Narcolepsy and influenza A(H1N1) pandemic 2009 vaccination in the United States
Identifieur interne : 001060 ( Main/Exploration ); précédent : 001059; suivant : 001061Narcolepsy and influenza A(H1N1) pandemic 2009 vaccination in the United States
Auteurs : Jonathan Duffy [États-Unis] ; Eric Weintraub [États-Unis] ; Claudia Vellozzi [États-Unis] ; Frank Destefano [États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccination.
English descriptors
- KwdEn :
Abstract
Objective: To assess the occurrence of narcolepsy after influenza vaccines used in the United States that contained the influenza A(H1Nl1)pdm09 virus strain. Methods: A population-based cohort study in the Vaccine Safety Datalink with an annual population of more than 8.5 million people. All persons younger than 30 years who received a 2009 pandemic or a 2010-2011 seasonal influenza vaccine were identified. Their medical visit history was searched for a first-ever occurrence of an ICD-9 narcolepsy diagnosis code through the end of 2011. Chart review was done to confirm the diagnosis and determine the date of symptom onset. Cases were patients who met the International Classification of Sleep Disorders, 2nd edition, narcolepsy diagnostic criteria. We compared the observed number of cases after vaccination to the number expected to occur by chance alone. Results: The number vaccinated with 2009 pandemic vaccine was 650,995 and with 2010-2011 seasonal vaccine was 870,530. Among these patients, 70 had a first-ever narcolepsy diagnosis code after vaccination, of which 16 had a chart-confirmed incident diagnosis of narcolepsy. None had their symptom onset during the 180 days after receipt of a 2009 pandemic vaccine compared with 6.52 expected, and 2 had onset after a 2010-2011 seasonal vaccine compared with 8.83 expected. Conclusions: Influenza vaccines containing the A(H1N1)pdm09 virus strain used in the United States were not associated with an increased risk of narcolepsy. Vaccination with the influenza A(H1N1)pdm09 vaccine viral antigens does not appear to be sufficient by itself to increase the incidence of narcolepsy in a population.
Affiliations:
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pandemic 2009 vaccination in the United States</title><author><name sortKey="Duffy, Jonathan" sort="Duffy, Jonathan" uniqKey="Duffy J" first="Jonathan" last="Duffy">Jonathan Duffy</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Immunization Safety Office, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Weintraub, Eric" sort="Weintraub, Eric" uniqKey="Weintraub E" first="Eric" last="Weintraub">Eric Weintraub</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Immunization Safety Office, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Vellozzi, Claudia" sort="Vellozzi, Claudia" uniqKey="Vellozzi C" first="Claudia" last="Vellozzi">Claudia Vellozzi</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Immunization Safety Office, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Destefano, Frank" sort="Destefano, Frank" uniqKey="Destefano F" first="Frank" last="Destefano">Frank Destefano</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Immunization Safety Office, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>H1N1 influenza</term><term>Influenza A</term><term>Narcolepsy</term><term>Nervous system diseases</term><term>United States</term><term>Vaccination</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Narcolepsie</term><term>Pathologie du système nerveux</term><term>Grippe A</term><term>Vaccination</term><term>Etats-Unis</term><term>Grippe H1N1</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To assess the occurrence of narcolepsy after influenza vaccines used in the United States that contained the influenza A(H1Nl1)pdm09 virus strain. Methods: A population-based cohort study in the Vaccine Safety Datalink with an annual population of more than 8.5 million people. All persons younger than 30 years who received a 2009 pandemic or a 2010-2011 seasonal influenza vaccine were identified. Their medical visit history was searched for a first-ever occurrence of an ICD-9 narcolepsy diagnosis code through the end of 2011. Chart review was done to confirm the diagnosis and determine the date of symptom onset. Cases were patients who met the International Classification of Sleep Disorders, 2nd edition, narcolepsy diagnostic criteria. We compared the observed number of cases after vaccination to the number expected to occur by chance alone. Results: The number vaccinated with 2009 pandemic vaccine was 650,995 and with 2010-2011 seasonal vaccine was 870,530. Among these patients, 70 had a first-ever narcolepsy diagnosis code after vaccination, of which 16 had a chart-confirmed incident diagnosis of narcolepsy. None had their symptom onset during the 180 days after receipt of a 2009 pandemic vaccine compared with 6.52 expected, and 2 had onset after a 2010-2011 seasonal vaccine compared with 8.83 expected. Conclusions: Influenza vaccines containing the A(H1N1)pdm09 virus strain used in the United States were not associated with an increased risk of narcolepsy. Vaccination with the influenza A(H1N1)pdm09 vaccine viral antigens does not appear to be sufficient by itself to increase the incidence of narcolepsy in a population.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Duffy, Jonathan" sort="Duffy, Jonathan" uniqKey="Duffy J" first="Jonathan" last="Duffy">Jonathan Duffy</name></region><name sortKey="Destefano, Frank" sort="Destefano, Frank" uniqKey="Destefano F" first="Frank" last="Destefano">Frank Destefano</name><name sortKey="Vellozzi, Claudia" sort="Vellozzi, Claudia" uniqKey="Vellozzi C" first="Claudia" last="Vellozzi">Claudia Vellozzi</name><name sortKey="Weintraub, Eric" sort="Weintraub, Eric" uniqKey="Weintraub E" first="Eric" last="Weintraub">Eric Weintraub</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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