Uptake and effectiveness of monovalent influenza A (H1N1) pandemic 2009 vaccine among healthcare personnel in Kenya, 2010
Identifieur interne : 001746 ( Main/Curation ); précédent : 001745; suivant : 001747Uptake and effectiveness of monovalent influenza A (H1N1) pandemic 2009 vaccine among healthcare personnel in Kenya, 2010
Auteurs : Henry Njuguna [Kenya] ; Jamal Ahmed [Kenya] ; Prisca A. Oria [Kenya] ; Geoffrey Arunga [Kenya] ; John Williamson [Kenya] ; Abigael Kosgey [Kenya] ; Philip Muthoka [Kenya] ; Joshua A. Mott [Kenya] ; Robert F. Breiman [Kenya] ; Mark A. Katz [Kenya]Source :
- Vaccine [ 0264-410X ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
Introduction: During April-June 2010, the Kenya Ministry of Public Health and Sanitation distributed free monovalent influenza A(H1N1)pdm09 vaccines to health care personnel (HCP) and other vulnerable groups. We conducted a prospective, cohort study among HCP to characterize influenza A(H1N1)pdm09 vaccine uptake, and to assess influenza A(H1N1)pdm09 vaccine effectiveness. Methods: We enrolled HCP from 5 hospitals and followed them for 6 months. At enrollment, we asked HCP if they had received the influenza A(H1N1)pdm09 vaccine and their reasons for their decision. We administered weekly questionnaires to participants about respiratory symptoms suffered during the previous week. Participants who had acute respiratory illness were asked to contact our surveillance clinician, and nasopharyngeal and oropharyngeal specimens were collected and later tested for influenza by real-time reverse-transcriptase polymerase-chain-reaction. Vaccine effectiveness was estimated by comparing the incidence of acute respiratory illness, absenteeism from work due to respiratory illness and laboratory-confirmed influenza among vaccinated and unvaccinated HCP. Results: We enrolled 3803 HCP from the five hospitals; 64% received influenza vaccine. Vaccinated HCP were more likely to develop acute respiratory illness (ARI) and more likely to report missed days of work due to respiratory illness compared to non-vaccinated HCP (adjusted incidence rate ratio (aIRR) 1.50, 95% confidence intervals (CI): 1.33-1.70) and (aIRR 2.02, 95% CI: 1.41-2.88), respectively. Of 531 samples collected from vaccinated and non-vaccinated HCP, 30 were influenza A and 3 were influenza B. Two influenza A(H1 N1)pdm09 subtypes were isolated; one from vaccinated and the other from non-vaccinated HCP. Discussion and conclusions: A majority of Kenyan HCP surveyed reported receiving the influenza A(H1N1)pdm09 vaccine. Because of low circulation of influenza A(H1N1)pdm09 virus during the study period, vaccine effectiveness could not be determined. The findings of increased ARI events and missed days of work among vaccinated HCP were likely confounded by vaccine-seeking behavioral factors.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000202
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :001C25
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000173
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001770
Links to Exploration step
Pascal:13-0355845Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Uptake and effectiveness of monovalent influenza A (H1N1) pandemic 2009 vaccine among healthcare personnel in Kenya, 2010</title><author><name sortKey="Njuguna, Henry" sort="Njuguna, Henry" uniqKey="Njuguna H" first="Henry" last="Njuguna">Henry Njuguna</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Jamal" sort="Ahmed, Jamal" uniqKey="Ahmed J" first="Jamal" last="Ahmed">Jamal Ahmed</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Oria, Prisca A" sort="Oria, Prisca A" uniqKey="Oria P" first="Prisca A." last="Oria">Prisca A. Oria</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</wicri:noRegion></affiliation></author><author><name sortKey="Arunga, Geoffrey" sort="Arunga, Geoffrey" uniqKey="Arunga G" first="Geoffrey" last="Arunga">Geoffrey Arunga</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</wicri:noRegion></affiliation></author><author><name sortKey="Williamson, John" sort="Williamson, John" uniqKey="Williamson J" first="John" last="Williamson">John Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Kosgey, Abigael" sort="Kosgey, Abigael" uniqKey="Kosgey A" first="Abigael" last="Kosgey">Abigael Kosgey</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</wicri:noRegion></affiliation></author><author><name sortKey="Muthoka, Philip" sort="Muthoka, Philip" uniqKey="Muthoka P" first="Philip" last="Muthoka">Philip Muthoka</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Ministry of Public Health and Sanitation</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>7 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Ministry of Public Health and Sanitation</wicri:noRegion></affiliation></author><author><name sortKey="Mott, Joshua A" sort="Mott, Joshua A" uniqKey="Mott J" first="Joshua A." last="Mott">Joshua A. Mott</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Breiman, Robert F" sort="Breiman, Robert F" uniqKey="Breiman R" first="Robert F." last="Breiman">Robert F. Breiman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Katz, Mark A" sort="Katz, Mark A" uniqKey="Katz M" first="Mark A." last="Katz">Mark A. Katz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0355845</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0355845 INIST</idno><idno type="RBID">Pascal:13-0355845</idno><idno type="wicri:Area/PascalFrancis/Corpus">000202</idno><idno type="wicri:Area/PascalFrancis/Curation">001C25</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000173</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000173</idno><idno type="wicri:doubleKey">0264-410X:2013:Njuguna H:uptake:and:effectiveness</idno><idno type="wicri:Area/Main/Merge">001770</idno><idno type="wicri:Area/Main/Curation">001746</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Uptake and effectiveness of monovalent influenza A (H1N1) pandemic 2009 vaccine among healthcare personnel in Kenya, 2010</title><author><name sortKey="Njuguna, Henry" sort="Njuguna, Henry" uniqKey="Njuguna H" first="Henry" last="Njuguna">Henry Njuguna</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Jamal" sort="Ahmed, Jamal" uniqKey="Ahmed J" first="Jamal" last="Ahmed">Jamal Ahmed</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Oria, Prisca A" sort="Oria, Prisca A" uniqKey="Oria P" first="Prisca A." last="Oria">Prisca A. Oria</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</wicri:noRegion></affiliation></author><author><name sortKey="Arunga, Geoffrey" sort="Arunga, Geoffrey" uniqKey="Arunga G" first="Geoffrey" last="Arunga">Geoffrey Arunga</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</wicri:noRegion></affiliation></author><author><name sortKey="Williamson, John" sort="Williamson, John" uniqKey="Williamson J" first="John" last="Williamson">John Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Kosgey, Abigael" sort="Kosgey, Abigael" uniqKey="Kosgey A" first="Abigael" last="Kosgey">Abigael Kosgey</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Kenya Medical Research Institute-Centers for Disease Control and Prevention (KEMRI-CDC)</wicri:noRegion></affiliation></author><author><name sortKey="Muthoka, Philip" sort="Muthoka, Philip" uniqKey="Muthoka P" first="Philip" last="Muthoka">Philip Muthoka</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Ministry of Public Health and Sanitation</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>7 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Ministry of Public Health and Sanitation</wicri:noRegion></affiliation></author><author><name sortKey="Mott, Joshua A" sort="Mott, Joshua A" uniqKey="Mott J" first="Joshua A." last="Mott">Joshua A. Mott</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Breiman, Robert F" sort="Breiman, Robert F" uniqKey="Breiman R" first="Robert F." last="Breiman">Robert F. Breiman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author><author><name sortKey="Katz, Mark A" sort="Katz, Mark A" uniqKey="Katz M" first="Mark A." last="Katz">Mark A. Katz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centers for Disease Control and Prevention-Kenya (CDC-K)</s1><s2>Nairobi</s2><s3>KEN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Kenya</country><wicri:noRegion>Centers for Disease Control and Prevention-Kenya (CDC-K)</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Influenza A</term><term>Influenza A virus</term><term>Kenya</term><term>Uptake</term><term>Vaccine</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus grippal A</term><term>Captation</term><term>Vaccin</term><term>Kenya</term><term>Grippe A</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Kenya</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Introduction: During April-June 2010, the Kenya Ministry of Public Health and Sanitation distributed free monovalent influenza A(H1N1)pdm09 vaccines to health care personnel (HCP) and other vulnerable groups. We conducted a prospective, cohort study among HCP to characterize influenza A(H1N1)pdm09 vaccine uptake, and to assess influenza A(H1N1)pdm09 vaccine effectiveness. Methods: We enrolled HCP from 5 hospitals and followed them for 6 months. At enrollment, we asked HCP if they had received the influenza A(H1N1)pdm09 vaccine and their reasons for their decision. We administered weekly questionnaires to participants about respiratory symptoms suffered during the previous week. Participants who had acute respiratory illness were asked to contact our surveillance clinician, and nasopharyngeal and oropharyngeal specimens were collected and later tested for influenza by real-time reverse-transcriptase polymerase-chain-reaction. Vaccine effectiveness was estimated by comparing the incidence of acute respiratory illness, absenteeism from work due to respiratory illness and laboratory-confirmed influenza among vaccinated and unvaccinated HCP. Results: We enrolled 3803 HCP from the five hospitals; 64% received influenza vaccine. Vaccinated HCP were more likely to develop acute respiratory illness (ARI) and more likely to report missed days of work due to respiratory illness compared to non-vaccinated HCP (adjusted incidence rate ratio (aIRR) 1.50, 95% confidence intervals (CI): 1.33-1.70) and (aIRR 2.02, 95% CI: 1.41-2.88), respectively. Of 531 samples collected from vaccinated and non-vaccinated HCP, 30 were influenza A and 3 were influenza B. Two influenza A(H1 N1)pdm09 subtypes were isolated; one from vaccinated and the other from non-vaccinated HCP. Discussion and conclusions: A majority of Kenyan HCP surveyed reported receiving the influenza A(H1N1)pdm09 vaccine. Because of low circulation of influenza A(H1N1)pdm09 virus during the study period, vaccine effectiveness could not be determined. The findings of increased ARI events and missed days of work among vaccinated HCP were likely confounded by vaccine-seeking behavioral factors.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001746 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001746 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= PandemieGrippaleV1
|flux= Main
|étape= Curation
|type= RBID
|clé= Pascal:13-0355845
|texte= Uptake and effectiveness of monovalent influenza A (H1N1) pandemic 2009 vaccine among healthcare personnel in Kenya, 2010
}}
| This area was generated with Dilib version V0.6.34. |  |