A Practical Synthesis of (−)‐Oseltamivir
Identifieur interne : 004D68 ( Main/Exploration ); précédent : 004D67; suivant : 004D69A Practical Synthesis of (−)‐Oseltamivir
Auteurs : Nobuhiro Satoh [Japon] ; Takahiro Akiba [Japon] ; Satoshi Yokoshima [Japon] ; Tohru Fukuyama [Japon]Source :
- Angewandte Chemie International Edition [ 1433-7851 ] ; 2007-07-23.
English descriptors
- Teeft :
- Angew, Asymmetric reaction, Benzyl, Benzyl chloroformate, Chem, Chloroformate, Hofmann rearrangement, Lactone, Lett, Oseltamivir, Oseltamivir phosphate, Practical synthesis, Rearrangement, Shikimic acid, Stockpile tamiflu, Synthetic route, Tamiflu, Tetrahedron, Tetrahedron lett, Verlag gmbh, Weinheim angew.
Abstract
Keep it simple: Still in hot demand, the influenza drug (−)‐oseltamivir phosphate (tamiflu; see scheme) has now been synthesized from pyridine by using inexpensive reagents. A strict minimum of purification steps are required in a synthetic route which features an asymmetric Diels–Alder reaction, a bromolactonization, a Hofmann rearrangement, and a domino transformation of a bicyclo[2.2.2] system into an aziridine intermediate.
Url:
DOI: 10.1002/anie.200701754
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Keep it simple: Still in hot demand, the influenza drug (−)‐oseltamivir phosphate (tamiflu; see scheme) has now been synthesized from pyridine by using inexpensive reagents. A strict minimum of purification steps are required in a synthetic route which features an asymmetric Diels–Alder reaction, a bromolactonization, a Hofmann rearrangement, and a domino transformation of a bicyclo[2.2.2] system into an aziridine intermediate.</div>
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