PandemieGrippaleV1, Main, Merge, bibRecord, 000270

The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses.

Identifieur interne : 000270 ( Main/Merge ); précédent : 000269; suivant : 000271

The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses.

Auteurs : Cheng-Qiang He [République populaire de Chine] ; Mei He [République populaire de Chine] ; Hong-Bin He [République populaire de Chine] ; Hong-Mei Wang [République populaire de Chine] ; Nai-Zheng Ding [République populaire de Chine]

Source :

Transboundary and emerging diseases [ 1865-1682 ] ; 2019.

RBID : pubmed:31241237

Descripteurs français

KwdFr :
- Animaux, Grippe chez les oiseaux (virologie), Grippe humaine (virologie), Humains, Pandémie de grippe de 1918-1919, Phylogénie, Poulets, Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité), Virus recombinants (génétique), Virus recombinants (pathogénicité).
MESH :
- génétique : Virus de la grippe A, Virus recombinants.
- pathogénicité : Virus de la grippe A, Virus recombinants.
- virologie : Grippe chez les oiseaux, Grippe humaine.
- Animaux, Humains, Pandémie de grippe de 1918-1919, Phylogénie, Poulets.

English descriptors

KwdEn :
- Animals, Chickens, Humans, Influenza A virus (genetics), Influenza A virus (pathogenicity), Influenza Pandemic, 1918-1919, Influenza in Birds (virology), Influenza, Human (virology), Phylogeny, Reassortant Viruses (genetics), Reassortant Viruses (pathogenicity).
MESH :
- genetics : Influenza A virus, Reassortant Viruses.
- pathogenicity : Influenza A virus, Reassortant Viruses.
- virology : Influenza in Birds, Influenza, Human.
- Animals, Chickens, Humans, Influenza Pandemic, 1918-1919, Phylogeny.

Abstract

The 1918 Spanish flu virus has claimed more than 50 million lives. However, the mechanism of its high pathogenicity remains elusive; and the origin of the virus is controversial. The matrix (M) segment regulates the replication of influenza A virus, thereby affecting its virulence and pathogenicity. This study found that the M segment of the Spanish flu virus is a recombinant chimera originating from avian influenza virus and human influenza virus. The unique mosaic M segment might confer the virus high replication capacity, showing that the recombination might play an important role in inducing high pathogenicity of the virus. In addition, this study also suggested that the NA and NS segments of the virus were generated by reassortment between mammalian and avian viruses. Direct phylogenetic evidence was also provided for its avian origin.

DOI: 10.1111/tbed.13282
PubMed: 31241237

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pubmed:31241237

Le document en format XML

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<term>Pandémie de grippe de 1918-1919</term>
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<term>Reassortant Viruses</term>
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<term>Chickens</term>
<term>Humans</term>
<term>Influenza Pandemic, 1918-1919</term>
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<term>Humains</term>
<term>Pandémie de grippe de 1918-1919</term>
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<front><div type="abstract" xml:lang="en">The 1918 Spanish flu virus has claimed more than 50 million lives. However, the mechanism of its high pathogenicity remains elusive; and the origin of the virus is controversial. The matrix (M) segment regulates the replication of influenza A virus, thereby affecting its virulence and pathogenicity. This study found that the M segment of the Spanish flu virus is a recombinant chimera originating from avian influenza virus and human influenza virus. The unique mosaic M segment might confer the virus high replication capacity, showing that the recombination might play an important role in inducing high pathogenicity of the virus. In addition, this study also suggested that the NA and NS segments of the virus were generated by reassortment between mammalian and avian viruses. Direct phylogenetic evidence was also provided for its avian origin.</div>
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The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses.

The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki