Vaccine design of hemagglutinin glycoprotein against influenza
Identifieur interne : 002994 ( Main/Exploration ); précédent : 002993; suivant : 002995Vaccine design of hemagglutinin glycoprotein against influenza
Auteurs : Juine-Ruey Chen [Taïwan] ; CHE MA [Taïwan] ; Chi-Huey Wong [Taïwan]Source :
- Trends in biotechnology : (Regular ed.) [ 0167-7799 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
Abstract
Influenza viruses continue to cause annual epidemics and pose the threat of a deadly global pandemic. Vaccination has remained the best approach for prevention and control of influenza infection. However, current influenza vaccines are only effective against closely-matched circulating strains, and therefore must be updated and administered every year. In this review, we discuss recent developments in the search for better influenza vaccines, especially using the major virus surface glycoprotein hemagglutinins (HAs). Understanding how glycans on HAs affect the immune response and knowledge of how broadly neutralizing antibodies are induced will pave the way for a cross-protective influenza vaccine that does not require frequent updates or annual immunizations.
Affiliations:
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Le document en format XML
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Vaccination has remained the best approach for prevention and control of influenza infection. However, current influenza vaccines are only effective against closely-matched circulating strains, and therefore must be updated and administered every year. In this review, we discuss recent developments in the search for better influenza vaccines, especially using the major virus surface glycoprotein hemagglutinins (HAs). Understanding how glycans on HAs affect the immune response and knowledge of how broadly neutralizing antibodies are induced will pave the way for a cross-protective influenza vaccine that does not require frequent updates or annual immunizations.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chen, Juine Ruey" sort="Chen, Juine Ruey" uniqKey="Chen J" first="Juine-Ruey" last="Chen">Juine-Ruey Chen</name></noRegion><name sortKey="Che Ma" sort="Che Ma" uniqKey="Che Ma" last="Che Ma">CHE MA</name><name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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