Influenza Vaccine is Protective Against Laboratory-Confirmed Influenza in Obese Children
Identifieur interne : 000873 ( Main/Exploration ); précédent : 000872; suivant : 000874Influenza Vaccine is Protective Against Laboratory-Confirmed Influenza in Obese Children
Auteurs : Michael A. Smit ; Hai-Lin Wang ; Edward Kim ; Noel Barragan ; Grace M. Aldrovandi [États-Unis] ; Alvin Nelson El Amin ; Laurene Mascola ; Pia S. Pannaraj [États-Unis]Source :
- The Pediatric infectious disease journal [ 0891-3668 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Grippe humaine (), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Mâle, Obésité (épidémiologie), Surveillance de la santé publique, Vaccination, Vaccins antigrippaux (immunologie), Virus de la grippe A (), Virus de la grippe A (génétique), Étudiants.
- MESH :
- génétique : Virus de la grippe A.
- immunologie : Vaccins antigrippaux.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine, Obésité.
- Adolescent, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Grippe humaine, Humains, Mâle, Surveillance de la santé publique, Vaccination, Virus de la grippe A, Étudiants.
English descriptors
- KwdEn :
- Adolescent, Child, Child, Preschool, Female, Humans, Influenza A virus (classification), Influenza A virus (genetics), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Influenza, Human (virology), Male, Obesity (epidemiology), Public Health Surveillance, Risk Factors, Students, Vaccination.
- MESH :
- chemical , immunology : Influenza Vaccines.
- classification : Influenza A virus.
- epidemiology : Influenza, Human, Obesity.
- genetics : Influenza A virus.
- prevention & control : Influenza, Human.
- virology : Influenza, Human.
- Adolescent, Child, Child, Preschool, Female, Humans, Male, Public Health Surveillance, Risk Factors, Students, Vaccination.
Abstract
Obesity emerged as a novel risk factor for severe disease during the 2009 H1N1 influenza pandemic. Murine studies indicate that obesity is associated with ineffective response to influenza vaccine, but few human studies exist. We aimed to determine if influenza vaccine is protective against laboratory-confirmed influenza in obese children.
Body mass index (BMI), vaccination status, and laboratory-confirmed influenza data were analyzed from a previously conducted prospective study in which active surveillance for influenza-like illness (ILI) was conducted in eight elementary schools in Los Angeles County during the 2010–2011 influenza season. Polymerase-chain reaction (PCR) was performed on combined nose/throat swabs collected from children with ILI at presentation to the school nurse or during absenteeism.
Of 4,260 children with height/weight data, 1,191 (28.0%) were obese (BMI ≥95th percentile). Respiratory specimens were obtained from 858 (20.1%) children. Unvaccinated obese compared with vaccinated obese children acquired three times more PCR-confirmed influenza (62 vs. 17 per 1000 children, p=0.003) and missed more school days (4.6 vs. 3.2 per 100 school days, p<0.001) during influenza season. Obese children with PCR-confirmed influenza were more likely to present with cough (86.2 vs. 72.4%, p=0.030) and missed more school per episode (2.4 vs.1.9 days, p=0.023) compared with non-obese children. Among vaccinated children, rates of PCR-confirmed influenza were similar in obese and non-obese children (17 vs. 20 per 1000 children, p=0.77).
Obese children with PCR-confirmed influenza suffered from more cough and missed more school days than their non-obese peers. Influenza vaccination protected obese children against PCR-proven influenza illness.
Url:
DOI: 10.1097/INF.0000000000001029
PubMed: 26658380
PubMed Central: 4788535
Affiliations:
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Smit</name><affiliation><nlm:aff id="A1">Division of Infectious Diseases, Hasbro Children’s Hospital</nlm:aff><wicri:noCountry code="subfield">Hasbro Children’s Hospital</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Alpert Medical School of Brown University</nlm:aff></affiliation></author><author><name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name><affiliation><nlm:aff id="A3">Division of Infectious Diseases, Children’s Hospital Los Angeles</nlm:aff><wicri:noCountry code="subfield">Children’s Hospital Los Angeles</wicri:noCountry></affiliation></author><author><name sortKey="Kim, Edward" sort="Kim, Edward" uniqKey="Kim E" first="Edward" last="Kim">Edward Kim</name><affiliation><nlm:aff id="A3">Division of Infectious Diseases, Children’s Hospital Los Angeles</nlm:aff><wicri:noCountry code="subfield">Children’s Hospital Los Angeles</wicri:noCountry></affiliation></author><author><name sortKey="Barragan, Noel" sort="Barragan, Noel" uniqKey="Barragan N" first="Noel" last="Barragan">Noel Barragan</name><affiliation><nlm:aff id="A3">Division of Infectious Diseases, Children’s Hospital Los Angeles</nlm:aff><wicri:noCountry code="subfield">Children’s Hospital Los Angeles</wicri:noCountry></affiliation><affiliation><nlm:aff id="A4">Los Angeles County Department of Public Health</nlm:aff></affiliation></author><author><name sortKey="Aldrovandi, Grace M" sort="Aldrovandi, Grace M" uniqKey="Aldrovandi G" first="Grace M." last="Aldrovandi">Grace M. Aldrovandi</name><affiliation><nlm:aff id="A3">Division of Infectious Diseases, Children’s Hospital Los Angeles</nlm:aff><wicri:noCountry code="subfield">Children’s Hospital Los Angeles</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A5">Keck School of Medicine, University of Southern California</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="El Amin, Alvin Nelson" sort="El Amin, Alvin Nelson" uniqKey="El Amin A" first="Alvin Nelson" last="El Amin">Alvin Nelson El Amin</name><affiliation><nlm:aff id="A4">Los Angeles County Department of Public Health</nlm:aff></affiliation></author><author><name sortKey="Mascola, Laurene" sort="Mascola, Laurene" uniqKey="Mascola L" first="Laurene" last="Mascola">Laurene Mascola</name><affiliation><nlm:aff id="A4">Los Angeles County Department of Public Health</nlm:aff></affiliation></author><author><name sortKey="Pannaraj, Pia S" sort="Pannaraj, Pia S" uniqKey="Pannaraj P" first="Pia S." last="Pannaraj">Pia S. Pannaraj</name><affiliation><nlm:aff id="A3">Division of Infectious Diseases, Children’s Hospital Los Angeles</nlm:aff><wicri:noCountry code="subfield">Children’s Hospital Los Angeles</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A5">Keck School of Medicine, University of Southern California</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></analytic><series><title level="j">The Pediatric infectious disease journal</title><idno type="ISSN">0891-3668</idno><idno type="eISSN">1532-0987</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Influenza A virus (classification)</term><term>Influenza A virus (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Obesity (epidemiology)</term><term>Public Health Surveillance</term><term>Risk Factors</term><term>Students</term><term>Vaccination</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Mâle</term><term>Obésité (épidémiologie)</term><term>Surveillance de la santé publique</term><term>Vaccination</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (génétique)</term><term>Étudiants</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Obésité</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Male</term><term>Public Health Surveillance</term><term>Risk Factors</term><term>Students</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Mâle</term><term>Surveillance de la santé publique</term><term>Vaccination</term><term>Virus de la grippe A</term><term>Étudiants</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Obesity emerged as a novel risk factor for severe disease during the 2009 H1N1 influenza pandemic. Murine studies indicate that obesity is associated with ineffective response to influenza vaccine, but few human studies exist. We aimed to determine if influenza vaccine is protective against laboratory-confirmed influenza in obese children.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Body mass index (BMI), vaccination status, and laboratory-confirmed influenza data were analyzed from a previously conducted prospective study in which active surveillance for influenza-like illness (ILI) was conducted in eight elementary schools in Los Angeles County during the 2010–2011 influenza season. Polymerase-chain reaction (PCR) was performed on combined nose/throat swabs collected from children with ILI at presentation to the school nurse or during absenteeism.</p></sec><sec id="S3"><title>Results</title><p id="P3">Of 4,260 children with height/weight data, 1,191 (28.0%) were obese (BMI ≥95th percentile). Respiratory specimens were obtained from 858 (20.1%) children. Unvaccinated obese compared with vaccinated obese children acquired three times more PCR-confirmed influenza (62 vs. 17 per 1000 children, p=0.003) and missed more school days (4.6 vs. 3.2 per 100 school days, p<0.001) during influenza season. Obese children with PCR-confirmed influenza were more likely to present with cough (86.2 vs. 72.4%, p=0.030) and missed more school per episode (2.4 vs.1.9 days, p=0.023) compared with non-obese children. Among vaccinated children, rates of PCR-confirmed influenza were similar in obese and non-obese children (17 vs. 20 per 1000 children, p=0.77).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Obese children with PCR-confirmed influenza suffered from more cough and missed more school days than their non-obese peers. Influenza vaccination protected obese children against PCR-proven influenza illness.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><noCountry><name sortKey="Barragan, Noel" sort="Barragan, Noel" uniqKey="Barragan N" first="Noel" last="Barragan">Noel Barragan</name><name sortKey="El Amin, Alvin Nelson" sort="El Amin, Alvin Nelson" uniqKey="El Amin A" first="Alvin Nelson" last="El Amin">Alvin Nelson El Amin</name><name sortKey="Kim, Edward" sort="Kim, Edward" uniqKey="Kim E" first="Edward" last="Kim">Edward Kim</name><name sortKey="Mascola, Laurene" sort="Mascola, Laurene" uniqKey="Mascola L" first="Laurene" last="Mascola">Laurene Mascola</name><name sortKey="Smit, Michael A" sort="Smit, Michael A" uniqKey="Smit M" first="Michael A." last="Smit">Michael A. Smit</name><name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Aldrovandi, Grace M" sort="Aldrovandi, Grace M" uniqKey="Aldrovandi G" first="Grace M." last="Aldrovandi">Grace M. Aldrovandi</name></region><name sortKey="Pannaraj, Pia S" sort="Pannaraj, Pia S" uniqKey="Pannaraj P" first="Pia S." last="Pannaraj">Pia S. Pannaraj</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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