> had <italic>SRA</italic> on both homologues. The mobility of <italic>SRA</italic> by genetic recombination readily explains the observed genetic variability of <italic>Tbr</italic> in East Africa. We conclude that new strains of the human pathogen <italic>Tbr</italic> are being generated continuously by recombination with the much larger pool of animal-infective trypanosomes. Such novel recombinants present a risk for future outbreaks of HAT.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xong, Vh" uniqKey="Xong V">VH Xong</name></author><author><name sortKey="Vanhamme, L" uniqKey="Vanhamme L">L Vanhamme</name></author><author><name sortKey="Chamekh, M" uniqKey="Chamekh M">M Chamekh</name></author><author><name sortKey="Chimfwembe, Ce" uniqKey="Chimfwembe C">CE Chimfwembe</name></author><author><name sortKey="Van Den Abbeele, J" uniqKey="Van Den Abbeele J">J Van den Abbeele</name></author><author><name sortKey="Pays, A" uniqKey="Pays A">A Pays</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radwanska, M" uniqKey="Radwanska M">M Radwanska</name></author><author><name sortKey="Chamekh, M" uniqKey="Chamekh M">M Chamekh</name></author><author><name 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Goodhead</name></author><author><name sortKey="Capewell, P" uniqKey="Capewell P">P Capewell</name></author><author><name sortKey="Bailey, Jw" uniqKey="Bailey J">JW Bailey</name></author><author><name sortKey="Beament, T" uniqKey="Beament T">T Beament</name></author><author><name sortKey="Chance, M" uniqKey="Chance M">M Chance</name></author><author><name sortKey="Kay, S" uniqKey="Kay S">S Kay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenni, L" uniqKey="Jenni L">L Jenni</name></author><author><name sortKey="Marti, S" uniqKey="Marti S">S Marti</name></author><author><name sortKey="Schweizer, J" uniqKey="Schweizer J">J Schweizer</name></author><author><name sortKey="Betschart, B" uniqKey="Betschart B">B Betschart</name></author><author><name sortKey="Lepage, Rwf" uniqKey="Lepage R">RWF Lepage</name></author><author><name sortKey="Wells, Jm" uniqKey="Wells J">JM Wells</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peacock, L" uniqKey="Peacock L">L Peacock</name></author><author><name sortKey="Ferris, V" uniqKey="Ferris V">V Ferris</name></author><author><name sortKey="Sharma, R" uniqKey="Sharma R">R Sharma</name></author><author><name sortKey="Sunter, J" uniqKey="Sunter J">J Sunter</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Carrington, M" uniqKey="Carrington M">M Carrington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peacock, L" uniqKey="Peacock L">L Peacock</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Carrington, M" uniqKey="Carrington M">M Carrington</name></author><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Wc" uniqKey="Gibson W">WC Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author><author><name sortKey="Garside, L" uniqKey="Garside L">L Garside</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author><author><name sortKey="Winters, K" uniqKey="Winters K">K Winters</name></author><author><name sortKey="Mizen, G" uniqKey="Mizen G">G Mizen</name></author><author><name sortKey="Kearns, J" uniqKey="Kearns J">J Kearns</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Wc" uniqKey="Gibson W">WC Gibson</name></author><author><name sortKey="Mizen, Vh" uniqKey="Mizen V">VH Mizen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author><author><name sortKey="Ferris, V" uniqKey="Ferris V">V Ferris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Cmr" uniqKey="Turner C">CMR Turner</name></author><author><name sortKey="Melville, Se" uniqKey="Melville S">SE Melville</name></author><author><name sortKey="Tait, A" uniqKey="Tait A">A Tait</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Becker, M" uniqKey="Becker M">M Becker</name></author><author><name sortKey="Aitcheson, N" uniqKey="Aitcheson N">N Aitcheson</name></author><author><name sortKey="Byles, E" uniqKey="Byles E">E Byles</name></author><author><name sortKey="Wickstead, B" uniqKey="Wickstead B">B Wickstead</name></author><author><name sortKey="Louis, E" uniqKey="Louis E">E Louis</name></author><author><name sortKey="Rudenko, G" uniqKey="Rudenko G">G Rudenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcculloch, R" uniqKey="Mcculloch R">R McCulloch</name></author><author><name sortKey="Horn, D" uniqKey="Horn D">D Horn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hertz Fowler, C" uniqKey="Hertz Fowler C">C Hertz-Fowler</name></author><author><name sortKey="Figueiredo, Lm" uniqKey="Figueiredo L">LM Figueiredo</name></author><author><name sortKey="Quail, Ma" uniqKey="Quail M">MA Quail</name></author><author><name sortKey="Becker, M" uniqKey="Becker M">M Becker</name></author><author><name sortKey="Jackson, A" uniqKey="Jackson A">A Jackson</name></author><author><name sortKey="Bason, N" uniqKey="Bason N">N Bason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, R" uniqKey="Young R">R Young</name></author><author><name sortKey="Taylor, Je" uniqKey="Taylor J">JE Taylor</name></author><author><name sortKey="Kurioka, A" uniqKey="Kurioka A">A Kurioka</name></author><author><name sortKey="Becker, M" uniqKey="Becker M">M Becker</name></author><author><name sortKey="Louis, Ej" uniqKey="Louis E">EJ Louis</name></author><author><name sortKey="Rudenko, G" uniqKey="Rudenko G">G Rudenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steverding, D" uniqKey="Steverding D">D Steverding</name></author><author><name sortKey="Stierhof, Yd" uniqKey="Stierhof Y">YD Stierhof</name></author><author><name sortKey="Chaudhri, M" uniqKey="Chaudhri M">M Chaudhri</name></author><author><name sortKey="Ligtenberg, M" uniqKey="Ligtenberg M">M Ligtenberg</name></author><author><name sortKey="Schell, D" uniqKey="Schell D">D Schell</name></author><author><name sortKey="Becksickinger, Ag" uniqKey="Becksickinger A">AG Becksickinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bitter, W" uniqKey="Bitter W">W Bitter</name></author><author><name sortKey="Gerrits, H" uniqKey="Gerrits H">H Gerrits</name></author><author><name sortKey="Kieft, R" uniqKey="Kieft R">R Kieft</name></author><author><name sortKey="Borst, P" uniqKey="Borst P">P Borst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerrits, H" uniqKey="Gerrits H">H Gerrits</name></author><author><name sortKey="Mussmann, R" uniqKey="Mussmann R">R Mussmann</name></author><author><name sortKey="Bitter, W" uniqKey="Bitter W">W Bitter</name></author><author><name sortKey="Kieft, R" uniqKey="Kieft R">R Kieft</name></author><author><name sortKey="Borst, P" uniqKey="Borst P">P Borst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Sv" uniqKey="Graham S">SV Graham</name></author><author><name sortKey="Terry, S" uniqKey="Terry S">S Terry</name></author><author><name sortKey="Barry, Jd" uniqKey="Barry J">JD Barry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Wc" uniqKey="Gibson W">WC Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author><author><name sortKey="Backhouse, T" uniqKey="Backhouse T">T Backhouse</name></author><author><name sortKey="Griffiths, A" uniqKey="Griffiths A">A Griffiths</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stevens, Jr" uniqKey="Stevens J">JR Stevens</name></author><author><name sortKey="Lanham, Sm" uniqKey="Lanham S">SM Lanham</name></author><author><name sortKey="Allingham, R" uniqKey="Allingham R">R Allingham</name></author><author><name sortKey="Gashumba, Jk" uniqKey="Gashumba J">JK Gashumba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Wc" uniqKey="Gibson W">WC Gibson</name></author><author><name sortKey="Fase Fowler, F" uniqKey="Fase Fowler F">F Fase-Fowler</name></author><author><name sortKey="Borst, P" uniqKey="Borst P">P Borst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peacock, L" uniqKey="Peacock L">L Peacock</name></author><author><name sortKey="Ferris, V" uniqKey="Ferris V">V Ferris</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bingle, Leh" uniqKey="Bingle L">LEH Bingle</name></author><author><name sortKey="Eastlake, Jl" uniqKey="Eastlake J">JL Eastlake</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Gibson, Wc" uniqKey="Gibson W">WC Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campbell, Re" uniqKey="Campbell R">RE Campbell</name></author><author><name sortKey="Tour, O" uniqKey="Tour O">O Tour</name></author><author><name sortKey="Palmer, Ae" uniqKey="Palmer A">AE Palmer</name></author><author><name sortKey="Steinbach, Pa" uniqKey="Steinbach P">PA Steinbach</name></author><author><name sortKey="Baird, Gs" uniqKey="Baird G">GS Baird</name></author><author><name sortKey="Zacharias, Da" uniqKey="Zacharias D">DA Zacharias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author><author><name sortKey="Peacock, L" uniqKey="Peacock L">L Peacock</name></author><author><name sortKey="Ferris, V" uniqKey="Ferris V">V Ferris</name></author><author><name sortKey="Williams, K" uniqKey="Williams K">K Williams</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cunningham, I" uniqKey="Cunningham I">I Cunningham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peacock, L" uniqKey="Peacock L">L Peacock</name></author><author><name sortKey="Ferris, V" uniqKey="Ferris V">V Ferris</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peacock, L" uniqKey="Peacock L">L Peacock</name></author><author><name sortKey="Ferris, V" uniqKey="Ferris V">V Ferris</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macleod, Et" uniqKey="Macleod E">ET Macleod</name></author><author><name sortKey="Maudlin, I" uniqKey="Maudlin I">I Maudlin</name></author><author><name sortKey="Darby, Ac" uniqKey="Darby A">AC Darby</name></author><author><name sortKey="Welburn, Sc" uniqKey="Welburn S">SC Welburn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirumi, H" uniqKey="Hirumi H">H Hirumi</name></author><author><name sortKey="Hirumi, K" uniqKey="Hirumi K">K Hirumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macleod, A" uniqKey="Macleod A">A MacLeod</name></author><author><name sortKey="Tweedie, A" uniqKey="Tweedie A">A Tweedie</name></author><author><name sortKey="Mclellan, S" uniqKey="Mclellan S">S McLellan</name></author><author><name sortKey="Taylor, S" uniqKey="Taylor S">S Taylor</name></author><author><name sortKey="Cooper, A" uniqKey="Cooper A">A Cooper</name></author><author><name sortKey="Sweeney, L" uniqKey="Sweeney L">L Sweeney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Ploeg, Lht" uniqKey="Van Der Ploeg L">LHT Van der Ploeg</name></author><author><name sortKey="Schwartz, Dc" uniqKey="Schwartz D">DC Schwartz</name></author><author><name sortKey="Cantor, Cr" uniqKey="Cantor C">CR Cantor</name></author><author><name sortKey="Borst, P" uniqKey="Borst P">P Borst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Wc" uniqKey="Gibson W">WC Gibson</name></author><author><name sortKey="Osinga, Ka" uniqKey="Osinga K">KA Osinga</name></author><author><name sortKey="Michels, Pam" uniqKey="Michels P">PAM Michels</name></author><author><name sortKey="Borst, P" uniqKey="Borst P">P Borst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tait, A" uniqKey="Tait A">A Tait</name></author><author><name sortKey="Barry, Jd" uniqKey="Barry J">JD Barry</name></author><author><name sortKey="Wink, R" uniqKey="Wink R">R Wink</name></author><author><name sortKey="Sanderson, A" uniqKey="Sanderson A">A Sanderson</name></author><author><name sortKey="Crowe, Js" uniqKey="Crowe J">JS Crowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Wc" uniqKey="Gibson W">WC Gibson</name></author><author><name sortKey="Wellde, Bt" uniqKey="Wellde B">BT Wellde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Komba, Ek" uniqKey="Komba E">EK Komba</name></author><author><name sortKey="Kibona, Sn" uniqKey="Kibona S">SN Kibona</name></author><author><name sortKey="Ambwene, Ak" uniqKey="Ambwene A">AK Ambwene</name></author><author><name sortKey="Stevens, Jr" uniqKey="Stevens J">JR Stevens</name></author><author><name sortKey="Gibson, Wc" uniqKey="Gibson W">WC Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maclean, L" uniqKey="Maclean L">L MacLean</name></author><author><name sortKey="Chisi, Je" uniqKey="Chisi J">JE Chisi</name></author><author><name sortKey="Odiit, M" uniqKey="Odiit M">M Odiit</name></author><author><name sortKey="Gibson, Wc" uniqKey="Gibson W">WC Gibson</name></author><author><name sortKey="Ferris, V" uniqKey="Ferris V">V Ferris</name></author><author><name sortKey="Picozzi, K" uniqKey="Picozzi K">K Picozzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godfrey, Dg" uniqKey="Godfrey D">DG Godfrey</name></author><author><name sortKey="Baker, Rd" uniqKey="Baker R">RD Baker</name></author><author><name sortKey="Rickman, Lr" uniqKey="Rickman L">LR Rickman</name></author><author><name sortKey="Mehlitz, D" uniqKey="Mehlitz D">D Mehlitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stevens, Jr" uniqKey="Stevens J">JR Stevens</name></author><author><name sortKey="Godfrey, Dg" uniqKey="Godfrey D">DG Godfrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Pg" uniqKey="Coleman P">PG Coleman</name></author><author><name sortKey="Welburn, Sc" uniqKey="Welburn S">SC Welburn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barry, Jd" uniqKey="Barry J">JD Barry</name></author><author><name sortKey="Graham, Sv" uniqKey="Graham S">SV Graham</name></author><author><name sortKey="Fotheringham, M" uniqKey="Fotheringham M">M Fotheringham</name></author><author><name sortKey="Graham, Vs" uniqKey="Graham V">VS Graham</name></author><author><name sortKey="Kobryn, K" uniqKey="Kobryn K">K Kobryn</name></author><author><name sortKey="Wymer, B" uniqKey="Wymer B">B Wymer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Greef, C" uniqKey="De Greef C">C De Greef</name></author><author><name sortKey="Hamers, R" uniqKey="Hamers R">R Hamers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campillo, N" uniqKey="Campillo N">N Campillo</name></author><author><name sortKey="Carrington, M" uniqKey="Carrington M">M Carrington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanhamme, L" uniqKey="Vanhamme L">L Vanhamme</name></author><author><name sortKey="Paturiaux Hanocq, F" uniqKey="Paturiaux Hanocq F">F Paturiaux-Hanocq</name></author><author><name sortKey="Poelvoorde, P" uniqKey="Poelvoorde P">P Poelvoorde</name></author><author><name sortKey="Nolan, D" uniqKey="Nolan D">D Nolan</name></author><author><name sortKey="Lins, L" uniqKey="Lins L">L Lins</name></author><author><name sortKey="Van Den Abbeele, J" uniqKey="Van Den Abbeele J">J Van den Abbeele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poelvoorde, P" uniqKey="Poelvoorde P">P Poelvoorde</name></author><author><name sortKey="Vanhamme, L" uniqKey="Vanhamme L">L Vanhamme</name></author><author><name sortKey="Van Den Abbeele, J" uniqKey="Van Den Abbeele J">J Van den Abbeele</name></author><author><name sortKey="Switzer, Wm" uniqKey="Switzer W">WM Switzer</name></author><author><name sortKey="Pays, E" uniqKey="Pays E">E Pays</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomson, R" uniqKey="Thomson R">R Thomson</name></author><author><name sortKey="Molina Portela, P" uniqKey="Molina Portela P">P Molina-Portela</name></author><author><name sortKey="Mott, H" uniqKey="Mott H">H Mott</name></author><author><name sortKey="Carrington, M" uniqKey="Carrington M">M Carrington</name></author><author><name sortKey="Raper, J" uniqKey="Raper J">J Raper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brun, R" uniqKey="Brun R">R Brun</name></author><author><name sortKey="Jenni, L" uniqKey="Jenni L">L Jenni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, W" uniqKey="Gibson W">W Gibson</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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