PandemieGrippaleV1, Main, Exploration, bibRecord, 002341

Virus-Like Particle Vaccine Containing Hemagglutinin Confers Protection against 2009 H1N1 Pandemic Influenza ▿

Identifieur interne : 002341 ( Main/Exploration ); précédent : 002340; suivant : 002342

Virus-Like Particle Vaccine Containing Hemagglutinin Confers Protection against 2009 H1N1 Pandemic Influenza ▿

Auteurs : M. Jaber Hossain [Géorgie (pays), États-Unis] ; Melissa Bourgeois [Géorgie (pays)] ; Fu-Shi Quan [Géorgie (pays)] ; Aleksandr S. Lipatov [Géorgie (pays)] ; Jae-Min Song [Géorgie (pays), États-Unis] ; Li-Mei Chen [Géorgie (pays)] ; Richard W. Compans [Géorgie (pays)] ; Ian York [Géorgie (pays)] ; Sang-Moo Kang [Géorgie (pays), États-Unis] ; Ruben O. Donis [Géorgie (pays)]

Source :

Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2011.

RBID : PMC:3232700

Descripteurs français

English descriptors

KwdEn :
- Administration, Intranasal, Animal Structures (virology), Animals, Antibodies, Viral (blood), Body Weight, Disease Models, Animal, Ferrets, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Injections, Intramuscular, Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (prevention & control), Vaccination (methods), Vaccines, Virosome (administration & dosage), Vaccines, Virosome (genetics), Vaccines, Virosome (immunology), Viral Load, Viral Matrix Proteins (genetics), Viral Matrix Proteins (immunology), Virus Shedding.
MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Virosome.
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Vaccines, Virosome, Viral Matrix Proteins.
- chemical , immunology : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Vaccines, Virosome, Viral Matrix Proteins.
- genetics : Influenza A Virus, H1N1 Subtype.
- immunology : Influenza A Virus, H1N1 Subtype.
- methods : Vaccination.
- pathology : Orthomyxoviridae Infections.
- prevention & control : Orthomyxoviridae Infections.
- virology : Animal Structures.
- Administration, Intranasal, Animals, Body Weight, Disease Models, Animal, Ferrets, Injections, Intramuscular, Viral Load, Virus Shedding.

Abstract

Immunization of the world population before an influenza pandemic such as the 2009 H1N1 virus spreads globally is not possible with current vaccine production platforms. New influenza vaccine technologies, such as virus-like-particles (VLPs), offer a promising alternative. Here, we tested the immunogenicity and protective efficacy of a VLP vaccine containing hemagglutinin (HA) and M1 from the 2009 pandemic H1N1 influenza virus (H1N1pdm) in ferrets and compared intramuscular (i.m.) and intranasal (i.n.) routes of immunization. Vaccination of ferrets with VLPs containing the M1 and HA proteins from A/California/04/2009 (H1N1pdm) induced high antibody titers and conferred significant protection against virus challenge. VLP-vaccinated animals lost less weight, shed less virus in nasal washes, and had markedly lower virus titers in all organs tested than naïve controls. A single dose of VLPs, either i.m. or i.n., induced higher levels of antibody than did two doses of commercial split vaccine. Ferrets vaccinated with split vaccine were incompletely protected against challenge; these animals had lower virus titers in olfactory bulbs, tonsils, and intestines, but lost weight and shed virus in nasal washes to a similar extent as naïve controls. Challenge with heterologous A/Brisbane/59/07 (H1N1) virus revealed that the VLPs conferred minimal cross-protection to heterologous infection, as revealed by the lack of reduction in nasal wash and lung virus titers and slightly higher weight loss relative to controls. In summary, these experiments demonstrate the strong immunogenicity and protective efficacy of VLPs compared to the split vaccine and show that i.n. vaccination with VLPs has the potential for highly efficacious vaccination against influenza.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232700

DOI: 10.1128/CVI.05206-11
PubMed: 22030367
PubMed Central: 3232700

Affiliations:

Le document en format XML

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</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Structures anatomiques de l'animal</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animal Structures</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term>
<term>Animals</term>
<term>Body Weight</term>
<term>Disease Models, Animal</term>
<term>Ferrets</term>
<term>Injections, Intramuscular</term>
<term>Viral Load</term>
<term>Virus Shedding</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term>
<term>Animaux</term>
<term>Charge virale</term>
<term>Excrétion virale</term>
<term>Furets</term>
<term>Infections à Orthomyxoviridae</term>
<term>Injections musculaires</term>
<term>Modèles animaux de maladie humaine</term>
<term>Poids du corps</term>
<term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Immunization of the world population before an influenza pandemic such as the 2009 H1N1 virus spreads globally is not possible with current vaccine production platforms. New influenza vaccine technologies, such as virus-like-particles (VLPs), offer a promising alternative. Here, we tested the immunogenicity and protective efficacy of a VLP vaccine containing hemagglutinin (HA) and M1 from the 2009 pandemic H1N1 influenza virus (H1N1pdm) in ferrets and compared intramuscular (i.m.) and intranasal (i.n.) routes of immunization. Vaccination of ferrets with VLPs containing the M1 and HA proteins from A/California/04/2009 (H1N1pdm) induced high antibody titers and conferred significant protection against virus challenge. VLP-vaccinated animals lost less weight, shed less virus in nasal washes, and had markedly lower virus titers in all organs tested than naïve controls. A single dose of VLPs, either i.m. or i.n., induced higher levels of antibody than did two doses of commercial split vaccine. Ferrets vaccinated with split vaccine were incompletely protected against challenge; these animals had lower virus titers in olfactory bulbs, tonsils, and intestines, but lost weight and shed virus in nasal washes to a similar extent as naïve controls. Challenge with heterologous A/Brisbane/59/07 (H1N1) virus revealed that the VLPs conferred minimal cross-protection to heterologous infection, as revealed by the lack of reduction in nasal wash and lung virus titers and slightly higher weight loss relative to controls. In summary, these experiments demonstrate the strong immunogenicity and protective efficacy of VLPs compared to the split vaccine and show that i.n. vaccination with VLPs has the potential for highly efficacious vaccination against influenza.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Géorgie (pays)</li>
<li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
</region>
</list>
<tree><country name="Géorgie (pays)"><noRegion><name sortKey="Hossain, M Jaber" sort="Hossain, M Jaber" uniqKey="Hossain M" first="M. Jaber" last="Hossain">M. Jaber Hossain</name>
</noRegion>
<name sortKey="Bourgeois, Melissa" sort="Bourgeois, Melissa" uniqKey="Bourgeois M" first="Melissa" last="Bourgeois">Melissa Bourgeois</name>
<name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name>
<name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name>
<name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name>
<name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name>
<name sortKey="Lipatov, Aleksandr S" sort="Lipatov, Aleksandr S" uniqKey="Lipatov A" first="Aleksandr S." last="Lipatov">Aleksandr S. Lipatov</name>
<name sortKey="Quan, Fu Shi" sort="Quan, Fu Shi" uniqKey="Quan F" first="Fu-Shi" last="Quan">Fu-Shi Quan</name>
<name sortKey="Song, Jae Min" sort="Song, Jae Min" uniqKey="Song J" first="Jae-Min" last="Song">Jae-Min Song</name>
<name sortKey="York, Ian" sort="York, Ian" uniqKey="York I" first="Ian" last="York">Ian York</name>
</country>
<country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Hossain, M Jaber" sort="Hossain, M Jaber" uniqKey="Hossain M" first="M. Jaber" last="Hossain">M. Jaber Hossain</name>
</region>
<name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name>
<name sortKey="Song, Jae Min" sort="Song, Jae Min" uniqKey="Song J" first="Jae-Min" last="Song">Jae-Min Song</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les pandémies grippales

Virus-Like Particle Vaccine Containing Hemagglutinin Confers Protection against 2009 H1N1 Pandemic Influenza ▿

Virus-Like Particle Vaccine Containing Hemagglutinin Confers Protection against 2009 H1N1 Pandemic Influenza ▿

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