PandemieGrippaleV1, Main, Exploration, bibRecord, 002106

Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain

Identifieur interne : 002106 ( Main/Exploration ); précédent : 002105; suivant : 002107

Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain

Auteurs : Juan Ledesma [Espagne] ; Francisco Pozo [Espagne] ; Gabriel Reina [Espagne] ; Miriam Blasco [Espagne] ; Guadalupe Rodriguez [Espagne] ; Milagrosa Montes [Espagne] ; Isabel Lopez-Miragaya [Espagne] ; Carmen Salvador [Espagne] ; Jordi Reina [Espagne] ; Raúl Ortiz De Lejarazu [Espagne] ; Pilar Egido [Espagne] ; José Lopez Barba [Espagne] ; Concepcion Delgado [Espagne] ; María Teresa Cuevas [Espagne] ; Inmaculada Casas [Espagne]

Source :

Journal of clinical virology [ 1386-6532 ] ; 2012.

RBID : Pascal:12-0053738

Descripteurs français

Pascal (Inist)
- Virus grippal A, Diversité génétique, Espagne, Hémagglutinine, Phylogenèse, Grippe A.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Genetic diversity, Hemagglutinin, Influenza A, Influenza A virus, Phylogeny, Spain.

Abstract

Background: Genetic diversity of influenza A(H1N1)2009 viruses has been reported since the pandemic virus emerged in April 2009. Different genetic clades have been identified and defined based on amino acid substitutions found in the haemagglutinin (HA) protein sequences. In Spain, circulating influenza viruses are monitored each season by the regional laboratories enrolled in the Spanish Influenza Surveillance System (SISS). The analysis of the HA gene sequence helps to detect the genetic diversity and viral evolution. Objectives: To perform an analysis of the genetic diversity of influenza A(H1N1 )2009 viruses circulating in Spain during the season 2010-2011 based on analysis of the HA sequence gene. Study design: Phylogenetic analysis based on the HA1 subunit of the haemagglutinin gene was carried out on 220 influenza A(H1N1)2009 viruses circulating during the season 2010-2011. Results: Six different genetic groups were identified among circulating A(H1N1 )2009 viruses, five of them were previously reported during season 2010-2011. A new group, characterized by E172K and K308E changes and a proline at position 83, was observed in 12.27% of the Spanish viruses. Conclusion: Co-circulation of six different genetic groups of influenza A(H1N1)2009 viruses was identified in Spain during the season 2010-2011. Nevertheless, at this stage, none of the groups identified to date have resulted in significant antigenic changes according to data collected by World Health Organization Collaborating Centres for influenza surveillance.

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Curation: 001619
to stream PascalFrancis, to step Checkpoint: 000629
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Le document en format XML

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<author><name sortKey="Cuevas, Maria Teresa" sort="Cuevas, Maria Teresa" uniqKey="Cuevas M" first="María Teresa" last="Cuevas">María Teresa Cuevas</name>
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<author><name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain</title>
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<author><name sortKey="Montes, Milagrosa" sort="Montes, Milagrosa" uniqKey="Montes M" first="Milagrosa" last="Montes">Milagrosa Montes</name>
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<author><name sortKey="Lopez Miragaya, Isabel" sort="Lopez Miragaya, Isabel" uniqKey="Lopez Miragaya I" first="Isabel" last="Lopez-Miragaya">Isabel Lopez-Miragaya</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Servicio de Mircrobiología del Complejo Hospitalario de Vigo</s1>
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<author><name sortKey="Salvador, Carmen" sort="Salvador, Carmen" uniqKey="Salvador C" first="Carmen" last="Salvador">Carmen Salvador</name>
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<author><name sortKey="De Lejarazu, Raul Ortiz" sort="De Lejarazu, Raul Ortiz" uniqKey="De Lejarazu R" first="Raúl Ortiz" last="De Lejarazu">Raúl Ortiz De Lejarazu</name>
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<author><name sortKey="Egido, Pilar" sort="Egido, Pilar" uniqKey="Egido P" first="Pilar" last="Egido">Pilar Egido</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Servicio de Microbiología, Hospital Miguel Servet, Zaragoza</s1>
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<author><name sortKey="Lopez Barba, Jose" sort="Lopez Barba, Jose" uniqKey="Lopez Barba J" first="José" last="Lopez Barba">José Lopez Barba</name>
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<s2>Madrid</s2>
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<author><name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National Influenza Centre-Madrid, Influenza and Respiratory Viruses Laboratory, Instituto de Salud Carlos III</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
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<series><title level="j" type="main">Journal of clinical virology</title>
<title level="j" type="abbreviated">J. clin. virol.</title>
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<front><div type="abstract" xml:lang="en">Background: Genetic diversity of influenza A(H1N1)2009 viruses has been reported since the pandemic virus emerged in April 2009. Different genetic clades have been identified and defined based on amino acid substitutions found in the haemagglutinin (HA) protein sequences. In Spain, circulating influenza viruses are monitored each season by the regional laboratories enrolled in the Spanish Influenza Surveillance System (SISS). The analysis of the HA gene sequence helps to detect the genetic diversity and viral evolution. Objectives: To perform an analysis of the genetic diversity of influenza A(H1N1 )2009 viruses circulating in Spain during the season 2010-2011 based on analysis of the HA sequence gene. Study design: Phylogenetic analysis based on the HA1 subunit of the haemagglutinin gene was carried out on 220 influenza A(H1N1)2009 viruses circulating during the season 2010-2011. Results: Six different genetic groups were identified among circulating A(H1N1 )2009 viruses, five of them were previously reported during season 2010-2011. A new group, characterized by E172K and K308E changes and a proline at position 83, was observed in 12.27% of the Spanish viruses. Conclusion: Co-circulation of six different genetic groups of influenza A(H1N1)2009 viruses was identified in Spain during the season 2010-2011. Nevertheless, at this stage, none of the groups identified to date have resulted in significant antigenic changes according to data collected by World Health Organization Collaborating Centres for influenza surveillance.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Communauté de Madrid</li>
</region>
<settlement><li>Madrid</li>
</settlement>
</list>
<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ledesma, Juan" sort="Ledesma, Juan" uniqKey="Ledesma J" first="Juan" last="Ledesma">Juan Ledesma</name>
</region>
<name sortKey="Blasco, Miriam" sort="Blasco, Miriam" uniqKey="Blasco M" first="Miriam" last="Blasco">Miriam Blasco</name>
<name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name>
<name sortKey="Cuevas, Maria Teresa" sort="Cuevas, Maria Teresa" uniqKey="Cuevas M" first="María Teresa" last="Cuevas">María Teresa Cuevas</name>
<name sortKey="De Lejarazu, Raul Ortiz" sort="De Lejarazu, Raul Ortiz" uniqKey="De Lejarazu R" first="Raúl Ortiz" last="De Lejarazu">Raúl Ortiz De Lejarazu</name>
<name sortKey="Delgado, Concepcion" sort="Delgado, Concepcion" uniqKey="Delgado C" first="Concepcion" last="Delgado">Concepcion Delgado</name>
<name sortKey="Egido, Pilar" sort="Egido, Pilar" uniqKey="Egido P" first="Pilar" last="Egido">Pilar Egido</name>
<name sortKey="Lopez Barba, Jose" sort="Lopez Barba, Jose" uniqKey="Lopez Barba J" first="José" last="Lopez Barba">José Lopez Barba</name>
<name sortKey="Lopez Miragaya, Isabel" sort="Lopez Miragaya, Isabel" uniqKey="Lopez Miragaya I" first="Isabel" last="Lopez-Miragaya">Isabel Lopez-Miragaya</name>
<name sortKey="Montes, Milagrosa" sort="Montes, Milagrosa" uniqKey="Montes M" first="Milagrosa" last="Montes">Milagrosa Montes</name>
<name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name>
<name sortKey="Reina, Gabriel" sort="Reina, Gabriel" uniqKey="Reina G" first="Gabriel" last="Reina">Gabriel Reina</name>
<name sortKey="Reina, Jordi" sort="Reina, Jordi" uniqKey="Reina J" first="Jordi" last="Reina">Jordi Reina</name>
<name sortKey="Rodriguez, Guadalupe" sort="Rodriguez, Guadalupe" uniqKey="Rodriguez G" first="Guadalupe" last="Rodriguez">Guadalupe Rodriguez</name>
<name sortKey="Salvador, Carmen" sort="Salvador, Carmen" uniqKey="Salvador C" first="Carmen" last="Salvador">Carmen Salvador</name>
</country>
</tree>
</affiliations>
</record>

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Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain

Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain

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