Genetic analysis of influenza B viruses isolated in Uganda during the 2009--2010 seasons.
Identifieur interne : 001191 ( Main/Curation ); précédent : 001190; suivant : 001192Genetic analysis of influenza B viruses isolated in Uganda during the 2009--2010 seasons.
Auteurs : Denis K. Byarugaba [Ouganda] ; Bernard Erima [Ouganda] ; Monica Millard [Ouganda] ; Hannah Kibuuka [Ouganda] ; L. Lukwago [Kenya] ; Josephine Bwogi [Ouganda] ; Derrick Mimbe [Ouganda] ; Edison A. Mworozi [Ouganda] ; Bridget Sharp [États-Unis] ; Scott Krauss [États-Unis] ; Richard Rj Webby [États-Unis] ; Robert G. Webster [États-Unis] ; Samuel K. Martin [Kenya] ; Fred Wabwire-Mangen [Ouganda] ; Mariette Ducatez [France]Source :
- Virology Journal [ 1743-422X ] ; 2013.
Descripteurs français
- mix :
- Wicri :
- geographic : Ouganda.
English descriptors
- mix :
Abstract
ABSTRACT: BACKGROUND: Influenza B viruses can cause morbidity and mortality in humans but due to the lack of an animal reservoir are not associated with pandemics. Because of this, there is relatively limited genetic sequence available for influenza B viruses, especially from developing countries. Complete genome analysis of one influenza B virus and several gene segments of other influenza B viruses isolated from Uganda from May 2009 through December 2010 was therefore undertaken in this study. METHODS: Samples were collected from patients showing influenza like illness and screened for influenza A and B by PCR. Influenza B viruses isolated on Madin-Darby Canine Kidney cells and selected isolates were subsequently sequenced and analyzed phylogenetically. FINDINGS: Of the 2,089 samples collected during the period, 292 were positive by PCR for influenza A or B; 12.3% of the PCR positives were influenza B. Thirty influenza B viruses were recovered and of these 25 that grew well consistently on subculture were subjected to further analysis. All the isolates belonged to the B/Victoria-lineage as identified by hemagglutination inhibition assay and genetic analysis except one isolate that grouped with the B-Yamagata-lineage. The Ugandan B/Victoria-lineage isolates grouped in clade 1 which was defined by the N75K, N165K and S172P substitutions in hemagglutinin protein clustered together with the B/Brisbane/60/2008 vaccine strain. The Yamagata-like Ugandan strain, B/Uganda/MUWRP-053/2009, clustered with clade 3 Yamagata viruses such as B/Bangladesh/3333/2007 which is characterized by S150I and N166Y substitutions in HA. CONCLUSION: In general there was limited variation among the Ugandan isolates but they were interestingly closer to viruses from West and North Africa than from neighboring Kenya. Our isolates closely matched the World Health Organization recommended vaccines for the seasons.
Url:
DOI: 10.1186/1743-422X-10-11
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Hal:hal-02650842Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic analysis of influenza B viruses isolated in Uganda during the 2009--2010 seasons.</title>
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<country>Ouganda</country>
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<country>Ouganda</country>
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<desc> <address> <addrLine>P. O. Box 7072, Kampala</addrLine>
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</address>
</desc>
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<country>Ouganda</country>
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<author><name sortKey="Sharp, Bridget" sort="Sharp, Bridget" uniqKey="Sharp B" first="Bridget" last="Sharp">Bridget Sharp</name>
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<desc> <address> <addrLine>Division of Virology Memphis - TN 38105</addrLine>
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<country>États-Unis</country>
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<author><name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name>
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<desc> <address> <addrLine>Division of Virology Memphis - TN 38105</addrLine>
<country key="US"></country>
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<country key="US"></country>
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</tutelles>
</hal:affiliation>
<country>États-Unis</country>
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</author>
<author><name sortKey="Webby, Richard Rj" sort="Webby, Richard Rj" uniqKey="Webby R" first="Richard Rj" last="Webby">Richard Rj Webby</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-164402" status="INCOMING"> <orgName>Department of Infectious Diseases</orgName>
<desc> <address> <addrLine>Division of Virology Memphis - TN 38105</addrLine>
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</address>
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</tutelles>
</hal:affiliation>
<country>États-Unis</country>
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<author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G" last="Webster">Robert G. Webster</name>
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<desc> <address> <addrLine>Division of Virology Memphis - TN 38105</addrLine>
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</address>
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</org>
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</tutelles>
</hal:affiliation>
<country>États-Unis</country>
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</author>
<author><name sortKey="Martin, Samuel K" sort="Martin, Samuel K" uniqKey="Martin S" first="Samuel K" last="Martin">Samuel K. Martin</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-1032452" status="INCOMING"> <orgName>United States Army Research Unit</orgName>
<desc> <address> <country key="KE"></country>
</address>
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</tutelles>
</hal:affiliation>
<country>Kenya</country>
</affiliation>
</author>
<author><name sortKey="Wabwire Mangen, Fred" sort="Wabwire Mangen, Fred" uniqKey="Wabwire Mangen F" first="Fred" last="Wabwire-Mangen">Fred Wabwire-Mangen</name>
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<desc> <address> <country key="UG"></country>
</address>
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<tutelles><tutelle active="#struct-328028" type="direct"><org type="institution" xml:id="struct-328028" status="VALID"> <orgName>Makerere University [Kampala, Ouganda]</orgName>
<orgName type="acronym">MAK</orgName>
<desc> <address> <addrLine>P.O. Box 7062 - Kampala</addrLine>
<country key="UG"></country>
</address>
<ref type="url">http://mak.ac.ug</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Ouganda</country>
</affiliation>
</author>
<author><name sortKey="Ducatez, Mariette" sort="Ducatez, Mariette" uniqKey="Ducatez M" first="Mariette" last="Ducatez">Mariette Ducatez</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-37937" status="OLD"> <orgName>Interactions hôtes-agents pathogènes [Toulouse]</orgName>
<orgName type="acronym">IHAP</orgName>
<date type="end">2019-12-31</date>
<desc> <address> <addrLine>23, Chemin des Capelles 31076 Toulouse cedex</addrLine>
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</address>
<ref type="url">http://www.envt.fr/node/78</ref>
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<tutelles><tutelle name="UMR1225" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD"> <orgName>Institut National de la Recherche Agronomique</orgName>
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<date type="start">1946-05-18</date>
<date type="end">2019-12-31</date>
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</address>
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</desc>
</org>
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<tutelle active="#struct-300421" type="direct"><org type="regrouplaboratory" xml:id="struct-300421" status="VALID"> <orgName>Ecole Nationale Vétérinaire de Toulouse</orgName>
<orgName type="acronym">ENVT</orgName>
<desc> <address> <addrLine>23 chemin des Capelles 31076 Toulouse Cedex</addrLine>
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</address>
<ref type="url">http://www.cge.asso.fr/ecoles/ECOLE103.phtml</ref>
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<idno type="ISNI">0000000121766169</idno>
<orgName>Institut National Polytechnique (Toulouse)</orgName>
<orgName type="acronym">Toulouse INP</orgName>
<desc> <address> <country key="FR"></country>
</address>
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<tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName>
<desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1186/1743-422X-10-11</idno>
<series><title level="j">Virology Journal</title>
<idno type="ISSN">1743-422X</idno>
<imprint><date type="datePub">2013</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Uganda</term>
<term>epidemic</term>
<term>evolutionary pattern</term>
<term>genetic analysis</term>
<term>genome</term>
<term>hemagglutinin gene</term>
<term>lineage</term>
<term>multiple genotype</term>
<term>origin</term>
</keywords>
<keywords scheme="mix" xml:lang="fr"><term>Influenza B</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ouganda</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>ABSTRACT: BACKGROUND: Influenza B viruses can cause morbidity and mortality in humans but due to the lack of an animal reservoir are not associated with pandemics. Because of this, there is relatively limited genetic sequence available for influenza B viruses, especially from developing countries. Complete genome analysis of one influenza B virus and several gene segments of other influenza B viruses isolated from Uganda from May 2009 through December 2010 was therefore undertaken in this study. METHODS: Samples were collected from patients showing influenza like illness and screened for influenza A and B by PCR. Influenza B viruses isolated on Madin-Darby Canine Kidney cells and selected isolates were subsequently sequenced and analyzed phylogenetically. FINDINGS: Of the 2,089 samples collected during the period, 292 were positive by PCR for influenza A or B; 12.3% of the PCR positives were influenza B. Thirty influenza B viruses were recovered and of these 25 that grew well consistently on subculture were subjected to further analysis. All the isolates belonged to the B/Victoria-lineage as identified by hemagglutination inhibition assay and genetic analysis except one isolate that grouped with the B-Yamagata-lineage. The Ugandan B/Victoria-lineage isolates grouped in clade 1 which was defined by the N75K, N165K and S172P substitutions in hemagglutinin protein clustered together with the B/Brisbane/60/2008 vaccine strain. The Yamagata-like Ugandan strain, B/Uganda/MUWRP-053/2009, clustered with clade 3 Yamagata viruses such as B/Bangladesh/3333/2007 which is characterized by S150I and N166Y substitutions in HA. CONCLUSION: In general there was limited variation among the Ugandan isolates but they were interestingly closer to viruses from West and North Africa than from neighboring Kenya. Our isolates closely matched the World Health Organization recommended vaccines for the seasons.</p>
</div>
</front>
</TEI>
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