PandemieGrippaleV1, Main, Exploration, bibRecord, 004D68

A Practical Synthesis of (−)‐Oseltamivir

Identifieur interne : 004D68 ( Main/Exploration ); précédent : 004D67; suivant : 004D69

A Practical Synthesis of (−)‐Oseltamivir

Auteurs : Nobuhiro Satoh [Japon] ; Takahiro Akiba [Japon] ; Satoshi Yokoshima [Japon] ; Tohru Fukuyama [Japon]

Source :

Angewandte Chemie International Edition [ 1433-7851 ] ; 2007-07-23.

RBID : ISTEX:1230607F34D6DAF85F327AC19FE752349EB75943

English descriptors

Teeft :
- Angew, Asymmetric reaction, Benzyl, Benzyl chloroformate, Chem, Chloroformate, Hofmann rearrangement, Lactone, Lett, Oseltamivir, Oseltamivir phosphate, Practical synthesis, Rearrangement, Shikimic acid, Stockpile tamiflu, Synthetic route, Tamiflu, Tetrahedron, Tetrahedron lett, Verlag gmbh, Weinheim angew.

Abstract

Keep it simple: Still in hot demand, the influenza drug (−)‐oseltamivir phosphate (tamiflu; see scheme) has now been synthesized from pyridine by using inexpensive reagents. A strict minimum of purification steps are required in a synthetic route which features an asymmetric Diels–Alder reaction, a bromolactonization, a Hofmann rearrangement, and a domino transformation of a bicyclo[2.2.2] system into an aziridine intermediate.

Url:

https://api.istex.fr/ark:/67375/WNG-3FC7NWDC-Q/fulltext.pdf

DOI: 10.1002/anie.200701754

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Keep it simple: Still in hot demand, the influenza drug (−)‐oseltamivir phosphate (tamiflu; see scheme) has now been synthesized from pyridine by using inexpensive reagents. A strict minimum of purification steps are required in a synthetic route which features an asymmetric Diels–Alder reaction, a bromolactonization, a Hofmann rearrangement, and a domino transformation of a bicyclo[2.2.2] system into an aziridine intermediate.</div>
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A Practical Synthesis of (−)‐Oseltamivir

A Practical Synthesis of (−)‐Oseltamivir

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri