Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant
Identifieur interne : 000882 ( Main/Exploration ); précédent : 000881; suivant : 000883Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant
Auteurs : David L. Gordon [Australie] ; Dimitar Sajkov [Australie] ; Yoshikazu Honda-Okubo [Australie] ; Samuel H. Wilks [Royaume-Uni] ; Malet Aban [Australie] ; Ian G. Barr [Australie] ; Nikolai Petrovsky [Australie]Source :
- Vaccine [ 0264-410X ] ; 2016.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Femelle, Grippe humaine (), Humains, Inuline (administration et posologie), Inuline (analogues et dérivés), Mâle, Méthode en simple aveugle, Sous-type H3N2 du virus de la grippe A, Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (usage thérapeutique), Vaccins inactivés (usage thérapeutique).
- MESH :
- administration et posologie : Adjuvants immunologiques, Inuline.
- analogues et dérivés : Inuline.
- sang : Anticorps antiviraux.
- usage thérapeutique : Vaccins antigrippaux, Vaccins inactivés.
- Adulte, Adulte d'âge moyen, Femelle, Grippe humaine, Humains, Mâle, Méthode en simple aveugle, Sous-type H3N2 du virus de la grippe A, Tests d'inhibition de l'hémagglutination.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Adult, Antibodies, Viral (blood), Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H3N2 Subtype, Influenza Vaccines (therapeutic use), Influenza, Human (prevention & control), Inulin (administration & dosage), Inulin (analogs & derivatives), Male, Middle Aged, Single-Blind Method, Vaccines, Inactivated (therapeutic use).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Inulin.
- chemical , analogs & derivatives : Inulin.
- chemical , blood : Antibodies, Viral.
- chemical , therapeutic use : Influenza Vaccines, Vaccines, Inactivated.
- prevention & control : Influenza, Human.
- Adult, Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H3N2 Subtype, Male, Middle Aged, Single-Blind Method.
Abstract
First-in-man study of seasonal influenza vaccine containing Advax delta inulin-based adjuvant. Advax adjuvant was safe and well tolerated. Advax adjuvant enabled up to 10-fold antigen dose-sparing. First use of antibody landscapes to compare adjuvanted and unadjuvanted vaccine groups.
Url:
DOI: 10.1016/j.vaccine.2016.05.071
PubMed: 27342914
PubMed Central: 4949042
Affiliations:
- Australie, Royaume-Uni
- Angleterre, Angleterre de l'Est, Victoria (État)
- Cambridge, Melbourne
- Université de Cambridge, Université de Melbourne
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Le document en format XML
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Gordon</name><affiliation wicri:level="1"><nlm:aff id="af005">Department of Microbiology and Infectious Diseases, SA Pathology, Flinders Medical Centre, and Flinders University, South Australia 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Infectious Diseases, SA Pathology, Flinders Medical Centre, and Flinders University, South Australia 5042</wicri:regionArea><wicri:noRegion>South Australia 5042</wicri:noRegion></affiliation></author><author><name sortKey="Sajkov, Dimitar" sort="Sajkov, Dimitar" uniqKey="Sajkov D" first="Dimitar" last="Sajkov">Dimitar Sajkov</name><affiliation wicri:level="1"><nlm:aff id="af010">Australian Respiratory and Sleep Medicine Institute, Adelaide, South Australia 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Respiratory and Sleep Medicine Institute, Adelaide, South Australia 5042</wicri:regionArea><wicri:noRegion>South Australia 5042</wicri:noRegion></affiliation></author><author><name sortKey="Honda Okubo, Yoshikazu" sort="Honda Okubo, Yoshikazu" uniqKey="Honda Okubo Y" first="Yoshikazu" last="Honda-Okubo">Yoshikazu Honda-Okubo</name><affiliation wicri:level="1"><nlm:aff id="af015">Department of Endocrinology, Flinders University, 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Endocrinology, Flinders University, 5042</wicri:regionArea><wicri:noRegion>5042</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Vaxine Pty Ltd, Flinders Medical Centre, Adelaide 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Vaxine Pty Ltd, Flinders Medical Centre, Adelaide 5042</wicri:regionArea><wicri:noRegion>Adelaide 5042</wicri:noRegion></affiliation></author><author><name sortKey="Wilks, Samuel H" sort="Wilks, Samuel H" uniqKey="Wilks S" first="Samuel H." last="Wilks">Samuel H. Wilks</name><affiliation wicri:level="4"><nlm:aff id="af025">Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af030">World Health Organization (WHO) Collaborating Center for Modeling, Evolution, and Control of Emerging Infectious Diseases, Cambridge CB2 3EJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>World Health Organization (WHO) Collaborating Center for Modeling, Evolution, and Control of Emerging Infectious Diseases, Cambridge CB2 3EJ</wicri:regionArea><wicri:noRegion>Cambridge CB2 3EJ</wicri:noRegion></affiliation></author><author><name sortKey="Aban, Malet" sort="Aban, Malet" uniqKey="Aban M" first="Malet" last="Aban">Malet Aban</name><affiliation wicri:level="1"><nlm:aff id="af035">WHO Collaborating Centre for Reference and Research on Influenza (VIDRL), Peter Doherty Institute for Infection & Immunity, 792 Elizabeth Street, Melbourne 3000, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza (VIDRL), Peter Doherty Institute for Infection & Immunity, 792 Elizabeth Street, Melbourne 3000</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Barr, Ian G" sort="Barr, Ian G" uniqKey="Barr I" first="Ian G." last="Barr">Ian G. Barr</name><affiliation wicri:level="1"><nlm:aff id="af035">WHO Collaborating Centre for Reference and Research on Influenza (VIDRL), Peter Doherty Institute for Infection & Immunity, 792 Elizabeth Street, Melbourne 3000, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza (VIDRL), Peter Doherty Institute for Infection & Immunity, 792 Elizabeth Street, Melbourne 3000</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af040">Department of Microbiology & Immunology, University of Melbourne, Victoria 3000, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology & Immunology, University of Melbourne, Victoria 3000</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Petrovsky, Nikolai" sort="Petrovsky, Nikolai" uniqKey="Petrovsky N" first="Nikolai" last="Petrovsky">Nikolai Petrovsky</name><affiliation wicri:level="1"><nlm:aff id="af010">Australian Respiratory and Sleep Medicine Institute, Adelaide, South Australia 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Respiratory and Sleep Medicine Institute, Adelaide, South Australia 5042</wicri:regionArea><wicri:noRegion>South Australia 5042</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">Department of Endocrinology, Flinders University, 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Endocrinology, Flinders University, 5042</wicri:regionArea><wicri:noRegion>5042</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Vaxine Pty Ltd, Flinders Medical Centre, Adelaide 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Vaxine Pty Ltd, Flinders Medical Centre, Adelaide 5042</wicri:regionArea><wicri:noRegion>Adelaide 5042</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic (administration & dosage)</term><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza Vaccines (therapeutic use)</term><term>Influenza, Human (prevention & control)</term><term>Inulin (administration & dosage)</term><term>Inulin (analogs & derivatives)</term><term>Male</term><term>Middle Aged</term><term>Single-Blind Method</term><term>Vaccines, Inactivated (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques (administration et posologie)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Femelle</term><term>Grippe humaine ()</term><term>Humains</term><term>Inuline (administration et posologie)</term><term>Inuline (analogues et dérivés)</term><term>Mâle</term><term>Méthode en simple aveugle</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccins antigrippaux (usage thérapeutique)</term><term>Vaccins inactivés (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Inulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Inulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Inuline</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Inuline</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H3N2 Subtype</term><term>Male</term><term>Middle Aged</term><term>Single-Blind Method</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Mâle</term><term>Méthode en simple aveugle</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Tests d'inhibition de l'hémagglutination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">First-in-man study of seasonal influenza vaccine containing Advax delta inulin-based adjuvant.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">Advax adjuvant was safe and well tolerated.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">Advax adjuvant enabled up to 10-fold antigen dose-sparing.</p></list-item><list-item id="o0020"><label>•</label><p id="p0020">First use of antibody landscapes to compare adjuvanted and unadjuvanted vaccine groups.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fleming, D M" uniqKey="Fleming D">D.M. Fleming</name></author><author><name sortKey="Elliot, A J" uniqKey="Elliot A">A.J. Elliot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, P D" uniqKey="Cooper P">P.D. Cooper</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, P D" uniqKey="Cooper P">P.D. Cooper</name></author><author><name sortKey="Barclay, T G" uniqKey="Barclay T">T.G. Barclay</name></author><author><name sortKey="Ginic Markovic, M" uniqKey="Ginic Markovic M">M. Ginic-Markovic</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, P D" uniqKey="Cooper P">P.D. Cooper</name></author><author><name sortKey="Barclay, T G" uniqKey="Barclay T">T.G. Barclay</name></author><author><name sortKey="Ginic Markovic, M" uniqKey="Ginic Markovic M">M. Ginic-Markovic</name></author><author><name sortKey="Gerson, A R" uniqKey="Gerson A">A.R. Gerson</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larena, M" uniqKey="Larena M">M. Larena</name></author><author><name sortKey="Prow, N A" uniqKey="Prow N">N.A. Prow</name></author><author><name sortKey="Hall, R A" uniqKey="Hall R">R.A. Hall</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author><author><name sortKey="Lobigs, M" uniqKey="Lobigs M">M. Lobigs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author><author><name sortKey="Larena, M" uniqKey="Larena M">M. Larena</name></author><author><name sortKey="Siddharthan, V" uniqKey="Siddharthan V">V. Siddharthan</name></author><author><name sortKey="Prow, N A" uniqKey="Prow N">N.A. Prow</name></author><author><name sortKey="Hall, R A" uniqKey="Hall R">R.A. Hall</name></author><author><name sortKey="Lobigs, M" uniqKey="Lobigs M">M. Lobigs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cristillo, A D" uniqKey="Cristillo A">A.D. Cristillo</name></author><author><name sortKey="Ferrari, M G" uniqKey="Ferrari M">M.G. Ferrari</name></author><author><name sortKey="Hudacik, L" uniqKey="Hudacik L">L. Hudacik</name></author><author><name sortKey="Lewis, B" uniqKey="Lewis B">B. Lewis</name></author><author><name sortKey="Galmin, L" uniqKey="Galmin L">L. Galmin</name></author><author><name sortKey="Bowen, B" uniqKey="Bowen B">B. Bowen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saade, F" uniqKey="Saade F">F. Saade</name></author><author><name sortKey="Honda Okubo, Y" uniqKey="Honda Okubo Y">Y. Honda-Okubo</name></author><author><name sortKey="Trec, S" uniqKey="Trec S">S. Trec</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda Okubo, Y" uniqKey="Honda Okubo Y">Y. Honda-Okubo</name></author><author><name sortKey="Barnard, D" uniqKey="Barnard D">D. Barnard</name></author><author><name sortKey="Ong, C H" uniqKey="Ong C">C.H. Ong</name></author><author><name sortKey="Peng, B H" uniqKey="Peng B">B.H. Peng</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez Del Rio, E" uniqKey="Rodriguez Del Rio E">E. Rodriguez-Del Rio</name></author><author><name sortKey="Marradi, M" uniqKey="Marradi M">M. Marradi</name></author><author><name sortKey="Calderon Gonzalez, R" uniqKey="Calderon Gonzalez R">R. Calderon-Gonzalez</name></author><author><name sortKey="Frande Cabanes, E" uniqKey="Frande Cabanes E">E. Frande-Cabanes</name></author><author><name sortKey="Penades, S" uniqKey="Penades S">S. Penades</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feinen, B" uniqKey="Feinen B">B. Feinen</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author><author><name sortKey="Verma, A" uniqKey="Verma A">A. Verma</name></author><author><name sortKey="Merkel, T J" uniqKey="Merkel T">T.J. Merkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Layton, R C" uniqKey="Layton R">R.C. Layton</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author><author><name sortKey="Gigliotti, A P" uniqKey="Gigliotti A">A.P. Gigliotti</name></author><author><name sortKey="Pollock, Z" uniqKey="Pollock Z">Z. Pollock</name></author><author><name sortKey="Knight, J" uniqKey="Knight J">J. Knight</name></author><author><name sortKey="Donart, N" uniqKey="Donart N">N. Donart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda Okubo, Y" uniqKey="Honda Okubo Y">Y. Honda-Okubo</name></author><author><name sortKey="Kolpe, A" uniqKey="Kolpe A">A. Kolpe</name></author><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda Okubo, Y" uniqKey="Honda Okubo Y">Y. Honda-Okubo</name></author><author><name sortKey="Ong, C H" uniqKey="Ong C">C.H. Ong</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gordon, D L" uniqKey="Gordon D">D.L. Gordon</name></author><author><name sortKey="Sajkov, D" uniqKey="Sajkov D">D. Sajkov</name></author><author><name sortKey="Woodman, R J" uniqKey="Woodman R">R.J. Woodman</name></author><author><name sortKey="Honda Okubo, Y" uniqKey="Honda Okubo Y">Y. Honda-Okubo</name></author><author><name sortKey="Cox, M M" uniqKey="Cox M">M.M. Cox</name></author><author><name sortKey="Heinzel, S" uniqKey="Heinzel S">S. Heinzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gordon, D" uniqKey="Gordon D">D. Gordon</name></author><author><name sortKey="Kelley, P" uniqKey="Kelley P">P. Kelley</name></author><author><name sortKey="Heinzel, S" uniqKey="Heinzel S">S. Heinzel</name></author><author><name sortKey="Cooper, P" uniqKey="Cooper P">P. Cooper</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heddle, R" uniqKey="Heddle R">R. Heddle</name></author><author><name sortKey="Russo, P" uniqKey="Russo P">P. Russo</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author><author><name sortKey="Hanna, R" uniqKey="Hanna R">R. Hanna</name></author><author><name sortKey="Smith, A" uniqKey="Smith A">A. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda Okubo, Y" uniqKey="Honda Okubo Y">Y. Honda-Okubo</name></author><author><name sortKey="Saade, F" uniqKey="Saade F">F. Saade</name></author><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fonville, J M" uniqKey="Fonville J">J.M. Fonville</name></author><author><name sortKey="Wilks, S H" uniqKey="Wilks S">S.H. Wilks</name></author><author><name sortKey="James, S L" uniqKey="James S">S.L. James</name></author><author><name sortKey="Fox, A" uniqKey="Fox A">A. Fox</name></author><author><name sortKey="Ventresca, M" uniqKey="Ventresca M">M. Ventresca</name></author><author><name sortKey="Aban, M" uniqKey="Aban M">M. Aban</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koyama, S" uniqKey="Koyama S">S. Koyama</name></author><author><name sortKey="Ishii, K J" uniqKey="Ishii K">K.J. Ishii</name></author><author><name sortKey="Kumar, H" uniqKey="Kumar H">H. Kumar</name></author><author><name sortKey="Tanimoto, T" uniqKey="Tanimoto T">T. Tanimoto</name></author><author><name sortKey="Coban, C" uniqKey="Coban C">C. Coban</name></author><author><name sortKey="Uematsu, S" uniqKey="Uematsu S">S. Uematsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Donato, S" uniqKey="De Donato S">S. De Donato</name></author><author><name sortKey="Granoff, D" uniqKey="Granoff D">D. Granoff</name></author><author><name sortKey="Minutello, M" uniqKey="Minutello M">M. Minutello</name></author><author><name sortKey="Lecchi, G" uniqKey="Lecchi G">G. Lecchi</name></author><author><name sortKey="Faccini, M" uniqKey="Faccini M">M. Faccini</name></author><author><name sortKey="Agnello, M" uniqKey="Agnello M">M. Agnello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frey, S" uniqKey="Frey S">S. Frey</name></author><author><name sortKey="Poland, G" uniqKey="Poland G">G. Poland</name></author><author><name sortKey="Percell, S" uniqKey="Percell S">S. Percell</name></author><author><name sortKey="Podda, A" uniqKey="Podda A">A. Podda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, T F" uniqKey="Tsai T">T.F. Tsai</name></author><author><name sortKey="Crucitti, A" uniqKey="Crucitti A">A. Crucitti</name></author><author><name sortKey="Nacci, P" uniqKey="Nacci P">P. Nacci</name></author><author><name sortKey="Nicolay, U" uniqKey="Nicolay U">U. Nicolay</name></author><author><name sortKey="Della Cioppa, G" uniqKey="Della Cioppa G">G. Della Cioppa</name></author><author><name sortKey="Ferguson, J" uniqKey="Ferguson J">J. Ferguson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nohynek, H" uniqKey="Nohynek H">H. Nohynek</name></author><author><name sortKey="Jokinen, J" uniqKey="Jokinen J">J. Jokinen</name></author><author><name sortKey="Partinen, M" uniqKey="Partinen M">M. Partinen</name></author><author><name sortKey="Vaarala, O" uniqKey="Vaarala O">O. Vaarala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, M" uniqKey="Price M">M. Price</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name></author><author><name sortKey="Cooper, P D" uniqKey="Cooper P">P.D. Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frenck, R W" uniqKey="Frenck R">R.W. Frenck</name></author><author><name sortKey="Belshe, R" uniqKey="Belshe R">R. Belshe</name></author><author><name sortKey="Brady, R C" uniqKey="Brady R">R.C. Brady</name></author><author><name sortKey="Winokur, P L" uniqKey="Winokur P">P.L. Winokur</name></author><author><name sortKey="Campbell, J D" uniqKey="Campbell J">J.D. Campbell</name></author><author><name sortKey="Treanor, J" uniqKey="Treanor J">J. Treanor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altenburg, A F" uniqKey="Altenburg A">A.F. Altenburg</name></author><author><name sortKey="Rimmelzwaan, G F" uniqKey="Rimmelzwaan G">G.F. Rimmelzwaan</name></author><author><name sortKey="De Vries, R D" uniqKey="De Vries R">R.D. de Vries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilkinson, T M" uniqKey="Wilkinson T">T.M. Wilkinson</name></author><author><name sortKey="Li, C K" uniqKey="Li C">C.K. Li</name></author><author><name sortKey="Chui, C S" uniqKey="Chui C">C.S. Chui</name></author><author><name sortKey="Huang, A K" uniqKey="Huang A">A.K. Huang</name></author><author><name sortKey="Perkins, M" uniqKey="Perkins M">M. Perkins</name></author><author><name sortKey="Liebner, J C" uniqKey="Liebner J">J.C. Liebner</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Victoria (État)</li></region><settlement><li>Cambridge</li><li>Melbourne</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Gordon, David L" sort="Gordon, David L" uniqKey="Gordon D" first="David L." last="Gordon">David L. Gordon</name></noRegion><name sortKey="Aban, Malet" sort="Aban, Malet" uniqKey="Aban M" first="Malet" last="Aban">Malet Aban</name><name sortKey="Barr, Ian G" sort="Barr, Ian G" uniqKey="Barr I" first="Ian G." last="Barr">Ian G. Barr</name><name sortKey="Barr, Ian G" sort="Barr, Ian G" uniqKey="Barr I" first="Ian G." last="Barr">Ian G. Barr</name><name sortKey="Honda Okubo, Yoshikazu" sort="Honda Okubo, Yoshikazu" uniqKey="Honda Okubo Y" first="Yoshikazu" last="Honda-Okubo">Yoshikazu Honda-Okubo</name><name sortKey="Honda Okubo, Yoshikazu" sort="Honda Okubo, Yoshikazu" uniqKey="Honda Okubo Y" first="Yoshikazu" last="Honda-Okubo">Yoshikazu Honda-Okubo</name><name sortKey="Petrovsky, Nikolai" sort="Petrovsky, Nikolai" uniqKey="Petrovsky N" first="Nikolai" last="Petrovsky">Nikolai Petrovsky</name><name sortKey="Petrovsky, Nikolai" sort="Petrovsky, Nikolai" uniqKey="Petrovsky N" first="Nikolai" last="Petrovsky">Nikolai Petrovsky</name><name sortKey="Petrovsky, Nikolai" sort="Petrovsky, Nikolai" uniqKey="Petrovsky N" first="Nikolai" last="Petrovsky">Nikolai Petrovsky</name><name sortKey="Sajkov, Dimitar" sort="Sajkov, Dimitar" uniqKey="Sajkov D" first="Dimitar" last="Sajkov">Dimitar Sajkov</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Wilks, Samuel H" sort="Wilks, Samuel H" uniqKey="Wilks S" first="Samuel H." last="Wilks">Samuel H. Wilks</name></region><name sortKey="Wilks, Samuel H" sort="Wilks, Samuel H" uniqKey="Wilks S" first="Samuel H." last="Wilks">Samuel H. Wilks</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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