A mouse model of dual infection with influenza virus and Streptococcus pneumoniae
Identifieur interne : 005A74 ( Main/Exploration ); précédent : 005A73; suivant : 005A75A mouse model of dual infection with influenza virus and Streptococcus pneumoniae
Auteurs : Jonathan A. Mccullers [États-Unis] ; Robert G. Webster [États-Unis]Source :
- International congress series [ 0531-5131 ] ; 2001.
English descriptors
- Teeft :
- Additive process, Bacteremic, Blood cultures, Chinchilla model, Clinical illness, Congress series, Difco laboratories, Dos, Dual infection, Elsevier science, Excess mortality, Further study, Infection, Infectious agent, Infectious diseases, Infectious doses, Influenza, Influenza epidemics, Influenza virus, Influenza virus infection, Jude research hospital, Lauderdale street, Lethal synergism, Lethal synergy, Mice sequentially, Mock infection, Morbidity, Mouse, Mouse model, Otitis media, Overwhelming sepsis, Pathogenic mechanisms, Pneumococcal, Pneumococcal challenge, Pneumococcal infection, Pneumococcus, Pneumoniae, Pneumoniae strain, Sepsis, Sequential, Sequential infection, Sequentially, Sheep erythrocytes, Small animal model, Synergism, Synergistic, Synergistic interaction, Synergistic lethality, Weight loss.
Abstract
Abstract: Background: A lethal synergism exists between influenza virus and Streptococcus pneumoniae accounting for excess mortality during influenza epidemics. A small animal model of dual infection with these organisms would be useful for study of pathogenic mechanisms underlying this interaction. Methods: Groups of mice were infected with either mouse adapted influenza virus A/Puerto Rico/8/34 (H1N1), S. pneumoniae strain D39, both simultaneously, or pneumococcus following influenza virus. Weight loss, as a measure of morbidity, and mortality were followed. Blood cultures were collected 24 h after infection. Results: Mice infected simultaneously with both influenza virus and pneumococcus exhibited gradual weight loss and mortality commensurate with expectations for an additive process. In contrast, mice infected with pneumococcus 7 days following infection with influenza virus uniformly died in less than 24 h and were highly bacteremic. Discussion: A mouse model of sequential infection with influenza virus and S. pneumoniae has been developed. Mice infected with pneumococcus seven days after infection with influenza virus exhibit a synergistic lethality caused by overwhelming sepsis. This model will be useful for study of the mechanisms involved in pathogenic interactions between influenza virus and pneumococcus.
Url:
DOI: 10.1016/S0531-5131(01)00631-8
Affiliations:
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Le document en format XML
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<term>Congress series</term>
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<term>Dual infection</term>
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<term>Infection</term>
<term>Infectious agent</term>
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<term>Influenza</term>
<term>Influenza epidemics</term>
<term>Influenza virus</term>
<term>Influenza virus infection</term>
<term>Jude research hospital</term>
<term>Lauderdale street</term>
<term>Lethal synergism</term>
<term>Lethal synergy</term>
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<term>Mouse model</term>
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<term>Overwhelming sepsis</term>
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<term>Pneumococcal challenge</term>
<term>Pneumococcal infection</term>
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<term>Pneumoniae strain</term>
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<term>Sequential infection</term>
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<term>Sheep erythrocytes</term>
<term>Small animal model</term>
<term>Synergism</term>
<term>Synergistic</term>
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<front><div type="abstract" xml:lang="en">Abstract: Background: A lethal synergism exists between influenza virus and Streptococcus pneumoniae accounting for excess mortality during influenza epidemics. A small animal model of dual infection with these organisms would be useful for study of pathogenic mechanisms underlying this interaction. Methods: Groups of mice were infected with either mouse adapted influenza virus A/Puerto Rico/8/34 (H1N1), S. pneumoniae strain D39, both simultaneously, or pneumococcus following influenza virus. Weight loss, as a measure of morbidity, and mortality were followed. Blood cultures were collected 24 h after infection. Results: Mice infected simultaneously with both influenza virus and pneumococcus exhibited gradual weight loss and mortality commensurate with expectations for an additive process. In contrast, mice infected with pneumococcus 7 days following infection with influenza virus uniformly died in less than 24 h and were highly bacteremic. Discussion: A mouse model of sequential infection with influenza virus and S. pneumoniae has been developed. Mice infected with pneumococcus seven days after infection with influenza virus exhibit a synergistic lethality caused by overwhelming sepsis. This model will be useful for study of the mechanisms involved in pathogenic interactions between influenza virus and pneumococcus.</div>
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