Passive immunization for influenza through antibody therapies, a review of the pipeline, challenges and potential applications
Identifieur interne : 000853 ( Main/Exploration ); précédent : 000852; suivant : 000854Passive immunization for influenza through antibody therapies, a review of the pipeline, challenges and potential applications
Auteurs : Erin Sparrow [Suisse, Australie] ; Martin Friede [Suisse] ; Mohamud Sheikh [Australie] ; Siranda Torvaldsen [Australie] ; Anthony T. Newall [Australie]Source :
- Vaccine [ 0264-410X ] ; 2016.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (immunologie), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (immunologie), Anticorps monoclonaux (usage thérapeutique), Anticorps neutralisants (immunologie), Anticorps neutralisants (usage thérapeutique), Essais cliniques comme sujet, Facteurs immunologiques (immunologie), Facteurs immunologiques (usage thérapeutique), Grippe humaine (), Humains, Immunisation passive (), Pandémies (), Prophylaxie pré-exposition (), Vaccins antigrippaux (immunologie).
- MESH :
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Anticorps neutralisants, Facteurs immunologiques, Vaccins antigrippaux.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux, Anticorps neutralisants, Facteurs immunologiques.
- Essais cliniques comme sujet, Grippe humaine, Humains, Immunisation passive, Pandémies, Prophylaxie pré-exposition.
English descriptors
- KwdEn :
- Antibodies, Monoclonal (immunology), Antibodies, Monoclonal (therapeutic use), Antibodies, Neutralizing (immunology), Antibodies, Neutralizing (therapeutic use), Antibodies, Viral (immunology), Antibodies, Viral (therapeutic use), Clinical Trials as Topic, Humans, Immunization, Passive (methods), Immunologic Factors (immunology), Immunologic Factors (therapeutic use), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Pandemics (prevention & control), Pre-Exposure Prophylaxis (methods).
- MESH :
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Immunologic Factors, Influenza Vaccines.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Immunologic Factors.
- methods : Immunization, Passive, Pre-Exposure Prophylaxis.
- prevention & control : Influenza, Human, Pandemics.
- Clinical Trials as Topic, Humans.
Abstract
The Global Action Plan for influenza vaccines (GAP) aims to increase the production capacity of vaccines so that in the event of a pandemic there is an adequate supply to meet global needs. However, it has been estimated that even in the best case scenario there would be a considerable delay of at least five to six months for the first supplies of vaccine to become available after the isolation of the strain and availability of the candidate vaccine virus to vaccine manufacturers. By this time, the virus is likely to have already infected millions of people worldwide, causing significant mortality, morbidity and economic loss.
Passive immunization through broadly neutralizing antibodies which bind to multiple, structurally diverse strains of influenza could be a promising solution to address the immediate health threat of an influenza pandemic while vaccines are being developed. These products may also have a role in seasonal influenza as an alternative to other options such as antivirals for the treatment of severe acute respiratory illness due to influenza.
This article provides an overview of the current clinical pipeline of anti-influenza antibodies and discusses potential uses and the challenges to product development.
Url:
DOI: 10.1016/j.vaccine.2016.08.057
PubMed: 27622299
PubMed Central: 5357764
Affiliations:
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Le document en format XML
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However, it has been estimated that even in the best case scenario there would be a considerable delay of at least five to six months for the first supplies of vaccine to become available after the isolation of the strain and availability of the candidate vaccine virus to vaccine manufacturers. By this time, the virus is likely to have already infected millions of people worldwide, causing significant mortality, morbidity and economic loss.</p><p>Passive immunization through broadly neutralizing antibodies which bind to multiple, structurally diverse strains of influenza could be a promising solution to address the immediate health threat of an influenza pandemic while vaccines are being developed. These products may also have a role in seasonal influenza as an alternative to other options such as antivirals for the treatment of severe acute respiratory illness due to influenza.</p><p>This article provides an overview of the current clinical pipeline of anti-influenza antibodies and discusses potential uses and the challenges to product development.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kelso, J K" uniqKey="Kelso J">J.K. Kelso</name></author><author><name sortKey="Halder, N" uniqKey="Halder N">N. Halder</name></author><author><name sortKey="Milne, G J" uniqKey="Milne G">G.J. Milne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prager, F" uniqKey="Prager F">F. Prager</name></author><author><name sortKey="Wei, D" uniqKey="Wei D">D. Wei</name></author><author><name sortKey="Rose, A" uniqKey="Rose A">A. 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Jefferson</name></author><author><name sortKey="Jones, M A" uniqKey="Jones M">M.A. Jones</name></author><author><name sortKey="Doshi, P" uniqKey="Doshi P">P. Doshi</name></author><author><name sortKey="Del Mar, C B" uniqKey="Del Mar C">C.B. Del Mar</name></author><author><name sortKey="Hama, R" uniqKey="Hama R">R. Hama</name></author><author><name sortKey="Thompson, M J" uniqKey="Thompson M">M.J. Thompson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chan Hui, P Y" uniqKey="Chan Hui P">P.Y. Chan-Hui</name></author><author><name sortKey="Swiderek, K M" uniqKey="Swiderek K">K.M. Swiderek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kelley, B" uniqKey="Kelley B">B. Kelley</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Suisse</li></country><region><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Suisse"><noRegion><name sortKey="Sparrow, Erin" sort="Sparrow, Erin" uniqKey="Sparrow E" first="Erin" last="Sparrow">Erin Sparrow</name></noRegion><name sortKey="Friede, Martin" sort="Friede, Martin" uniqKey="Friede M" first="Martin" last="Friede">Martin Friede</name></country><country name="Australie"><noRegion><name sortKey="Sparrow, Erin" sort="Sparrow, Erin" uniqKey="Sparrow E" first="Erin" last="Sparrow">Erin Sparrow</name></noRegion><name sortKey="Newall, Anthony T" sort="Newall, Anthony T" uniqKey="Newall A" first="Anthony T." last="Newall">Anthony T. Newall</name><name sortKey="Sheikh, Mohamud" sort="Sheikh, Mohamud" uniqKey="Sheikh M" first="Mohamud" last="Sheikh">Mohamud Sheikh</name><name sortKey="Torvaldsen, Siranda" sort="Torvaldsen, Siranda" uniqKey="Torvaldsen S" first="Siranda" last="Torvaldsen">Siranda Torvaldsen</name><name sortKey="Torvaldsen, Siranda" sort="Torvaldsen, Siranda" uniqKey="Torvaldsen S" first="Siranda" last="Torvaldsen">Siranda Torvaldsen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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