Longitudinal Study of Influenza Molecular Viral Shedding in Hutterite Communities
Identifieur interne : 002029 ( Main/Exploration ); précédent : 002028; suivant : 002030Longitudinal Study of Influenza Molecular Viral Shedding in Hutterite Communities
Auteurs : Mark Loeb [Canada] ; Paramjit K. Singh [Canada] ; Julie Fox [Canada] ; Margaret L. Russell [Canada] ; Kanti Pabbaraju [Canada] ; Danielle Zarra [Canada] ; Sallene Wong [Canada] ; Binod Neupane [Canada] ; Pardeep Singh [Canada] ; Richard Webby [États-Unis] ; Kevin Fonseca [Canada]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background. The nature of influenza viral shedding during naturally acquired infection is not well understood. Methods. A cohort study was conducted in Hutterite colonies in Alberta, Canada. Flocked nasal swabs were collected during 3 influenza seasons (2007-2008 to 2009-2010) from both symptomatic and asymptomatic individuals infected with influenza. Samples were tested by real-time reverse-transcription polymerase chain reaction for influenza A and influenza B, and the viral load (VL) was determined for influenza A positive samples. Results. Eight hundred thirty-nine participants were included in the cohort; 25% (208) tested positive for influenza viruses. They experienced 238 episodes of viral shedding, of which 23 (10%) were not accompanied by symptoms. For seasonal and pandemic H1N1, VL peaked at or before onset of acute respiratory infection. For H3N2, VL peaked 2 days after the onset of acute respiratory infection, which corresponded to peaks in systemic and respiratory symptom scores. Although the duration of shedding was shorter for asymptomatic participants, the peak level of VL shedding was similar to that of symptomatic participants. Viral loads for children and adults revealed similar patterns. Conclusions. Molecular viral shedding values follow symptom scores, but timing of peak VL varies by subtype. Asymptomatic infections are infrequent.
Affiliations:
- Canada, États-Unis
- Alberta, Ontario, Tennessee
- Calgary, Hamilton (Ontario)
- Université McMaster, Université de Calgary
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000500
- to stream PascalFrancis, to step Curation: 001938
- to stream PascalFrancis, to step Checkpoint: 000551
- to stream Main, to step Merge: 002087
- to stream Main, to step Curation: 002029
Le document en format XML
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<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>St Jude Children's Research Hospital and World Health Organization Collaborating Center</s1>
<s2>Memphis, Tennessee</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fonseca, Kevin" sort="Fonseca, Kevin" uniqKey="Fonseca K" first="Kevin" last="Fonseca">Kevin Fonseca</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Provincial Laboratory for Public Health and Department of Microbiology and Infectious Diseases, University of Calgary</s1>
<s2>Alberta</s2>
<s3>CAN</s3>
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<region type="state">Alberta</region>
</placeName>
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<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2012">2012</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dissemination</term>
<term>Follow up study</term>
<term>Infection</term>
<term>Influenza</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Etude longitudinale</term>
<term>Dissémination</term>
<term>Infection</term>
<term>Grippe</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Background. The nature of influenza viral shedding during naturally acquired infection is not well understood. Methods. A cohort study was conducted in Hutterite colonies in Alberta, Canada. Flocked nasal swabs were collected during 3 influenza seasons (2007-2008 to 2009-2010) from both symptomatic and asymptomatic individuals infected with influenza. Samples were tested by real-time reverse-transcription polymerase chain reaction for influenza A and influenza B, and the viral load (VL) was determined for influenza A positive samples. Results. Eight hundred thirty-nine participants were included in the cohort; 25% (208) tested positive for influenza viruses. They experienced 238 episodes of viral shedding, of which 23 (10%) were not accompanied by symptoms. For seasonal and pandemic H1N1, VL peaked at or before onset of acute respiratory infection. For H3N2, VL peaked 2 days after the onset of acute respiratory infection, which corresponded to peaks in systemic and respiratory symptom scores. Although the duration of shedding was shorter for asymptomatic participants, the peak level of VL shedding was similar to that of symptomatic participants. Viral loads for children and adults revealed similar patterns. Conclusions. Molecular viral shedding values follow symptom scores, but timing of peak VL varies by subtype. Asymptomatic infections are infrequent.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Alberta</li>
<li>Ontario</li>
<li>Tennessee</li>
</region>
<settlement><li>Calgary</li>
<li>Hamilton (Ontario)</li>
</settlement>
<orgName><li>Université McMaster</li>
<li>Université de Calgary</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
</region>
<name sortKey="Fonseca, Kevin" sort="Fonseca, Kevin" uniqKey="Fonseca K" first="Kevin" last="Fonseca">Kevin Fonseca</name>
<name sortKey="Fox, Julie" sort="Fox, Julie" uniqKey="Fox J" first="Julie" last="Fox">Julie Fox</name>
<name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
<name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
<name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
<name sortKey="Neupane, Binod" sort="Neupane, Binod" uniqKey="Neupane B" first="Binod" last="Neupane">Binod Neupane</name>
<name sortKey="Pabbaraju, Kanti" sort="Pabbaraju, Kanti" uniqKey="Pabbaraju K" first="Kanti" last="Pabbaraju">Kanti Pabbaraju</name>
<name sortKey="Russell, Margaret L" sort="Russell, Margaret L" uniqKey="Russell M" first="Margaret L." last="Russell">Margaret L. Russell</name>
<name sortKey="Singh, Paramjit K" sort="Singh, Paramjit K" uniqKey="Singh P" first="Paramjit K." last="Singh">Paramjit K. Singh</name>
<name sortKey="Singh, Pardeep" sort="Singh, Pardeep" uniqKey="Singh P" first="Pardeep" last="Singh">Pardeep Singh</name>
<name sortKey="Wong, Sallene" sort="Wong, Sallene" uniqKey="Wong S" first="Sallene" last="Wong">Sallene Wong</name>
<name sortKey="Zarra, Danielle" sort="Zarra, Danielle" uniqKey="Zarra D" first="Danielle" last="Zarra">Danielle Zarra</name>
</country>
<country name="États-Unis"><region name="Tennessee"><name sortKey="Webby, Richard" sort="Webby, Richard" uniqKey="Webby R" first="Richard" last="Webby">Richard Webby</name>
</region>
</country>
</tree>
</affiliations>
</record>
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