Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine
Identifieur interne : 001085 ( Main/Exploration ); précédent : 001084; suivant : 001086Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine
Auteurs : YING JU [République populaire de Chine] ; HONGXIA FAN [République populaire de Chine] ; JUN LIU [République populaire de Chine] ; JUN HU [République populaire de Chine] ; XINGHUI LI [République populaire de Chine] ; CHANGFEI LI [République populaire de Chine] ; LIZHAO CHEN [République populaire de Chine] ; QIANG GAO [République populaire de Chine] ; George F. Gao [République populaire de Chine] ; SONGDONG MENG [République populaire de Chine]Source :
- Vaccine [ 0264-410X ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
Abstract
The commonly used inactivated or split influenza vaccines induce only induce minimal T cell responses and are less effective in preventing heterologous virus infection. Thus, developing cross-protective influenza vaccines against the spread of a new influenza virus is an important strategy against pandemic emergence. Here we demonstrated that immunization with heat shock protein gp96 as adjuvant led to a dramatic increased antigen-specific T cell response to a pandemic H1N1 split vaccine. Notably, gp96 elicited a cross-protective CD8+ T cell response to the internal conserved viral protein NP. Although the split pH1N1vaccine alone has low cross-protective efficiency, adding gp96 as an adjuvant effectively improved the cross-protection against challenge with a heterologous virus in mice. Our study reveals the novel property of gp96 in boosting the T cell response against conserved epitopes of influenza virus and its potential use as an adjuvant for human pre-pandemic inactivated influenza vaccines against different viral subtypes.
Affiliations:
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and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Changfei Li" sort="Changfei Li" uniqKey="Changfei Li" last="Changfei Li">CHANGFEI LI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lizhao Chen" sort="Lizhao Chen" uniqKey="Lizhao Chen" last="Lizhao Chen">LIZHAO CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qiang Gao" sort="Qiang Gao" uniqKey="Qiang Gao" last="Qiang Gao">QIANG GAO</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sinovac Biotech Co., Ltd</s1><s2>Beijing</s2><s3>CHN</s3><sZ>8 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type="wicri:Area/Main/Exploration">001085</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine</title><author><name sortKey="Ying Ju" sort="Ying Ju" uniqKey="Ying Ju" last="Ying Ju">YING JU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hongxia Fan" sort="Hongxia Fan" uniqKey="Hongxia Fan" last="Hongxia Fan">HONGXIA FAN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jun Liu" sort="Jun Liu" uniqKey="Jun Liu" last="Jun Liu">JUN LIU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jun Hu" sort="Jun Hu" uniqKey="Jun Hu" last="Jun Hu">JUN HU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xinghui Li" sort="Xinghui Li" uniqKey="Xinghui Li" last="Xinghui Li">XINGHUI LI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Changfei Li" sort="Changfei Li" uniqKey="Changfei Li" last="Changfei Li">CHANGFEI LI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lizhao Chen" sort="Lizhao Chen" uniqKey="Lizhao Chen" last="Lizhao Chen">LIZHAO CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qiang Gao" sort="Qiang Gao" uniqKey="Qiang Gao" last="Qiang Gao">QIANG GAO</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sinovac Biotech Co., Ltd</s1><s2>Beijing</s2><s3>CHN</s3><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Songdong Meng" sort="Songdong Meng" uniqKey="Songdong Meng" last="Songdong Meng">SONGDONG MENG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), No. 1 West Beichen Road</s1><s2>Chaoyang District, Beijing 100101</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigenic determinant</term><term>Cellular immunity</term><term>Cross protection</term><term>Heat shock protein</term><term>Immunological adjuvant</term><term>Influenza A</term><term>Vaccine</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Protéine choc thermique</term><term>Adjuvant immunologique</term><term>Immunité cellulaire</term><term>Protection croisée</term><term>Vaccin</term><term>Déterminant antigénique</term><term>Grippe A</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The commonly used inactivated or split influenza vaccines induce only induce minimal T cell responses and are less effective in preventing heterologous virus infection. Thus, developing cross-protective influenza vaccines against the spread of a new influenza virus is an important strategy against pandemic emergence. Here we demonstrated that immunization with heat shock protein gp96 as adjuvant led to a dramatic increased antigen-specific T cell response to a pandemic H1N1 split vaccine. Notably, gp96 elicited a cross-protective CD8<sup>+</sup> T cell response to the internal conserved viral protein NP. Although the split pH1N1vaccine alone has low cross-protective efficiency, adding gp96 as an adjuvant effectively improved the cross-protection against challenge with a heterologous virus in mice. Our study reveals the novel property of gp96 in boosting the T cell response against conserved epitopes of influenza virus and its potential use as an adjuvant for human pre-pandemic inactivated influenza vaccines against different viral subtypes.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Ying Ju" sort="Ying Ju" uniqKey="Ying Ju" last="Ying Ju">YING JU</name></noRegion><name sortKey="Changfei Li" sort="Changfei Li" uniqKey="Changfei Li" last="Changfei Li">CHANGFEI LI</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Hongxia Fan" sort="Hongxia Fan" uniqKey="Hongxia Fan" last="Hongxia Fan">HONGXIA FAN</name><name sortKey="Jun Hu" sort="Jun Hu" uniqKey="Jun Hu" last="Jun Hu">JUN HU</name><name sortKey="Jun Liu" sort="Jun Liu" uniqKey="Jun Liu" last="Jun Liu">JUN LIU</name><name sortKey="Lizhao Chen" sort="Lizhao Chen" uniqKey="Lizhao Chen" last="Lizhao Chen">LIZHAO CHEN</name><name sortKey="Qiang Gao" sort="Qiang Gao" uniqKey="Qiang Gao" last="Qiang Gao">QIANG GAO</name><name sortKey="Songdong Meng" sort="Songdong Meng" uniqKey="Songdong Meng" last="Songdong Meng">SONGDONG MENG</name><name sortKey="Xinghui Li" sort="Xinghui Li" uniqKey="Xinghui Li" last="Xinghui Li">XINGHUI LI</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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