Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009
Identifieur interne : 002437 ( Main/Exploration ); précédent : 002436; suivant : 002438Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009
Auteurs : Koussay Dellagi [France] ; Olivier Rollot ; Sarah Temmam [France] ; Nicolas Salez [France] ; Vanina Guernier [France] ; Hervé Pascalis [France] ; Patrick Gérardin ; Adrian Fianu ; Nathanael Lapidus [France] ; Nadège Naty ; Pablo Tortosa ; Karim Boussaïd ; Marie-Christine Jaffar-Banjee ; Laurent Filleul ; Antoine Flahault [France] ; Fabrice Carrat [France] ; Francois Favier ; Xavier De Lamballerie [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, France (épidémiologie), Grippe humaine (immunologie), Grippe humaine (sang), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Jeune adulte, Mâle, Pandémies, Réaction de polymérisation en chaîne, Saisons, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H1N1 du virus de la grippe A (pathogénicité), Tests sérologiques, Études de cohortes, Études prospectives.
- MESH :
- génétique : Sous-type H1N1 du virus de la grippe A.
- immunologie : Grippe humaine, Sous-type H1N1 du virus de la grippe A.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- sang : Grippe humaine.
- virologie : Grippe humaine.
- épidémiologie : France, Grippe humaine.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Pandémies, Réaction de polymérisation en chaîne, Saisons, Tests sérologiques, Études de cohortes, Études prospectives.
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Adult, Cohort Studies, Female, France (epidemiology), Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza, Human (blood), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (virology), Male, Middle Aged, Pandemics, Polymerase Chain Reaction, Prospective Studies, Seasons, Serologic Tests, Young Adult.
- MESH :
- geographic , epidemiology : France.
- blood : Influenza, Human.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza, Human.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adult, Cohort Studies, Female, Humans, Male, Middle Aged, Pandemics, Polymerase Chain Reaction, Prospective Studies, Seasons, Serologic Tests, Young Adult.
Abstract
To date, there is little information that reflects the true extent of spread of the pH1N1/2009v influenza pandemic at the community level as infection often results in mild or no clinical symptoms. This study aimed at assessing through a prospective study, the attack rate of pH1N1/2009 virus in Reunion Island and risk factors of infection, during the 2009 season.
A serosurvey was conducted during the 2009 austral winter, in the frame of a prospective population study. Pairs of sera were collected from 1687 individuals belonging to 772 households, during and after passage of the pandemic wave. Antibodies to pH1N1/2009v were titered using the hemagglutination inhibition assay (HIA) with titers ≥1/40 being considered positive. Seroprevalence during the first two weeks of detection of pH1N1/2009v in Reunion Island was 29.8% in people under 20 years of age, 35.6% in adults (20–59 years) and 73.3% in the elderly (≥60 years) (P<0.0001). Baseline corrected cumulative incidence rates, were 42.9%, 13.9% and 0% in these age groups respectively (P<0.0001). A significant decline in antibody titers occurred soon after the passage of the epidemic wave. Seroconversion rates to pH1N1/2009 correlated negatively with age: 63.2%, 39.4% and 16.7%, in each age group respectively (P<0.0001). Seroconversion occurred in 65.2% of individuals who were seronegative at inclusion compared to 6.8% in those who were initially seropositive.
Seroincidence of pH1N1/2009v infection was three times that estimated from clinical surveillance, indicating that almost two thirds of infections occurring at the community level have escaped medical detection. People under 20 years of age were the most affected group. Pre-epidemic titers ≥1/40 prevented seroconversion and are likely protective against infection. A concern was raised about the long term stability of the antibody responses.
Url:
DOI: 10.1371/journal.pone.0025738
PubMed: 21980532
PubMed Central: 3183080
Affiliations:
- France
- Auvergne-Rhône-Alpes, Provence-Alpes-Côte d'Azur, Rhône-Alpes, Île-de-France
- Lyon, Marseille, Paris
- Université de la Méditerranée
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Le document en format XML
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id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les Maladies Emergentes dans l'Océan Indien, Saint-Denis, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de Recherche pour le Développement (IRD), Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Rollot, Olivier" sort="Rollot, Olivier" uniqKey="Rollot O" first="Olivier" last="Rollot">Olivier Rollot</name><affiliation><nlm:aff id="aff3"><addr-line>Centre d'Investigation Clinique-Epidémiologie Clinique (CIC-EC) de La Réunion (INSERM/CHR/Université/URMLR), Centre Hospitalier Régional, Saint-Pierre, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation></author><author><name sortKey="Temmam, Sarah" sort="Temmam, Sarah" uniqKey="Temmam S" first="Sarah" last="Temmam">Sarah Temmam</name><affiliation><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les Maladies Emergentes dans l'Océan Indien, Saint-Denis, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Ecologie Microbienne (UMR 5557) CNRS-Université de Lyon, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Ecologie Microbienne (UMR 5557) CNRS-Université de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Salez, Nicolas" sort="Salez, Nicolas" uniqKey="Salez N" first="Nicolas" last="Salez">Nicolas Salez</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université de la Méditerranée</orgName></affiliation></author><author><name sortKey="Guernier, Vanina" sort="Guernier, Vanina" uniqKey="Guernier V" first="Vanina" last="Guernier">Vanina Guernier</name><affiliation><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les Maladies Emergentes dans l'Océan Indien, Saint-Denis, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de Recherche pour le Développement (IRD), Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Pascalis, Herve" sort="Pascalis, Herve" uniqKey="Pascalis H" first="Hervé" last="Pascalis">Hervé Pascalis</name><affiliation><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les Maladies Emergentes dans l'Océan Indien, Saint-Denis, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institut de Recherche pour le Développement (IRD), Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de Recherche pour le Développement (IRD), Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Gerardin, Patrick" sort="Gerardin, Patrick" uniqKey="Gerardin P" first="Patrick" last="Gérardin">Patrick Gérardin</name><affiliation><nlm:aff id="aff3"><addr-line>Centre d'Investigation Clinique-Epidémiologie Clinique (CIC-EC) de La Réunion (INSERM/CHR/Université/URMLR), Centre Hospitalier Régional, Saint-Pierre, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation></author><author><name sortKey="Fianu, Adrian" sort="Fianu, Adrian" uniqKey="Fianu A" first="Adrian" last="Fianu">Adrian Fianu</name><affiliation><nlm:aff id="aff3"><addr-line>Centre d'Investigation Clinique-Epidémiologie Clinique (CIC-EC) de La Réunion (INSERM/CHR/Université/URMLR), Centre Hospitalier Régional, Saint-Pierre, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation></author><author><name sortKey="Lapidus, Nathanael" sort="Lapidus, Nathanael" uniqKey="Lapidus N" first="Nathanael" last="Lapidus">Nathanael Lapidus</name><affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Epidémiologie des Maladies Infectieuses et Modélisation (UMR-S 707), INSERM-Université Pierre et Marie Curie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Epidémiologie des Maladies Infectieuses et Modélisation (UMR-S 707), INSERM-Université Pierre et Marie Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Naty, Nadege" sort="Naty, Nadege" uniqKey="Naty N" first="Nadège" last="Naty">Nadège Naty</name><affiliation><nlm:aff id="aff3"><addr-line>Centre d'Investigation Clinique-Epidémiologie Clinique (CIC-EC) de La Réunion (INSERM/CHR/Université/URMLR), Centre Hospitalier Régional, Saint-Pierre, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation></author><author><name sortKey="Tortosa, Pablo" sort="Tortosa, Pablo" uniqKey="Tortosa P" first="Pablo" last="Tortosa">Pablo Tortosa</name><affiliation><nlm:aff id="aff1"><addr-line>GIS CRVOI, Centre de Recherche et de Veille sur les Maladies Emergentes dans l'Océan Indien, Saint-Denis, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff7"><addr-line>Chaire mixte CNRS INEE-Université de La Réunion, Saint Denis, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation></author><author><name sortKey="Boussaid, Karim" sort="Boussaid, Karim" uniqKey="Boussaid K" first="Karim" last="Boussaïd">Karim Boussaïd</name><affiliation><nlm:aff id="aff3"><addr-line>Centre d'Investigation Clinique-Epidémiologie Clinique (CIC-EC) de La Réunion (INSERM/CHR/Université/URMLR), Centre Hospitalier Régional, Saint-Pierre, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation></author><author><name sortKey="Jaffar Banjee, Marie Christine" sort="Jaffar Banjee, Marie Christine" uniqKey="Jaffar Banjee M" first="Marie-Christine" last="Jaffar-Banjee">Marie-Christine Jaffar-Banjee</name><affiliation><nlm:aff id="aff8"><addr-line>Département de Microbiologie, Centre Hospitalier Régional, Saint Denis, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation></author><author><name sortKey="Filleul, Laurent" sort="Filleul, Laurent" uniqKey="Filleul L" first="Laurent" last="Filleul">Laurent Filleul</name><affiliation><nlm:aff id="aff9"><addr-line>Cellule Interrégionale d'Epidémiologie (CIRE) Réunion-Mayotte (InVS), Saint-Denis, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation></author><author><name sortKey="Flahault, Antoine" sort="Flahault, Antoine" uniqKey="Flahault A" first="Antoine" last="Flahault">Antoine Flahault</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Ecole des Hautes Etudes en Santé Publique, EHESP, Rennes-Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Ecole des Hautes Etudes en Santé Publique, EHESP, Rennes-Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name><affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Epidémiologie des Maladies Infectieuses et Modélisation (UMR-S 707), INSERM-Université Pierre et Marie Curie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Epidémiologie des Maladies Infectieuses et Modélisation (UMR-S 707), INSERM-Université Pierre et Marie Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Favier, Francois" sort="Favier, Francois" uniqKey="Favier F" first="Francois" last="Favier">Francois Favier</name><affiliation><nlm:aff id="aff3"><addr-line>Centre d'Investigation Clinique-Epidémiologie Clinique (CIC-EC) de La Réunion (INSERM/CHR/Université/URMLR), Centre Hospitalier Régional, Saint-Pierre, La Réunion</addr-line></nlm:aff><wicri:noCountry code="subfield">La Réunion</wicri:noCountry></affiliation></author><author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité des Virus Emergents (UMR-S 190), IRD-Université de la Méditerranée, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université de la Méditerranée</orgName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Female</term><term>France (epidemiology)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza, Human (blood)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Polymerase Chain Reaction</term><term>Prospective Studies</term><term>Seasons</term><term>Serologic Tests</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>France (épidémiologie)</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (sang)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Réaction de polymérisation en chaîne</term><term>Saisons</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term><term>Tests sérologiques</term><term>Études de cohortes</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>France</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Polymerase Chain Reaction</term><term>Prospective Studies</term><term>Seasons</term><term>Serologic Tests</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Réaction de polymérisation en chaîne</term><term>Saisons</term><term>Tests sérologiques</term><term>Études de cohortes</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>To date, there is little information that reflects the true extent of spread of the pH1N1/2009v influenza pandemic at the community level as infection often results in mild or no clinical symptoms. This study aimed at assessing through a prospective study, the attack rate of pH1N1/2009 virus in Reunion Island and risk factors of infection, during the 2009 season.</p></sec><sec><title>Methodology/Principal Findings</title><p>A serosurvey was conducted during the 2009 austral winter, in the frame of a prospective population study. Pairs of sera were collected from 1687 individuals belonging to 772 households, during and after passage of the pandemic wave. Antibodies to pH1N1/2009v were titered using the hemagglutination inhibition assay (HIA) with titers ≥1/40 being considered positive. Seroprevalence during the first two weeks of detection of pH1N1/2009v in Reunion Island was 29.8% in people under 20 years of age, 35.6% in adults (20–59 years) and 73.3% in the elderly (≥60 years) (P<0.0001). Baseline corrected cumulative incidence rates, were 42.9%, 13.9% and 0% in these age groups respectively (P<0.0001). A significant decline in antibody titers occurred soon after the passage of the epidemic wave. Seroconversion rates to pH1N1/2009 correlated negatively with age: 63.2%, 39.4% and 16.7%, in each age group respectively (P<0.0001). Seroconversion occurred in 65.2% of individuals who were seronegative at inclusion compared to 6.8% in those who were initially seropositive.</p></sec><sec><title>Conclusions</title><p>Seroincidence of pH1N1/2009v infection was three times that estimated from clinical surveillance, indicating that almost two thirds of infections occurring at the community level have escaped medical detection. People under 20 years of age were the most affected group. Pre-epidemic titers ≥1/40 prevented seroconversion and are likely protective against infection. 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last="Boussaïd">Karim Boussaïd</name><name sortKey="Favier, Francois" sort="Favier, Francois" uniqKey="Favier F" first="Francois" last="Favier">Francois Favier</name><name sortKey="Fianu, Adrian" sort="Fianu, Adrian" uniqKey="Fianu A" first="Adrian" last="Fianu">Adrian Fianu</name><name sortKey="Filleul, Laurent" sort="Filleul, Laurent" uniqKey="Filleul L" first="Laurent" last="Filleul">Laurent Filleul</name><name sortKey="Gerardin, Patrick" sort="Gerardin, Patrick" uniqKey="Gerardin P" first="Patrick" last="Gérardin">Patrick Gérardin</name><name sortKey="Jaffar Banjee, Marie Christine" sort="Jaffar Banjee, Marie Christine" uniqKey="Jaffar Banjee M" first="Marie-Christine" last="Jaffar-Banjee">Marie-Christine Jaffar-Banjee</name><name sortKey="Naty, Nadege" sort="Naty, Nadege" uniqKey="Naty N" first="Nadège" last="Naty">Nadège Naty</name><name sortKey="Rollot, Olivier" sort="Rollot, Olivier" uniqKey="Rollot O" first="Olivier" last="Rollot">Olivier Rollot</name><name sortKey="Tortosa, 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Lapidus</name><name sortKey="Pascalis, Herve" sort="Pascalis, Herve" uniqKey="Pascalis H" first="Hervé" last="Pascalis">Hervé Pascalis</name><name sortKey="Salez, Nicolas" sort="Salez, Nicolas" uniqKey="Salez N" first="Nicolas" last="Salez">Nicolas Salez</name><name sortKey="Temmam, Sarah" sort="Temmam, Sarah" uniqKey="Temmam S" first="Sarah" last="Temmam">Sarah Temmam</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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