Infectivity and Transmissibility of Avian H9N2 Influenza Viruses in Pigs
Identifieur interne : 000878 ( Main/Exploration ); précédent : 000877; suivant : 000879Infectivity and Transmissibility of Avian H9N2 Influenza Viruses in Pigs
Auteurs : Jia Wang [République populaire de Chine] ; Maocai Wu [République populaire de Chine] ; Wenshan Hong [République populaire de Chine] ; Xiaohui Fan [République populaire de Chine] ; Rirong Chen [République populaire de Chine] ; Zuoyi Zheng [République populaire de Chine] ; Yu Zeng [République populaire de Chine] ; Ren Huang [République populaire de Chine] ; Yu Zhang [République populaire de Chine] ; Tommy Tsan-Yuk Lam [République populaire de Chine] ; David K. Smith [République populaire de Chine] ; Huachen Zhu [République populaire de Chine] ; Yi Guan [République populaire de Chine]Source :
- Journal of Virology [ 0022-538X ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Chine, Embryon de poulet, Grippe chez les oiseaux (transmission), Grippe chez les oiseaux (virologie), Grippe humaine (virologie), Humains, Infections à Orthomyxoviridae (médecine vétérinaire), Infections à Orthomyxoviridae (transmission), Infections à Orthomyxoviridae (virologie), Maladies de la volaille (transmission), Maladies de la volaille (virologie), Maladies des porcs (virologie), Sous-type H9N2 du virus de la grippe A (pathogénicité), Suidae, Volaille (virologie).
- MESH :
- médecine vétérinaire : Infections à Orthomyxoviridae.
- pathogénicité : Sous-type H9N2 du virus de la grippe A.
- virologie : Grippe chez les oiseaux, Grippe humaine, Infections à Orthomyxoviridae, Maladies de la volaille, Maladies des porcs, Volaille.
- transmission : Animaux, Chine, Embryon de poulet, Grippe chez les oiseaux, Humains, Infections à Orthomyxoviridae, Maladies de la volaille, Suidae.
English descriptors
- KwdEn :
- Animals, Chick Embryo, China, Humans, Influenza A Virus, H9N2 Subtype (pathogenicity), Influenza in Birds (transmission), Influenza in Birds (virology), Influenza, Human (virology), Orthomyxoviridae Infections (transmission), Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Poultry (virology), Poultry Diseases (transmission), Poultry Diseases (virology), Swine, Swine Diseases (virology).
- MESH :
- pathogenicity : Influenza A Virus, H9N2 Subtype.
- transmission : Influenza in Birds, Orthomyxoviridae Infections, Poultry Diseases.
- veterinary : Orthomyxoviridae Infections.
- virology : Influenza in Birds, Influenza, Human, Orthomyxoviridae Infections, Poultry, Poultry Diseases, Swine Diseases.
- Animals, Chick Embryo, China, Humans, Swine.
Abstract
The H9N2 influenza viruses that are enzootic in terrestrial poultry in China pose a persistent pandemic threat to humans. To investigate whether the continuous circulation and adaptation of these viruses in terrestrial poultry increased their infectivity to pigs, we conducted a serological survey in pig herds with H9N2 viruses selected from the aquatic avian gene pool (Y439 lineage) and the enzootic terrestrial poultry viruses (G1 and Y280 lineages). We also compared the infectivity and transmissibility of these viruses in pigs. It was found that more than 15% of the pigs sampled from 2010 to 2012 in southern China were seropositive to either G1 or Y280 lineage viruses, but none of the sera were positive to the H9 viruses from the Y439 lineage. Viruses of the G1 and Y280 lineages were able to infect experimental pigs, with detectable nasal shedding of the viruses and seroconversion, whereas viruses of the Y439 lineage did not cause a productive infection in pigs. Thus, adaptation and prevalence in terrestrial poultry could lead to interspecies transmission of H9N2 viruses from birds to pigs. Although H9N2 viruses do not appear to be continuously transmissible among pigs, repeated introductions of H9 viruses to pigs naturally increase the risk of generating mammalian-adapted or reassorted variants that are potentially infectious to humans. This study highlights the importance of monitoring the activity of H9N2 viruses in terrestrial poultry and pigs.
Url:
DOI: 10.1128/JVI.02605-15
PubMed: 26764002
PubMed Central: 4794674
Affiliations:
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Le document en format XML
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<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Chick Embryo</term>
<term>China</term>
<term>Humans</term>
<term>Influenza A Virus, H9N2 Subtype (pathogenicity)</term>
<term>Influenza in Birds (transmission)</term>
<term>Influenza in Birds (virology)</term>
<term>Influenza, Human (virology)</term>
<term>Orthomyxoviridae Infections (transmission)</term>
<term>Orthomyxoviridae Infections (veterinary)</term>
<term>Orthomyxoviridae Infections (virology)</term>
<term>Poultry (virology)</term>
<term>Poultry Diseases (transmission)</term>
<term>Poultry Diseases (virology)</term>
<term>Swine</term>
<term>Swine Diseases (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chine</term>
<term>Embryon de poulet</term>
<term>Grippe chez les oiseaux (transmission)</term>
<term>Grippe chez les oiseaux (virologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae (médecine vétérinaire)</term>
<term>Infections à Orthomyxoviridae (transmission)</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
<term>Maladies de la volaille (transmission)</term>
<term>Maladies de la volaille (virologie)</term>
<term>Maladies des porcs (virologie)</term>
<term>Sous-type H9N2 du virus de la grippe A (pathogénicité)</term>
<term>Suidae</term>
<term>Volaille (virologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H9N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H9N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza in Birds</term>
<term>Orthomyxoviridae Infections</term>
<term>Poultry Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term>
<term>Grippe humaine</term>
<term>Infections à Orthomyxoviridae</term>
<term>Maladies de la volaille</term>
<term>Maladies des porcs</term>
<term>Volaille</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term>
<term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
<term>Poultry</term>
<term>Poultry Diseases</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chick Embryo</term>
<term>China</term>
<term>Humans</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Animaux</term>
<term>Chine</term>
<term>Embryon de poulet</term>
<term>Grippe chez les oiseaux</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae</term>
<term>Maladies de la volaille</term>
<term>Suidae</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>The H9N2 influenza viruses that are enzootic in terrestrial poultry in China pose a persistent pandemic threat to humans. To investigate whether the continuous circulation and adaptation of these viruses in terrestrial poultry increased their infectivity to pigs, we conducted a serological survey in pig herds with H9N2 viruses selected from the aquatic avian gene pool (Y439 lineage) and the enzootic terrestrial poultry viruses (G1 and Y280 lineages). We also compared the infectivity and transmissibility of these viruses in pigs. It was found that more than 15% of the pigs sampled from 2010 to 2012 in southern China were seropositive to either G1 or Y280 lineage viruses, but none of the sera were positive to the H9 viruses from the Y439 lineage. Viruses of the G1 and Y280 lineages were able to infect experimental pigs, with detectable nasal shedding of the viruses and seroconversion, whereas viruses of the Y439 lineage did not cause a productive infection in pigs. Thus, adaptation and prevalence in terrestrial poultry could lead to interspecies transmission of H9N2 viruses from birds to pigs. Although H9N2 viruses do not appear to be continuously transmissible among pigs, repeated introductions of H9 viruses to pigs naturally increase the risk of generating mammalian-adapted or reassorted variants that are potentially infectious to humans. This study highlights the importance of monitoring the activity of H9N2 viruses in terrestrial poultry and pigs.</p>
<p><bold>IMPORTANCE</bold>
H9N2 subtype of influenza viruses has repeatedly been introduced into mammalian hosts, including humans and pigs, so awareness of their activity and evolution is important for influenza pandemic preparedness. However, since H9N2 viruses usually cause mild or even asymptomatic infections in mammalian hosts, they may be overlooked in influenza surveillance. Here, we found that the H9N2 viruses established in terrestrial poultry had higher infectivity in pigs than those from aquatic birds, which suggests that adaptation of the H9N2 viruses in terrestrial poultry might have increased the infectivity of the virus to mammals. Therefore, monitoring the prevalence and evolution of H9 viruses prevalent in terrestrial birds and conducting risk assessment of their threat to mammals are critical for evaluating the pandemic potential of this virus.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Guangdong</li>
</region>
<settlement><li>Jiangmen</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Jia" sort="Wang, Jia" uniqKey="Wang J" first="Jia" last="Wang">Jia Wang</name>
</noRegion>
<name sortKey="Chen, Rirong" sort="Chen, Rirong" uniqKey="Chen R" first="Rirong" last="Chen">Rirong Chen</name>
<name sortKey="Fan, Xiaohui" sort="Fan, Xiaohui" uniqKey="Fan X" first="Xiaohui" last="Fan">Xiaohui Fan</name>
<name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
<name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
<name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
<name sortKey="Hong, Wenshan" sort="Hong, Wenshan" uniqKey="Hong W" first="Wenshan" last="Hong">Wenshan Hong</name>
<name sortKey="Huang, Ren" sort="Huang, Ren" uniqKey="Huang R" first="Ren" last="Huang">Ren Huang</name>
<name sortKey="Lam, Tommy Tsan Yuk" sort="Lam, Tommy Tsan Yuk" uniqKey="Lam T" first="Tommy Tsan-Yuk" last="Lam">Tommy Tsan-Yuk Lam</name>
<name sortKey="Smith, David K" sort="Smith, David K" uniqKey="Smith D" first="David K." last="Smith">David K. Smith</name>
<name sortKey="Wang, Jia" sort="Wang, Jia" uniqKey="Wang J" first="Jia" last="Wang">Jia Wang</name>
<name sortKey="Wu, Maocai" sort="Wu, Maocai" uniqKey="Wu M" first="Maocai" last="Wu">Maocai Wu</name>
<name sortKey="Zeng, Yu" sort="Zeng, Yu" uniqKey="Zeng Y" first="Yu" last="Zeng">Yu Zeng</name>
<name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name>
<name sortKey="Zheng, Zuoyi" sort="Zheng, Zuoyi" uniqKey="Zheng Z" first="Zuoyi" last="Zheng">Zuoyi Zheng</name>
<name sortKey="Zhu, Huachen" sort="Zhu, Huachen" uniqKey="Zhu H" first="Huachen" last="Zhu">Huachen Zhu</name>
<name sortKey="Zhu, Huachen" sort="Zhu, Huachen" uniqKey="Zhu H" first="Huachen" last="Zhu">Huachen Zhu</name>
</country>
</tree>
</affiliations>
</record>
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