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Novel Avian-Origin Human Influenza A(H7N9) Can Be Transmitted Between Ferrets via Respiratory Droplets

Identifieur interne : 001057 ( Main/Exploration ); précédent : 001056; suivant : 001058

Novel Avian-Origin Human Influenza A(H7N9) Can Be Transmitted Between Ferrets via Respiratory Droplets

Auteurs : LILI XU [République populaire de Chine] ; LINLIN BAO [République populaire de Chine] ; WEI DENG [République populaire de Chine] ; LIBO DONG [République populaire de Chine] ; HUA ZHU [République populaire de Chine] ; TING CHEN [République populaire de Chine] ; QI LV [République populaire de Chine] ; FENGDI LI [République populaire de Chine] ; JING YUAN [République populaire de Chine] ; ZHIGUANG XIANG [République populaire de Chine] ; KAI GAO [République populaire de Chine] ; YANFENG XU [République populaire de Chine] ; LAN HUANG [République populaire de Chine] ; YANHONG LI [République populaire de Chine] ; JIANGNING LIU [République populaire de Chine] ; YANFENG YAO [République populaire de Chine] ; PIN YU [République populaire de Chine] ; XIYAN LI [République populaire de Chine] ; WEIJUAN HUANG [République populaire de Chine] ; XIANG ZHAO [République populaire de Chine] ; YU LAN [République populaire de Chine] ; JUNFENG GUO [République populaire de Chine] ; WEIDONG YONG [République populaire de Chine] ; QIANG WEI [République populaire de Chine] ; HONGLIN CHEN [Hong Kong] ; LIANFENG ZHANG [République populaire de Chine] ; CHUAN QIN [République populaire de Chine]

Source :

RBID : Pascal:14-0105268

Descripteurs français

English descriptors

Abstract

The outbreak of human infections caused by novel avian-origin influenza A(H7N9) in China since March 2013 underscores the need to better understand the pathogenicity and transmissibility of these viruses in mammals. In a ferret model, the pathogenicity of influenza A(H7N9) was found to be less than that of an influenza A(H5N1) strain but comparable to that of 2009 pandemic influenza A(H1N1), based on the clinical signs, mortality, virus dissemination, and results of histopathologic analyses. Influenza A(H7N9) could replicate in the upper and lower respiratory tract, the heart, the liver, and the olfactory bulb. It is worth noting that influenza A(H7N9) exhibited a low level of transmission between ferrets via respiratory droplets. There were 4 mutations in the virus isolated from the contact ferret: D678Y in the gene encoding PB2, R157K in the gene encoding hemagglutinin (H3 numbering), I109T in the gene encoding nucleoprotein, and T10I in the gene encoding neuraminidase. These data emphasized that avian-origin influenza A(H7N9) can be transmitted between mammals, highlighting its potential for human-to-human transmissibility.


Affiliations:


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<title xml:lang="en" level="a">Novel Avian-Origin Human Influenza A(H7N9) Can Be Transmitted Between Ferrets via Respiratory Droplets</title>
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<name sortKey="Lili Xu" sort="Lili Xu" uniqKey="Lili Xu" last="Lili Xu">LILI XU</name>
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<s1>State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention</s1>
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<name sortKey="Weidong Yong" sort="Weidong Yong" uniqKey="Weidong Yong" last="Weidong Yong">WEIDONG YONG</name>
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<name sortKey="Qiang Wei" sort="Qiang Wei" uniqKey="Qiang Wei" last="Qiang Wei">QIANG WEI</name>
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<name sortKey="Honglin Chen" sort="Honglin Chen" uniqKey="Honglin Chen" last="Honglin Chen">HONGLIN CHEN</name>
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<s1>State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology and the Research Centre of Infection and Immunology, University of Hong Kong</s1>
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<country>Hong Kong</country>
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<author>
<name sortKey="Lianfeng Zhang" sort="Lianfeng Zhang" uniqKey="Lianfeng Zhang" last="Lianfeng Zhang">LIANFENG ZHANG</name>
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<inist:fA14 i1="01">
<s1>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</s1>
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</author>
<author>
<name sortKey="Chuan Qin" sort="Chuan Qin" uniqKey="Chuan Qin" last="Chuan Qin">CHUAN QIN</name>
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<inist:fA14 i1="01">
<s1>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</s1>
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<country>République populaire de Chine</country>
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</analytic>
<series>
<title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
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</sourceDesc>
<seriesStmt>
<title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
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</fileDesc>
<profileDesc>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Avian influenza</term>
<term>Ferret</term>
<term>Human</term>
<term>Infection</term>
<term>Influenza A</term>
<term>Origin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Homme</term>
<term>Origine</term>
<term>Furet</term>
<term>Infection</term>
<term>Grippe aviaire</term>
<term>Grippe A</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Homme</term>
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<front>
<div type="abstract" xml:lang="en">The outbreak of human infections caused by novel avian-origin influenza A(H7N9) in China since March 2013 underscores the need to better understand the pathogenicity and transmissibility of these viruses in mammals. In a ferret model, the pathogenicity of influenza A(H7N9) was found to be less than that of an influenza A(H5N1) strain but comparable to that of 2009 pandemic influenza A(H1N1), based on the clinical signs, mortality, virus dissemination, and results of histopathologic analyses. Influenza A(H7N9) could replicate in the upper and lower respiratory tract, the heart, the liver, and the olfactory bulb. It is worth noting that influenza A(H7N9) exhibited a low level of transmission between ferrets via respiratory droplets. There were 4 mutations in the virus isolated from the contact ferret: D678Y in the gene encoding PB2, R157K in the gene encoding hemagglutinin (H3 numbering), I109T in the gene encoding nucleoprotein, and T10I in the gene encoding neuraminidase. These data emphasized that avian-origin influenza A(H7N9) can be transmitted between mammals, highlighting its potential for human-to-human transmissibility.</div>
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