PandemieGrippaleV1, Main, Exploration, bibRecordById, pubmed:25790305

Surveillance and Clinical Characterization of Influenza in a University Cohort in Singapore

Identifieur interne : 000A89 ( Main/Exploration ); précédent : 000A88; suivant : 000A90

Surveillance and Clinical Characterization of Influenza in a University Cohort in Singapore

Auteurs : Aidan Lyanzhiang Tan [Singapour] ; Ramandeep Kaur Virk [Singapour] ; Paul Anantharajah Tambyah [Singapour] ; Masafumi Inoue [Singapour] ; Elizabeth Ai-Sim Lim [Singapour] ; Ka-Wei Chan [Singapour] ; C. Senthamarai Chelvi [Singapour] ; Say-Tat Ooi [Singapour] ; Catherine Chua [Singapour] ; Boon-Huan Tan [Singapour]

Source :

PLoS ONE [ 1932-6203 ] ; 2015.

RBID : PMC:4366074

Descripteurs français

KwdFr :
- ARN viral (analyse), Adulte, Démographie, Facteurs de risque, Femelle, Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Jeune adulte, Mâle, Odds ratio, Partie nasale du pharynx (virologie), RT-PCR, Singapour (épidémiologie), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), Universités, Virus influenza B (génétique), Virus influenza B (isolement et purification), Études de cohortes.
MESH :
- analyse : ARN viral.
- génétique : Sous-type H1N1 du virus de la grippe A, Virus influenza B.
- isolement et purification : Sous-type H1N1 du virus de la grippe A, Virus influenza B.
- virologie : Grippe humaine, Partie nasale du pharynx.
- épidémiologie : Grippe humaine, Singapour.
- Adulte, Démographie, Facteurs de risque, Femelle, Humains, Jeune adulte, Mâle, Odds ratio, RT-PCR, Universités, Études de cohortes.
Wicri :
- geographic : Singapour.

English descriptors

KwdEn :
- Adult, Cohort Studies, Demography, Female, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza B virus (genetics), Influenza B virus (isolation & purification), Influenza, Human (epidemiology), Influenza, Human (virology), Male, Nasopharynx (virology), Odds Ratio, RNA, Viral (analysis), Reverse Transcriptase Polymerase Chain Reaction, Risk Factors, Singapore (epidemiology), Universities, Young Adult.
MESH :
- chemical , analysis : RNA, Viral.
- geographic , epidemiology : Singapore.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza B virus.
- isolation & purification : Influenza A Virus, H1N1 Subtype, Influenza B virus.
- virology : Influenza, Human, Nasopharynx.
- Adult, Cohort Studies, Demography, Female, Humans, Male, Odds Ratio, Reverse Transcriptase Polymerase Chain Reaction, Risk Factors, Universities, Young Adult.

Abstract

Background

Southeast Asia is a potential locus for the emergence of novel influenza strains. However, information on influenza within the region is limited.

Objectives

This study was to determine the proportion of influenza-like illness (ILI) caused by influenza A and B viruses in a university cohort in Singapore, identify important distinctive clinical features of influenza infection and potential factors associated with influenza infection compared with other causes of ILI.

Methodology

A surveillance study was conducted from 2007 to 2009, at the University Health and Wellness Centre, National University of Singapore (NUS). Basic demographic information and nasopharyngeal swabs were collected from consenting students and staff with ILI, with Influenza A and B identified by both culture and molecular methods.

Results

Proportions of influenza A and B virus infections in subjects with ILI were 153/500 (30.6%) and 11/500 (2.2%) respectively. The predominant subtype was A/H1N1, including both the seasonal strain (20/153) and the pandemic strain (72/153). The clinical symptom of fever was more common in subjects with laboratory confirmed influenza than other ILIs. On-campus hostel residence and being a student (compared with staff) were associated with increased risk of laboratory confirmed influenza A/H1N1 2009 infection.

Conclusions

This study provides a baseline prevalence of influenza infection within young adults in Singapore in a university setting. Potential risk factors, such as hostel residence, were identified, allowing for more targeted infection control measures in the event of a future influenza pandemic.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366074

DOI: 10.1371/journal.pone.0119485
PubMed: 25790305
PubMed Central: 4366074

Affiliations:

Le document en format XML

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<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
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<term>Cohort Studies</term>
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<term>Jeune adulte</term>
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<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title>
<p>Southeast Asia is a potential locus for the emergence of novel influenza strains. However, information on influenza within the region is limited.</p>
</sec>
<sec id="sec002"><title>Objectives</title>
<p>This study was to determine the proportion of influenza-like illness (ILI) caused by influenza A and B viruses in a university cohort in Singapore, identify important distinctive clinical features of influenza infection and potential factors associated with influenza infection compared with other causes of ILI.</p>
</sec>
<sec id="sec003"><title>Methodology</title>
<p>A surveillance study was conducted from 2007 to 2009, at the University Health and Wellness Centre, National University of Singapore (NUS). Basic demographic information and nasopharyngeal swabs were collected from consenting students and staff with ILI, with Influenza A and B identified by both culture and molecular methods.</p>
</sec>
<sec id="sec004"><title>Results</title>
<p>Proportions of influenza A and B virus infections in subjects with ILI were 153/500 (30.6%) and 11/500 (2.2%) respectively. The predominant subtype was A/H1N1, including both the seasonal strain (20/153) and the pandemic strain (72/153). The clinical symptom of fever was more common in subjects with laboratory confirmed influenza than other ILIs. On-campus hostel residence and being a student (compared with staff) were associated with increased risk of laboratory confirmed influenza A/H1N1 2009 infection.</p>
</sec>
<sec id="sec005"><title>Conclusions</title>
<p>This study provides a baseline prevalence of influenza infection within young adults in Singapore in a university setting. Potential risk factors, such as hostel residence, were identified, allowing for more targeted infection control measures in the event of a future influenza pandemic.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ng, Tp" uniqKey="Ng T">TP Ng</name>
</author>
<author><name sortKey="Pwee, Kh" uniqKey="Pwee K">KH Pwee</name>
</author>
<author><name sortKey="Niti, M" uniqKey="Niti M">M Niti</name>
</author>
<author><name sortKey="Goh, Lp" uniqKey="Goh L">LP Goh</name>
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</TEI>
<affiliations><list><country><li>Singapour</li>
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<name sortKey="Chelvi, C Senthamarai" sort="Chelvi, C Senthamarai" uniqKey="Chelvi C" first="C. Senthamarai" last="Chelvi">C. Senthamarai Chelvi</name>
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</record>

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Serveur d'exploration sur les pandémies grippales

Surveillance and Clinical Characterization of Influenza in a University Cohort in Singapore

Surveillance and Clinical Characterization of Influenza in a University Cohort in Singapore

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	Serveur d'exploration sur les pandémies grippales
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