Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant
Identifieur interne : 000882 ( Main/Exploration ); précédent : 000881; suivant : 000883Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant
Auteurs : David L. Gordon [Australie] ; Dimitar Sajkov [Australie] ; Yoshikazu Honda-Okubo [Australie] ; Samuel H. Wilks [Royaume-Uni] ; Malet Aban [Australie] ; Ian G. Barr [Australie] ; Nikolai Petrovsky [Australie]Source :
- Vaccine [ 0264-410X ] ; 2016.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Femelle, Grippe humaine (), Humains, Inuline (administration et posologie), Inuline (analogues et dérivés), Mâle, Méthode en simple aveugle, Sous-type H3N2 du virus de la grippe A, Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (usage thérapeutique), Vaccins inactivés (usage thérapeutique).
- MESH :
- administration et posologie : Adjuvants immunologiques, Inuline.
- analogues et dérivés : Inuline.
- sang : Anticorps antiviraux.
- usage thérapeutique : Vaccins antigrippaux, Vaccins inactivés.
- Adulte, Adulte d'âge moyen, Femelle, Grippe humaine, Humains, Mâle, Méthode en simple aveugle, Sous-type H3N2 du virus de la grippe A, Tests d'inhibition de l'hémagglutination.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Adult, Antibodies, Viral (blood), Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H3N2 Subtype, Influenza Vaccines (therapeutic use), Influenza, Human (prevention & control), Inulin (administration & dosage), Inulin (analogs & derivatives), Male, Middle Aged, Single-Blind Method, Vaccines, Inactivated (therapeutic use).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Inulin.
- chemical , analogs & derivatives : Inulin.
- chemical , blood : Antibodies, Viral.
- chemical , therapeutic use : Influenza Vaccines, Vaccines, Inactivated.
- prevention & control : Influenza, Human.
- Adult, Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H3N2 Subtype, Male, Middle Aged, Single-Blind Method.
Abstract
First-in-man study of seasonal influenza vaccine containing Advax delta inulin-based adjuvant. Advax adjuvant was safe and well tolerated. Advax adjuvant enabled up to 10-fold antigen dose-sparing. First use of antibody landscapes to compare adjuvanted and unadjuvanted vaccine groups.
Url:
DOI: 10.1016/j.vaccine.2016.05.071
PubMed: 27342914
PubMed Central: 4949042
Affiliations:
- Australie, Royaume-Uni
- Angleterre, Angleterre de l'Est, Victoria (État)
- Cambridge, Melbourne
- Université de Cambridge, Université de Melbourne
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Le document en format XML
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<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza Vaccines (therapeutic use)</term>
<term>Influenza, Human (prevention & control)</term>
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<term>Inulin (analogs & derivatives)</term>
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<term>Adulte d'âge moyen</term>
<term>Anticorps antiviraux (sang)</term>
<term>Femelle</term>
<term>Grippe humaine ()</term>
<term>Humains</term>
<term>Inuline (administration et posologie)</term>
<term>Inuline (analogues et dérivés)</term>
<term>Mâle</term>
<term>Méthode en simple aveugle</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
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<term>Vaccins antigrippaux (usage thérapeutique)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term>
<term>Vaccines, Inactivated</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term>
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<term>Influenza A Virus, H3N2 Subtype</term>
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<term>Mâle</term>
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label>
<p id="p0005">First-in-man study of seasonal influenza vaccine containing Advax delta inulin-based adjuvant.</p>
</list-item>
<list-item id="o0010"><label>•</label>
<p id="p0010">Advax adjuvant was safe and well tolerated.</p>
</list-item>
<list-item id="o0015"><label>•</label>
<p id="p0015">Advax adjuvant enabled up to 10-fold antigen dose-sparing.</p>
</list-item>
<list-item id="o0020"><label>•</label>
<p id="p0020">First use of antibody landscapes to compare adjuvanted and unadjuvanted vaccine groups.</p>
</list-item>
</list>
</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fleming, D M" uniqKey="Fleming D">D.M. Fleming</name>
</author>
<author><name sortKey="Elliot, A J" uniqKey="Elliot A">A.J. Elliot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cooper, P D" uniqKey="Cooper P">P.D. Cooper</name>
</author>
<author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cooper, P D" uniqKey="Cooper P">P.D. Cooper</name>
</author>
<author><name sortKey="Barclay, T G" uniqKey="Barclay T">T.G. Barclay</name>
</author>
<author><name sortKey="Ginic Markovic, M" uniqKey="Ginic Markovic M">M. Ginic-Markovic</name>
</author>
<author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N. Petrovsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cooper, P D" uniqKey="Cooper P">P.D. Cooper</name>
</author>
<author><name sortKey="Barclay, T G" uniqKey="Barclay T">T.G. Barclay</name>
</author>
<author><name sortKey="Ginic Markovic, M" uniqKey="Ginic Markovic M">M. Ginic-Markovic</name>
</author>
<author><name sortKey="Gerson, A R" uniqKey="Gerson A">A.R. Gerson</name>
</author>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Victoria (État)</li>
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<settlement><li>Cambridge</li>
<li>Melbourne</li>
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<li>Université de Melbourne</li>
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</list>
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<name sortKey="Barr, Ian G" sort="Barr, Ian G" uniqKey="Barr I" first="Ian G." last="Barr">Ian G. Barr</name>
<name sortKey="Barr, Ian G" sort="Barr, Ian G" uniqKey="Barr I" first="Ian G." last="Barr">Ian G. Barr</name>
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<name sortKey="Petrovsky, Nikolai" sort="Petrovsky, Nikolai" uniqKey="Petrovsky N" first="Nikolai" last="Petrovsky">Nikolai Petrovsky</name>
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</country>
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<name sortKey="Wilks, Samuel H" sort="Wilks, Samuel H" uniqKey="Wilks S" first="Samuel H." last="Wilks">Samuel H. Wilks</name>
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</tree>
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</record>
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