PandemieGrippaleV1, Main, Exploration, bibRecordById, PMC:2758658

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

Identifieur interne : 004459 ( Main/Exploration ); précédent : 004458; suivant : 004460

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

Auteurs : Damian C. Ekiert [États-Unis] ; Gira Bhabha [États-Unis] ; Marc-André Elsliger [États-Unis] ; Robert H. E. Friesen [Pays-Bas] ; Mandy Jongeneelen [Pays-Bas] ; Mark Throsby [Pays-Bas] ; Jaap Goudsmit [Pays-Bas] ; Ian A. Wilson [États-Unis]

Source :

Science : (Washington, D.C.) [ 0036-8075 ] ; 2009.

RBID : Pascal:09-0253228

Descripteurs français

English descriptors

Abstract

Influenza virus presents an important and persistent threat to public health worldwide, and current vaccines provide immunity to viral isolates similar to the vaccine strain. High-affinity antibodies against a conserved epitope could provide immunity to the diverse influenza subtypes and protection against future pandemic viruses. Cocrystal structures were determined at 2.2 and 2.7 angstrom resolutions for broadly neutralizing human antibody CR6261 Fab in complexes with the major surface antigen (hemagglutinin, HA) from viruses responsible for the 1918 H1N1 influenza pandemic and a recent lethal case of H5N1 avian influenza. In contrast to other structurally characterized influenza antibodies, CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of HA1 and HA2. The antibody neutralizes the virus by blocking conformational rearrangements associated with membrane fusion. The CR6261 epitope identified here should accelerate the design and implementation of improved vaccines that can elicit CR6261-like antibodies, as well as antibody-based therapies for the treatment of influenza.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758658

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Antibody Recognition of a Highly Conserved Influenza Virus Epitope</title>
<author><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C." last="Ekiert">Damian C. Ekiert</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhabha, Gira" sort="Bhabha, Gira" uniqKey="Bhabha G" first="Gira" last="Bhabha">Gira Bhabha</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elsliger, Marc Andre" sort="Elsliger, Marc Andre" uniqKey="Elsliger M" first="Marc-André" last="Elsliger">Marc-André Elsliger</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Friesen, Robert H E" sort="Friesen, Robert H E" uniqKey="Friesen R" first="Robert H. E." last="Friesen">Robert H. E. Friesen</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Crucell Holland BV, Archimedesweg 4-6</s1>
<s2>2301 CA Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2301 CA Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jongeneelen, Mandy" sort="Jongeneelen, Mandy" uniqKey="Jongeneelen M" first="Mandy" last="Jongeneelen">Mandy Jongeneelen</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Crucell Holland BV, Archimedesweg 4-6</s1>
<s2>2301 CA Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2301 CA Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Throsby, Mark" sort="Throsby, Mark" uniqKey="Throsby M" first="Mark" last="Throsby">Mark Throsby</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Crucell Holland BV, Archimedesweg 4-6</s1>
<s2>2301 CA Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2301 CA Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goudsmit, Jaap" sort="Goudsmit, Jaap" uniqKey="Goudsmit J" first="Jaap" last="Goudsmit">Jaap Goudsmit</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Crucell Holland BV, Archimedesweg 4-6</s1>
<s2>2301 CA Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2301 CA Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0253228</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0253228 INIST</idno>
<idno type="RBID">Pascal:09-0253228</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001828</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000672</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001749</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001749</idno>
<idno type="wicri:doubleKey">0036-8075:2009:Ekiert D:antibody:recognition:of</idno>
<idno type="wicri:Area/Main/Merge">004706</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758658</idno>
<idno type="RBID">PMC:2758658</idno>
<idno type="wicri:Area/Pmc/Corpus">000529</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000529</idno>
<idno type="wicri:Area/Pmc/Curation">000529</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000529</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C53</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C53</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19251591</idno>
<idno type="wicri:Area/PubMed/Corpus">001802</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001802</idno>
<idno type="wicri:Area/PubMed/Curation">001802</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001802</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001677</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001677</idno>
<idno type="wicri:Area/Ncbi/Merge">000838</idno>
<idno type="wicri:Area/Ncbi/Curation">000838</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000838</idno>
<idno type="wicri:doubleKey">0036-8075:2009:Ekiert D:antibody:recognition:of</idno>
<idno type="wicri:Area/Main/Merge">004070</idno>
<idno type="wicri:Area/Main/Curation">004459</idno>
<idno type="wicri:Area/Main/Exploration">004459</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Antibody Recognition of a Highly Conserved Influenza Virus Epitope</title>
<author><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C." last="Ekiert">Damian C. Ekiert</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhabha, Gira" sort="Bhabha, Gira" uniqKey="Bhabha G" first="Gira" last="Bhabha">Gira Bhabha</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elsliger, Marc Andre" sort="Elsliger, Marc Andre" uniqKey="Elsliger M" first="Marc-André" last="Elsliger">Marc-André Elsliger</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Friesen, Robert H E" sort="Friesen, Robert H E" uniqKey="Friesen R" first="Robert H. E." last="Friesen">Robert H. E. Friesen</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Crucell Holland BV, Archimedesweg 4-6</s1>
<s2>2301 CA Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2301 CA Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jongeneelen, Mandy" sort="Jongeneelen, Mandy" uniqKey="Jongeneelen M" first="Mandy" last="Jongeneelen">Mandy Jongeneelen</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Crucell Holland BV, Archimedesweg 4-6</s1>
<s2>2301 CA Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2301 CA Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Throsby, Mark" sort="Throsby, Mark" uniqKey="Throsby M" first="Mark" last="Throsby">Mark Throsby</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Crucell Holland BV, Archimedesweg 4-6</s1>
<s2>2301 CA Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2301 CA Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goudsmit, Jaap" sort="Goudsmit, Jaap" uniqKey="Goudsmit J" first="Jaap" last="Goudsmit">Jaap Goudsmit</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Crucell Holland BV, Archimedesweg 4-6</s1>
<s2>2301 CA Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2301 CA Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1>
<s2>La Jolla, CA 92037</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Science : (Washington, D.C.)</title>
<title level="j" type="abbreviated">Science : (Wash. D.C.)</title>
<idno type="ISSN">0036-8075</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Science : (Washington, D.C.)</title>
<title level="j" type="abbreviated">Science : (Wash. D.C.)</title>
<idno type="ISSN">0036-8075</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (chemistry)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibody</term>
<term>Antibody Affinity</term>
<term>Antigenic determinant</term>
<term>Antigens, Viral (chemistry)</term>
<term>Antigens, Viral (immunology)</term>
<term>Binding Sites, Antibody</term>
<term>Crystallization</term>
<term>Crystallography, X-Ray</term>
<term>Epitopes (immunology)</term>
<term>Fab-Fragment</term>
<term>Glycosylation</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Humans</term>
<term>Hydrogen Bonding</term>
<term>Hydrogen-Ion Concentration</term>
<term>Hydrophobic and Hydrophilic Interactions</term>
<term>Immunoglobulin Fab Fragments (chemistry)</term>
<term>Immunoglobulin Fab Fragments (immunology)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H5N1 Subtype (immunology)</term>
<term>Influenza A virus</term>
<term>Influenza Vaccines</term>
<term>Mechanism of action</term>
<term>Membrane Fusion</term>
<term>Models, Molecular</term>
<term>Neutralization Tests</term>
<term>Protein Conformation</term>
<term>Protein Structure, Secondary</term>
<term>Protein Structure, Tertiary</term>
<term>Recognition</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Affinité des anticorps</term>
<term>Anticorps antiviraux ()</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Antigènes viraux ()</term>
<term>Antigènes viraux (immunologie)</term>
<term>Concentration en ions d'hydrogène</term>
<term>Conformation des protéines</term>
<term>Cristallisation</term>
<term>Cristallographie aux rayons X</term>
<term>Fragments Fab d'immunoglobuline ()</term>
<term>Fragments Fab d'immunoglobuline (immunologie)</term>
<term>Fusion membranaire</term>
<term>Glycoprotéine hémagglutinine du virus influenza ()</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Glycosylation</term>
<term>Humains</term>
<term>Interactions hydrophobes et hydrophiles</term>
<term>Liaison hydrogène</term>
<term>Modèles moléculaires</term>
<term>Sites de fixation des anticorps</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H5N1 du virus de la grippe A (immunologie)</term>
<term>Structure secondaire des protéines</term>
<term>Structure tertiaire des protéines</term>
<term>Tests de neutralisation</term>
<term>Vaccins antigrippaux</term>
<term>Épitopes (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Viral</term>
<term>Antigens, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Immunoglobulin Fab Fragments</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
<term>Antigens, Viral</term>
<term>Epitopes</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Immunoglobulin Fab Fragments</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Antigènes viraux</term>
<term>Fragments Fab d'immunoglobuline</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Antibody Affinity</term>
<term>Binding Sites, Antibody</term>
<term>Crystallization</term>
<term>Crystallography, X-Ray</term>
<term>Glycosylation</term>
<term>Humans</term>
<term>Hydrogen Bonding</term>
<term>Hydrogen-Ion Concentration</term>
<term>Hydrophobic and Hydrophilic Interactions</term>
<term>Influenza Vaccines</term>
<term>Membrane Fusion</term>
<term>Models, Molecular</term>
<term>Neutralization Tests</term>
<term>Protein Conformation</term>
<term>Protein Structure, Secondary</term>
<term>Protein Structure, Tertiary</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Affinité des anticorps</term>
<term>Anticorps antiviraux</term>
<term>Antigènes viraux</term>
<term>Concentration en ions d'hydrogène</term>
<term>Conformation des protéines</term>
<term>Cristallisation</term>
<term>Cristallographie aux rayons X</term>
<term>Fragments Fab d'immunoglobuline</term>
<term>Fusion membranaire</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Glycosylation</term>
<term>Humains</term>
<term>Interactions hydrophobes et hydrophiles</term>
<term>Liaison hydrogène</term>
<term>Modèles moléculaires</term>
<term>Sites de fixation des anticorps</term>
<term>Structure secondaire des protéines</term>
<term>Structure tertiaire des protéines</term>
<term>Tests de neutralisation</term>
<term>Vaccins antigrippaux</term>
<term>Virus grippal A</term>
<term>Déterminant antigénique</term>
<term>Reconnaissance</term>
<term>Anticorps</term>
<term>Fragment peptidique Fab</term>
<term>Mécanisme action</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Influenza virus presents an important and persistent threat to public health worldwide, and current vaccines provide immunity to viral isolates similar to the vaccine strain. High-affinity antibodies against a conserved epitope could provide immunity to the diverse influenza subtypes and protection against future pandemic viruses. Cocrystal structures were determined at 2.2 and 2.7 angstrom resolutions for broadly neutralizing human antibody CR6261 Fab in complexes with the major surface antigen (hemagglutinin, HA) from viruses responsible for the 1918 H1N1 influenza pandemic and a recent lethal case of H5N1 avian influenza. In contrast to other structurally characterized influenza antibodies, CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of HA1 and HA2. The antibody neutralizes the virus by blocking conformational rearrangements associated with membrane fusion. The CR6261 epitope identified here should accelerate the design and implementation of improved vaccines that can elicit CR6261-like antibodies, as well as antibody-based therapies for the treatment of influenza.</div>
</front>
</TEI>
<affiliations><list><country><li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C." last="Ekiert">Damian C. Ekiert</name>
</region>
<name sortKey="Bhabha, Gira" sort="Bhabha, Gira" uniqKey="Bhabha G" first="Gira" last="Bhabha">Gira Bhabha</name>
<name sortKey="Elsliger, Marc Andre" sort="Elsliger, Marc Andre" uniqKey="Elsliger M" first="Marc-André" last="Elsliger">Marc-André Elsliger</name>
<name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name>
<name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Friesen, Robert H E" sort="Friesen, Robert H E" uniqKey="Friesen R" first="Robert H. E." last="Friesen">Robert H. E. Friesen</name>
</noRegion>
<name sortKey="Goudsmit, Jaap" sort="Goudsmit, Jaap" uniqKey="Goudsmit J" first="Jaap" last="Goudsmit">Jaap Goudsmit</name>
<name sortKey="Jongeneelen, Mandy" sort="Jongeneelen, Mandy" uniqKey="Jongeneelen M" first="Mandy" last="Jongeneelen">Mandy Jongeneelen</name>
<name sortKey="Throsby, Mark" sort="Throsby, Mark" uniqKey="Throsby M" first="Mark" last="Throsby">Mark Throsby</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004459 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004459 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    PandemieGrippaleV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:09-0253228
   |texte=   Antibody Recognition of a Highly Conserved Influenza Virus Epitope
}}

This area was generated with Dilib version V0.6.34.
Data generation: Wed Jun 10 11:04:28 2020. Site generation: Sun Mar 28 09:10:28 2021

Serveur d'exploration sur les pandémies grippales

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les pandémies grippales
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.