Guillain-Barré syndrome associated with the D222E variant of the 2009 pandemic influenza A (H1N1) virus: Case report and review of the literature
Identifieur interne : 002103 ( Main/Exploration ); précédent : 002102; suivant : 002104Guillain-Barré syndrome associated with the D222E variant of the 2009 pandemic influenza A (H1N1) virus: Case report and review of the literature
Auteurs : Andrea Cortese [Italie] ; Fausto Baldanti [Italie] ; Eleonora Tavazzi [Italie] ; Livio Carnevale [Italie] ; Lorenzo Minoli [Italie] ; Alessandro Lozza [Italie] ; Enrico Marchioni [Italie]Source :
- Journal of the neurological sciences [ 0022-510X ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccination.
English descriptors
- KwdEn :
Abstract
Guillain-Barré syndrome (GBS) is an acute immune-mediated disorder of the peripheral nervous system and a triggering infectious event is often reported in the weeks before the disease onset. Influenza viruses have been associated with Guillain-Barré syndrome (GBS), both after infection and, in rare cases, after vaccination. However, GBS has rarely reported to be a neurological complication of the recent pandemic influenza A (H1N1) 2009 virus infections. Here we describe the case of a young man, who developed acute severe motor inflammatory demyelinating polyradiculoneuropathy during influenza A(H1N1)2009 infection. Peculiar features are the findings of a mutated haemagglutinin gene (D222E variant), which has never previously been associated with neurological involvement, and the almost simultaneous appearance of respiratory infectious and immune-mediated neurological symptoms. Moreover we review the clinical presentation, laboratory findings and outcome of influenza-related GBS.
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Guillain-Barré syndrome (GBS) is an acute immune-mediated disorder of the peripheral nervous system and a triggering infectious event is often reported in the weeks before the disease onset. Influenza viruses have been associated with Guillain-Barré syndrome (GBS), both after infection and, in rare cases, after vaccination. However, GBS has rarely reported to be a neurological complication of the recent pandemic influenza A (H1N1) 2009 virus infections. Here we describe the case of a young man, who developed acute severe motor inflammatory demyelinating polyradiculoneuropathy during influenza A(H1N1)2009 infection. Peculiar features are the findings of a mutated haemagglutinin gene (D222E variant), which has never previously been associated with neurological involvement, and the almost simultaneous appearance of respiratory infectious and immune-mediated neurological symptoms. Moreover we review the clinical presentation, laboratory findings and outcome of influenza-related GBS.</div>
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