Safety and Immunogenicity of a Vero Cell Culture-Derived Whole-Virus Influenza A(H5N1) Vaccine in a Pediatric Population
Identifieur interne : 001025 ( Main/Curation ); précédent : 001024; suivant : 001026Safety and Immunogenicity of a Vero Cell Culture-Derived Whole-Virus Influenza A(H5N1) Vaccine in a Pediatric Population
Auteurs : Maikel V. W. Van Der Velden [Autriche] ; Richard Fritz [Autriche] ; Eva Maria Pöllabauer [Autriche] ; Daniel Portsmouth [Autriche] ; M. Keith Howard [Autriche] ; Thomas R. Kreil [Autriche] ; Thomas Dvorak [Autriche] ; Sandor Fritsch [Autriche] ; Timo Vesikari [Finlande] ; Javier Diez-Domingo [Espagne] ; Peter Richmond [Australie] ; BEE WAH LEE [Singapour] ; Otfried Kistner [Autriche] ; Hartmut J. Ehrlich [Autriche] ; P. Noel Barrett [Autriche] ; Gerald Aichinger [Autriche]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
Abstract
Background. Children are highly vulnerable to infection with novel influenza viruses. It is essential to develop candidate pandemic influenza vaccines that are safe and effective in the pediatric population. Methods. Infants and children aged 6-35 months and 3-8 years, respectively, were randomized to receive 2 immunizations with a 7.5-μg or 3.75-μg hemagglutinin (HA) dose of a nonadjuvanted whole-virus A/Vietnam(H5N1) vaccine; adolescents aged 9-17 years received a 7.5-μg dose only. A subset of participants received a booster immunization with an A/Indonesia(H5N1) vaccine approximately 1 year later. HA and neuraminidase antibody responses were assessed. Results. Vaccination was safe and well tolerated; adverse reactions were transient and predominantly mild. Two immunizations with the 7.5-μg dose of A/Vietnam vaccine induced virus microneutralization (MN) titers of ≥1:20 against the A/Vietnam strain in 68.8%-85.4% of participants in the different age groups. After the booster, 93.1%-100% of participants achieved MN titers of ≥ 1:20 against the A/Vietnam and A/Indonesia strains. Neuraminidase-inhibiting antibodies were induced in ≥90% of participants after 2 immunizations with the 7.5 μg A/Vietnam vaccine and in 100% of participants after the booster. Conclusions. A whole-virus influenza A(H5N1) vaccine is suitable for prepandemic or pandemic immunization in a pediatric population. Clinical Trials Registration. NCT01052402.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000157
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :001C61
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000032
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001033
Links to Exploration step
Pascal:14-0047758Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Safety and Immunogenicity of a Vero Cell Culture-Derived Whole-Virus Influenza A(H5N1) Vaccine in a Pediatric Population</title>
<author><name sortKey="Van Der Velden, Maikel V W" sort="Van Der Velden, Maikel V W" uniqKey="Van Der Velden M" first="Maikel V. W." last="Van Der Velden">Maikel V. W. Van Der Velden</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fritz, Richard" sort="Fritz, Richard" uniqKey="Fritz R" first="Richard" last="Fritz">Richard Fritz</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pollabauer, Eva Maria" sort="Pollabauer, Eva Maria" uniqKey="Pollabauer E" first="Eva Maria" last="Pöllabauer">Eva Maria Pöllabauer</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Portsmouth, Daniel" sort="Portsmouth, Daniel" uniqKey="Portsmouth D" first="Daniel" last="Portsmouth">Daniel Portsmouth</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Howard, M Keith" sort="Howard, M Keith" uniqKey="Howard M" first="M. Keith" last="Howard">M. Keith Howard</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kreil, Thomas R" sort="Kreil, Thomas R" uniqKey="Kreil T" first="Thomas R." last="Kreil">Thomas R. Kreil</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dvorak, Thomas" sort="Dvorak, Thomas" uniqKey="Dvorak T" first="Thomas" last="Dvorak">Thomas Dvorak</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Global Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fritsch, Sandor" sort="Fritsch, Sandor" uniqKey="Fritsch S" first="Sandor" last="Fritsch">Sandor Fritsch</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Global Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vesikari, Timo" sort="Vesikari, Timo" uniqKey="Vesikari T" first="Timo" last="Vesikari">Timo Vesikari</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University of Tampere Medical School</s1>
<s3>FIN</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>University of Tampere Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diez Domingo, Javier" sort="Diez Domingo, Javier" uniqKey="Diez Domingo J" first="Javier" last="Diez-Domingo">Javier Diez-Domingo</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centro Superior de Investigación en Salud Pública</s1>
<s2>Valencia</s2>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centro Superior de Investigación en Salud Pública</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Richmond, Peter" sort="Richmond, Peter" uniqKey="Richmond P" first="Peter" last="Richmond">Peter Richmond</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University of Western Australia School of Paediatrics and Child Health</s1>
<s2>Subiaco</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>University of Western Australia School of Paediatrics and Child Health</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Vaccine Trials Group, Telethon Institute for Child Health Research</s1>
<s2>Subiaco</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Subiaco</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Princess Margaret Hospital for Children</s1>
<s2>Subiaco</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Princess Margaret Hospital for Children</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bee Wah Lee" sort="Bee Wah Lee" uniqKey="Bee Wah Lee" last="Bee Wah Lee">BEE WAH LEE</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Child and Allergy Clinic, Mount Elizabeth Medical Centre</s1>
<s3>SGP</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>The Child and Allergy Clinic, Mount Elizabeth Medical Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kistner, Otfried" sort="Kistner, Otfried" uniqKey="Kistner O" first="Otfried" last="Kistner">Otfried Kistner</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ehrlich, Hartmut J" sort="Ehrlich, Hartmut J" uniqKey="Ehrlich H" first="Hartmut J." last="Ehrlich">Hartmut J. Ehrlich</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Global Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barrett, P Noel" sort="Barrett, P Noel" uniqKey="Barrett P" first="P. Noel" last="Barrett">P. Noel Barrett</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aichinger, Gerald" sort="Aichinger, Gerald" uniqKey="Aichinger G" first="Gerald" last="Aichinger">Gerald Aichinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0047758</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 14-0047758 INIST</idno>
<idno type="RBID">Pascal:14-0047758</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000157</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001C61</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000032</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000032</idno>
<idno type="wicri:doubleKey">0022-1899:2014:Van Der Velden M:safety:and:immunogenicity</idno>
<idno type="wicri:Area/Main/Merge">001033</idno>
<idno type="wicri:Area/Main/Curation">001025</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Safety and Immunogenicity of a Vero Cell Culture-Derived Whole-Virus Influenza A(H5N1) Vaccine in a Pediatric Population</title>
<author><name sortKey="Van Der Velden, Maikel V W" sort="Van Der Velden, Maikel V W" uniqKey="Van Der Velden M" first="Maikel V. W." last="Van Der Velden">Maikel V. W. Van Der Velden</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fritz, Richard" sort="Fritz, Richard" uniqKey="Fritz R" first="Richard" last="Fritz">Richard Fritz</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pollabauer, Eva Maria" sort="Pollabauer, Eva Maria" uniqKey="Pollabauer E" first="Eva Maria" last="Pöllabauer">Eva Maria Pöllabauer</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Portsmouth, Daniel" sort="Portsmouth, Daniel" uniqKey="Portsmouth D" first="Daniel" last="Portsmouth">Daniel Portsmouth</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Howard, M Keith" sort="Howard, M Keith" uniqKey="Howard M" first="M. Keith" last="Howard">M. Keith Howard</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kreil, Thomas R" sort="Kreil, Thomas R" uniqKey="Kreil T" first="Thomas R." last="Kreil">Thomas R. Kreil</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dvorak, Thomas" sort="Dvorak, Thomas" uniqKey="Dvorak T" first="Thomas" last="Dvorak">Thomas Dvorak</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Global Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fritsch, Sandor" sort="Fritsch, Sandor" uniqKey="Fritsch S" first="Sandor" last="Fritsch">Sandor Fritsch</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Global Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vesikari, Timo" sort="Vesikari, Timo" uniqKey="Vesikari T" first="Timo" last="Vesikari">Timo Vesikari</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University of Tampere Medical School</s1>
<s3>FIN</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>University of Tampere Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diez Domingo, Javier" sort="Diez Domingo, Javier" uniqKey="Diez Domingo J" first="Javier" last="Diez-Domingo">Javier Diez-Domingo</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centro Superior de Investigación en Salud Pública</s1>
<s2>Valencia</s2>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centro Superior de Investigación en Salud Pública</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Richmond, Peter" sort="Richmond, Peter" uniqKey="Richmond P" first="Peter" last="Richmond">Peter Richmond</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University of Western Australia School of Paediatrics and Child Health</s1>
<s2>Subiaco</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>University of Western Australia School of Paediatrics and Child Health</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Vaccine Trials Group, Telethon Institute for Child Health Research</s1>
<s2>Subiaco</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Subiaco</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Princess Margaret Hospital for Children</s1>
<s2>Subiaco</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Princess Margaret Hospital for Children</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bee Wah Lee" sort="Bee Wah Lee" uniqKey="Bee Wah Lee" last="Bee Wah Lee">BEE WAH LEE</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Child and Allergy Clinic, Mount Elizabeth Medical Centre</s1>
<s3>SGP</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>The Child and Allergy Clinic, Mount Elizabeth Medical Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kistner, Otfried" sort="Kistner, Otfried" uniqKey="Kistner O" first="Otfried" last="Kistner">Otfried Kistner</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ehrlich, Hartmut J" sort="Ehrlich, Hartmut J" uniqKey="Ehrlich H" first="Hartmut J." last="Ehrlich">Hartmut J. Ehrlich</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Global Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barrett, P Noel" sort="Barrett, P Noel" uniqKey="Barrett P" first="P. Noel" last="Barrett">P. Noel Barrett</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Orth/Donau</s2>
<s3>AUT</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Orth/Donau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aichinger, Gerald" sort="Aichinger, Gerald" uniqKey="Aichinger G" first="Gerald" last="Aichinger">Gerald Aichinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Vaccine Research and Development, Baxter BioScience</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell culture</term>
<term>Immunogenicity</term>
<term>Infection</term>
<term>Influenzavirus A(H5N1)</term>
<term>Vaccine</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Immunogénicité</term>
<term>Culture cellulaire</term>
<term>Vaccin</term>
<term>Infection</term>
<term>Virus grippal A(H5N1)</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. Children are highly vulnerable to infection with novel influenza viruses. It is essential to develop candidate pandemic influenza vaccines that are safe and effective in the pediatric population. Methods. Infants and children aged 6-35 months and 3-8 years, respectively, were randomized to receive 2 immunizations with a 7.5-μg or 3.75-μg hemagglutinin (HA) dose of a nonadjuvanted whole-virus A/Vietnam(H5N1) vaccine; adolescents aged 9-17 years received a 7.5-μg dose only. A subset of participants received a booster immunization with an A/Indonesia(H5N1) vaccine approximately 1 year later. HA and neuraminidase antibody responses were assessed. Results. Vaccination was safe and well tolerated; adverse reactions were transient and predominantly mild. Two immunizations with the 7.5-μg dose of A/Vietnam vaccine induced virus microneutralization (MN) titers of ≥1:20 against the A/Vietnam strain in 68.8%-85.4% of participants in the different age groups. After the booster, 93.1%-100% of participants achieved MN titers of ≥ 1:20 against the A/Vietnam and A/Indonesia strains. Neuraminidase-inhibiting antibodies were induced in ≥90% of participants after 2 immunizations with the 7.5 μg A/Vietnam vaccine and in 100% of participants after the booster. Conclusions. A whole-virus influenza A(H5N1) vaccine is suitable for prepandemic or pandemic immunization in a pediatric population. Clinical Trials Registration. NCT01052402.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001025 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001025 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Main |étape= Curation |type= RBID |clé= Pascal:14-0047758 |texte= Safety and Immunogenicity of a Vero Cell Culture-Derived Whole-Virus Influenza A(H5N1) Vaccine in a Pediatric Population }}
This area was generated with Dilib version V0.6.34. |