Influenza A virus replication induces cell cycle arrest in G0/G1 phase.
Identifieur interne : 002F85 ( Main/Curation ); précédent : 002F84; suivant : 002F86Influenza A virus replication induces cell cycle arrest in G0/G1 phase.
Auteurs : Yuan He [République populaire de Chine] ; Ke Xu [République populaire de Chine] ; Bjoern Keiner [Allemagne] ; Jianfang Zhou [République populaire de Chine] ; Volker Czudai [Allemagne] ; Tianxian Li [République populaire de Chine] ; Ze Chen [République populaire de Chine] ; Jinhua Liu [République populaire de Chine] ; Hans-Dieter Klenk [Allemagne] ; Yue Long Shu [République populaire de Chine] ; Bing Sun [République populaire de Chine]Source :
- Journal of Virology [ 0022-538X ] ; 2010-12.
Abstract
Many viruses interact with the host cell division cycle to favor their own growth. In this study, we examined the ability of influenza A virus to manipulate cell cycle progression. Our results show that influenza A virus A/WSN/33 (H1N1) replication results in G(0)/G(1)-phase accumulation of infected cells and that this accumulation is caused by the prevention of cell cycle entry from G(0)/G(1) phase into S phase. Consistent with the G(0)/G(1)-phase accumulation, the amount of hyperphosphorylated retinoblastoma protein, a necessary active form for cell cycle progression through late G(1) into S phase, decreased after infection with A/WSN/33 (H1N1) virus. In addition, other key molecules in the regulation of the cell cycle, such as p21, cyclin E, and cyclin D1, were also changed and showed a pattern of G(0)/G(1)-phase cell cycle arrest. It is interesting that increased viral protein expression and progeny virus production in cells synchronized in the G(0)/G(1) phase were observed compared to those in either unsynchronized cells or cells synchronized in the G(2)/M phase. G(0)/G(1)-phase cell cycle arrest is likely a common strategy, since the effect was also observed in other strains, such as H3N2, H9N2, PR8 H1N1, and pandemic swine H1N1 viruses. These findings, in all, suggest that influenza A virus may provide favorable conditions for viral protein accumulation and virus production by inducing a G(0)/G(1)-phase cell cycle arrest in infected cells.
Url:
DOI: 10.1128/JVI.01216-10
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000322
- to stream Hal, to step Curation: Pour aller vers cette notice dans l'étape Curation :000322
- to stream Hal, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000658
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003100
Links to Exploration step
Hal:pasteur-00624904Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza A virus replication induces cell cycle arrest in G0/G1 phase.</title>
<author><name sortKey="He, Yuan" sort="He, Yuan" uniqKey="He Y" first="Yuan" last="He">Yuan He</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168263" status="VALID"> <orgName>Key Laboratory of Molecular Virology & Immunology</orgName>
<orgName type="acronym">LMVI</orgName>
<desc> <address> <country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54027" type="direct"></relation>
<relation active="#struct-301247" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54027" type="direct"><org type="institution" xml:id="struct-54027" status="VALID"> <orgName>Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences</orgName>
<orgName type="acronym">IPS-CAS</orgName>
<desc> <address> <addrLine>225 South Chongqing Road, Shanghai 200025</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.shanghaipasteur.cas.cn/</ref>
</desc>
<listRelation> <relation active="#struct-301247" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName>
<orgName type="acronym">RIIP</orgName>
<desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://research.pasteur.fr/ip-network</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Xu, Ke" sort="Xu, Ke" uniqKey="Xu K" first="Ke" last="Xu">Ke Xu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168263" status="VALID"> <orgName>Key Laboratory of Molecular Virology & Immunology</orgName>
<orgName type="acronym">LMVI</orgName>
<desc> <address> <country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54027" type="direct"></relation>
<relation active="#struct-301247" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54027" type="direct"><org type="institution" xml:id="struct-54027" status="VALID"> <orgName>Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences</orgName>
<orgName type="acronym">IPS-CAS</orgName>
<desc> <address> <addrLine>225 South Chongqing Road, Shanghai 200025</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.shanghaipasteur.cas.cn/</ref>
</desc>
<listRelation> <relation active="#struct-301247" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName>
<orgName type="acronym">RIIP</orgName>
<desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://research.pasteur.fr/ip-network</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Keiner, Bjoern" sort="Keiner, Bjoern" uniqKey="Keiner B" first="Bjoern" last="Keiner">Bjoern Keiner</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-221820" status="VALID"> <orgName>Institut für Virologie</orgName>
<desc> <address> <addrLine>AG Parasitologie, Marburg D-35043</addrLine>
<country key="DE"></country>
</address>
</desc>
<listRelation> <relation active="#struct-304549" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-304549" type="direct"><org type="institution" xml:id="struct-304549" status="INCOMING"> <orgName>Philipps University</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Zhou, Jianfang" sort="Zhou, Jianfang" uniqKey="Zhou J" first="Jianfang" last="Zhou">Jianfang Zhou</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-222141" status="VALID"> <orgName>Chinese Center for Disease Control and Prevention</orgName>
<desc> <address> <addrLine>155 Changbai Road Changping District ,Beijing 102206,China</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://www.chinacdc.cn/en/</ref>
</desc>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Czudai, Volker" sort="Czudai, Volker" uniqKey="Czudai V" first="Volker" last="Czudai">Volker Czudai</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-221820" status="VALID"> <orgName>Institut für Virologie</orgName>
<desc> <address> <addrLine>AG Parasitologie, Marburg D-35043</addrLine>
<country key="DE"></country>
</address>
</desc>
<listRelation> <relation active="#struct-304549" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-304549" type="direct"><org type="institution" xml:id="struct-304549" status="INCOMING"> <orgName>Philipps University</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Li, Tianxian" sort="Li, Tianxian" uniqKey="Li T" first="Tianxian" last="Li">Tianxian Li</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168940" status="INCOMING"> <orgName>State Key Laboratory of Virology</orgName>
<desc> <address> <addrLine>Wuhan Institute of Virology Wuhan 430071, Hubei, China</addrLine>
<country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-239582" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-239582" type="direct"><org type="institution" xml:id="struct-239582" status="VALID"> <orgName>Chinese Academy of Sciences [Changchun Branch]</orgName>
<orgName type="acronym">CAS</orgName>
<desc> <address> <addrLine>Dong Nanhu Road 3888 Changchun Jilin</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.cas.cn/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168194" status="INCOMING"> <orgName>Shanghai Institute of Biological Products</orgName>
<desc> <address> <country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-331766" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-331766" type="direct"><org type="institution" xml:id="struct-331766" status="INCOMING"> <orgName>China</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Liu, Jinhua" sort="Liu, Jinhua" uniqKey="Liu J" first="Jinhua" last="Liu">Jinhua Liu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168898" status="INCOMING"> <orgName>Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine</orgName>
<desc> <address> <addrLine>Beijing 100193, China</addrLine>
<country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-462209" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-462209" type="direct"><org type="institution" xml:id="struct-462209" status="VALID"> <orgName>China Agriculture University [Beijing]</orgName>
<date type="start">2016-07-29</date>
<desc> <address> <addrLine>Beijing 100062 China</addrLine>
<country key="CN"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-20544" status="INCOMING"> <orgName>Institut fur Virologie</orgName>
<desc> <address> <addrLine>D-35033 Marburg</addrLine>
<country key="DE"></country>
</address>
</desc>
<listRelation> <relation active="#struct-307289" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-307289" type="direct"><org type="institution" xml:id="struct-307289" status="INCOMING"> <orgName>Universitatsklinikum Giessen und Marburg</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Shu, Yue Long" sort="Shu, Yue Long" uniqKey="Shu Y" first="Yue Long" last="Shu">Yue Long Shu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168940" status="INCOMING"> <orgName>State Key Laboratory of Virology</orgName>
<desc> <address> <addrLine>Wuhan Institute of Virology Wuhan 430071, Hubei, China</addrLine>
<country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-239582" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-239582" type="direct"><org type="institution" xml:id="struct-239582" status="VALID"> <orgName>Chinese Academy of Sciences [Changchun Branch]</orgName>
<orgName type="acronym">CAS</orgName>
<desc> <address> <addrLine>Dong Nanhu Road 3888 Changchun Jilin</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.cas.cn/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168263" status="VALID"> <orgName>Key Laboratory of Molecular Virology & Immunology</orgName>
<orgName type="acronym">LMVI</orgName>
<desc> <address> <country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54027" type="direct"></relation>
<relation active="#struct-301247" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54027" type="direct"><org type="institution" xml:id="struct-54027" status="VALID"> <orgName>Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences</orgName>
<orgName type="acronym">IPS-CAS</orgName>
<desc> <address> <addrLine>225 South Chongqing Road, Shanghai 200025</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.shanghaipasteur.cas.cn/</ref>
</desc>
<listRelation> <relation active="#struct-301247" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName>
<orgName type="acronym">RIIP</orgName>
<desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://research.pasteur.fr/ip-network</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:pasteur-00624904</idno>
<idno type="halId">pasteur-00624904</idno>
<idno type="halUri">https://hal-riip.archives-ouvertes.fr/pasteur-00624904</idno>
<idno type="url">https://hal-riip.archives-ouvertes.fr/pasteur-00624904</idno>
<idno type="doi">10.1128/JVI.01216-10</idno>
<date when="2010-12">2010-12</date>
<idno type="wicri:Area/Hal/Corpus">000322</idno>
<idno type="wicri:Area/Hal/Curation">000322</idno>
<idno type="wicri:Area/Hal/Checkpoint">000658</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000658</idno>
<idno type="wicri:doubleKey">0022-538X:2010:He Y:influenza:a:virus</idno>
<idno type="wicri:Area/Main/Merge">003100</idno>
<idno type="wicri:Area/Main/Curation">002F85</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza A virus replication induces cell cycle arrest in G0/G1 phase.</title>
<author><name sortKey="He, Yuan" sort="He, Yuan" uniqKey="He Y" first="Yuan" last="He">Yuan He</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168263" status="VALID"> <orgName>Key Laboratory of Molecular Virology & Immunology</orgName>
<orgName type="acronym">LMVI</orgName>
<desc> <address> <country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54027" type="direct"></relation>
<relation active="#struct-301247" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54027" type="direct"><org type="institution" xml:id="struct-54027" status="VALID"> <orgName>Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences</orgName>
<orgName type="acronym">IPS-CAS</orgName>
<desc> <address> <addrLine>225 South Chongqing Road, Shanghai 200025</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.shanghaipasteur.cas.cn/</ref>
</desc>
<listRelation> <relation active="#struct-301247" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName>
<orgName type="acronym">RIIP</orgName>
<desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://research.pasteur.fr/ip-network</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Xu, Ke" sort="Xu, Ke" uniqKey="Xu K" first="Ke" last="Xu">Ke Xu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168263" status="VALID"> <orgName>Key Laboratory of Molecular Virology & Immunology</orgName>
<orgName type="acronym">LMVI</orgName>
<desc> <address> <country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54027" type="direct"></relation>
<relation active="#struct-301247" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54027" type="direct"><org type="institution" xml:id="struct-54027" status="VALID"> <orgName>Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences</orgName>
<orgName type="acronym">IPS-CAS</orgName>
<desc> <address> <addrLine>225 South Chongqing Road, Shanghai 200025</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.shanghaipasteur.cas.cn/</ref>
</desc>
<listRelation> <relation active="#struct-301247" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName>
<orgName type="acronym">RIIP</orgName>
<desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://research.pasteur.fr/ip-network</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Keiner, Bjoern" sort="Keiner, Bjoern" uniqKey="Keiner B" first="Bjoern" last="Keiner">Bjoern Keiner</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-221820" status="VALID"> <orgName>Institut für Virologie</orgName>
<desc> <address> <addrLine>AG Parasitologie, Marburg D-35043</addrLine>
<country key="DE"></country>
</address>
</desc>
<listRelation> <relation active="#struct-304549" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-304549" type="direct"><org type="institution" xml:id="struct-304549" status="INCOMING"> <orgName>Philipps University</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Zhou, Jianfang" sort="Zhou, Jianfang" uniqKey="Zhou J" first="Jianfang" last="Zhou">Jianfang Zhou</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-222141" status="VALID"> <orgName>Chinese Center for Disease Control and Prevention</orgName>
<desc> <address> <addrLine>155 Changbai Road Changping District ,Beijing 102206,China</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://www.chinacdc.cn/en/</ref>
</desc>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Czudai, Volker" sort="Czudai, Volker" uniqKey="Czudai V" first="Volker" last="Czudai">Volker Czudai</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-221820" status="VALID"> <orgName>Institut für Virologie</orgName>
<desc> <address> <addrLine>AG Parasitologie, Marburg D-35043</addrLine>
<country key="DE"></country>
</address>
</desc>
<listRelation> <relation active="#struct-304549" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-304549" type="direct"><org type="institution" xml:id="struct-304549" status="INCOMING"> <orgName>Philipps University</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Li, Tianxian" sort="Li, Tianxian" uniqKey="Li T" first="Tianxian" last="Li">Tianxian Li</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168940" status="INCOMING"> <orgName>State Key Laboratory of Virology</orgName>
<desc> <address> <addrLine>Wuhan Institute of Virology Wuhan 430071, Hubei, China</addrLine>
<country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-239582" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-239582" type="direct"><org type="institution" xml:id="struct-239582" status="VALID"> <orgName>Chinese Academy of Sciences [Changchun Branch]</orgName>
<orgName type="acronym">CAS</orgName>
<desc> <address> <addrLine>Dong Nanhu Road 3888 Changchun Jilin</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.cas.cn/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168194" status="INCOMING"> <orgName>Shanghai Institute of Biological Products</orgName>
<desc> <address> <country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-331766" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-331766" type="direct"><org type="institution" xml:id="struct-331766" status="INCOMING"> <orgName>China</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Liu, Jinhua" sort="Liu, Jinhua" uniqKey="Liu J" first="Jinhua" last="Liu">Jinhua Liu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168898" status="INCOMING"> <orgName>Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine</orgName>
<desc> <address> <addrLine>Beijing 100193, China</addrLine>
<country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-462209" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-462209" type="direct"><org type="institution" xml:id="struct-462209" status="VALID"> <orgName>China Agriculture University [Beijing]</orgName>
<date type="start">2016-07-29</date>
<desc> <address> <addrLine>Beijing 100062 China</addrLine>
<country key="CN"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-20544" status="INCOMING"> <orgName>Institut fur Virologie</orgName>
<desc> <address> <addrLine>D-35033 Marburg</addrLine>
<country key="DE"></country>
</address>
</desc>
<listRelation> <relation active="#struct-307289" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-307289" type="direct"><org type="institution" xml:id="struct-307289" status="INCOMING"> <orgName>Universitatsklinikum Giessen und Marburg</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Shu, Yue Long" sort="Shu, Yue Long" uniqKey="Shu Y" first="Yue Long" last="Shu">Yue Long Shu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168940" status="INCOMING"> <orgName>State Key Laboratory of Virology</orgName>
<desc> <address> <addrLine>Wuhan Institute of Virology Wuhan 430071, Hubei, China</addrLine>
<country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-239582" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-239582" type="direct"><org type="institution" xml:id="struct-239582" status="VALID"> <orgName>Chinese Academy of Sciences [Changchun Branch]</orgName>
<orgName type="acronym">CAS</orgName>
<desc> <address> <addrLine>Dong Nanhu Road 3888 Changchun Jilin</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.cas.cn/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-168263" status="VALID"> <orgName>Key Laboratory of Molecular Virology & Immunology</orgName>
<orgName type="acronym">LMVI</orgName>
<desc> <address> <country key="CN"></country>
</address>
</desc>
<listRelation> <relation active="#struct-54027" type="direct"></relation>
<relation active="#struct-301247" type="indirect"></relation>
</listRelation>
<tutelles><tutelle active="#struct-54027" type="direct"><org type="institution" xml:id="struct-54027" status="VALID"> <orgName>Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences</orgName>
<orgName type="acronym">IPS-CAS</orgName>
<desc> <address> <addrLine>225 South Chongqing Road, Shanghai 200025</addrLine>
<country key="CN"></country>
</address>
<ref type="url">http://english.shanghaipasteur.cas.cn/</ref>
</desc>
<listRelation> <relation active="#struct-301247" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName>
<orgName type="acronym">RIIP</orgName>
<desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://research.pasteur.fr/ip-network</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1128/JVI.01216-10</idno>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date type="datePub">2010-12</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>Many viruses interact with the host cell division cycle to favor their own growth. In this study, we examined the ability of influenza A virus to manipulate cell cycle progression. Our results show that influenza A virus A/WSN/33 (H1N1) replication results in G(0)/G(1)-phase accumulation of infected cells and that this accumulation is caused by the prevention of cell cycle entry from G(0)/G(1) phase into S phase. Consistent with the G(0)/G(1)-phase accumulation, the amount of hyperphosphorylated retinoblastoma protein, a necessary active form for cell cycle progression through late G(1) into S phase, decreased after infection with A/WSN/33 (H1N1) virus. In addition, other key molecules in the regulation of the cell cycle, such as p21, cyclin E, and cyclin D1, were also changed and showed a pattern of G(0)/G(1)-phase cell cycle arrest. It is interesting that increased viral protein expression and progeny virus production in cells synchronized in the G(0)/G(1) phase were observed compared to those in either unsynchronized cells or cells synchronized in the G(2)/M phase. G(0)/G(1)-phase cell cycle arrest is likely a common strategy, since the effect was also observed in other strains, such as H3N2, H9N2, PR8 H1N1, and pandemic swine H1N1 viruses. These findings, in all, suggest that influenza A virus may provide favorable conditions for viral protein accumulation and virus production by inducing a G(0)/G(1)-phase cell cycle arrest in infected cells.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F85 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002F85 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Main |étape= Curation |type= RBID |clé= Hal:pasteur-00624904 |texte= Influenza A virus replication induces cell cycle arrest in G0/G1 phase. }}
![]() | This area was generated with Dilib version V0.6.34. | ![]() |