Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic
Identifieur interne : 000905 ( Main/Exploration ); précédent : 000904; suivant : 000906Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic
Auteurs : Gudrun S. Freidl ; Henk-Jan Van Den Ham ; Maciej F. Boni [Viêt Nam, Royaume-Uni] ; Erwin De Bruin ; Marion P. G. KoopmansSource :
- Scientific Reports [ 2045-2322 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Femelle, Grippe chez les oiseaux (immunologie), Grippe humaine (immunologie), Grippe humaine (virologie), Humains, Immunoglobuline G (immunologie), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Jeune adulte, Nouveau-né, Oiseaux, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (immunologie).
- MESH :
- immunologie : Anticorps antiviraux, Grippe chez les oiseaux, Grippe humaine, Immunoglobuline G, Infections à Orthomyxoviridae, Sous-type H1N1 du virus de la grippe A.
- sang : Anticorps antiviraux.
- virologie : Grippe humaine, Infections à Orthomyxoviridae.
- Adulte, Animaux, Femelle, Humains, Jeune adulte, Nouveau-né, Oiseaux, Sous-type H1N1 du virus de la grippe A.
English descriptors
- KwdEn :
- Adult, Animals, Antibodies, Viral (blood), Antibodies, Viral (immunology), Birds, Female, Humans, Immunoglobulin G (immunology), Infant, Newborn, Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (immunology), Influenza in Birds (immunology), Influenza, Human (immunology), Influenza, Human (virology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (virology), Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Antibodies, Viral, Immunoglobulin G.
- classification : Influenza A Virus, H1N1 Subtype.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza in Birds, Influenza, Human, Orthomyxoviridae Infections.
- virology : Influenza, Human, Orthomyxoviridae Infections.
- Adult, Animals, Birds, Female, Humans, Infant, Newborn, Young Adult.
Abstract
Seropositivity to avian influenza (AI) via low-level antibody titers has been reported in the general population and poultry-exposed individuals, raising the question whether these findings reflect true infection with AI or cross-reactivity. Here we investigated serological profiles against human and avian influenza viruses in the general population using a protein microarray platform. We hypothesized that higher antibody diversity across recent H1 and H3 influenza viruses would be associated with heterosubtypic reactivity to older pandemic- and AI viruses. We found significant heterogeneity in antibody profiles. Increased antibody diversity to seasonal influenza viruses was associated with low-level heterosubtypic antibodies to H9 and H7, but not to H5 AI virus. Individuals exposed to the recent 2009 A(H1N1) pandemic showed higher heterosubtypic reactivity. We show that there is a complex interplay between prior exposures to seasonal and recent pandemic influenza viruses and the development of heterosubtypic antibody reactivity to animal influenza viruses.
Url:
DOI: 10.1038/srep20385
PubMed: 26853924
PubMed Central: 4745054
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Seropositivity to avian influenza (AI) via low-level antibody titers has been reported in the general population and poultry-exposed individuals, raising the question whether these findings reflect true infection with AI or cross-reactivity. Here we investigated serological profiles against human and avian influenza viruses in the general population using a protein microarray platform. We hypothesized that higher antibody diversity across recent H1 and H3 influenza viruses would be associated with heterosubtypic reactivity to older pandemic- and AI viruses. We found significant heterogeneity in antibody profiles. Increased antibody diversity to seasonal influenza viruses was associated with low-level heterosubtypic antibodies to H9 and H7, but not to H5 AI virus. Individuals exposed to the recent 2009 A(H1N1) pandemic showed higher heterosubtypic reactivity. We show that there is a complex interplay between prior exposures to seasonal and recent pandemic influenza viruses and the development of heterosubtypic antibody reactivity to animal influenza viruses.</p>
</div>
</front>
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