Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients
Identifieur interne : 001116 ( Main/Exploration ); précédent : 001115; suivant : 001117Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients
Auteurs : Nathalie Dhedin [France] ; Anne Krivine [France] ; Nicole Le Corre [France] ; Alain Mallet [France] ; Bruno Lioure [France] ; Jacques-Olivier Bay [France] ; Marie-Thérèse Rubio [France] ; Philippe Agape [Réunion] ; Anne Thiebaut [France] ; Jérôme Le Goff [France] ; Brigitte Autran [France] ; Patricia Ribaud [France]Source :
- Vaccine [ 0264-410X ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccin, Cellule souche, Vaccination.
English descriptors
- KwdEn :
Abstract
Background: The present study evaluated immunogenicity and tolerance of two-dose influenza A/H1N1pdm09 vaccination in allogeneic hematopoietic stem cell transplantation (HSCT) recipients, and compared the vaccine-induced humoral response to that triggered by natural infection in another group of HSCT patients. Methods: Adult allogeneic HSCT recipients vaccinated with two doses of influenza A/H1N1pdm09 vaccine, separated by 3 weeks, and patients with proven influenza A/H1N1pdm09 infection were included. Antibody responses were measured by hemagglutination-inhibition assay 1) on days 0, 21, 42 and 6 months after the first vaccine injection in vaccinated patients and 2) before pandemic and after influenza A/H1N1pdm09 infection, in patients presented natural infection. Results: At baseline, 3% of 59 recipients of adjuvanted vaccine and 0% of 20 infected patients were seroprotected (antibody titer ≥ 1/40). Seroprotection rate observed 42 days after vaccination was not different from that observed after natural infection (66% and 60% respectively, p = 0.78). In vaccinated patients, seroprotection rate increased significantly from 54% to 66% between day 21 and 42 (p = 0.015). Moreover, after 6 months, seroprotection rate in 21 vaccinated patients was similar to that observed in 10 infected patients evaluated at least 76 days after infection (D76-217) (60% and 81% respectively, p = 0.2). In multivariate analysis, no immunosuppressive treatment or chronic graft-versus-host disease (GVHD) and longer time between transplantation and vaccination/infection were associated with a stronger humoral response. The adjuvanted vaccine was safe with low rate of GVHD worsening. Conclusion: In HSCT recipients, two doses of influenza A/H1N1pdm09 adjuvanted vaccine were safe and induced a humoral response comparable to that triggered by natural infection in these patients.
Affiliations:
- France, Réunion
- Auvergne (région administrative), Auvergne-Rhône-Alpes, Rhône-Alpes, Île-de-France
- Clermont-Ferrand, Grenoble, Paris
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000140
- to stream PascalFrancis, to step Curation: 001C78
- to stream PascalFrancis, to step Checkpoint: 000125
- to stream Main, to step Merge: 001126
- to stream Main, to step Curation: 001116
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients</title>
<author><name sortKey="Dhedin, Nathalie" sort="Dhedin, Nathalie" uniqKey="Dhedin N" first="Nathalie" last="Dhedin">Nathalie Dhedin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service d'Hématologie-Adolescents Jeunes Adultes, Hôpital Saint-Louis, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service d'Hématologie, Groupe Hospitalier Pitié Salpêtrière, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krivine, Anne" sort="Krivine, Anne" uniqKey="Krivine A" first="Anne" last="Krivine">Anne Krivine</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Service de Virologie, Hôpital Saint-Vincent-de-Paul Cochin, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Corre, Nicole" sort="Le Corre, Nicole" uniqKey="Le Corre N" first="Nicole" last="Le Corre">Nicole Le Corre</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>UPMC Université Paris 06, UMR S 945, Laboratory Immunity and Infection</s1>
<s2>75013 Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>INSERM, UMR S 945, Laboratory Immunity and Infection</s1>
<s2>75013 Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mallet, Alain" sort="Mallet, Alain" uniqKey="Mallet A" first="Alain" last="Mallet">Alain Mallet</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Unité de Recherche Clinique, Groupe Hospitalier Pitié Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lioure, Bruno" sort="Lioure, Bruno" uniqKey="Lioure B" first="Bruno" last="Lioure">Bruno Lioure</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Département d'Hématologie, Hôpitaux Universitaires Strasbourg</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpitaux Universitaires Strasbourg</wicri:noRegion>
<wicri:noRegion>Département d'Hématologie, Hôpitaux Universitaires Strasbourg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bay, Jacques Olivier" sort="Bay, Jacques Olivier" uniqKey="Bay J" first="Jacques-Olivier" last="Bay">Jacques-Olivier Bay</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Service d'Hématologie, Centre Hospitalier-Universitaire Estaing</s1>
<s2>Clermont-Ferrand</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rubio, Marie Therese" sort="Rubio, Marie Therese" uniqKey="Rubio M" first="Marie-Thérèse" last="Rubio">Marie-Thérèse Rubio</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Service d'Hématologie, Hôpital Saint-Antoine, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agape, Philippe" sort="Agape, Philippe" uniqKey="Agape P" first="Philippe" last="Agape">Philippe Agape</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Service d'Hématologie et d'Oncologie médicale. Centre Hospitalier Universitaire de la Réunion. Hôpital Felix Guyon</s1>
<s2>Saint Denis</s2>
<s3>REU</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Réunion</country>
<wicri:noRegion>Service d'Hématologie et d'Oncologie médicale. Centre Hospitalier Universitaire de la Réunion. Hôpital Felix Guyon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thiebaut, Anne" sort="Thiebaut, Anne" uniqKey="Thiebaut A" first="Anne" last="Thiebaut">Anne Thiebaut</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Service d'Hématologie, Hôpital Michallon</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Goff, Jerome" sort="Le Goff, Jerome" uniqKey="Le Goff J" first="Jérôme" last="Le Goff">Jérôme Le Goff</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Service de virologie, Hôpital Saint-Louis, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Université Paris-Diderot, Sorbonne Paris, Cité</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>UPMC Université Paris 06, UMR S 945, Laboratory Immunity and Infection</s1>
<s2>75013 Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>INSERM, UMR S 945, Laboratory Immunity and Infection</s1>
<s2>75013 Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ribaud, Patricia" sort="Ribaud, Patricia" uniqKey="Ribaud P" first="Patricia" last="Ribaud">Patricia Ribaud</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Université Paris-Diderot, Sorbonne Paris, Cité</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Service d'Hématologie-Greffe de Moelle, Hôpital Saint-Louis, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0076696</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 14-0076696 INIST</idno>
<idno type="RBID">Pascal:14-0076696</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000140</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001C78</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000125</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000125</idno>
<idno type="wicri:doubleKey">0264-410X:2014:Dhedin N:comparable:humoral:response</idno>
<idno type="wicri:Area/Main/Merge">001126</idno>
<idno type="wicri:Area/Main/Curation">001116</idno>
<idno type="wicri:Area/Main/Exploration">001116</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients</title>
<author><name sortKey="Dhedin, Nathalie" sort="Dhedin, Nathalie" uniqKey="Dhedin N" first="Nathalie" last="Dhedin">Nathalie Dhedin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service d'Hématologie-Adolescents Jeunes Adultes, Hôpital Saint-Louis, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service d'Hématologie, Groupe Hospitalier Pitié Salpêtrière, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krivine, Anne" sort="Krivine, Anne" uniqKey="Krivine A" first="Anne" last="Krivine">Anne Krivine</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Service de Virologie, Hôpital Saint-Vincent-de-Paul Cochin, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Corre, Nicole" sort="Le Corre, Nicole" uniqKey="Le Corre N" first="Nicole" last="Le Corre">Nicole Le Corre</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>UPMC Université Paris 06, UMR S 945, Laboratory Immunity and Infection</s1>
<s2>75013 Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>INSERM, UMR S 945, Laboratory Immunity and Infection</s1>
<s2>75013 Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mallet, Alain" sort="Mallet, Alain" uniqKey="Mallet A" first="Alain" last="Mallet">Alain Mallet</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Unité de Recherche Clinique, Groupe Hospitalier Pitié Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lioure, Bruno" sort="Lioure, Bruno" uniqKey="Lioure B" first="Bruno" last="Lioure">Bruno Lioure</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Département d'Hématologie, Hôpitaux Universitaires Strasbourg</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpitaux Universitaires Strasbourg</wicri:noRegion>
<wicri:noRegion>Département d'Hématologie, Hôpitaux Universitaires Strasbourg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bay, Jacques Olivier" sort="Bay, Jacques Olivier" uniqKey="Bay J" first="Jacques-Olivier" last="Bay">Jacques-Olivier Bay</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Service d'Hématologie, Centre Hospitalier-Universitaire Estaing</s1>
<s2>Clermont-Ferrand</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rubio, Marie Therese" sort="Rubio, Marie Therese" uniqKey="Rubio M" first="Marie-Thérèse" last="Rubio">Marie-Thérèse Rubio</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Service d'Hématologie, Hôpital Saint-Antoine, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agape, Philippe" sort="Agape, Philippe" uniqKey="Agape P" first="Philippe" last="Agape">Philippe Agape</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Service d'Hématologie et d'Oncologie médicale. Centre Hospitalier Universitaire de la Réunion. Hôpital Felix Guyon</s1>
<s2>Saint Denis</s2>
<s3>REU</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Réunion</country>
<wicri:noRegion>Service d'Hématologie et d'Oncologie médicale. Centre Hospitalier Universitaire de la Réunion. Hôpital Felix Guyon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thiebaut, Anne" sort="Thiebaut, Anne" uniqKey="Thiebaut A" first="Anne" last="Thiebaut">Anne Thiebaut</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Service d'Hématologie, Hôpital Michallon</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Goff, Jerome" sort="Le Goff, Jerome" uniqKey="Le Goff J" first="Jérôme" last="Le Goff">Jérôme Le Goff</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Service de virologie, Hôpital Saint-Louis, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Université Paris-Diderot, Sorbonne Paris, Cité</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>UPMC Université Paris 06, UMR S 945, Laboratory Immunity and Infection</s1>
<s2>75013 Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>INSERM, UMR S 945, Laboratory Immunity and Infection</s1>
<s2>75013 Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ribaud, Patricia" sort="Ribaud, Patricia" uniqKey="Ribaud P" first="Patricia" last="Ribaud">Patricia Ribaud</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Université Paris-Diderot, Sorbonne Paris, Cité</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Service d'Hématologie-Greffe de Moelle, Hôpital Saint-Louis, AP-HP</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Hematopoietic cell</term>
<term>Humoral immunity</term>
<term>Immune response</term>
<term>Immunological adjuvant</term>
<term>Influenza A</term>
<term>Recipient</term>
<term>Stem cell</term>
<term>Transplantation</term>
<term>Vaccination</term>
<term>Vaccine</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Immunité humorale</term>
<term>Adjuvant immunologique</term>
<term>Vaccin</term>
<term>Cellule souche</term>
<term>Receveur</term>
<term>Vaccination</term>
<term>Cellule hématopoïétique</term>
<term>Transplantation</term>
<term>Grippe A</term>
<term>Réponse immune</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
<term>Cellule souche</term>
<term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: The present study evaluated immunogenicity and tolerance of two-dose influenza A/H1N1pdm09 vaccination in allogeneic hematopoietic stem cell transplantation (HSCT) recipients, and compared the vaccine-induced humoral response to that triggered by natural infection in another group of HSCT patients. Methods: Adult allogeneic HSCT recipients vaccinated with two doses of influenza A/H1N1pdm09 vaccine, separated by 3 weeks, and patients with proven influenza A/H1N1pdm09 infection were included. Antibody responses were measured by hemagglutination-inhibition assay 1) on days 0, 21, 42 and 6 months after the first vaccine injection in vaccinated patients and 2) before pandemic and after influenza A/H1N1pdm09 infection, in patients presented natural infection. Results: At baseline, 3% of 59 recipients of adjuvanted vaccine and 0% of 20 infected patients were seroprotected (antibody titer ≥ 1/40). Seroprotection rate observed 42 days after vaccination was not different from that observed after natural infection (66% and 60% respectively, p = 0.78). In vaccinated patients, seroprotection rate increased significantly from 54% to 66% between day 21 and 42 (p = 0.015). Moreover, after 6 months, seroprotection rate in 21 vaccinated patients was similar to that observed in 10 infected patients evaluated at least 76 days after infection (D76-217) (60% and 81% respectively, p = 0.2). In multivariate analysis, no immunosuppressive treatment or chronic graft-versus-host disease (GVHD) and longer time between transplantation and vaccination/infection were associated with a stronger humoral response. The adjuvanted vaccine was safe with low rate of GVHD worsening. Conclusion: In HSCT recipients, two doses of influenza A/H1N1pdm09 adjuvanted vaccine were safe and induced a humoral response comparable to that triggered by natural infection in these patients.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Réunion</li>
</country>
<region><li>Auvergne (région administrative)</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
<li>Île-de-France</li>
</region>
<settlement><li>Clermont-Ferrand</li>
<li>Grenoble</li>
<li>Paris</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Dhedin, Nathalie" sort="Dhedin, Nathalie" uniqKey="Dhedin N" first="Nathalie" last="Dhedin">Nathalie Dhedin</name>
</region>
<name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name>
<name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name>
<name sortKey="Bay, Jacques Olivier" sort="Bay, Jacques Olivier" uniqKey="Bay J" first="Jacques-Olivier" last="Bay">Jacques-Olivier Bay</name>
<name sortKey="Dhedin, Nathalie" sort="Dhedin, Nathalie" uniqKey="Dhedin N" first="Nathalie" last="Dhedin">Nathalie Dhedin</name>
<name sortKey="Krivine, Anne" sort="Krivine, Anne" uniqKey="Krivine A" first="Anne" last="Krivine">Anne Krivine</name>
<name sortKey="Le Corre, Nicole" sort="Le Corre, Nicole" uniqKey="Le Corre N" first="Nicole" last="Le Corre">Nicole Le Corre</name>
<name sortKey="Le Corre, Nicole" sort="Le Corre, Nicole" uniqKey="Le Corre N" first="Nicole" last="Le Corre">Nicole Le Corre</name>
<name sortKey="Le Goff, Jerome" sort="Le Goff, Jerome" uniqKey="Le Goff J" first="Jérôme" last="Le Goff">Jérôme Le Goff</name>
<name sortKey="Le Goff, Jerome" sort="Le Goff, Jerome" uniqKey="Le Goff J" first="Jérôme" last="Le Goff">Jérôme Le Goff</name>
<name sortKey="Lioure, Bruno" sort="Lioure, Bruno" uniqKey="Lioure B" first="Bruno" last="Lioure">Bruno Lioure</name>
<name sortKey="Mallet, Alain" sort="Mallet, Alain" uniqKey="Mallet A" first="Alain" last="Mallet">Alain Mallet</name>
<name sortKey="Ribaud, Patricia" sort="Ribaud, Patricia" uniqKey="Ribaud P" first="Patricia" last="Ribaud">Patricia Ribaud</name>
<name sortKey="Ribaud, Patricia" sort="Ribaud, Patricia" uniqKey="Ribaud P" first="Patricia" last="Ribaud">Patricia Ribaud</name>
<name sortKey="Rubio, Marie Therese" sort="Rubio, Marie Therese" uniqKey="Rubio M" first="Marie-Thérèse" last="Rubio">Marie-Thérèse Rubio</name>
<name sortKey="Thiebaut, Anne" sort="Thiebaut, Anne" uniqKey="Thiebaut A" first="Anne" last="Thiebaut">Anne Thiebaut</name>
</country>
<country name="Réunion"><noRegion><name sortKey="Agape, Philippe" sort="Agape, Philippe" uniqKey="Agape P" first="Philippe" last="Agape">Philippe Agape</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001116 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001116 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:14-0076696 |texte= Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients }}
![]() | This area was generated with Dilib version V0.6.34. | ![]() |