Oseltamivir Is Effective against 1918 Influenza Virus Infection of Macaques but Vulnerable to Escape
Identifieur interne : 000303 ( Main/Merge ); précédent : 000302; suivant : 000304Oseltamivir Is Effective against 1918 Influenza Virus Infection of Macaques but Vulnerable to Escape
Auteurs : Friederike Feldmann [Canada, États-Unis] ; Darwyn Kobasa [Canada] ; Carissa Embury-Hyatt [Canada] ; Allen Grolla [Canada] ; Tracy Taylor [Canada] ; Maki Kiso [Japon] ; Satoshi Kakugawa [Japon] ; Jason Gren [Canada] ; Steven M. Jones [Canada] ; Yoshihiro Kawaoka [Japon, États-Unis] ; Heinz Feldmann [Canada, États-Unis]Source :
- mBio [ 2150-7511 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- traitement médicamenteux : Infections à Orthomyxoviridae.
- usage thérapeutique : Oséltamivir.
- virologie : Infections à Orthomyxoviridae.
- Animaux, Macaca, Sous-type H1N1 du virus de la grippe A.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Oseltamivir.
- drug effects : Influenza A Virus, H1N1 Subtype.
- drug therapy : Orthomyxoviridae Infections.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- virology : Orthomyxoviridae Infections.
- Animals, Macaca.
Abstract
Oseltamivir phosphate is used as a first line of defense in the event of an influenza pandemic prior to vaccine administration. Treatment failure through selection and replication of drug-resistant viruses is a known complication in the field and was also demonstrated in our study with spread of resistant 1918 influenza virus in multiple respiratory tissues. This emphasizes the importance of early treatment and the possibility that noncompliance may exacerbate treatment effectiveness. It also demonstrates the importance of implementing combination therapy and vaccination strategies as soon as possible in a pandemic situation.
Url:
DOI: 10.1128/mBio.02059-19
PubMed: 31641086
PubMed Central: 6805992
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PMC:6805992Le document en format XML
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba</wicri:regionArea>
<wicri:noRegion>Manitoba</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">mBio</title>
<idno type="eISSN">2150-7511</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Influenza A Virus, H1N1 Subtype (drug effects)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Macaca</term>
<term>Orthomyxoviridae Infections (drug therapy)</term>
<term>Orthomyxoviridae Infections (virology)</term>
<term>Oseltamivir (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Infections à Orthomyxoviridae (traitement médicamenteux)</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
<term>Macaca</term>
<term>Oséltamivir (usage thérapeutique)</term>
<term>Sous-type H1N1 du virus de la grippe A ()</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Oseltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Oséltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Macaca</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Macaca</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en"><p>Oseltamivir phosphate is used as a first line of defense in the event of an influenza pandemic prior to vaccine administration. Treatment failure through selection and replication of drug-resistant viruses is a known complication in the field and was also demonstrated in our study with spread of resistant 1918 influenza virus in multiple respiratory tissues. This emphasizes the importance of early treatment and the possibility that noncompliance may exacerbate treatment effectiveness. It also demonstrates the importance of implementing combination therapy and vaccination strategies as soon as possible in a pandemic situation.</p>
</div>
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