Protection induced by early stage vaccination with pandemic influenza virus-like particles.
Identifieur interne : 000848 ( Main/Exploration ); précédent : 000847; suivant : 000849Protection induced by early stage vaccination with pandemic influenza virus-like particles.
Auteurs : Gi-Ja Lee [Corée du Sud] ; Fu-Shi Quan [Corée du Sud]Source :
- Vaccine [ 1873-2518 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Cytokines (immunologie), Femelle, Immunité humorale, Immunoglobuline G (sang), Infections à Orthomyxoviridae (), Poumon (virologie), Protéines de la matrice virale (immunologie), Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A, Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (immunologie), Vaccins à pseudo-particules virales (immunologie).
- MESH :
- immunologie : Cytokines, Protéines de la matrice virale, Vaccins antigrippaux, Vaccins à pseudo-particules virales.
- sang : Anticorps antiviraux, Anticorps neutralisants, Immunoglobuline G.
- virologie : Poumon.
- Animaux, Femelle, Immunité humorale, Infections à Orthomyxoviridae, Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A, Tests d'inhibition de l'hémagglutination.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Cytokines (immunology), Female, Hemagglutination Inhibition Tests, Immunity, Humoral, Immunoglobulin G (blood), Influenza A Virus, H1N1 Subtype, Influenza Vaccines (immunology), Lung (virology), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (prevention & control), Vaccines, Virus-Like Particle (immunology), Viral Matrix Proteins (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G.
- chemical , immunology : Cytokines, Influenza Vaccines, Vaccines, Virus-Like Particle, Viral Matrix Proteins.
- prevention & control : Orthomyxoviridae Infections.
- virology : Lung.
- Animals, Female, Hemagglutination Inhibition Tests, Immunity, Humoral, Influenza A Virus, H1N1 Subtype, Mice, Mice, Inbred BALB C.
Abstract
The 2009 worldwide influenza pandemic emphasized the need for new approaches to develop emergency vaccines. In this study, a virus-like particle vaccine comprised of hemagglutinin (HA) and M1 from the pandemic influenza virus A/California/04/09 were used and its ability to induce protective immunity during the early stage of vaccination was assessed in a mouse model. A single intramuscular vaccination with virus-like particles (VLPs) provided protection on days 4 and 7 post-vaccination against lethal virus challenge with only moderate body weight loss. VLP vaccination induced significantly higher IgG antibody responses and high hemagglutinin inhibition (HAI) titers on day 4 post-vaccination. A predominant IgG2a antibody response and viral neutralizing antibodies were induced on day 7. These immune responses were closely correlated with protection. Lung virus titers decreased significantly on day 7 compared to those on day 4 post-vaccination. The lung virus titer on day 4 post-vaccination also decreased significantly compared to that of the naïve control. These results demonstrate that VLP vaccination confers effective protection during the early stage after vaccination in a mouse model.
DOI: 10.1016/j.vaccine.2016.06.011
PubMed: 27317263
Affiliations:
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Le document en format XML
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<term>Cytokines (immunology)</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Immunity, Humoral</term>
<term>Immunoglobulin G (blood)</term>
<term>Influenza A Virus, H1N1 Subtype</term>
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<term>Mice</term>
<term>Mice, Inbred BALB C</term>
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<term>Viral Matrix Proteins (immunology)</term>
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<term>Anticorps neutralisants (sang)</term>
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<term>Femelle</term>
<term>Immunité humorale</term>
<term>Immunoglobuline G (sang)</term>
<term>Infections à Orthomyxoviridae ()</term>
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<term>Protéines de la matrice virale (immunologie)</term>
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<term>Souris de lignée BALB C</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins à pseudo-particules virales (immunologie)</term>
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<term>Vaccines, Virus-Like Particle</term>
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<term>Vaccins antigrippaux</term>
<term>Vaccins à pseudo-particules virales</term>
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<term>Anticorps neutralisants</term>
<term>Immunoglobuline G</term>
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<term>Hemagglutination Inhibition Tests</term>
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<term>Immunité humorale</term>
<term>Infections à Orthomyxoviridae</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
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<front><div type="abstract" xml:lang="en">The 2009 worldwide influenza pandemic emphasized the need for new approaches to develop emergency vaccines. In this study, a virus-like particle vaccine comprised of hemagglutinin (HA) and M1 from the pandemic influenza virus A/California/04/09 were used and its ability to induce protective immunity during the early stage of vaccination was assessed in a mouse model. A single intramuscular vaccination with virus-like particles (VLPs) provided protection on days 4 and 7 post-vaccination against lethal virus challenge with only moderate body weight loss. VLP vaccination induced significantly higher IgG antibody responses and high hemagglutinin inhibition (HAI) titers on day 4 post-vaccination. A predominant IgG2a antibody response and viral neutralizing antibodies were induced on day 7. These immune responses were closely correlated with protection. Lung virus titers decreased significantly on day 7 compared to those on day 4 post-vaccination. The lung virus titer on day 4 post-vaccination also decreased significantly compared to that of the naïve control. These results demonstrate that VLP vaccination confers effective protection during the early stage after vaccination in a mouse model.</div>
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