PandemieGrippaleV1, Main, Exploration, bibRecord, 002532

Epidemiology and transmission dynamics of the 1918-19 pandemic influenza in Florence, Italy.

Identifieur interne : 002532 ( Main/Exploration ); précédent : 002531; suivant : 002533

Epidemiology and transmission dynamics of the 1918-19 pandemic influenza in Florence, Italy.

Auteurs : Caterina Rizzo [Italie] ; Marco Ajelli ; Stefano Merler ; Andrea Pugliese ; Ilaria Barbetta ; Stefania Salmaso ; Piero Manfredi

Source :

Vaccine [ 1873-2518 ] ; 2011.

RBID : pubmed:21757100

Descripteurs français

KwdFr :
- Grippe humaine (mortalité), Grippe humaine (transmission), Grippe humaine (épidémiologie), Hospitalisation (), Humains, Italie (épidémiologie), Modèles théoriques, Pandémies, Répartition par âge, Saisons.
MESH :
- mortalité : Grippe humaine.
- épidémiologie : Grippe humaine, Italie.
- Hospitalisation, Humains, Modèles théoriques, Pandémies, Répartition par âge, Saisons.
Wicri :
- geographic : Italie.

English descriptors

KwdEn :
- Age Distribution, Hospitalization (statistics & numerical data), Humans, Influenza, Human (epidemiology), Influenza, Human (mortality), Influenza, Human (transmission), Italy (epidemiology), Models, Theoretical, Pandemics, Seasons.
MESH :
- geographic , epidemiology : Italy.
- epidemiology : Influenza, Human.
- mortality : Influenza, Human.
- statistics & numerical data : Hospitalization.
- transmission : Influenza, Human.
- Age Distribution, Humans, Models, Theoretical, Pandemics, Seasons.

Abstract

To investigate the 1918/19 influenza pandemic daily number of new hospitalizations in the only hospital in Florence (Central Italy) were analyzed. In order to describe the transmission dynamics of the 1918/1919 pandemic influenza a compartmental epidemic model was used. Model simulations show a high level of agreement with the observed epidemic data. By assuming both latent and infectious period equal to 1.5 days, the estimated basic reproduction number was R(0)(1) = 1.03 (95% CI: 1.00-1.08) during the summer wave and R(0)(2) = 1.38 (95% CI: 1.32-1.48) during the fall wave. Varying the length of the generation time or the estimation method, R(0)(2) ranges from 1.32 to 1.71. The hospitalization rate was found significantly different between summer and fall waves. Notably, the estimated basic reproductive numbers are lower compared to those observed in other countries, while the age distribution of deaths resulted to be consistent with the patterns generally observed during of the 1918-1919 pandemic. Our knowledge on past pandemics, as for the 1918-19 Spanish influenza, would help improving mathematical modeling accuracy and understanding the mechanisms underlying the dynamics of future pandemics.

DOI: 10.1016/j.vaccine.2011.02.049
PubMed: 21757100

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">To investigate the 1918/19 influenza pandemic daily number of new hospitalizations in the only hospital in Florence (Central Italy) were analyzed. In order to describe the transmission dynamics of the 1918/1919 pandemic influenza a compartmental epidemic model was used. Model simulations show a high level of agreement with the observed epidemic data. By assuming both latent and infectious period equal to 1.5 days, the estimated basic reproduction number was R(0)(1) = 1.03 (95% CI: 1.00-1.08) during the summer wave and R(0)(2) = 1.38 (95% CI: 1.32-1.48) during the fall wave. Varying the length of the generation time or the estimation method, R(0)(2) ranges from 1.32 to 1.71. The hospitalization rate was found significantly different between summer and fall waves. Notably, the estimated basic reproductive numbers are lower compared to those observed in other countries, while the age distribution of deaths resulted to be consistent with the patterns generally observed during of the 1918-1919 pandemic. Our knowledge on past pandemics, as for the 1918-19 Spanish influenza, would help improving mathematical modeling accuracy and understanding the mechanisms underlying the dynamics of future pandemics.</div>
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Serveur d'exploration sur les pandémies grippales

Epidemiology and transmission dynamics of the 1918-19 pandemic influenza in Florence, Italy.

Epidemiology and transmission dynamics of the 1918-19 pandemic influenza in Florence, Italy.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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